1962 …2019
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Research Output 1962 2019

2019

Discovery of Anticancer Clinical Candidate, Tosedostat, As an Analgesic Agent

Singh, R., Xie, W., Williams, J., Vince, R. & More, S. S., Sep 18 2019, In : ACS Chemical Neuroscience. 10, 9, p. 4007-4017 11 p.

Research output: Contribution to journalArticle

Analgesics
Neurology
Pharmacology
Phase II Clinical Trials
Aminopeptidases

Guanabenz Attenuates Acetaminophen-Induced Liver Toxicity and Synergizes Analgesia in Mice

Xie, W., Xie, J., Vince, R. & More, S. S., Jan 1 2019, (Accepted/In press) In : Chemical research in toxicology.

Research output: Contribution to journalArticle

Guanabenz
Acetaminophen
Liver
Analgesia
Toxicity
Biomarkers
Early Diagnosis
Alzheimer Disease
Skin Pigmentation
Retina
2017
2 Citations (Scopus)

Hepatoprotective effect of ψ-glutathione in a murine model of acetaminophen-induced liver toxicity

More, S. S., Nugent, J., Vartak, A. P., Nye, S. M. & Vince, R., Jan 1 2017, In : Chemical Research in Toxicology. 30, 3, p. 777-784 8 p.

Research output: Contribution to journalArticle

Acetaminophen
Liver
Glutathione
Toxicity
Acetylcysteine
2 Citations (Scopus)
Puromycin
Aminopeptidases
Hematologic Neoplasms
Peptide Hydrolases
Cells
2016
7 Citations (Scopus)

Development of sulfanegen for mass cyanide casualties

Patterson, S., Moeller, B., Nagasawa, H. T., Vince, R., Crankshaw, D. L., Briggs, J., Stutelberg, M. W., Vinnakota, C. V. & Logue, B. A., Jan 1 2016, In : Annals of the New York Academy of Sciences. 1374, 1, p. 202-209 8 p.

Research output: Contribution to journalArticle

Mass Casualty Incidents
Cyanides
Antidotes
Occupational Accidents
Detoxification
16 Citations (Scopus)

Early detection of amyloidopathy in Alzheimer’s mice by hyperspectral endoscopy

More, S. S., Beach, J. M. & Vince, R., Jun 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

Endoscopy
Retina
Light
Amyloid
Endoscopes
3 Citations (Scopus)

Hemolytic and antimalarial effects of tight-binding glyoxalase 1 inhibitors on the host-parasite unit of erythrocytes infected with Plasmodium falciparum

Wezena, C. A., Urscher, M., Vince, R., More, S. S. & Deponte, M., Aug 1 2016, In : Redox Biology. 8, p. 348-353 6 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Parasites
Erythrocytes
Glutathione
2015
23 Citations (Scopus)
Amyloid
Retina
Brain
Alzheimer Disease
Databases

Topical acyclothymidine dinucleosides (aTds) promote non-UV-mediated endogenous defense mechanisms in Guinea pig skin

Nugent, J. S., Vince, R. & Raza, A., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 6, p. 1687-1689 3 p.

Research output: Contribution to journalLetter

Topical Administration
Uracil
Skin Neoplasms
Ultraviolet Rays
Nucleosides
2014
1 Citation (Scopus)

A bio-mimetic approach to DNA photoprotection

Raza, A., Ericson, M. E., Nugent, J. S., Dreis, C. D. & Vince, R., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 2, p. 559-562 4 p.

Research output: Contribution to journalLetter

Hairless Mouse
Animal Disease Models
Biomimetics
Radiation Protection
Uracil
17 Citations (Scopus)

NAD-based inhibitors with anticancer potential

Felczak, K. Z., Vince, R. & Pankiewicz, K. W., Jan 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 1, p. 332-336 5 p.

Research output: Contribution to journalArticle

Cell proliferation
Adenine
Amides
NAD
K562 Cells
2013
19 Citations (Scopus)

Cyanide antidotes for mass casualties: Water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration

Patterson, S. E., Monteil, A. R., Cohen, J. F., Crankshaw, D. L., Vince, R. & Nagasawa, H. T., Feb 14 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 1346-1349 4 p.

Research output: Contribution to journalArticle

Mass Casualty Incidents
Antidotes
Cyanides
Salts
Water
3 Citations (Scopus)

Photoprotection of DNA (in vitro) by acyclothymidine dinucleosides

Raza, A., Dreis, C. D. & Vince, R., Feb 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 3, p. 620-623 4 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Skin
Radiation Scattering
DNA
Ultraviolet radiation
19 Citations (Scopus)

Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease

More, S. S., Vartak, A. P. & Vince, R., Feb 20 2013, In : ACS Chemical Neuroscience. 4, 2, p. 330-338 9 p.

Research output: Contribution to journalArticle

Enzyme activity
Restoration
Alzheimer Disease
Glyoxal
Pyruvaldehyde
2012
68 Citations (Scopus)
Lactams
Substrates
Cyclopentanes
Stereoisomerism
Enantiomers
7 Citations (Scopus)

C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus

Chen, Y. L., Zacharias, J., Vince, R., Geraghty, R. J. & Wang, Z., Aug 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 15, p. 4790-4800 11 p.

Research output: Contribution to journalArticle

Replicon
Carboxylic Acids
Viruses
Hepacivirus
Cell Culture Techniques
18 Citations (Scopus)

Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium

Belani, K. G., Singh, H., Beebe, D. S., George, P., Patterson, S. E., Nagasawa, H. T. & Vince, R., May 1 2012, In : Anesthesia and analgesia. 114, 5, p. 956-961 6 p.

Research output: Contribution to journalArticle

Prodrugs
Cyanides
Swine
Sodium
Nitroprusside
7 Citations (Scopus)

Potential of a γ-Glutamyl-Transpeptidase-Stable Glutathione Analogue against Amyloid-β Toxicity

More, S. S. & Vince, R., Mar 21 2012, In : ACS Chemical Neuroscience. 3, 3, p. 204-210 7 p.

Research output: Contribution to journalArticle

Oxidative stress
gamma-Glutamyltransferase
Amyloid
Amides
Glutathione
22 Citations (Scopus)

The butter flavorant, diacetyl, exacerbates β-amyloid cytotoxicity

More, S. S., Vartak, A. P. & Vince, R., Oct 15 2012, In : Chemical research in toxicology. 25, 10, p. 2083-2091 9 p.

Research output: Contribution to journalArticle

Diacetyl
Butter
Cytotoxicity
Amyloid
Agglomeration
26 Citations (Scopus)
Diacetyl
Butter
diacetyl
Deoxyguanosine
butter
41 Citations (Scopus)
Viruses
Hepacivirus
Ribonuclease H
Replicon
Catalytic Domain
13 Citations (Scopus)

Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1

Urscher, M., More, S. S., Alisch, R., Vince, R. & Deponte, M., Jul 1 2012, In : FEBS Journal. 279, 14, p. 2568-2578 11 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Pyruvaldehyde
Parasites
Falciparum Malaria
Application programs
2011
40 Citations (Scopus)

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

TANG, JING., Maddali, K., Metifiot, M., Sham, Y. Y., Vince, R., Pommier, Y. & Wang, Z., Apr 14 2011, In : Journal of Medicinal Chemistry. 54, 7, p. 2282-2292 11 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Integrases
HIV
Antiviral Agents
HIV Reverse Transcriptase
28 Citations (Scopus)

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase

TANG, JING., Maddali, K., Dreis, C. D., Sham, Y. Y., Vince, R., Pommier, Y. & Wang, Z., Apr 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 8, p. 2400-2402 3 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
Integrases
Antiviral Agents
Hydroxylation
RNA-Directed DNA Polymerase
20 Citations (Scopus)

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain

Felczak, K. Z., Chen, L., Wilson, D., Williams, J., Vince, R., Petrelli, R., Jayaram, H. N., Kusumanchi, P., Kumar, M. & Pankiewicz, K. W., Mar 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 5, p. 1594-1605 12 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
Oxidoreductases
Binding Sites
Mycophenolic Acid
Organophosphonates
3 Citations (Scopus)

Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Raza, A. & Vince, R., May 2 2011, In : ChemBioChem. 12, 7, p. 1015-1017 3 p.

Research output: Contribution to journalArticle

Dehydroascorbic Acid
Guanosine
Biosynthesis
Protein Biosynthesis
Ascorbic Acid
46 Citations (Scopus)

N-3 hydroxylation of pyrimidine-2,4-diones yields dual inhibitors of HIV reverse transcriptase and integrase

TANG, JING., Maddali, K., Dreis, C. D., Sham, Y. Y., Vince, R., Pommier, Y. & Wang, Z., Jan 13 2011, In : ACS Medicinal Chemistry Letters. 2, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
Integrases
Hydroxylation
RNA-Directed DNA Polymerase
Reverse Transcriptase Inhibitors
2010
24 Citations (Scopus)
HIV Protease Inhibitors
Protease Inhibitors
Peptidomimetics
Lead compounds
Molecular modeling
27 Citations (Scopus)
HIV Reverse Transcriptase
Integrases
Structure-Activity Relationship
Scaffolds
RNA-Directed DNA Polymerase
2009
42 Citations (Scopus)

Inhibition of glyoxalase I: The first low-nanomolar tight-binding inhibitors

More, S. S. & Vince, R., Aug 13 2009, In : Journal of Medicinal Chemistry. 52, 15, p. 4650-4656 7 p.

Research output: Contribution to journalArticle

Lactoylglutathione Lyase
Glutathione
2008
3 Citations (Scopus)

A brief history of the development of ziagen

Vince, R., Apr 1 2008, In : Chemtracts. 21, 4, p. 127-134 8 p.

Research output: Contribution to journalReview article

abacavir
Protease Inhibitors
Human immunodeficiency virus 1 p16 protease
corrigendum
48 Citations (Scopus)
Peptidomimetics
Prodrugs
Blood-Brain Barrier
Glutathione
Pharmaceutical Preparations
36 Citations (Scopus)
Delavirdine
HIV Reverse Transcriptase
Integrases
Assays
HIV
25 Citations (Scopus)

Design and synthesis of sulfoximine based inhibitors for HIV-1 protease

Raza, A., Sham, Y. Y. & Vince, R., Oct 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 20, p. 5406-5410 5 p.

Research output: Contribution to journalArticle

Indinavir
Substitution reactions
Observation
Human immunodeficiency virus 1 p16 protease
34 Citations (Scopus)
HIV Reverse Transcriptase
Integrases
Quinolones
Scaffolds
Assays
2007
7 Citations (Scopus)

Carbovir-related compounds and phosphonate analogues

Pham, P. T. & Vince, R., Apr 1 2007, In : Phosphorus, Sulfur and Silicon and the Related Elements. 182, 4, p. 779-791 13 p.

Research output: Contribution to journalArticle

carbovir
Lactams
Organophosphonates
Cyclopentanes
Antiviral Agents
12 Citations (Scopus)
Lactoylglutathione Lyase
Chelation
Zinc
Glutamic Acid
Esters
30 Citations (Scopus)

Discovery of potent HIV-1 protease inhibitors incorporating sulfoximine functionality

Lu, D. & Vince, R., Oct 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 20, p. 5614-5619 6 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Protease Inhibitors
Inhibitory Concentration 50
Stereoisomerism
HIV-1
35 Citations (Scopus)

Novel, orally effective cyanide antidotes

Nagasawa, H. T., Goon, D. J. W., Crankshaw, D. L., Vince, R. & Patterson, S. E., Dec 27 2007, In : Journal of Medicinal Chemistry. 50, 26, p. 6462-6464 3 p.

Research output: Contribution to journalArticle

Antidotes
Cyanides
Prodrugs
Enzymes
3-mercaptopyruvic acid
74 Citations (Scopus)

Rationally designed dual inhibitors of HIV reverse transcriptase and integrase

Wang, Z., Bennett, E. M., Wilson, D., Salomon, C. & Vince, R., Jul 26 2007, In : Journal of Medicinal Chemistry. 50, 15, p. 3416-3419 4 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
Integrases
RNA-Directed DNA Polymerase
Inhibitory Concentration 50
Integrase Inhibitors
2006
22 Citations (Scopus)

A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I

More, S. S. & Vince, R., Dec 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 23, p. 6039-6042 4 p.

Research output: Contribution to journalArticle

Lactoylglutathione Lyase
glutamyl-cysteinyl-alanine
Hydroxamic Acids
Enzyme kinetics
Chelating Agents
42 Citations (Scopus)

Conformationally restrained carbazolone-containing α,γ-diketo acids as inhibitors of HIV integrase

Li, X. & Vince, R., May 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 9, p. 2942-2955 14 p.

Research output: Contribution to journalArticle

HIV Integrase Inhibitors
Acids
Integrases
Bearings (structural)
Nitrogen
10 Citations (Scopus)

Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Tang, Y., Muthyala, R. & Vince, R., Sep 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 17, p. 5866-5875 10 p.

Research output: Contribution to journalArticle

Nucleosides
Ganciclovir
Isomers
Antiviral Agents
Geometry
29 Citations (Scopus)
HIV Integrase Inhibitors
Chelation
Metals
Integrase Inhibitors
HIV Integrase
2 Citations (Scopus)
carbovir
Lactams
Nucleosides
HIV
Derivatives
2004
1 Citation (Scopus)

Vinyl and aryl metals

Muthyala, R. & Vince, R., Dec 1 2004, Comprehensive Organic Functional Group Transformations II. Elsevier Ltd., Vol. 2. p. 1025-1057 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metals
2002
4 Citations (Scopus)

Synthesis and biological evaluation of endocyclic 2′,3′-didehydro-2′,3′-dideoxymethanocarba adenosine

Quirk Dorr, D. R. & Vince, R., Jan 1 2002, In : Nucleosides, Nucleotides and Nucleic Acids. 21, 10, p. 665-680 16 p.

Research output: Contribution to journalArticle

Nucleosides
Adenosine
Conformations
Adenosine Deaminase Inhibitors
Crystallography
24 Citations (Scopus)
Anti-HIV Agents
Reverse Transcriptase Inhibitors
X Ray Crystallography
Nucleosides
Antiviral Agents