1979 …2020
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Research Output 1979 2019

2007
88 Citations (Scopus)

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation

Senekeo-Effenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M. F., Argikar, U., Kaeding, J., Trottier, J., Remmel, R. P., Ritter, J. K., Barbier, O. & Tukey, R. H., Mar 1 2007, In : Drug Metabolism and Disposition. 35, 3, p. 419-427 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolism
Transgenic Mice
Chemical activation
Liver
2 Citations (Scopus)

Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension

Clemens, P. L., Cloyd, J. C., Kriel, R. L. & Remmel, R. P., Mar 23 2007, In : Clinical Drug Investigation. 27, 4, p. 243-250 8 p.

Research output: Contribution to journalArticle

Biological Availability
Suspensions
Rectal Administration
Oral Administration
Urine
22 Citations (Scopus)
Dextromethorphan
Flurbiprofen
Midazolam
Metabolites
Cytochrome P-450 Enzyme System
2006
12 Citations (Scopus)
gemcitabine
Bioreactors
Cell Culture Techniques
Pharmaceutical Preparations
S Phase
5 Citations (Scopus)
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Plasmas
Assays
45 Citations (Scopus)
gemcitabine
Tissue culture
Culture Media
Plasmas
Liquids
40 Citations (Scopus)

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG

Otteneder, M. B., Knutson, C. G., Daniels, J. S., Hashim, M., Crews, B. C., Remmel, R. P., Wang, H., Rizzo, C. & Marnett, L. J., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6665-6669 5 p.

Research output: Contribution to journalArticle

DNA Adducts
Cytosol
DNA Damage
DNA
Oxidative Stress
18 Citations (Scopus)

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients

Argikar, U. A., Cloyd, J. C., Birnbaum, A. K., Leppik, I. E., Conway, J. M., Kshirsagar, S., Oetting, W. S., Klein, E. C. & Remmel, R. P., Sep 1 2006, In : Epilepsy Research. 71, 1, p. 54-63 10 p.

Research output: Contribution to journalArticle

Phenytoin
Urine
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2C19
Urine Specimen Collection
15 Citations (Scopus)

Pharmacokinetics of tiletamine and zolazepam (Telazol®) in anesthetized pigs

Kumar, A., Mann, H. J. & Remmel, R. P., Dec 1 2006, In : Journal of Veterinary Pharmacology and Therapeutics. 29, 6, p. 587-589 3 p.

Research output: Contribution to journalArticle

Dissociative Anesthetics
Zolazepam
Tiletamine
tiletamine
tranquilizers
31 Citations (Scopus)

Safety of high-dose naltrexone treatment: Hepatic transaminase profiles among outpatients

Kim, S. W., Grant, J. E., Yoon, G., Williams, K. A. & Remmel, R. P., Mar 1 2006, In : Clinical Neuropharmacology. 29, 2, p. 77-79 3 p.

Research output: Contribution to journalArticle

Naltrexone
Transaminases
Outpatients
Safety
Disruptive, Impulse Control, and Conduct Disorders
136 Citations (Scopus)

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

Nagar, S. & Remmel, R. P., Mar 13 2006, In : Oncogene. 25, 11, p. 1659-1672 14 p.

Research output: Contribution to journalReview article

Uridine
Pharmacogenetics
Neoplasms
Genetic Polymorphisms
Isoenzymes
2005
13 Citations (Scopus)

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

Burleigh, M. E., Babaev, V. R., Patel, M. B., Crews, B. C., Remmel, R. P., Morrow, J. D., Oates, J. A., Marnett, L. J., Fazio, S. & Linton, M. F., Aug 1 2005, In : Biochemical Pharmacology. 70, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Prostaglandin-Endoperoxide Synthases
Atherosclerosis
Cyclooxygenase 2
Aorta
99 Citations (Scopus)

Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver

Nyberg, S. L., Hardin, J., Amiot, B., Argikar, U. A., Remmel, R. P. & Rinaldo, P., Aug 1 2005, In : Liver Transplantation. 11, 8, p. 901-910 10 p.

Research output: Contribution to journalArticle

Artificial Liver
Hepatocytes
Swine
Bioreactors
Cell Count
61 Citations (Scopus)

Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation

Jacobson, P., Rogosheske, J., Barker, J. N., Green, K., Ng, J., Weisdorf, D., Tan, Y., Long, J., Remmel, R., Sawchuk, R. & Mc Glave, P. B., Nov 1 2005, In : Clinical Pharmacology and Therapeutics. 78, 5, p. 486-500 15 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Cell Transplantation
Area Under Curve
Graft vs Host Disease
Cyclosporine
63 Citations (Scopus)

The clinical pharmacokinetics of rifampin and ethambutol in HIV-infected persons with tuberculosis

Perlman, D. C., Segal, Y., Rosenkranz, S., Rainey, P. M., Remmel, R. P., Salomon, N., Hafner, R. & Peloquin, C. A., Dec 1 2005, In : Clinical Infectious Diseases. 41, 11, p. 1638-1647 10 p.

Research output: Contribution to journalArticle

Ethambutol
Rifampin
Tuberculosis
Pharmacokinetics
HIV
101 Citations (Scopus)

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus

Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R. P., Trottier, J., Barbier, O., Ritter, J. K. & Tukey, R. H., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37547-37557 11 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Pregnenolone Carbonitrile
Transgenic Mice
Liver
Tissue
2004
Cyclooxygenase 2 Inhibitors
Liver Microsomes
Metabolites
Metabolism
Liver
17 Citations (Scopus)

Inhibition of murine cytochrome P4501A by tacrine: In vitro studies

Peng, J. Z., Remmel, R. P. & Sawchuk, R. J., Aug 1 2004, In : Drug Metabolism and Disposition. 32, 8, p. 805-812 8 p.

Research output: Contribution to journalArticle

Tacrine
Cytochromes
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Area Under Curve
26 Citations (Scopus)

Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice

Nagar, S., Remmel, R. P., Hebbel, R. P. & Zimmerman, C. L., Jan 1 2004, In : Drug Metabolism and Disposition. 32, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

Globins
Sickle Cell Anemia
Liver Microsomes
Metabolism
Liver
24 Citations (Scopus)

Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: Identification of active metabolites

Remmel, R. P., Crews, B. C., Kozak, K. R., Algutkar, A. S. & Marnett, L. J., Jan 1 2004, In : Drug Metabolism and Disposition. 32, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Liver Microsomes
Indomethacin
Inhibitory Concentration 50
indomethacin phenethylamide
17 Citations (Scopus)

The Clinical Pharmacokinetics of Pyrazinamide in HIV-Infected Persons with Tuberculosis

Perlman, D. C., Segal, Y., Rosenkranz, S., Rainey, P. M., Peloquin, C. A., Remmel, R. P., Chirgwin, K., Salomon, N. & Hafner, R., Feb 15 2004, In : Clinical Infectious Diseases. 38, 4, p. 556-564 9 p.

Research output: Contribution to journalArticle

Pyrazinamide
Tuberculosis
Pharmacokinetics
HIV
Drug Monitoring
2002
42 Citations (Scopus)
Triethylenephosphoramide
Thiotepa
Cytochrome P-450 CYP3A
Metabolism
Isoenzymes
191 Citations (Scopus)

Lamotrigine clearance during pregnancy

Tran, T. A., Leppik, I. E., Blesi, K., Sathanandan, S. T. & Remmel, R. P., Jul 23 2002, In : Neurology. 59, 2, p. 251-255 5 p.

Research output: Contribution to journalArticle

Pregnancy
Postpartum Period
Third Pregnancy Trimester
Second Pregnancy Trimester
Students
13 Citations (Scopus)

Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer

Tzanakakis, E. S., Waxman, D. J., Hansen, L. K., Remmel, R. P. & Hu, W-S., Apr 13 2002, In : Cell Biology and Toxicology. 18, 1, p. 13-27 15 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2B1
Gene transfer
Adenoviridae
Rats
Hepatocytes
2001
29 Citations (Scopus)

A preliminary report on possible naltrexone and nonsteroidal analgesic interaction [11]

Kim, S. W., Grant, J. E., Adson, D. E. & Remmel, R. P., Dec 17 2001, In : Journal of Clinical Psychopharmacology. 21, 6, p. 632-634 3 p.

Research output: Contribution to journalLetter

Naltrexone
Narcotic Antagonists
Non-Steroidal Anti-Inflammatory Agents
Drug Interactions
Double-Blind Method
39 Citations (Scopus)

Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors

Nelson, M. H., Birnbaum, A. K. & Remmel, R. P., Mar 24 2001, In : Epilepsy Research. 44, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

Hydantoins
Serotonin Uptake Inhibitors
Phenytoin
Liver Microsomes
Hydroxylation
27 Citations (Scopus)

Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy

Tzanakakis, E. S., Hsiao, C. C., Matsushita, T., Remmel, R. P. & Hu, W-S., Jan 1 2001, In : Cell transplantation. 10, 3, p. 329-342 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2B1
Dealkylation
Confocal Microscopy
Rats
Hepatocytes
20 Citations (Scopus)

Relative bioavailability of lamotrigine chewable dispersible tablets administered rectally

Birnbaum, A. K., Kriel, R. L., Im, Y. & Remmel, R. P., Jan 1 2001, In : Pharmacotherapy. 21, 2, p. 158-162 5 p.

Research output: Contribution to journalArticle

Biological Availability
Tablets
Rectal Administration
Pharmaceutical Preparations
Cross-Over Studies
5 Citations (Scopus)

Review of human UDP-glucuronosyltransferases and their role in drug-drug interactions

Remmel, R. P., Jan 1 2001, Drug-Drug Interactions. CRC Press, p. 89-121 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glucuronosyltransferase
Drug Interactions
Glucuronic Acid
Enzymes
Pharmaceutical Preparations
2000
51 Citations (Scopus)

Antiepileptic drug pharmacokinetics and interactions: Impact on treatment of epilepsy

Cloyd, J. C. & Remmel, R. P., Aug 24 2000, In : Pharmacotherapy. 20, 8 II

Research output: Contribution to journalArticle

Drug Interactions
Anticonvulsants
Epilepsy
Pharmacokinetics
Pharmaceutical Preparations
227 Citations (Scopus)

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Kalgutkar, A. S., Crews, B. C., Rowlinson, S. W., Marnett, A. B., Kozak, K. R., Remmel, R. P. & Marnett, L. J., Jan 18 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 2, p. 925-930 6 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Amides
Anti-Inflammatory Agents
Indomethacin
5,8,11,14-Eicosatetraynoic Acid
45 Citations (Scopus)

Competing drug-drug interactions among multidrug antiretroviral regimens used in the treatment of HIV-infected subjects: ACTG 884

Fletcher, C. V., Acosta, E. P., Cheng, H., Haubrich, R., Fischl, M., Raasch, R., Mills, C., Hu, X. J., Katzenstein, D., Remmel, R. P. & Gulick, R. M., Nov 27 2000, In : AIDS. 14, 16, p. 2495-2501 7 p.

Research output: Contribution to journalArticle

Delavirdine
Drug Interactions
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
308 Citations (Scopus)

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

Kalgutkar, A. S., Marnett, A. B., Crews, B. C., Remmel, R. P. & Marnett, L. J., Jul 27 2000, In : Journal of Medicinal Chemistry. 43, 15, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Amides
Indomethacin
Esters
Anti-Inflammatory Agents
11 Citations (Scopus)

Evaluation of the effect of culture matrices on induction of CYP3A isoforms in cultured porcine hepatocytes

Hosagrahara, V. P., Hansen, L. K., Beilman, G. J. & Remmel, R. P., Jun 15 2000, In : Chemico-Biological Interactions. 127, 1, p. 91-106 16 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Hepatocytes
Protein Isoforms
Swine
Collagen
9 Citations (Scopus)

First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism

Zimmerman, C. L., Wen, Y. & Remmel, R. P., Jun 30 2000, In : Drug Metabolism and Disposition. 28, 6, p. 672-679 8 p.

Research output: Contribution to journalArticle

carbovir
Adenosine Deaminase Inhibitors
Pentostatin
Brain
Adenosine Deaminase
51 Citations (Scopus)

Indinavir plasma protein binding in HIV-1-infected adults

Anderson, P. L., Brundage, R. C., Bushman, L., Kakuda, T. N., Remmel, R. P. & Fletcher, C. V., Nov 23 2000, In : AIDS. 14, 15, p. 2293-2297 5 p.

Research output: Contribution to journalArticle

Indinavir
Protein Binding
HIV-1
Blood Proteins
HIV
62 Citations (Scopus)

Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy

Fletcher, C. V., Brundage, R., Remmel, R. P., Page, L. M., Weller, D., Calles, N. R., Simon, C. & Kline, M. W., Apr 1 2000, In : Antimicrobial agents and chemotherapy. 44, 4, p. 1029-1034 6 p.

Research output: Contribution to journalArticle

Indinavir
Stavudine
Didanosine
HIV
Pharmacokinetics
16 Citations (Scopus)

Rectal absorption of lamotrigine compressed tablets

Birnbaum, A. K., Kriel, R. L., Burkhardt, R. T. & Remmel, R. P., Jan 1 2000, In : Epilepsia. 41, 7, p. 850-853 4 p.

Research output: Contribution to journalArticle

Rectal Administration
Tablets
Oral Administration
Rectal Absorption
lamotrigine
57 Citations (Scopus)

Simultaneous HPLC assay for quantification of indinavir, nelfinavir, ritonavir, and saquinavir in human plasma

Remmel, R. P., Kawle, S. P., Weller, D. & Fletcher, C. V., Feb 23 2000, In : Clinical chemistry. 46, 1, p. 73-81 9 p.

Research output: Contribution to journalArticle

Nelfinavir
Saquinavir
Indinavir
Plasma (human)
Ritonavir
108 Citations (Scopus)

Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons

Fletcher, C. V., Kawle, S. P., Kakuda, T. N., Anderson, P. L., Weller, D., Bushman, L. R., Brundage, R. & Remmel, R. P., Nov 2 2000, In : AIDS. 14, 14, p. 2137-2144 8 p.

Research output: Contribution to journalArticle

HIV
Lamivudine
RNA
Reverse Transcriptase Inhibitors
Zidovudine
1999
139 Citations (Scopus)

Concise review of the cytochrome P450s and their roles in toxicology

Omiecinski, C. J., Remmel, R. P. & Hosagrahara, V. P., May 25 1999, In : Toxicological Sciences. 48, 2, p. 151-156 6 p.

Research output: Contribution to journalReview article

Xenobiotics
Cytochromes
Toxicology
Cytochrome P-450 Enzyme System
68 Citations (Scopus)

Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids

Wu, F. J., Friend, J. R., Remmel, R. P., Cerra, F. B. & Hu, W-S., Jan 1 1999, In : Cell Transplantation. 8, 3, p. 233-246 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Rats
Hepatocytes
Monolayers
Dealkylation
14 Citations (Scopus)

First-pass disposition of (-)-6-aminocarbovlr in rats. I. Prodrug activation may be limited by access to enzyme

Wen, Y., Remmel, R. P. & Zimmerman, C. L., Jan 1 1999, In : Drug Metabolism and Disposition. 27, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Prodrugs
Intestines
Rats
Chemical activation
Enzymes
18 Citations (Scopus)

Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: Preliminary evidence for CYP3A isoforms in pigs

Hosagrahara, V. P., Hansen, L. K. & Remmel, R. P., Dec 15 1999, In : Drug Metabolism and Disposition. 27, 12, p. 1512-1518 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Midazolam
Rifampin
Hepatocytes
Protein Isoforms
30 Citations (Scopus)

Receding cytochrome P450 activity in disassembling hepatocyte spheroids

Hsiao, C. C., Friend, J. R., Wu, F. J., Ko, W. J., Remmel, R. P. & Hu, W. S., Jun 1 1999, In : Tissue Engineering. 5, 3, p. 207-221 15 p.

Research output: Contribution to journalArticle

Collagen
Monolayers
Confocal microscopy
Liver
Rats
1998
14 Citations (Scopus)
Pharmacokinetics
Phenytoin
Plasmas
Assays
Isotopes
49 Citations (Scopus)

A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

Kline, M. W., Fletcher, C. V., Harris, A. T., Evans, K. D., Brundage, R. C., Remmel, R. P., Calles, N. R., Kirkpatrick, S. B. & Simon, C., Jan 1 1998, In : Journal of Pediatrics. 132, 3 I, p. 543-546 4 p.

Research output: Contribution to journalArticle

Indinavir
Stavudine
Didanosine
HIV
CD4 Lymphocyte Count
81 Citations (Scopus)

Concentration-controlled zidovudine therapy

Fletcher, C. V., Acosta, E. P., Henry, K., Page, L. M., Gross, C. R., Kawle, S. P., Remmel, R. P., Erice, A. & Balfour, H. H., Sep 1 1998, In : Clinical pharmacology and therapeutics. 64, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle

Zidovudine
HIV
Virus Diseases
Nucleosides
Blood Cells
40 Citations (Scopus)

Enhanced morphology and function in hepatocyte spheroids: A model of tissue self-assembly

Hansen, L. K., Hsiao, C. C., Friend, J. R., Wu, F. J., Bridge, G. A., Remmel, R. P., Cerra, F. B. & Hu, W. S., Mar 31 1998, In : Tissue Engineering. 4, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

Self assembly
Monolayers
Tissue
Fluorescence
Cell adhesion
1997
46 Citations (Scopus)

Development of a bioartificial liver employing xenogeneic hepatocytes

Hu, W-S., Friend, J. R., Wu, F. J., Sielaff, T., Peshwa, M. V., Lazar, A., Nyberg, S. L., Remmel, R. P. & Cerra, F. B., Jan 1 1997, In : Cytotechnology. 23, 1-3, p. 29-38 10 p.

Research output: Contribution to journalArticle

Artificial Liver
Liver
Hepatocytes
Bioreactors
Liver Failure