1979 …2021

Research output per year

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Research Output

2020

PharmGKB summary: Lamotrigine pathway, pharmacokinetics and pharmacodynamics

Mitra-Ghosh, T., Callisto, S. P., Lamba, J. K., Remmel, R. P., Birnbaum, A. K., Barbarino, J. M., Klein, T. E. & Altman, R. B., Jan 1 2020, (Accepted/In press) In : Pharmacogenetics and genomics. p. 81-90 10 p.

Research output: Contribution to journalArticle

2019

Analysis of 75 candidate SNPs associated with acute rejection in kidney transplant recipients: Validation of rs2910164 in MicroRNA MIR146A

Oetting, W. S., Schladt, D. P., Dorr, C. R., Wu, B., Guan, W., Remmel, R. P., Iklé, D., Mannon, R. B., Matas, A. J., Israni, A. K. & Jacobson, P. A., Aug 1 2019, In : Transplantation. 103, 8, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Birnbaum, A. K., Karanam, A., Marino, S. E., Barkley, C. M., Remmel, R. P., Roslawski, M., Gramling-Aden, M. & Leppik, I. E., Jan 1 2019, In : Epilepsia. 60, 8, p. 1586-1592 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic variants associated with immunosuppressant pharmacokinetics and adverse effects in the DeKAF genomics genome-wide association studies

Oetting, W. S., Wu, B., Schladt, D. P., Guan, W., Van Setten, J., Keating, B. J., Iklé, D., Remmel, R. P., Dorr, C. R., Mannon, R. B., Matas, A. J., Israni, A. K. & Jacobson, P. A., Jun 1 2019, In : Transplantation. 103, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
3 Scopus citations
4 Scopus citations

Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups

the DeKAF Genomics and GEN03 Investigators, Oct 1 2019, In : American Journal of Transplantation. 19, 10, p. 2795-2804 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients

Oetting, W. S., Wu, B., Schladt, D. P., Guan, W., Remmel, R. P., Dorr, C., Mannon, R. B., Matas, A. J., Israni, A. K. & Jacobson, P. A., Feb 2018, In : Pharmacogenomics. 19, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

beta-Glucuronidase Gene Expression in Stool Samples Associated with Chronic Allograft Dysfunction in Kidney Transplants.

Israni, A., Knights, D., Al-Ghalith, G., Muthusamy, A., Wu, B., Oetting, W., Schaldt, D., Remmel, R. & Jacobson, P., 2018, p. 807. 1 p.

Research output: Contribution to conferencePaper

14 Scopus citations

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Polepally, A. R., Brundage, R. C., Remmel, R. P., Leppik, I. E., Pennell, P. B., White, J. R., Ramsay, R. E., Kistner, B. M. & Birnbaum, A. K., Sep 2018, In : Epilepsia. 59, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination

Scheibner, A., Remmel, R. P., Schladt, D., Oetting, W. S., Guan, W., Wu, B., Dorr, C., Israni, A. & Jacobson, P. A., Jul 2018, In : Pharmacotherapy. 38, 7, p. e46-e52

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
5 Scopus citations

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

Wu, J. F., Muthusamy, A., Al-Ghalith, G. A., Knights, D., Guo, B., Wu, B., Remmel, R. P., Schladt, D. P., Alegre, M. L., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Dec 2018, In : Clinical Transplantation. 32, 12, e13436.

Research output: Contribution to journalArticle

4 Scopus citations

Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs.

Jacobson, P., Schladt, D., Guan, W., van Setten, J., Remmel, R., Wu, B., Dorr, C., Keating, B., Ikle, D. & Mannon, R., 2018, p. 793. 1 p.

Research output: Contribution to conferencePaper

2017

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

Sanghavi, K., Brundage, R. C., Miller, M. B., Schladt, D. P., Israni, A. K., Guan, W., Oetting, W. S., Mannon, R. B., Remmel, R. P., Matas, A. J. & Jacobson, P. A., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Personalized Tacrolimus (TAC) Dosing Using Genetic Variants in Caucasian Kidney Transplant (Tx) Recipients

Margraf, D., Brundage, R., Schladt, D., Guan, W., Wu, B., Remmel, R., Dorr, C., Berglund, D., Mannon, R. & Matas, A., 2017, p. 736. 1 p.

Research output: Contribution to conferenceAbstract

Tacrolimus Dose Variability, CYP3A5 Genotype, and Acute Rejection in African American and European American Kidney Transplant Recipients

Seibert, S. R., Schladt, D., Wu, B., Guan, W., Dorr, C., Berglund, D., Remmel, R., Matas, A., Mannon, R. & Israni, A., 2017, p. 732. 1 p.

Research output: Contribution to conferencePaper

2016

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles

Oetting, W. S., Schladt, D. P., Guan, W., Miller, M. B., Remmel, R. P., Dorr, C., Sanghavi, K., Mannon, R. B., Herrera, B., Matas, A. J., Salomon, D. R., Kwok, P. Y., Keating, B. J., Israni, A. K. & Jacobson, P. A., Feb 1 2016, In : American Journal of Transplantation. 16, 2, p. 574-582 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

High-Risk Pharmacogenetic (PGx) Variants in Kidney Transplant (tx) Recipients

Berglund, D., Schladt, D., Sanghavi, K., Guan, W., Wu, B., Dorr, C., Remmel, R., Mannon, R., Matas, A. & Oetting, W., 2016, p. 321. 1 p.

Research output: Contribution to conferencePaper

Marked Alterations in Gene Expression in Peripheral Blood Leukocytes of Kidney Transplant (tx) Recipients Following Mycophenolic Acid (MPA) Treatment.

Sanghavi, K., Wu, B., Dorr, C., Muthuswamy, A., Guan, W., Schladt, D., Remmel, R., Ilke, D., Matas, A. & Israni, A., 2016, p. 783. 1 p.

Research output: Contribution to conferencePaper

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis

Dawadi, S., Kawamura, S., Rubenstein, A., Remmel, R. P. & Aldrich, C., Mar 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 6, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Multigene predictors of tacrolimus exposure in kidney transplant recipients

Pulk, R. A., Schladt, D. S., Oetting, W. S., Guan, W., Israni, A. K., Matas, A. J., Remmel, R. P. & Jacobson, P. A., Jul 1 2015, In : Pharmacogenomics. 16, 8, p. 841-854 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Single nucleotide polymorphisms (SNPs) Associated with Acute Rejection in European American Kidney Transplant Recipients: a Genome Wide Association Study (GWAS)

Israni, A., Dorr, C., Miller, M., Schladt, D., Sanghavi, K., Muthusamy, A., Remmel, R., Guan, W., Wu, B. & Oetting, W., 2015.

Research output: Contribution to conferencePaper

7 Scopus citations
2014
6 Scopus citations

Safety of an intravenous formulation of lamotrigine

Conway, J. M., Birnbaum, A. K., Leppik, I. E., Pennell, P. B., White, J. R., Rarick, J. O. & Remmel, R. P., May 2014, In : Seizure. 23, 5, p. 390-392 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013
51 Scopus citations

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats

Jones, J. M., Raleigh, M. D., Pentel, P. R., Harmon, T. M., Keyler, D. E., Remmel, R. P. & Birnbaum, A. K., Feb 3 2013, In : Journal of Pharmaceutical and Biomedical Analysis. 74, p. 291-297 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis

Teitelbaum, A. M., Meissner, A., Harding, R. A., Wong, C. A., Aldrich, C. C. & Remmel, R. P., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5605-5617 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, A. M., Gallardo, J. L., Bedi, J., Giri, R., Benoit, A. R., Olin, M. R., Morizio, K. M., Ohlfest, J. R., Remmel, R. P. & Ferguson, D. M., Jun 1 2012, In : Cancer chemotherapy and pharmacology. 69, 6, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
8 Scopus citations
2011
53 Scopus citations
5 Scopus citations
4 Scopus citations

Functional analysis of UGT1A4 P24T and UGT1A4 L48V variant enzymes

Zhou, J., Argikar, U. A. & Remmel, R. P., Dec 1 2011, In : Pharmacogenomics. 12, 12, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Bilirubin glucuronidation revisited: Proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1

Zhou, J., Tracy, T. S. & Remmel, R. P., Nov 1 2010, In : Drug Metabolism and Disposition. 38, 11, p. 1907-1911 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose

Chaudhry, A. S., Urban, T. J., Lamba, J. K., Birnbaum, A. K., Remmel, R. P., Subramanian, M., Strom, S., You, J. H., Kasperaviciute, D., Catarino, C. B., Radtke, R. A., Sisodiya, S. M., Goldstein, D. B. & Schuetz, E. G., Feb 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 2, p. 599-611 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jan 1 2010, In : Cells Tissues Organs. 191, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
48 Scopus citations

Inhibitors of the salicylate synthase (Mbti) from Mycobacterium tuberculosis discovered by high-throughput screening

Vasan, M., Neres, J., Williams, J., Wilson, D. J., Teitelbaum, A. M., Remmel, R. P. & Aldrich, C. C., Dec 3 2010, In : ChemMedChem. 5, 12, p. 2079-2087 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009
91 Scopus citations

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Khan, H., Remmel, R. P., Rinaldo, P. & Nyberg, S. L., Jun 24 2009, In : Hepatology. 49, 2, p. 578-586 9 p.

Research output: Contribution to journalArticle

109 Scopus citations

Studies on induction of lamotrigine metabolism in transgenic UGT1 mice Lamotrigine metabolism in transgenic UGT1 mice

Argikar, U. A., Senekeo-Effenberger, K., Larson, E. E., Tukey, R. H. & Remmel, R. P., Nov 1 2009, In : Xenobiotica. 39, 11, p. 826-835 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Variation in glucuronidation of lamotrigine in human liver microsomes

Argikar, U. A. & Remmel, R. P., Nov 9 2009, In : Xenobiotica. 39, 5, p. 355-363 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

Goodell, J. R., Ougolkov, A. V., Hiasa, H., Kaur, H., Remmel, R., Billadeau, D. D. & Ferguson, D. M., Jan 24 2008, In : Journal of medicinal chemistry. 51, 2, p. 179-182 4 p.

Research output: Contribution to journalArticle

89 Scopus citations

Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation

Johnson, LA., Orchard, P. J., Baker, K. S., Brundage, R., Cao, Q., Wang, X., Langer, E., Farag-El Maasah, S., Ross, J. A., Remmel, R. & Jacobson, P. A., Sep 1 2008, In : Journal of Clinical Pharmacology. 48, 9, p. 1052-1062 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

High-speed simultaneous determination of nine antiepileptic drugs using liquid chromatography-mass spectrometry

Subramanian, M., Birnbaum, A. K. & Remmel, R. P., Jun 1 2008, In : Therapeutic drug monitoring. 30, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

79 Scopus citations
2007

A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment

Schifitto, G., Zhang, J., Evans, S. R., Sacktor, N., Simpson, D., Millar, L. L., Hung, V. L., Miller, E. N., Smith, E., Ellis, R. J., Valcour, V., Singer, E., Marra, C. M., Kolson, D., Weihe, J., Remmel, R. P., Katzenstein, D., Clifford, D. B., Nuffer, K., Cahill, S. & 26 others, Burgess, D., Carter, K., Shoemaker, M., Weisbeck, A., Hanks, N., Watters, M., Chafey, S. A., Dunaway, S., Perrin, M., Quinn, J., Venna, N., Flynn, T., Spitz, T., Gould, M., Cohen, B., Reisberg, L., Diaz-Arrastia, R., Lohner, C., Marder, K., Clouse, R., Mildvan, D., Bailey, J., Tashima, K., Sousa, H., Currin, D. & Pedersen, S., Sep 2007, In : Neurology. 69, 13, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

54 Scopus citations