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Research Output 1979 2019

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2019

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A

DeKAF Genomics and GEN03 Investigators, Aug 1 2019, In : Transplantation. 103, 8, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Single Nucleotide Polymorphism
Allografts
Kidney
African Americans
1 Citation (Scopus)

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Birnbaum, A. K., Karanam, A., Marino, S. E., Barkley, C. M., Remmel, R. P., Roslawski, M., Gramling-Aden, M. & Leppik, I. E., Jan 1 2019, In : Epilepsia. 60, 8, p. 1586-1592 7 p.

Research output: Contribution to journalArticle

Cannabidiol
Capsules
Epilepsy
Pharmacokinetics
Food

Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies

DeKAF Genomics and GEN-03 Investigators, Jun 1 2019, In : Transplantation. 103, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Tacrolimus
Immunosuppressive Agents
Genomics
Pharmacokinetics
1 Citation (Scopus)
Tacrolimus
African Americans
Phenotype
Kidney
Genomics
1 Citation (Scopus)
Cannabidiol
Cannabinoids
Tandem Mass Spectrometry
Liquid Chromatography
Epilepsy

Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups

the DeKAF Genomics and GEN03 Investigators, Jan 1 2019, In : American Journal of Transplantation.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Tacrolimus
North American Indians
Kidney
African Americans
2018
3 Citations (Scopus)

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients

Oetting, W. S., Wu, B., Schladt, D. P., Guan, W., Remmel, R. P., Dorr, C., Mannon, R. B., Matas, A. J., Israni, A. K. & Jacobson, P. A., Feb 1 2018, In : Pharmacogenomics. 19, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

Tacrolimus
Cytochrome P-450 CYP3A
Single Nucleotide Polymorphism
Allografts
Kidney
8 Citations (Scopus)
Cytochrome P-450 CYP3A
Genome-Wide Association Study
Tacrolimus
Kidney
Gene Frequency
2 Citations (Scopus)

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Polepally, A. R., Brundage, R., Remmel, R. P., Leppik, I. E., Pennell, P. B., White, J. R., Ramsay, R. E., Kistner, B. M. & Birnbaum, A. K., Sep 1 2018, In : Epilepsia. 59, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Intravenous Administration
Young Adult
Epilepsy
Pharmacokinetics
Biological Availability
2 Citations (Scopus)

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination

Scheibner, A., Remmel, R. P., Schladt, D., Oetting, W. S., Guan, W., Wu, B., Dorr, C., Israni, A. & Jacobson, P. A., Jul 1 2018, In : Pharmacotherapy. 38, 7, p. e46-e52

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Tacrolimus
Genotype
Kidney
1 Citation (Scopus)
Cytochrome P-450 CYP3A
Graft Rejection
Tacrolimus
African Americans
Genotype
2 Citations (Scopus)

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

Wu, J. F., Muthusamy, A., Al-Ghalith, G. A., Knights, D., Guo, B., Wu, B., Remmel, R. P., Schladt, D. P., Alegre, M. L., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Dec 1 2018, In : Clinical Transplantation. 32, 12, e13436.

Research output: Contribution to journalArticle

Microbiota
Allografts
Kidney
Corynebacterium
Transplant Recipients
2017
10 Citations (Scopus)

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Cytochrome P-450 CYP3A
Midazolam
Tacrolimus
Hepatocytes
24 Citations (Scopus)

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

Sanghavi, K., Brundage, R. C., Miller, M. B., Schladt, D. P., Israni, A. K., Guan, W., Oetting, W. S., Mannon, R. B., Remmel, R. P., Matas, A. J. & Jacobson, P. A., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Tacrolimus
African Americans
Genotype
Kidney
Cytochrome P-450 CYP3A
2016
35 Citations (Scopus)

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles

Oetting, W. S., Schladt, D. P., Guan, W., Miller, M. B., Remmel, R. P., Dorr, C., Sanghavi, K., Mannon, R. B., Herrera, B., Matas, A. J., Salomon, D. R., Kwok, P. Y., Keating, B. J., Israni, A. K. & Jacobson, P. A., Feb 1 2016, In : American Journal of Transplantation. 16, 2, p. 574-582 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Tacrolimus
African Americans
Alleles
Kidney
10 Citations (Scopus)

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis

Dawadi, S., Kawamura, S., Rubenstein, A., Remmel, R. P. & Aldrich, C., Mar 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 6, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Prodrugs
Mycobacterium tuberculosis
Nucleosides
2015
21 Citations (Scopus)

Multigene predictors of tacrolimus exposure in kidney transplant recipients

Pulk, R. A., Schladt, D. S., Oetting, W. S., Guan, W., Israni, A. K., Matas, A. J., Remmel, R. P. & Jacobson, P. A., Jul 1 2015, In : Pharmacogenomics. 16, 8, p. 841-854 14 p.

Research output: Contribution to journalArticle

Tacrolimus
Kidney
Haplotypes
Alleles
Cytochrome P-450 CYP3A
7 Citations (Scopus)
Isotopes
Biological Availability
Epilepsy
Pharmacokinetics
lamotrigine
2014
5 Citations (Scopus)
Pharmacokinetics
Liver Microsomes
Metabolism
Liver
Swine
5 Citations (Scopus)

Safety of an intravenous formulation of lamotrigine

Conway, J. M., Birnbaum, A. K., Leppik, I. E., Pennell, P. B., White, J. R., Rarick, J. O. & Remmel, R. P., Jan 1 2014, In : Seizure. 23, 5, p. 390-392 3 p.

Research output: Contribution to journalArticle

Safety
Epilepsy
Pharmacokinetics
Cyclodextrins
Exanthema
2013
46 Citations (Scopus)
Carbamazepine
Epilepsy
Pharmacokinetics
Single Nucleotide Polymorphism
Cytochrome P-450 CYP3A
18 Citations (Scopus)

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats

Jones, J. M., Raleigh, M. D., Pentel, P. R., Harmon, T. M., Keyler, D. E., Remmel, R. P. & Birnbaum, A. K., Feb 3 2013, In : Journal of Pharmaceutical and Biomedical Analysis. 74, p. 291-297 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Heroin
Morphine
Rats
Assays
13 Citations (Scopus)

Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis

Teitelbaum, A. M., Meissner, A., Harding, R. A., Wong, C. A., Aldrich, C. & Remmel, R. P., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5605-5617 13 p.

Research output: Contribution to journalArticle

meropenem
Multidrug-Resistant Tuberculosis
Plasma stability
Prodrugs
Pharmaceutical Preparations
2012
10 Citations (Scopus)

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, A. M., Gallardo, J. L., Bedi, J., Giri, R., Benoit, A. R., Olin, M. R., Morizio, K. M., Ohlfest, J. R., Remmel, R. P. & Ferguson, D. M., Jun 1 2012, In : Cancer chemotherapy and pharmacology. 69, 6, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

Acridines
Pharmacokinetics
Glioma
Brain
Biological Availability
8 Citations (Scopus)
Plasmas
Assays
Pharmacokinetics
Solid Phase Extraction
Migraine Disorders
2011
53 Citations (Scopus)
Bilirubin
Estradiol
irinotecan
Inhibitory Concentration 50
UGT1A1 enzyme
4 Citations (Scopus)
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Hemorrhagic Shock
Swine
Pharmacokinetics
4 Citations (Scopus)
Phenytoin
Isotopes
Biological Availability
Epilepsy
Anticonvulsants
22 Citations (Scopus)

Functional analysis of UGT1A4 P24T and UGT1A4 L48V variant enzymes

Zhou, J., Argikar, U. A. & Remmel, R. P., Dec 1 2011, In : Pharmacogenomics. 12, 12, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Tamoxifen
Enzymes
bilirubin glucuronoside glucuronosyltransferase
HEK293 Cells
2010
21 Citations (Scopus)

Bilirubin glucuronidation revisited: Proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1

Zhou, J., Tracy, T. S. & Remmel, R. P., Nov 1 2010, In : Drug Metabolism and Disposition. 38, 11, p. 1907-1911 5 p.

Research output: Contribution to journalArticle

Bilirubin
Enzymes
Kernicterus
Glucuronic Acid
Proteins
35 Citations (Scopus)

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose

Chaudhry, A. S., Urban, T. J., Lamba, J. K., Birnbaum, A. K., Remmel, R. P., Subramanian, M., Strom, S., You, J. H., Kasperaviciute, D., Catarino, C. B., Radtke, R. A., Sisodiya, S. M., Goldstein, D. B. & Schuetz, E. G., Feb 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 2, p. 599-611 13 p.

Research output: Contribution to journalArticle

Phenytoin
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Yin-Yang
Linkage Disequilibrium
6 Citations (Scopus)

Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jan 1 2010, In : Cells Tissues Organs. 191, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Nanofibers
Hepatocytes
Gene Expression
Laminin
Plastics
45 Citations (Scopus)
bilirubin glucuronoside glucuronosyltransferase
Glucuronosyltransferase
Dihydrotestosterone
Tamoxifen
Androsterone
32 Citations (Scopus)

Inhibitors of the salicylate synthase (Mbti) from Mycobacterium tuberculosis discovered by high-throughput screening

Vasan, M., Neres, J., Williams, J., Wilson, D., Teitelbaum, A. M., Remmel, R. P. & Aldrich, C., Dec 3 2010, In : ChemMedChem. 5, 12, p. 2079-2087 9 p.

Research output: Contribution to journalArticle

Thiones
Salicylates
Biosynthesis
Mycobacterium tuberculosis
Assays
2009
89 Citations (Scopus)
Valproic Acid
Liver Microsomes
Glucuronosyltransferase
Glucuronides
Anticonvulsants
102 Citations (Scopus)

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Khan, H., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jun 24 2009, In : Hepatology. 49, 2, p. 578-586 9 p.

Research output: Contribution to journalArticle

Hepatocytes
Gene Expression
Artificial Liver
Liver
Bile Canaliculi
9 Citations (Scopus)

Studies on induction of lamotrigine metabolism in transgenic UGT1 mice Lamotrigine metabolism in transgenic UGT1 mice

Argikar, U. A., Senekeo-Effenberger, K., Larson, E. E., Tukey, R. H. & Remmel, R. P., Nov 1 2009, In : Xenobiotica. 39, 11, p. 826-835 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolism
Transgenic Mice
Animals
Phenobarbital
34 Citations (Scopus)

Variation in glucuronidation of lamotrigine in human liver microsomes

Argikar, U. A. & Remmel, R. P., Nov 9 2009, In : Xenobiotica. 39, 5, p. 355-363 9 p.

Research output: Contribution to journalArticle

Liver Microsomes
Liver
Uridine
Tissue Donors
Lorazepam
2008
86 Citations (Scopus)

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

Goodell, J. R., Ougolkov, A. V., Hiasa, H., Kaur, H., Remmel, R. P., Billadeau, D. D. & Ferguson, D. M., Jan 24 2008, In : Journal of Medicinal Chemistry. 51, 2, p. 179-182 4 p.

Research output: Contribution to journalArticle

Acridines
Type II DNA Topoisomerase
Pancreatic Neoplasms
Aminacrine
Cell Proliferation
45 Citations (Scopus)

Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation

Johnson, LA. A., Orchard, P. J., Baker, K. S., Brundage, R., Cao, Q., Wang, X., Langer, E. K., Farag-El Maasah, S., Ross, J. A., Remmel, R. P. & Jacobson, P. A., Sep 1 2008, In : Journal of Clinical Pharmacology. 48, 9, p. 1052-1062 11 p.

Research output: Contribution to journalArticle

Busulfan
Cell Transplantation
Glutathione Transferase
Pharmacokinetics
Genotype
77 Citations (Scopus)

High-speed simultaneous determination of nine antiepileptic drugs using liquid chromatography-mass spectrometry

Subramanian, M., Birnbaum, A. K. & Remmel, R. P., Jun 1 2008, In : Therapeutic Drug Monitoring. 30, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

Liquid chromatography
Liquid Chromatography
Anticonvulsants
Mass spectrometry
Mass Spectrometry
2007
52 Citations (Scopus)

A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment

Schifitto, G., Zhang, J., Evans, S. R., Sacktor, N., Simpson, D., Millar, L. L., Hung, V. L., Miller, E. N., Smith, E., Ellis, R. J., Valcour, V., Singer, E., Marra, C. M., Kolson, D., Weihe, J., Remmel, R. P., Katzenstein, D., Clifford, D. B., Nuffer, K., Cahill, S. & 26 others, Burgess, D., Carter, K., Shoemaker, M., Weisbeck, A., Hanks, N., Watters, M., Chafey, S. A., Dunaway, S., Perrin, M., Quinn, J., Venna, N., Flynn, T., Spitz, T., Gould, M., Cohen, B., Reisberg, L., Diaz-Arrastia, R., Lohner, C., Marder, K., Clouse, R., Mildvan, D., Bailey, J., Tashima, K., Sousa, H., Currin, D. & Pedersen, S., Jan 1 2007, In : Neurology. 69, 13, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

Selegiline
Multicenter Studies
HIV
Placebos
AIDS Dementia Complex
88 Citations (Scopus)

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation

Senekeo-Effenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M. F., Argikar, U., Kaeding, J., Trottier, J., Remmel, R. P., Ritter, J. K., Barbier, O. & Tukey, R. H., Mar 1 2007, In : Drug Metabolism and Disposition. 35, 3, p. 419-427 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolism
Transgenic Mice
Chemical activation
Liver
2 Citations (Scopus)

Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension

Clemens, P. L., Cloyd, J. C., Kriel, R. L. & Remmel, R. P., Mar 23 2007, In : Clinical Drug Investigation. 27, 4, p. 243-250 8 p.

Research output: Contribution to journalArticle

Biological Availability
Suspensions
Rectal Administration
Oral Administration
Urine
22 Citations (Scopus)
Dextromethorphan
Flurbiprofen
Midazolam
Metabolites
Cytochrome P-450 Enzyme System
2006
12 Citations (Scopus)
gemcitabine
Bioreactors
Cell Culture Techniques
Pharmaceutical Preparations
S Phase
5 Citations (Scopus)
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Plasmas
Assays
45 Citations (Scopus)
gemcitabine
Tissue culture
Culture Media
Plasmas
Liquids
40 Citations (Scopus)

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG

Otteneder, M. B., Knutson, C. G., Daniels, J. S., Hashim, M., Crews, B. C., Remmel, R. P., Wang, H., Rizzo, C. & Marnett, L. J., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6665-6669 5 p.

Research output: Contribution to journalArticle

DNA Adducts
Cytosol
DNA Damage
DNA
Oxidative Stress
18 Citations (Scopus)

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients

Argikar, U. A., Cloyd, J. C., Birnbaum, A. K., Leppik, I. E., Conway, J. M., Kshirsagar, S., Oetting, W. S., Klein, E. C. & Remmel, R. P., Sep 1 2006, In : Epilepsy Research. 71, 1, p. 54-63 10 p.

Research output: Contribution to journalArticle

Phenytoin
Urine
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2C19
Urine Specimen Collection