1979 …2020
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Research Output 1979 2019

Article
10 Citations (Scopus)

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, A. M., Gallardo, J. L., Bedi, J., Giri, R., Benoit, A. R., Olin, M. R., Morizio, K. M., Ohlfest, J. R., Remmel, R. P. & Ferguson, D. M., Jun 1 2012, In : Cancer chemotherapy and pharmacology. 69, 6, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

Acridines
Pharmacokinetics
Glioma
Brain
Biological Availability
13 Citations (Scopus)

Absorption of Valproic Acid Suppositories in Human Volunteers

Graves, N. M., Remmel, R. P., Rosenfeld, W. E., Carlson, G. H., Kriel, R. D. & Holmes, G. B., Jan 1 1989, In : Archives of Neurology. 46, 8, p. 906-909 4 p.

Research output: Contribution to journalArticle

Suppositories
Valproic Acid
Volunteers
Serum
Oral Administration
14 Citations (Scopus)
Pharmacokinetics
Phenytoin
Plasmas
Assays
Isotopes
86 Citations (Scopus)

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

Goodell, J. R., Ougolkov, A. V., Hiasa, H., Kaur, H., Remmel, R. P., Billadeau, D. D. & Ferguson, D. M., Jan 24 2008, In : Journal of Medicinal Chemistry. 51, 2, p. 179-182 4 p.

Research output: Contribution to journalArticle

Acridines
Type II DNA Topoisomerase
Pancreatic Neoplasms
Aminacrine
Cell Proliferation
52 Citations (Scopus)

A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment

Schifitto, G., Zhang, J., Evans, S. R., Sacktor, N., Simpson, D., Millar, L. L., Hung, V. L., Miller, E. N., Smith, E., Ellis, R. J., Valcour, V., Singer, E., Marra, C. M., Kolson, D., Weihe, J., Remmel, R. P., Katzenstein, D., Clifford, D. B., Nuffer, K., Cahill, S. & 26 others, Burgess, D., Carter, K., Shoemaker, M., Weisbeck, A., Hanks, N., Watters, M., Chafey, S. A., Dunaway, S., Perrin, M., Quinn, J., Venna, N., Flynn, T., Spitz, T., Gould, M., Cohen, B., Reisberg, L., Diaz-Arrastia, R., Lohner, C., Marder, K., Clouse, R., Mildvan, D., Bailey, J., Tashima, K., Sousa, H., Currin, D. & Pedersen, S., Jan 1 2007, In : Neurology. 69, 13, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

Selegiline
Multicenter Studies
HIV
Placebos
AIDS Dementia Complex

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A

DeKAF Genomics and GEN03 Investigators, Aug 1 2019, In : Transplantation. 103, 8, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Single Nucleotide Polymorphism
Allografts
Kidney
African Americans
38 Citations (Scopus)
Ion chromatography
Liquid chromatography
Liquid Chromatography
Guinea Pigs
Blood
29 Citations (Scopus)
Metoprolol
Enantiomers
Liquid chromatography
Cellulose
Adrenergic Antagonists
51 Citations (Scopus)

Antiepileptic drug pharmacokinetics and interactions: Impact on treatment of epilepsy

Cloyd, J. C. & Remmel, R. P., Aug 24 2000, In : Pharmacotherapy. 20, 8 II

Research output: Contribution to journalArticle

Drug Interactions
Anticonvulsants
Epilepsy
Pharmacokinetics
Pharmaceutical Preparations
49 Citations (Scopus)

A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

Kline, M. W., Fletcher, C. V., Harris, A. T., Evans, K. D., Brundage, R. C., Remmel, R. P., Calles, N. R., Kirkpatrick, S. B. & Simon, C., Jan 1 1998, In : Journal of Pediatrics. 132, 3 I, p. 543-546 4 p.

Research output: Contribution to journalArticle

Indinavir
Stavudine
Didanosine
HIV
CD4 Lymphocyte Count
30 Citations (Scopus)

A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs: In vitro and in vivo studies

Remmel, R. P. & Sinz, M. W., Jun 24 1991, In : Drug Metabolism and Disposition. 19, 3, p. 630-636 7 p.

Research output: Contribution to journalArticle

Glucuronides
Metabolites
Ammonium Compounds
Guinea Pigs
Hepatocytes
8 Citations (Scopus)
Plasmas
Assays
Pharmacokinetics
Solid Phase Extraction
Migraine Disorders
31 Citations (Scopus)

Assay of itraconazole in leukemic patient plasma by reversed-phase small-bore liquid chromatography

Remmel, R. P., Dombrovskis, D. & Canafax, D. M., Jan 1 1988, In : Journal of Chromatography B: Biomedical Sciences and Applications. 432, C, p. 388-394 7 p.

Research output: Contribution to journalArticle

Ultraviolet Spectrophotometry
Ketoconazole
Itraconazole
Antifungal Agents
Liquid Chromatography
47 Citations (Scopus)
Carbamazepine
Epilepsy
Pharmacokinetics
Single Nucleotide Polymorphism
Cytochrome P-450 CYP3A
56 Citations (Scopus)

A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture

Sielaff, T. D., Hu, M. Y., Rao, S., Groehler, K., Olson, D., Mann, H. J., Remmel, R. P., Shatford, R. A. D., Amiot, B., Hu, W-S. & Cerra, F. B., Jan 1 1995, In : Transplantation. 59, 10, p. 1459-1463 5 p.

Research output: Contribution to journalArticle

Hepatocytes
Swine
Artificial Liver
Hymecromone
Equipment and Supplies
4 Citations (Scopus)

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients

Oetting, W. S., Wu, B., Schladt, D. P., Guan, W., Remmel, R. P., Dorr, C., Mannon, R. B., Matas, A. J., Israni, A. K. & Jacobson, P. A., Feb 1 2018, In : Pharmacogenomics. 19, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

Tacrolimus
Cytochrome P-450 CYP3A
Single Nucleotide Polymorphism
Allografts
Kidney
38 Citations (Scopus)

Biliary excretion of a glutathione conjugate of busulfan and 1,4-diiodobutane in the rat

Marchand, D. H., Remmel, R. P. & Abdel-Monem, M. M., Jan 1 1988, In : Drug Metabolism and Disposition. 16, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Busulfan
Glutathione
Rats
Bile
Metabolites
22 Citations (Scopus)

Bilirubin glucuronidation revisited: Proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1

Zhou, J., Tracy, T. S. & Remmel, R. P., Nov 1 2010, In : Drug Metabolism and Disposition. 38, 11, p. 1907-1911 5 p.

Research output: Contribution to journalArticle

Bilirubin
Enzymes
Kernicterus
Glucuronic Acid
Proteins
227 Citations (Scopus)

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Kalgutkar, A. S., Crews, B. C., Rowlinson, S. W., Marnett, A. B., Kozak, K. R., Remmel, R. P. & Marnett, L. J., Jan 18 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 2, p. 925-930 6 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Amides
Anti-Inflammatory Agents
Indomethacin
5,8,11,14-Eicosatetraynoic Acid
12 Citations (Scopus)
gemcitabine
Bioreactors
Cell Culture Techniques
Pharmaceutical Preparations
S Phase
11 Citations (Scopus)
carbovir
Intravenous Infusions
Rats
Brain
Tissue
37 Citations (Scopus)

Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference

Cloyd, J. C., Kriel, R. L., Jones-Saete, C. M., Ong, B. Y., Jancik, J. T. & Remmel, R. P., Jan 1 1992, In : The Journal of pediatrics. 120, 4 PART 1, p. 634-638 5 p.

Research output: Contribution to journalArticle

Valproic Acid
Biological Availability
Parents
Patient Preference
Cross-Over Studies
45 Citations (Scopus)

Competing drug-drug interactions among multidrug antiretroviral regimens used in the treatment of HIV-infected subjects: ACTG 884

Fletcher, C. V., Acosta, E. P., Cheng, H., Haubrich, R., Fischl, M., Raasch, R., Mills, C., Hu, X. J., Katzenstein, D., Remmel, R. P. & Gulick, R. M., Nov 27 2000, In : AIDS. 14, 16, p. 2495-2501 7 p.

Research output: Contribution to journalArticle

Delavirdine
Drug Interactions
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
81 Citations (Scopus)

Concentration-controlled zidovudine therapy

Fletcher, C. V., Acosta, E. P., Henry, K., Page, L. M., Gross, C. R., Kawle, S. P., Remmel, R. P., Erice, A. & Balfour, H. H., Sep 1 1998, In : Clinical pharmacology and therapeutics. 64, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle

Zidovudine
HIV
Virus Diseases
Nucleosides
Blood Cells
53 Citations (Scopus)
Bilirubin
Estradiol
irinotecan
Inhibitory Concentration 50
UGT1A1 enzyme
10 Citations (Scopus)

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Cytochrome P-450 CYP3A
Midazolam
Tacrolimus
Hepatocytes
35 Citations (Scopus)

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose

Chaudhry, A. S., Urban, T. J., Lamba, J. K., Birnbaum, A. K., Remmel, R. P., Subramanian, M., Strom, S., You, J. H., Kasperaviciute, D., Catarino, C. B., Radtke, R. A., Sisodiya, S. M., Goldstein, D. B. & Schuetz, E. G., Feb 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 2, p. 599-611 13 p.

Research output: Contribution to journalArticle

Phenytoin
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Yin-Yang
Linkage Disequilibrium
42 Citations (Scopus)
Triethylenephosphoramide
Thiotepa
Cytochrome P-450 CYP3A
Metabolism
Isoenzymes
22 Citations (Scopus)

Demonstration of biochemical function by extracorporeal xenohepatocytes in an anhepatic animal model

Nyberg, S. L., Payne, W. D., Amiot, B., Shirabe, K., Remmel, R. P., Hu, W-S. & Cerra, F. B., Jan 1 1993, In : Transplantation proceedings. 25, 2, p. 1944-1945 2 p.

Research output: Contribution to journalArticle

Lactates
Artificial Organs
Heterologous Transplantation
Hepatectomy
Ammonia
5 Citations (Scopus)

Determination of 4-Methyl Umbelliferone and Metabolites in Williams E Media and Dog Plasma by High Performance Liquid Chromatography

Lovdahl, M. J., Reher, K. E., Mann, H. J. & Remmel, R. P., Apr 1 1994, In : Journal of Liquid Chromatography. 17, 8, p. 1795-1809 15 p.

Research output: Contribution to journalArticle

7-hydroxycoumarin
High performance liquid chromatography
Metabolites
High Pressure Liquid Chromatography
Dogs
5 Citations (Scopus)
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Plasmas
Assays
46 Citations (Scopus)

Development of a bioartificial liver employing xenogeneic hepatocytes

Hu, W-S., Friend, J. R., Wu, F. J., Sielaff, T., Peshwa, M. V., Lazar, A., Nyberg, S. L., Remmel, R. P. & Cerra, F. B., Jan 1 1997, In : Cytotechnology. 23, 1-3, p. 29-38 10 p.

Research output: Contribution to journalArticle

Artificial Liver
Liver
Hepatocytes
Bioreactors
Liver Failure
61 Citations (Scopus)

Discontinuation of Phenytoin and Carbamazepine in Patients Receiving Felbamate

Wagner, M. L., Graves, N. M., Marienau, K., Holmes, G. B., Remmel, R. P. & Leppik, I. E., Jun 1991, In : Epilepsia. 32, 3, p. 398-406 9 p.

Research output: Contribution to journalArticle

felbamate
Carbamazepine
Phenytoin
16 Citations (Scopus)
Pharmacokinetics
Carbamazepine
Rats
Protein Binding
Metabolism
4 Citations (Scopus)
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Hemorrhagic Shock
Swine
Pharmacokinetics
90 Citations (Scopus)
Valproic Acid
Liver Microsomes
Glucuronosyltransferase
Glucuronides
Anticonvulsants
51 Citations (Scopus)

Effect of felbamate on carbamazepine and its major metabolites

Wagner, M. L., Remmel, R. P., Graves, N. M. & Leppik, I. E., Jan 1 1993, In : Clinical Pharmacology & Therapeutics. 53, 5, p. 536-543 8 p.

Research output: Contribution to journalArticle

felbamate
Epoxy Compounds
Carbamazepine
Placebos
Clinical Pharmacology
15 Citations (Scopus)

Effects of hepatocyte growth factor on viability and biotransformation functions of hepatocytes in gel entrapped and monolayer culture

Hu, M. Y., Cipolle, M., Sielaff, T., Lovdahl, M. J., Mann, H. J., Remmel, R. P. & Cerra, F. B., Jul 26 1995, In : Critical care medicine. 23, 7, p. 1237-1242 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Biotransformation
Hepatocytes
Gels
Collagen Type I
68 Citations (Scopus)

Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids

Wu, F. J., Friend, J. R., Remmel, R. P., Cerra, F. B. & Hu, W-S., Jan 1 1999, In : Cell Transplantation. 8, 3, p. 233-246 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Rats
Hepatocytes
Monolayers
Dealkylation
40 Citations (Scopus)

Enhanced morphology and function in hepatocyte spheroids: A model of tissue self-assembly

Hansen, L. K., Hsiao, C. C., Friend, J. R., Wu, F. J., Bridge, G. A., Remmel, R. P., Cerra, F. B. & Hu, W. S., Mar 31 1998, In : Tissue Engineering. 4, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

Self assembly
Monolayers
Tissue
Fluorescence
Cell adhesion
308 Citations (Scopus)

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

Kalgutkar, A. S., Marnett, A. B., Crews, B. C., Remmel, R. P. & Marnett, L. J., Jul 27 2000, In : Journal of Medicinal Chemistry. 43, 15, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Amides
Indomethacin
Esters
Anti-Inflammatory Agents
11 Citations (Scopus)

Evaluation of the effect of culture matrices on induction of CYP3A isoforms in cultured porcine hepatocytes

Hosagrahara, V. P., Hansen, L. K., Beilman, G. J. & Remmel, R. P., Jun 15 2000, In : Chemico-Biological Interactions. 127, 1, p. 91-106 16 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Hepatocytes
Protein Isoforms
Swine
Collagen
4 Citations (Scopus)
Phenytoin
Isotopes
Biological Availability
Epilepsy
Anticonvulsants
88 Citations (Scopus)

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation

Senekeo-Effenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M. F., Argikar, U., Kaeding, J., Trottier, J., Remmel, R. P., Ritter, J. K., Barbier, O. & Tukey, R. H., Mar 1 2007, In : Drug Metabolism and Disposition. 35, 3, p. 419-427 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolism
Transgenic Mice
Chemical activation
Liver
85 Citations (Scopus)

Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel

Lazar, A., Mann, H. J., Remmel, R. P., Shatford, R. A., Cerra, F. B. & Hu, W. S., May 1 1995, In : In Vitro Cellular & Developmental Biology - Animal. 31, 5, p. 340-346 7 p.

Research output: Contribution to journalArticle

Liver
Hepatocytes
Swine
Collagen
Gels
79 Citations (Scopus)

Extracorporeal application of a gel-entrapment, bioartificial liver: Demonstration of drug metabolism and other biochemical functions

Nyberg, S. L., Shirabe, K., Peshwa, M. V., Sielaff, T. D., Crotty, P. L., Mann, H. J., Remmel, R. P., Payne, W. D., Hu, W-S. & Cerra, F. B., Jan 1 1993, In : Cell transplantation. 2, 6, p. 441-452 12 p.

Research output: Contribution to journalArticle

Artificial Liver
Metabolism
Liver
Hepatocytes
Demonstrations
12 Citations (Scopus)

Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit

Nyberg, S. L., Mann, H. J., Hu, M. Y., Payne, W. D., Hu, W-S., Cerra, F. B. & Remmel, R. P., Jun 1 1996, In : Drug Metabolism and Disposition. 24, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

Hymecromone
Lidocaine
Metabolism
Rabbits
Metabolites
68 Citations (Scopus)

Felbamate Increases Phenytoin but Decreases Carbamazepine Concentrations

Fuerst, R. H., Graves, N. M., Leppik, I. E., Brundage, R., Holmes, G. B. & Remmel, R. P., Jan 1 1988, In : Epilepsia. 29, 4, p. 488-491 4 p.

Research output: Contribution to journalArticle

felbamate
Carbamazepine
Phenytoin
9 Citations (Scopus)

First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism

Zimmerman, C. L., Wen, Y. & Remmel, R. P., Jun 30 2000, In : Drug Metabolism and Disposition. 28, 6, p. 672-679 8 p.

Research output: Contribution to journalArticle

carbovir
Adenosine Deaminase Inhibitors
Pentostatin
Brain
Adenosine Deaminase
14 Citations (Scopus)

First-pass disposition of (-)-6-aminocarbovlr in rats. I. Prodrug activation may be limited by access to enzyme

Wen, Y., Remmel, R. P. & Zimmerman, C. L., Jan 1 1999, In : Drug Metabolism and Disposition. 27, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Prodrugs
Intestines
Rats
Chemical activation
Enzymes