1979 …2020
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Research Output 1979 2019

1996
12 Citations (Scopus)

Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit

Nyberg, S. L., Mann, H. J., Hu, M. Y., Payne, W. D., Hu, W-S., Cerra, F. B. & Remmel, R. P., Jun 1 1996, In : Drug Metabolism and Disposition. 24, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

Hymecromone
Lidocaine
Metabolism
Rabbits
Metabolites
48 Citations (Scopus)

Hollow fiber bioartificial liver utilizing collagen-entrapped porcine hepatocyte spheroids

Wu, F. J., Friend, J. R., Lazar, A., Mann, H. J., Remmel, R. P., Cerra, F. B. & Hu, W-S., Oct 5 1996, In : Biotechnology and bioengineering. 52, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Artificial Liver
Collagen
Liver
Hepatocytes
Swine
67 Citations (Scopus)

Reactivity of mefenamic acid 1-O-acyl glucuronide with proteins in vitro and ex vivo

McGurk, K. A., Remmel, R. P., Hosagrahara, V. P., Tosh, D. & Burchell, B., Aug 1 1996, In : Drug Metabolism and Disposition. 24, 8, p. 842-849 8 p.

Research output: Contribution to journalArticle

Mefenamic Acid
Glucuronides
Pharmaceutical Preparations
Interstitial Nephritis
Glucuronosyltransferase
1995
56 Citations (Scopus)

A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture

Sielaff, T. D., Hu, M. Y., Rao, S., Groehler, K., Olson, D., Mann, H. J., Remmel, R. P., Shatford, R. A. D., Amiot, B., Hu, W-S. & Cerra, F. B., Jan 1 1995, In : Transplantation. 59, 10, p. 1459-1463 5 p.

Research output: Contribution to journalArticle

Hepatocytes
Swine
Artificial Liver
Hymecromone
Equipment and Supplies
11 Citations (Scopus)
carbovir
Intravenous Infusions
Rats
Brain
Tissue
15 Citations (Scopus)

Effects of hepatocyte growth factor on viability and biotransformation functions of hepatocytes in gel entrapped and monolayer culture

Hu, M. Y., Cipolle, M., Sielaff, T., Lovdahl, M. J., Mann, H. J., Remmel, R. P. & Cerra, F. B., Jul 26 1995, In : Critical care medicine. 23, 7, p. 1237-1242 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Biotransformation
Hepatocytes
Gels
Collagen Type I
85 Citations (Scopus)

Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel

Lazar, A., Mann, H. J., Remmel, R. P., Shatford, R. A., Cerra, F. B. & Hu, W. S., May 1 1995, In : In Vitro Cellular & Developmental Biology - Animal. 31, 5, p. 340-346 7 p.

Research output: Contribution to journalArticle

Liver
Hepatocytes
Swine
Collagen
Gels
1994
5 Citations (Scopus)

Determination of 4-Methyl Umbelliferone and Metabolites in Williams E Media and Dog Plasma by High Performance Liquid Chromatography

Lovdahl, M. J., Reher, K. E., Mann, H. J. & Remmel, R. P., Apr 1 1994, In : Journal of Liquid Chromatography. 17, 8, p. 1795-1809 15 p.

Research output: Contribution to journalArticle

7-hydroxycoumarin
High performance liquid chromatography
Metabolites
High Pressure Liquid Chromatography
Dogs
183 Citations (Scopus)

Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver

Nyberg, S. L., Remmel, R. P., Mann, H. J., Peshwa, M. V., Hu, W-S. & Cerra, F. B., Jul 1 1994, In : Annals of Surgery. 220, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Artificial Liver
Hep G2 Cells
Biotransformation
Hepatocytes
Liver
42 Citations (Scopus)

The effect of felbamate on valproic acid disposition

Wagner, M. L., Graves, N. M., Leppik, I. E., Remmel, R. P., Shumaker, R. C., Ward, D. L. & Perhach, J. L., Jan 1 1994, In : Clinical Pharmacology & Therapeutics. 56, 5, p. 494-502 9 p.

Research output: Contribution to journalArticle

felbamate
Valproic Acid
Clinical Pharmacology
Protein Binding
Anticonvulsants
1993
22 Citations (Scopus)

Demonstration of biochemical function by extracorporeal xenohepatocytes in an anhepatic animal model

Nyberg, S. L., Payne, W. D., Amiot, B., Shirabe, K., Remmel, R. P., Hu, W-S. & Cerra, F. B., Jan 1 1993, In : Transplantation proceedings. 25, 2, p. 1944-1945 2 p.

Research output: Contribution to journalArticle

Lactates
Artificial Organs
Heterologous Transplantation
Hepatectomy
Ammonia
51 Citations (Scopus)

Effect of felbamate on carbamazepine and its major metabolites

Wagner, M. L., Remmel, R. P., Graves, N. M. & Leppik, I. E., Jan 1 1993, In : Clinical Pharmacology & Therapeutics. 53, 5, p. 536-543 8 p.

Research output: Contribution to journalArticle

felbamate
Epoxy Compounds
Carbamazepine
Placebos
Clinical Pharmacology
79 Citations (Scopus)

Extracorporeal application of a gel-entrapment, bioartificial liver: Demonstration of drug metabolism and other biochemical functions

Nyberg, S. L., Shirabe, K., Peshwa, M. V., Sielaff, T. D., Crotty, P. L., Mann, H. J., Remmel, R. P., Payne, W. D., Hu, W-S. & Cerra, F. B., Jan 1 1993, In : Cell transplantation. 2, 6, p. 441-452 12 p.

Research output: Contribution to journalArticle

Artificial Liver
Metabolism
Liver
Hepatocytes
Demonstrations
5 Citations (Scopus)

Glucuronidation as a transient intermediate metabolic step in the elimination of (-)-carbovir: Identification of (-)-carbovir-5'-O-glucuronide in rat bile

Zimmerman, C. L., Iyer, K. R., Faudskar, A. L. & Remmel, R. P., Jan 1 1993, In : Drug Metabolism and Disposition. 21, 5, p. 902-910 9 p.

Research output: Contribution to journalArticle

carbovir
Bile
Glucuronides
Radioactivity
Bile Ducts
115 Citations (Scopus)

Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol

Ebner, T., Remmel, R. P. & Burchell, B., Jan 1 1993, In : Molecular Pharmacology. 43, 4, p. 649-654 6 p.

Research output: Contribution to journalArticle

bilirubin glucuronoside glucuronosyltransferase
Ethinyl Estradiol
Glucuronides
Glucuronosyltransferase
Liver Microsomes
32 Citations (Scopus)

Pharmacokinetic analysis verifies P450 function during in vitro and in vivo application of a bioartificial liver

Nyberg, S. L., Mann, H. J., Remmel, R. P., Hu, W. S. & Cerra, F. B., Jan 1 1993, In : ASAIO Journal. 39, 3

Research output: Contribution to journalArticle

Artificial Liver
Pharmacokinetics
Lidocaine
Liver
Hepatocytes
60 Citations (Scopus)
Drug interactions
Recombinant Proteins
Metabolism
Catalysis
Animals
1992
37 Citations (Scopus)

Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference

Cloyd, J. C., Kriel, R. L., Jones-Saete, C. M., Ong, B. Y., Jancik, J. T. & Remmel, R. P., Jan 1 1992, In : The Journal of pediatrics. 120, 4 PART 1, p. 634-638 5 p.

Research output: Contribution to journalArticle

Valproic Acid
Biological Availability
Parents
Patient Preference
Cross-Over Studies
12 Citations (Scopus)

Pharmacokinetic evaluation of (-)-6-aminocarbovir as a prodrug for (-)-carbovir in rats

Zimmerman, C. L., Remmel, R. P., Ibrahim, S. S., Beers, S. A. & Vince, R., Jan 1 1992, In : Drug Metabolism and Disposition. 20, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

carbovir
Prodrugs
Biological Availability
Pharmacokinetics
Urine
1991
38 Citations (Scopus)
Ion chromatography
Liquid chromatography
Liquid Chromatography
Guinea Pigs
Blood
30 Citations (Scopus)

A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs: In vitro and in vivo studies

Remmel, R. P. & Sinz, M. W., Jun 24 1991, In : Drug Metabolism and Disposition. 19, 3, p. 630-636 7 p.

Research output: Contribution to journalArticle

Glucuronides
Metabolites
Ammonium Compounds
Guinea Pigs
Hepatocytes
61 Citations (Scopus)

Discontinuation of Phenytoin and Carbamazepine in Patients Receiving Felbamate

Wagner, M. L., Graves, N. M., Marienau, K., Holmes, G. B., Remmel, R. P. & Leppik, I. E., Jun 1991, In : Epilepsia. 32, 3, p. 398-406 9 p.

Research output: Contribution to journalArticle

felbamate
Carbamazepine
Phenytoin
52 Citations (Scopus)

Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine

Sinz, M. W. & Remmel, R. P., Mar 1 1991, In : Drug Metabolism and Disposition. 19, 1, p. 149-153 5 p.

Research output: Contribution to journalArticle

Glucuronides
Ammonium Compounds
Triazines
Hydrolysis
Enzymatic hydrolysis
22 Citations (Scopus)

The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the Rat

Huang, S. H., Remmel, R. P. & Zimmerman, C. L., Jan 1 1991, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8, 6, p. 739-743 5 p.

Research output: Contribution to journalArticle

carbovir
Biological Availability
Rats
Blood
Kidney
8 Citations (Scopus)

The effects of hemodilution, pH, and protamine on lidocaine plasma protein binding and red blood-cell uptake in vitro

Remmel, R. P., Copa, A. K. & Angaran, D. M., Jan 29 1991, In : Pharmaceutical Research. 8, 1, p. 127-130 4 p.

Research output: Contribution to journalArticle

pH
Hemodilution
Protamines
Lidocaine
Protein Binding
1990
29 Citations (Scopus)
Metoprolol
Enantiomers
Liquid chromatography
Cellulose
Adrenergic Antagonists
16 Citations (Scopus)
Pharmacokinetics
Carbamazepine
Rats
Protein Binding
Metabolism
35 Citations (Scopus)

Flexible N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Analogues: Synthesis and Monoamine Oxidase Catalyzed Bioactivation

Efange, S. M. N., Michelson, R. H., Remmel, R. P., Boudreau, R. J., Dutta, A. K. & Freshler, A., Jan 1 1990, In : Journal of Medicinal Chemistry. 33, 12, p. 3133-3138 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Monoamine Oxidase
Binding Sites
Enzymes
ethylene
5 Citations (Scopus)

Improved fluorometric high-performance liquid chromatographic assay for (-)-carbovir in rat blood and urine

Remmel, R. P., Huang, S. H., Hoff, D. & Zimmerman, C. L., Jan 1 1990, In : Journal of Chromatography B: Biomedical Sciences and Applications. 534, C, p. 109-118 10 p.

Research output: Contribution to journalArticle

carbovir
Rats
Assays
Blood
Guanosine
47 Citations (Scopus)

Simultaneous assay of felbamate plus carbamazepine, phenytoin, and their metabolites by liquid chromatography with mobile phase optimization

Remmel, R. P., Miller, S. A. & Graves, N. M., Jan 1 1990, In : Therapeutic Drug Monitoring. 12, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

felbamate
Carbamazepine
Phenytoin
Liquid Chromatography
Serum
1989
13 Citations (Scopus)

Absorption of Valproic Acid Suppositories in Human Volunteers

Graves, N. M., Remmel, R. P., Rosenfeld, W. E., Carlson, G. H., Kriel, R. D. & Holmes, G. B., Jan 1 1989, In : Archives of Neurology. 46, 8, p. 906-909 4 p.

Research output: Contribution to journalArticle

Suppositories
Valproic Acid
Volunteers
Serum
Oral Administration
8 Citations (Scopus)

Liquid chromatographic assay of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus

Remmel, R. P., Yeom, Y. H., Hua, M., Vince, R. & Zimmerman, C. L., Jan 1 1989, In : Journal of Chromatography B: Biomedical Sciences and Applications. 489, 2, p. 323-331 9 p.

Research output: Contribution to journalArticle

carbovir
Viruses
Nucleosides
Assays
Blood
20 Citations (Scopus)

Pharmacokinetics and bioavailability of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus, in rats

Yeom, Y. H., Remmel, R. P., Huang, S. H., Hua, M., Vince, R. & Zimmerman, C. L., Jan 1 1989, In : Antimicrobial agents and chemotherapy. 33, 2, p. 171-175 5 p.

Research output: Contribution to journalArticle

carbovir
Nucleosides
Biological Availability
Pharmacokinetics
HIV
1988
31 Citations (Scopus)

Assay of itraconazole in leukemic patient plasma by reversed-phase small-bore liquid chromatography

Remmel, R. P., Dombrovskis, D. & Canafax, D. M., Jan 1 1988, In : Journal of Chromatography B: Biomedical Sciences and Applications. 432, C, p. 388-394 7 p.

Research output: Contribution to journalArticle

Ultraviolet Spectrophotometry
Ketoconazole
Itraconazole
Antifungal Agents
Liquid Chromatography
38 Citations (Scopus)

Biliary excretion of a glutathione conjugate of busulfan and 1,4-diiodobutane in the rat

Marchand, D. H., Remmel, R. P. & Abdel-Monem, M. M., Jan 1 1988, In : Drug Metabolism and Disposition. 16, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Busulfan
Glutathione
Rats
Bile
Metabolites
68 Citations (Scopus)

Felbamate Increases Phenytoin but Decreases Carbamazepine Concentrations

Fuerst, R. H., Graves, N. M., Leppik, I. E., Brundage, R., Holmes, G. B. & Remmel, R. P., Jan 1 1988, In : Epilepsia. 29, 4, p. 488-491 4 p.

Research output: Contribution to journalArticle

felbamate
Carbamazepine
Phenytoin
1987
19 Citations (Scopus)

The disposition and pharmacokinetics of ketoconazole in the rat

Remmel, R. P., Amoh, K. & Abdel-Monem, M. M., Dec 1 1987, In : Drug Metabolism and Disposition. 15, 6, p. 735-739 5 p.

Research output: Contribution to journalArticle

Ketoconazole
Pharmacokinetics
Rats
Radioactivity
Biological Availability
1984
32 Citations (Scopus)

Role of the intestinal microflora in clonazepam metabolism in the rat

Elmer, G. W. & Remmel, R. P., Jan 1 1984, In : Xenobiotica. 14, 11, p. 829-840 12 p.

Research output: Contribution to journalArticle

Clonazepam
Metabolism
Rats
Metabolites
Animals
1983
2 Citations (Scopus)
Clonazepam
Metabolites
Liver
Rats
High Pressure Liquid Chromatography
1981
19 Citations (Scopus)

Influence of the intestinal microflora on the elimination of warfarin in the rat

Remmel, R. P., Pohl, L. R. & Elmer, G. W., Dec 1 1981, In : Drug Metabolism and Disposition. 9, 5, p. 410-414 5 p.

Research output: Contribution to journalArticle

Warfarin
Rats
Radioactivity
Animals
Anti-Bacterial Agents
2 Citations (Scopus)

The effect of broad-spectrum antibiotics on warfarin excretion and metabolism in the rat

Remmel, R. P. & Elmer, G. W., Dec 1 1981, In : Research Communications in Chemical Pathology and Pharmacology. 34, 3, p. 503-514 12 p.

Research output: Contribution to journalArticle

Warfarin
Metabolism
Feces
Rats
Anti-Bacterial Agents
1980

The effect of elimination of the gut flora on warfarin metabolism and excretion in rats

Remmel, R. P. & Elmer, G. W., Jan 1 1980, In : Pharmacologist. 22, 3, 1 p.

Research output: Contribution to journalArticle

Warfarin
Gastrointestinal Microbiome
1979

Gut flora influences on the elimination of warfarin in the rat

Remmel, R. P. & Elmer, G. W., Jan 1 1979, In : Journal of Natural Products. 42, 6, 1 p.

Research output: Contribution to journalArticle

warfarin
intestinal microorganisms
rats