1979 …2020
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Research Output 1979 2019

Article
35 Citations (Scopus)

Flexible N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Analogues: Synthesis and Monoamine Oxidase Catalyzed Bioactivation

Efange, S. M. N., Michelson, R. H., Remmel, R. P., Boudreau, R. J., Dutta, A. K. & Freshler, A., Jan 1 1990, In : Journal of Medicinal Chemistry. 33, 12, p. 3133-3138 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Monoamine Oxidase
Binding Sites
Enzymes
ethylene
2 Citations (Scopus)

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Birnbaum, A. K., Karanam, A., Marino, S. E., Barkley, C. M., Remmel, R. P., Roslawski, M., Gramling-Aden, M. & Leppik, I. E., Jan 1 2019, In : Epilepsia. 60, 8, p. 1586-1592 7 p.

Research output: Contribution to journalArticle

Cannabidiol
Capsules
Epilepsy
Pharmacokinetics
Food
22 Citations (Scopus)

Functional analysis of UGT1A4 P24T and UGT1A4 L48V variant enzymes

Zhou, J., Argikar, U. A. & Remmel, R. P., Dec 1 2011, In : Pharmacogenomics. 12, 12, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Tamoxifen
Enzymes
bilirubin glucuronoside glucuronosyltransferase
HEK293 Cells
6 Citations (Scopus)

Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jan 1 2010, In : Cells Tissues Organs. 191, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Nanofibers
Hepatocytes
Gene Expression
Laminin
Plastics

Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies

DeKAF Genomics and GEN-03 Investigators, Jun 1 2019, In : Transplantation. 103, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Tacrolimus
Immunosuppressive Agents
Genomics
Pharmacokinetics
10 Citations (Scopus)
Cytochrome P-450 CYP3A
Genome-Wide Association Study
Tacrolimus
Kidney
Gene Frequency
37 Citations (Scopus)

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles

Oetting, W. S., Schladt, D. P., Guan, W., Miller, M. B., Remmel, R. P., Dorr, C., Sanghavi, K., Mannon, R. B., Herrera, B., Matas, A. J., Salomon, D. R., Kwok, P. Y., Keating, B. J., Israni, A. K. & Jacobson, P. A., Feb 1 2016, In : American Journal of Transplantation. 16, 2, p. 574-582 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Tacrolimus
African Americans
Alleles
Kidney
27 Citations (Scopus)

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

Sanghavi, K., Brundage, R. C., Miller, M. B., Schladt, D. P., Israni, A. K., Guan, W., Oetting, W. S., Mannon, R. B., Remmel, R. P., Matas, A. J. & Jacobson, P. A., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Tacrolimus
African Americans
Genotype
Kidney
Cytochrome P-450 CYP3A
5 Citations (Scopus)

Glucuronidation as a transient intermediate metabolic step in the elimination of (-)-carbovir: Identification of (-)-carbovir-5'-O-glucuronide in rat bile

Zimmerman, C. L., Iyer, K. R., Faudskar, A. L. & Remmel, R. P., Jan 1 1993, In : Drug Metabolism and Disposition. 21, 5, p. 902-910 9 p.

Research output: Contribution to journalArticle

carbovir
Bile
Glucuronides
Radioactivity
Bile Ducts
45 Citations (Scopus)
bilirubin glucuronoside glucuronosyltransferase
Glucuronosyltransferase
Dihydrotestosterone
Tamoxifen
Androsterone
46 Citations (Scopus)

Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation

Johnson, LA., Orchard, P. J., Baker, K. S., Brundage, R., Cao, Q., Wang, X., Langer, E., Farag-El Maasah, S., Ross, J. A., Remmel, R. & Jacobson, P. A., Sep 1 2008, In : Journal of Clinical Pharmacology. 48, 9, p. 1052-1062 11 p.

Research output: Contribution to journalArticle

Busulfan
Cell Transplantation
Glutathione Transferase
Pharmacokinetics
Genotype

Gut flora influences on the elimination of warfarin in the rat

Remmel, R. P. & Elmer, G. W., Jan 1 1979, In : Journal of Natural Products. 42, 6, 1 p.

Research output: Contribution to journalArticle

warfarin
intestinal microorganisms
rats
45 Citations (Scopus)
gemcitabine
Tissue culture
Culture Media
Plasmas
Liquids
77 Citations (Scopus)

High-speed simultaneous determination of nine antiepileptic drugs using liquid chromatography-mass spectrometry

Subramanian, M., Birnbaum, A. K. & Remmel, R. P., Jun 1 2008, In : Therapeutic Drug Monitoring. 30, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

Liquid chromatography
Liquid Chromatography
Anticonvulsants
Mass spectrometry
Mass Spectrometry
48 Citations (Scopus)

Hollow fiber bioartificial liver utilizing collagen-entrapped porcine hepatocyte spheroids

Wu, F. J., Friend, J. R., Lazar, A., Mann, H. J., Remmel, R. P., Cerra, F. B. & Hu, W-S., Oct 5 1996, In : Biotechnology and bioengineering. 52, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Artificial Liver
Collagen
Liver
Hepatocytes
Swine
115 Citations (Scopus)

Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol

Ebner, T., Remmel, R. P. & Burchell, B., Jan 1 1993, In : Molecular Pharmacology. 43, 4, p. 649-654 6 p.

Research output: Contribution to journalArticle

bilirubin glucuronoside glucuronosyltransferase
Ethinyl Estradiol
Glucuronides
Glucuronosyltransferase
Liver Microsomes
1 Citation (Scopus)
Tacrolimus
African Americans
Phenotype
Kidney
Genomics
5 Citations (Scopus)

Improved fluorometric high-performance liquid chromatographic assay for (-)-carbovir in rat blood and urine

Remmel, R. P., Huang, S. H., Hoff, D. & Zimmerman, C. L., 1990, In : Journal of Chromatography B: Biomedical Sciences and Applications. 534, C, p. 109-118 10 p.

Research output: Contribution to journalArticle

carbovir
Rats
Assays
Blood
Guanosine
51 Citations (Scopus)

Indinavir plasma protein binding in HIV-1-infected adults

Anderson, P. L., Brundage, R. C., Bushman, L., Kakuda, T. N., Remmel, R. P. & Fletcher, C. V., Nov 23 2000, In : AIDS. 14, 15, p. 2293-2297 5 p.

Research output: Contribution to journalArticle

Indinavir
Protein Binding
HIV-1
Blood Proteins
HIV
18 Citations (Scopus)

Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: Preliminary evidence for CYP3A isoforms in pigs

Hosagrahara, V. P., Hansen, L. K. & Remmel, R. P., Dec 15 1999, In : Drug Metabolism and Disposition. 27, 12, p. 1512-1518 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Midazolam
Rifampin
Hepatocytes
Protein Isoforms
19 Citations (Scopus)

Influence of the intestinal microflora on the elimination of warfarin in the rat

Remmel, R. P., Pohl, L. R. & Elmer, G. W., Dec 1 1981, In : Drug Metabolism and Disposition. 9, 5, p. 410-414 5 p.

Research output: Contribution to journalArticle

Warfarin
Rats
Radioactivity
Animals
Anti-Bacterial Agents
13 Citations (Scopus)

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

Burleigh, M. E., Babaev, V. R., Patel, M. B., Crews, B. C., Remmel, R. P., Morrow, J. D., Oates, J. A., Marnett, L. J., Fazio, S. & Linton, M. F., Aug 1 2005, In : Biochemical Pharmacology. 70, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Prostaglandin-Endoperoxide Synthases
Atherosclerosis
Cyclooxygenase 2
Aorta
17 Citations (Scopus)

Inhibition of murine cytochrome P4501A by tacrine: In vitro studies

Peng, J. Z., Remmel, R. P. & Sawchuk, R. J., Aug 1 2004, In : Drug Metabolism and Disposition. 32, 8, p. 805-812 8 p.

Research output: Contribution to journalArticle

Tacrine
Cytochromes
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Area Under Curve
39 Citations (Scopus)

Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors

Nelson, M. H., Birnbaum, A. K. & Remmel, R. P., Mar 24 2001, In : Epilepsy Research. 44, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

Hydantoins
Serotonin Uptake Inhibitors
Phenytoin
Liver Microsomes
Hydroxylation
32 Citations (Scopus)

Inhibitors of the salicylate synthase (Mbti) from Mycobacterium tuberculosis discovered by high-throughput screening

Vasan, M., Neres, J., Williams, J., Wilson, D. J., Teitelbaum, A. M., Remmel, R. P. & Aldrich, C. C., Dec 3 2010, In : ChemMedChem. 5, 12, p. 2079-2087 9 p.

Research output: Contribution to journalArticle

Thiones
Salicylates
Biosynthesis
Mycobacterium tuberculosis
Assays
40 Citations (Scopus)

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG

Otteneder, M. B., Knutson, C. G., Daniels, J. S., Hashim, M., Crews, B. C., Remmel, R. P., Wang, H., Rizzo, C. & Marnett, L. J., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6665-6669 5 p.

Research output: Contribution to journalArticle

DNA Adducts
Cytosol
DNA Damage
DNA
Oxidative Stress
52 Citations (Scopus)

Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine

Sinz, M. W. & Remmel, R. P., Mar 1 1991, In : Drug Metabolism and Disposition. 19, 1, p. 149-153 5 p.

Research output: Contribution to journalArticle

Glucuronides
Ammonium Compounds
Triazines
Hydrolysis
Enzymatic hydrolysis
191 Citations (Scopus)

Lamotrigine clearance during pregnancy

Tran, T. A., Leppik, I. E., Blesi, K., Sathanandan, S. T. & Remmel, R. P., Jul 23 2002, In : Neurology. 59, 2, p. 251-255 5 p.

Research output: Contribution to journalArticle

Pregnancy
Postpartum Period
Third Pregnancy Trimester
Second Pregnancy Trimester
Students
2 Citations (Scopus)

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Polepally, A. R., Brundage, R. C., Remmel, R. P., Leppik, I. E., Pennell, P. B., White, J. R., Ramsay, R. E., Kistner, B. M. & Birnbaum, A. K., Sep 2018, In : Epilepsia. 59, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Intravenous Administration
Young Adult
Epilepsy
Pharmacokinetics
Biological Availability
8 Citations (Scopus)

Liquid chromatographic assay of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus

Remmel, R. P., Yeom, Y. H., Hua, M., Vince, R. & Zimmerman, C. L., Jan 1 1989, In : Journal of Chromatography B: Biomedical Sciences and Applications. 489, 2, p. 323-331 9 p.

Research output: Contribution to journalArticle

carbovir
Viruses
Nucleosides
Assays
Blood
13 Citations (Scopus)

Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer

Tzanakakis, E. S., Waxman, D. J., Hansen, L. K., Remmel, R. P. & Hu, W-S., Apr 13 2002, In : Cell Biology and Toxicology. 18, 1, p. 13-27 15 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2B1
Gene transfer
Adenoviridae
Rats
Hepatocytes
26 Citations (Scopus)

Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice

Nagar, S., Remmel, R. P., Hebbel, R. P. & Zimmerman, C. L., Jan 1 2004, In : Drug Metabolism and Disposition. 32, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

Globins
Sickle Cell Anemia
Liver Microsomes
Metabolism
Liver
22 Citations (Scopus)

Multigene predictors of tacrolimus exposure in kidney transplant recipients

Pulk, R. A., Schladt, D. S., Oetting, W. S., Guan, W., Israni, A. K., Matas, A. J., Remmel, R. P. & Jacobson, P. A., Jul 1 2015, In : Pharmacogenomics. 16, 8, p. 841-854 14 p.

Research output: Contribution to journalArticle

Tacrolimus
Kidney
Haplotypes
Alleles
Cytochrome P-450 CYP3A
18 Citations (Scopus)

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients

Argikar, U. A., Cloyd, J. C., Birnbaum, A. K., Leppik, I. E., Conway, J. M., Kshirsagar, S., Oetting, W. S., Klein, E. C. & Remmel, R. P., Sep 1 2006, In : Epilepsy Research. 71, 1, p. 54-63 10 p.

Research output: Contribution to journalArticle

Phenytoin
Urine
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2C19
Urine Specimen Collection
32 Citations (Scopus)

Pharmacokinetic analysis verifies P450 function during in vitro and in vivo application of a bioartificial liver

Nyberg, S. L., Mann, H. J., Remmel, R. P., Hu, W. S. & Cerra, F. B., Jan 1 1993, In : ASAIO Journal. 39, 3

Research output: Contribution to journalArticle

Artificial Liver
Pharmacokinetics
Lidocaine
Liver
Hepatocytes
12 Citations (Scopus)

Pharmacokinetic evaluation of (-)-6-aminocarbovir as a prodrug for (-)-carbovir in rats

Zimmerman, C. L., Remmel, R. P., Ibrahim, S. S., Beers, S. A. & Vince, R., Jan 1 1992, In : Drug Metabolism and Disposition. 20, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

carbovir
Prodrugs
Biological Availability
Pharmacokinetics
Urine
20 Citations (Scopus)

Pharmacokinetics and bioavailability of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus, in rats

Yeom, Y. H., Remmel, R. P., Huang, S. H., Hua, M., Vince, R. & Zimmerman, C. L., Jan 1 1989, In : Antimicrobial agents and chemotherapy. 33, 2, p. 171-175 5 p.

Research output: Contribution to journalArticle

carbovir
Nucleosides
Biological Availability
Pharmacokinetics
HIV
15 Citations (Scopus)

Pharmacokinetics of tiletamine and zolazepam (Telazol®) in anesthetized pigs

Kumar, A., Mann, H. J. & Remmel, R. P., Dec 1 2006, In : Journal of Veterinary Pharmacology and Therapeutics. 29, 6, p. 587-589 3 p.

Research output: Contribution to journalArticle

Dissociative Anesthetics
Zolazepam
Tiletamine
tiletamine
tranquilizers
5 Citations (Scopus)
Pharmacokinetics
Liver Microsomes
Metabolism
Liver
Swine
62 Citations (Scopus)

Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy

Fletcher, C. V., Brundage, R., Remmel, R. P., Page, L. M., Weller, D., Calles, N. R., Simon, C. & Kline, M. W., Apr 1 2000, In : Antimicrobial agents and chemotherapy. 44, 4, p. 1029-1034 6 p.

Research output: Contribution to journalArticle

Indinavir
Stavudine
Didanosine
HIV
Pharmacokinetics
183 Citations (Scopus)

Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver

Nyberg, S. L., Remmel, R. P., Mann, H. J., Peshwa, M. V., Hu, W-S. & Cerra, F. B., Jul 1 1994, In : Annals of Surgery. 220, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Artificial Liver
Hep G2 Cells
Biotransformation
Hepatocytes
Liver
27 Citations (Scopus)

Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy

Tzanakakis, E. S., Hsiao, C. C., Matsushita, T., Remmel, R. P. & Hu, W-S., Jan 1 2001, In : Cell transplantation. 10, 3, p. 329-342 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2B1
Dealkylation
Confocal Microscopy
Rats
Hepatocytes
99 Citations (Scopus)

Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver

Nyberg, S. L., Hardin, J., Amiot, B., Argikar, U. A., Remmel, R. P. & Rinaldo, P., Aug 1 2005, In : Liver Transplantation. 11, 8, p. 901-910 10 p.

Research output: Contribution to journalArticle

Artificial Liver
Hepatocytes
Swine
Bioreactors
Cell Count
104 Citations (Scopus)

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Khan, H., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jun 24 2009, In : Hepatology. 49, 2, p. 578-586 9 p.

Research output: Contribution to journalArticle

Hepatocytes
Gene Expression
Artificial Liver
Liver
Bile Canaliculi
67 Citations (Scopus)

Reactivity of mefenamic acid 1-O-acyl glucuronide with proteins in vitro and ex vivo

McGurk, K. A., Remmel, R. P., Hosagrahara, V. P., Tosh, D. & Burchell, B., Aug 1 1996, In : Drug Metabolism and Disposition. 24, 8, p. 842-849 8 p.

Research output: Contribution to journalArticle

Mefenamic Acid
Glucuronides
Pharmaceutical Preparations
Interstitial Nephritis
Glucuronosyltransferase
30 Citations (Scopus)

Receding cytochrome P450 activity in disassembling hepatocyte spheroids

Hsiao, C. C., Friend, J. R., Wu, F. J., Ko, W. J., Remmel, R. P. & Hu, W. S., Jun 1 1999, In : Tissue Engineering. 5, 3, p. 207-221 15 p.

Research output: Contribution to journalArticle

Collagen
Monolayers
Confocal microscopy
Liver
Rats
16 Citations (Scopus)

Rectal absorption of lamotrigine compressed tablets

Birnbaum, A. K., Kriel, R. L., Burkhardt, R. T. & Remmel, R. P., Jan 1 2000, In : Epilepsia. 41, 7, p. 850-853 4 p.

Research output: Contribution to journalArticle

Rectal Administration
Tablets
Oral Administration
Rectal Absorption
lamotrigine
61 Citations (Scopus)

Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation

Jacobson, P., Rogosheske, J., Barker, J. N., Green, K., Ng, J., Weisdorf, D., Tan, Y., Long, J., Remmel, R., Sawchuk, R. & McGlave, P., Nov 1 2005, In : Clinical pharmacology and therapeutics. 78, 5, p. 486-500 15 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Cell Transplantation
Area Under Curve
Graft vs Host Disease
Cyclosporine
2 Citations (Scopus)

Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension

Clemens, P. L., Cloyd, J. C., Kriel, R. L. & Remmel, R. P., Mar 23 2007, In : Clinical Drug Investigation. 27, 4, p. 243-250 8 p.

Research output: Contribution to journalArticle

Biological Availability
Suspensions
Rectal Administration
Oral Administration
Urine
20 Citations (Scopus)

Relative bioavailability of lamotrigine chewable dispersible tablets administered rectally

Birnbaum, A. K., Kriel, R. L., Im, Y. & Remmel, R. P., Jan 1 2001, In : Pharmacotherapy. 21, 2, p. 158-162 5 p.

Research output: Contribution to journalArticle

Biological Availability
Tablets
Rectal Administration
Pharmaceutical Preparations
Cross-Over Studies