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Research Output 1983 2020

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2020

Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity

Lawana, V., Um, S. Y., Rochet, J. C., Turesky, R. J., Shannahan, J. H. & Cannon, J. R., Jan 1 2020, In : Toxicological sciences : an official journal of the Society of Toxicology. 173, 1, p. 171-188 18 p.

Research output: Contribution to journalArticle

Amines
Parkinson Disease
Monophenol Monooxygenase
Rodent Diseases
neuromelanin
2019
1 Citation (Scopus)

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Bellamri, M., Yao, L., Bonala, R., Johnson, F., von Weymarn, L. B. & Turesky, R., Jul 1 2019, In : Archives of Toxicology. 93, 7, p. 1893-1902 10 p.

Research output: Contribution to journalArticle

Tobacco
Carcinogens
DNA Adducts
Urinary Bladder
Amines
3 Citations (Scopus)

Quantitation of Apurinic/Apyrimidinic Sites in Isolated DNA and in Mammalian Tissue with a Reduced Level of Artifacts

Chen, H., Yao, L., Brown, C., Rizzo, C. J. & Turesky, R. J., Jun 4 2019, In : Analytical chemistry. 91, 11, p. 7403-7410 8 p.

Research output: Contribution to journalArticle

Tissue
DNA
Mechlorethamine
Hydroxylamine
Oxidative stress
1 Citation (Scopus)

Quantitation of Lipid Peroxidation Product DNA Adducts in Human Prostate by Tandem Mass Spectrometry: A Method That Mitigates Artifacts

Chen, H., Krishnamachari, S., Guo, J., Yao, L., Murugan, P., Weight, C. J. & Turesky, R. J., Sep 16 2019, In : Chemical research in toxicology. 32, 9, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

DNA Adducts
Tandem Mass Spectrometry
Artifacts
Lipid Peroxidation
Mass spectrometry
2018
3 Citations (Scopus)

Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in humans

Bellamri, M., Wang, Y., Yonemori, K., White, K. K., Wilkens, L. R., Le Marchand, L. & Turesky, R., Dec 31 2018, In : Carcinogenesis. 39, 12, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

Environmental Monitoring
Carcinogens
Meat
Albumins
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

Hwa Yun, B., Guo, J., Bellamri, M. & Turesky, R. J., 2018, In : Mass Spectrometry Reviews.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Meats
Nitroso Compounds
Epidemiology
DNA Adducts
DNA
4 Citations (Scopus)
Open Access
Meats
Carcinogens
Meat
Prostate
Chemical activation
3 Citations (Scopus)

Method for Biomonitoring DNA Adducts in Exfoliated Urinary Cells by Mass Spectrometry

Yun, B. H., Bellamri, M., Rosenquist, T. A. & Turesky, R. J., Aug 21 2018, In : Analytical chemistry. 90, 16, p. 9943-9950 8 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Mass spectrometry
Tobacco
Carcinogens
Smoke
23 Citations (Scopus)

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., Vandenbussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Cytology
Aneuploidy
Urinary Bladder Neoplasms
Genes
Cell Biology
7 Citations (Scopus)
DNA Adducts
High performance liquid chromatography
Carcinogens
Amines
Mass spectrometry
2017
4 Citations (Scopus)

A Rapid Throughput Method to Extract DNA from Formalin-Fixed Paraffin-Embedded Tissues for Biomonitoring Carcinogenic DNA Adducts

Yun, B. H., Xiao, S., Yao, L., Krishnamachari, S., Rosenquist, T. A., Dickman, K. G., Grollman, A. P., Murugan, P., Weight, C. J. & Turesky, R. J., Dec 18 2017, In : Chemical research in toxicology. 30, 12, p. 2130-2139 10 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Environmental Monitoring
Paraffin
Formaldehyde
Throughput
13 Citations (Scopus)

Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts

Guo, J., Villalta, P. W. & Turesky, R. J., Nov 7 2017, In : Analytical chemistry. 89, 21, p. 11728-11736 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Mass spectrometry
Screening
Ions
Deoxyribose
5 Citations (Scopus)

Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans

Wang, Y., Villalta, P. W., Peng, L., Dingley, K., Malfatti, M. A., Turteltaub, K. W. & Turesky, R. J., Feb 20 2017, In : Chemical research in toxicology. 30, 2, p. 705-714 10 p.

Research output: Contribution to journalArticle

Open Access
Albumins
Acids
Mass spectrometry
Mass Spectrometry
Metabolites
5 Citations (Scopus)

Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes

Bellamri, M., Le Hegarat, L., Turesky, R. J. & Langouët, S., Feb 20 2017, In : Chemical research in toxicology. 30, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Open Access
Tobacco
Glucuronides
Metabolism
Carcinogens
Hepatocytes
6 Citations (Scopus)
Open Access
Tobacco
DNA Adducts
Liquid chromatography
Liquid Chromatography
Carcinogens
2016
18 Citations (Scopus)

Aristolochic acid exposure in Romania and implications for renal cell carcinoma

Turesky, R. J., Yun, B. H., Brennan, P., Mates, D., Jinga, V., Harnden, P., Banks, R. E., Blanche, H., Bihoreau, M. T., Chopard, P., Letourneau, L., Lathrop, G. M. & Scelo, G., Jan 12 2016, In : British Journal of Cancer. 114, 1, p. 76-80 5 p.

Research output: Contribution to journalArticle

Romania
Renal Cell Carcinoma
Balkan Peninsula
Food Contamination
DNA Adducts
21 Citations (Scopus)

Aristolochic acid in the etiology of renal cell carcinoma

Hoang, M. L., Chen, C. H., Chen, P. C., Roberts, N. J., Dickman, K. G., Yun, B. H., Turesky, R. J., Pu, Y. S., Vogelstein, B., Papadopoulos, N., Grollman, A. P., Kinzler, K. W. & Rosenquist, T. A., Dec 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 12, p. 1600-1608 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Aristolochia
Exome
Taiwan
aristolochic acid I
14 Citations (Scopus)

Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases

Cai, T., Yao, L. & Turesky, R., May 16 2016, In : Chemical research in toxicology. 29, 5, p. 879-891 13 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Glucuronides
Amines
Metabolites
Liver
23 Citations (Scopus)
Deoxyguanosine
DNA Adducts
Meats
Liquid chromatography
Carcinogens
16 Citations (Scopus)
2-amino-3,4-dimethylimidazo(4,5-f)quinoline
Aberrant Crypt Foci
Azoxymethane
DNA Adducts
Colonic Neoplasms
8 Citations (Scopus)

Dose validation of PhIP hair level as a biomarker of heterocyclic aromatic amines exposure: A feeding study

Le Marchand, L., Yonemori, K., White, K. K., Franke, A. A., Wilkens, L. R. & Turesky, R. J., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 685-691 7 p.

Research output: Contribution to journalArticle

Amines
Biomarkers
Cytochrome P-450 CYP1A2
Melanins
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
6 Citations (Scopus)

Human biomonitoring of DNA adducts by ion trap multistage mass spectrometry

Guo, J. & Turesky, R. J., Jan 1 2016, In : Current Protocols in Nucleic Acid Chemistry. 2016, p. 7.24.1-7.24.25

Research output: Contribution to journalArticle

DNA Adducts
Environmental Monitoring
Mass spectrometry
Mass Spectrometry
Ions
7 Citations (Scopus)

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts

Bellamri, M., Le Hegarat, L., Vernhet, L., Baffet, G., Turesky, R. J. & Langouët, S., Dec 1 2016, In : Environmental and Molecular Mutagenesis. 57, 9, p. 656-667 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Amines
T-Lymphocytes
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
Nucleotides
16 Citations (Scopus)

Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines

Pathak, K. V., Chiu, T. L., Amin, E. A. & Turesky, R. J., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 255-269 15 p.

Research output: Contribution to journalArticle

Methemoglobin
Amines
Hemoglobins
Methemoglobinemia
Metabolites
21 Citations (Scopus)

Multiclass Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

Guo, J., Yun, B. H., Upadhyaya, P., Yao, L., Krishnamachari, S., Rosenquist, T. A., Grollman, A. P. & Turesky, R. J., May 3 2016, In : Analytical chemistry. 88, 9, p. 4780-4787 8 p.

Research output: Contribution to journalArticle

Deoxyguanosine
DNA Adducts
Liquid chromatography
Paraffin
Formaldehyde
7 Citations (Scopus)

Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure

Sheng, J., Wang, Y., Turesky, R. J., Kluetzman, K., Zhang, Q. Y. & Ding, X., May 16 2016, In : Chemical research in toxicology. 29, 5, p. 797-809 13 p.

Research output: Contribution to journalArticle

Biomarkers
Serum Albumin
Transgenic Mice
Albumins
Xenobiotics
2015
14 Citations (Scopus)

2-Amino-9H-pyrido[2,3-b]indole (AαC) adducts and thiol oxidation of serum albumin as potential biomarkers of tobacco smoke

Pathak, K. V., Bellamri, M., Wang, Y., Langouët, S. & Turesky, R. J., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 16304-16318 15 p.

Research output: Contribution to journalArticle

Tobacco
Biomarkers
Sulfhydryl Compounds
Serum Albumin
Smoke
5 Citations (Scopus)

Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans

Turesky, R. J., White, K. K., Wilkens, L. R. & Le Marchand, L., Aug 17 2015, In : Chemical research in toxicology. 28, 8, p. 1603-1615 13 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Meats
Caffeine
Metabolism
Meat
10 Citations (Scopus)

Characterization of Nitrogen Mustard Formamidopyrimidine Adduct Formation of Bis(2-chloroethyl)ethylamine with Calf Thymus DNA and a Human Mammary Cancer Cell Line

Gruppi, F., Hejazi, L., Christov, P. P., Krishnamachari, S., Turesky, R. J. & Rizzo, C. J., Aug 19 2015, In : Chemical research in toxicology. 28, 9, p. 1850-1860 11 p.

Research output: Contribution to journalArticle

Mechlorethamine
Cells
Breast Neoplasms
Cell Line
Guanine
13 Citations (Scopus)

Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice

Turesky, R. J., Konorev, D., Fan, X., Tang, Y., Yao, L., Ding, X., Xie, F., Zhu, Y. & Zhang, Q. Y., Dec 21 2015, In : Chemical research in toxicology. 28, 12, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
DNA Adducts
Metabolism
Liver
Tissue
11 Citations (Scopus)
Plasma (human)
Metabolites
Serum Albumin
Hepatocytes
Albumins
10 Citations (Scopus)
Tobacco Products
Amines
Smoking
Urine
Tobacco
7 Citations (Scopus)
Meats
High performance liquid chromatography
Carcinogens
Mass spectrometry
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
11 Citations (Scopus)

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid

Yun, B. H., Sidorenko, V. S., Rosenquist, T. A., Dickman, K. G., Grollman, A. P. & Turesky, R. J., Jul 1 2015, In : Toxicology Research. 4, 4, p. 763-776 14 p.

Research output: Contribution to journalArticle

Aristolochic Acids
Environmental Monitoring
Carcinogens
DNA Adducts
Aristolochia
31 Citations (Scopus)

Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS

Monien, B. H., Schumacher, F., Herrmann, K., Glatt, H., Turesky, R. J. & Chesné, C., Jan 6 2015, In : Analytical chemistry. 87, 1, p. 641-648 8 p.

Research output: Contribution to journalArticle

methyleugenol
DNA Adducts
Liquid chromatography
Liquid Chromatography
Isotopes
2014
12 Citations (Scopus)

Formalin-fixed paraffin-embedded tissue as a source for quantitation of carcinogen DNA adducts: Aristolochic acid as a prototype carcinogen

Yun, B. H., Yao, L., Jelaković, B., Nikolić, J., Dickman, K. G., Grollman, A. P., Rosenquist, T. A. & Turesky, R. J., Sep 2014, In : Carcinogenesis. 35, 9, p. 2055-2061 7 p., bgu101.

Research output: Contribution to journalArticle

DNA Adducts
Aristolochic Acids
Carcinogens
Paraffin
Formaldehyde
10 Citations (Scopus)
Meats
Serum Albumin
Carcinogens
Meat
Digestion
2013
14 Citations (Scopus)

Biomonitoring the cooked meat carcinogen 2-Amino-1- Methyl-6- Phenylimidazo[4,5-b]Pyridine in hair: Impact of exposure, hair pigmentation, and cytochrome P450 1A2 phenotype

Turesky, R. J., Liu, L., Gu, D., Yonemori, K. M., White, K. K., Wilkens, L. R. & Marchand, L. L., Mar 1 2013, In : Cancer Epidemiology Biomarkers and Prevention. 22, 3, p. 356-364 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Environmental Monitoring
Pigmentation
Carcinogens
Hair
13 Citations (Scopus)

Capturing labile sulfenamide and sulfinamide serum albumin adducts of carcinogenic arylamines by chemical oxidation

Peng, L. & Turesky, R. J., Jan 15 2013, In : Analytical Chemistry. 85, 2, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Serum Albumin
Amines
Oxidation
Tobacco
Carcinogens
10 Citations (Scopus)
2-amino-3,4-dimethylimidazo(4,5-f)quinoline
DNA Adducts
Liver
Tissue
Inbred C57BL Mouse
17 Citations (Scopus)

DNA adducts of the tobacco carcinogens 2-amino-9 H -pyrido[2,3- b ]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes

Nauwelaërs, G., Bellamri, M., Fessard, V., Turesky, R. J. & Langouët, S., Sep 16 2013, In : Chemical research in toxicology. 26, 9, p. 1367-1377 11 p.

Research output: Contribution to journalArticle

Tobacco
DNA Adducts
Environmental Exposure
Carcinogens
Hepatocytes
20 Citations (Scopus)

Human formalin-fixed paraffin-embedded tissues: An untapped specimen for biomonitoring of carcinogen DNA adducts by mass spectrometry

Yun, B. H., Rosenquist, T. A., Nikolić, J., Dragičević, D., Tomić, K., Jelaković, B., Dickman, K. G., Grollman, A. P. & Turesky, R. J., May 7 2013, In : Analytical chemistry. 85, 9, p. 4251-4258 8 p.

Research output: Contribution to journalArticle

DNA Adducts
Carcinogens
Paraffin
Formaldehyde
Mass spectrometry
132 Citations (Scopus)

Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing

Hoang, M. L., Chen, C. H., Sidorenko, V. S., He, J., Dickman, K. G., Yun, B. H., Moriya, M., Niknafs, N., Douville, C., Karchin, R., Turesky, R. J., Pu, Y. S., Vogelstein, B., Papadopoulos, N., Grollman, A. P., Kinzler, K. W. & Rosenquist, T. A., Aug 7 2013, In : Science Translational Medicine. 5, 197, 197ra102.

Research output: Contribution to journalArticle

Exome
Mutation
Neoplasms
RNA Splice Sites
Consensus Sequence
2012
118 Citations (Scopus)

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid

Jelaković, B., Karanović, S., Vuković-Lela, I., Miller, F., Edwards, K. L., Nikolić, J., Tomić, K., Slade, N., Brdar, B., Turesky, R. J., Stipancić, Ž., Dittrich, D., Grollman, A. P. & Dickman, K. G., Mar 2 2012, In : Kidney international. 81, 6, p. 559-567 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Environmental Exposure
Urinary Tract
Biomarkers
Carcinoma
228 Citations (Scopus)

Aristolochic acid-associated urothelial cancer in Taiwan

Chen, C. H., Dickman, K. G., Moriya, M., Zavadil, J., Sidorenko, V. S., Edwards, K. L., Gnatenko, D. V., Wu, L., Turesky, R. J., Wu, X. R., Pu, Y. S. & Grollman, A. P., May 22 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 21, p. 8241-8246 6 p.

Research output: Contribution to journalArticle

Urinary Tract
Taiwan
DNA Adducts
Aristolochia
Neoplasms
55 Citations (Scopus)

Biomonitoring of aristolactam-DNA adducts in human tissues using ultra-performance liquid chromatography/ion-trap mass spectrometry

Yun, B. H., Rosenquist, T. A., Sidorenko, V., Iden, C. R., Chen, C. H., Pu, Y. S., Bonala, R., Johnson, F., Dickman, K. G., Grollman, A. P. & Turesky, R. J., May 21 2012, In : Chemical research in toxicology. 25, 5, p. 1119-1131 13 p.

Research output: Contribution to journalArticle

Aristolochic Acids
DNA Adducts
Environmental Monitoring
Liquid chromatography
Liquid Chromatography
8 Citations (Scopus)

Biomonitoring the cooked meat carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b ]pyridine in canine fur

Gu, D., Neuman, Z. L., Modiano, J. F. & Turesky, R. J., Sep 12 2012, In : Journal of agricultural and food chemistry. 60, 36, p. 9371-9375 5 p.

Research output: Contribution to journalArticle

Meats
Environmental Monitoring
pyridines
carcinogens
Carcinogens
4 Citations (Scopus)

Cytochrome P450-mediated metabolism and DNA binding of 2-Amino-1,7- dimethylimidazo[4,5-g]quinoxaline and its carcinogenic isomer 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in mice

Turesky, R. J., Bessette, E. E., Dunbar, D., Liberman, R. G. & Skipper, P. L., Feb 20 2012, In : Chemical research in toxicology. 25, 2, p. 410-421 12 p.

Research output: Contribution to journalArticle

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
Metabolism
Isomers
Cytochrome P-450 Enzyme System
Liver
29 Citations (Scopus)

DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry

Gu, D., Turesky, R. J., Tao, Y., Langouët, S. A., Nauwelaërs, G. C., Yuan, J. M., Yee, D. & Yu, M. C., Jan 9 2012, In : Carcinogenesis. 33, 1, p. 124-130 7 p.

Research output: Contribution to journalArticle

DNA Adducts
Tandem Mass Spectrometry
Liquid Chromatography
Breast
Breast Neoplasms