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Research Output 1983 2019

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2019

Tissue-engineered transcatheter vein valve

Syedain, Z. H., Jenson, A. C., Patel, P. S., Feagler, C., Bahmer, L., Faizer, R. & Tranquillo, R. T., Sep 1 2019, In : Biomaterials. 216, 119229.

Research output: Contribution to journalArticle

Stents
Veins
Durability
Tissue
Hydrodynamics
2018
6 Citations (Scopus)

A cardiac patch from aligned microvessel and cardiomyocyte patches

Schaefer, J. A., Guzman, P. A., Riemenschneider, S. B., Kamp, T. J. & Tranquillo, R. T., Feb 1 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 2, p. 546-556 11 p.

Research output: Contribution to journalArticle

Microvessels
Stem cells
Cardiac Myocytes
Tissue
Endothelial cells
3 Citations (Scopus)

Shear Conditioning of Adipose Stem Cells for Reduced Platelet Binding to Engineered Vascular Grafts

La, A. & Tranquillo, R. T., Aug 1 2018, In : Tissue Engineering - Part A. 24, 15-16, p. 1242-1250 9 p.

Research output: Contribution to journalArticle

Platelets
Stem cells
Grafts
Blood Vessels
Shear stress
2017
15 Citations (Scopus)

A completely biological "off-the-shelf" arteriovenous graft that recellularizes in baboons

Syedain, Z. H., Graham, M. L., Dunn, T. B., O'Brien, T. D., Johnson, S. L., Schumacher, R. J. & Tranquillo, R. T., Nov 1 2017, In : Science Translational Medicine. 9, 414, eaan4209.

Research output: Contribution to journalArticle

Papio
Transplants
Renal Dialysis
Veins
Head

Corrigendum: Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

Syedain, Z. H., Reimer, J., Lahti, M., Berry, J., Johnson, S., Bianco, R. W. & Tranquillo, R. T., Jan 17 2017, In : Nature Communications. 8, 1 p.

Research output: Contribution to journalArticle

Open Access
tissue engineering
Tissue Engineering
Tissue engineering
Grafts
Blood Vessels
17 Citations (Scopus)

Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs

Reimer, J., Syedain, Z. H., Haynie, B., Lahti, M., Berry, J. & Tranquillo, R. T., Feb 1 2017, In : Annals of Biomedical Engineering. 45, 2, p. 439-451 13 p.

Research output: Contribution to journalArticle

Pediatrics
Tissue
Elastin
Histology
Collagen
2016
4 Citations (Scopus)

Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes

Schmidt, J. B. & Tranquillo, R. T., May 1 2016, In : Annals of Biomedical Engineering. 44, 5, p. 1785-1797 13 p.

Research output: Contribution to journalArticle

Bioreactors
Tissue
Latexes
Pulsatile flow
Fibroblasts
1 Citation (Scopus)

Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue

Schmidt, J. B., Chen, K. & Tranquillo, R. T., Mar 1 2016, In : Cellular and Molecular Bioengineering. 9, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

Collagen
Stretch
Stretching
Tissue
Fibroblasts
18 Citations (Scopus)

Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction

Riemenschneider, S. B., Mattia, D. J., Wendel, J. S., Schaefer, J. A., Ye, L., Guzman, P. A. & Tranquillo, R. T., Aug 1 2016, In : Biomaterials. 97, p. 51-61 11 p.

Research output: Contribution to journalArticle

Microvessels
Perfusion
Myocardial Infarction
Tissue
Rats
13 Citations (Scopus)

Swelling of Collagen-Hyaluronic Acid Co-Gels: An In Vitro Residual Stress Model

Lai, V., Nedrelow, D., Lake, S. P., Kim, B., Weiss, E. M., Tranquillo, R. T. & Barocas, V. H., Oct 1 2016, In : Annals of Biomedical Engineering. 44, 10, p. 2984-2993 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Collagen
Swelling
Residual stresses
Gels
7 Citations (Scopus)

Tissue Contraction Force Microscopy for Optimization of Engineered Cardiac Tissue

Schaefer, J. A. & Tranquillo, R. T., Jan 1 2016, In : Tissue Engineering - Part C: Methods. 22, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Polydimethylsiloxane
Microscopic examination
Tissue
Gels
41 Citations (Scopus)

Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

Syedain, Z. H., Reimer, J., Lahti, M., Berry, J., Johnson, S. & Tranquillo, R. T., Sep 27 2016, In : Nature communications. 7, 12951.

Research output: Contribution to journalArticle

tissue engineering
Tissue Engineering
Tissue engineering
Grafts
Blood Vessels
2015
38 Citations (Scopus)

6-Month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep

Syedain, Z., Reimer, J., Schmidt, J., Lahti, M., Berry, J., Bianco, R. & Tranquillo, R. T., Dec 1 2015, In : Biomaterials. 73, p. 175-184 10 p.

Research output: Contribution to journalArticle

Aortic Valve
Sheep
Tissue
Hemodynamics
Orifices
1 Citation (Scopus)

A mathematical model for understanding fluid flow through engineered tissues containing microvessels

Morin, K. T., Lenz, M. S., Labat, C. A. & Tranquillo, R. T., May 1 2015, In : Journal of Biomechanical Engineering. 137, 5, 051003.

Research output: Contribution to journalArticle

Microvessels
Flow of fluids
Theoretical Models
Tissue
Mathematical models
31 Citations (Scopus)

Functional effects of a tissue-engineered cardiac patch from human induced pluripotent stem cell-derived cardiomyocytes in a rat infarct model

Wendel, J. S., Ye, L., Tao, R., Zhang, J., Zhang, J., Kamp, T. J. & Tranquillo, R. T., Nov 1 2015, In : Stem Cells Translational Medicine. 4, 11, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pericytes
Cardiac Myocytes
Infarction
Myocardium
9 Citations (Scopus)

Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues

Weidenhamer, N. K., Moore, D. L., Lobo, F. L., Klair, N. T. & Tranquillo, R. T., May 1 2015, In : Journal of Tissue Engineering and Regenerative Medicine. 9, 5, p. 605-618 14 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Extracellular Matrix
Tissue
Ascorbic acid
18 Citations (Scopus)

Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes

Reimer, J. M., Syedain, Z. H., Haynie, B. H. T. & Tranquillo, R. T., Sep 1 2015, In : Biomaterials. 62, p. 88-94 7 p.

Research output: Contribution to journalArticle

Pulmonary Valve
Pediatrics
Heart Valves
Tissue
Pressure gradient
2014
19 Citations (Scopus)

Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery

Meier, L. A., Syedain, Z. H., Lahti, M. T., Johnson, S. S., Chen, M. H., Hebbel, R. P. & Tranquillo, R. T., Jan 1 2014, In : Journal of cardiovascular translational research. 7, 2, p. 242-249 8 p.

Research output: Contribution to journalArticle

Femoral Artery
Sheep
Endothelial Cells
Transplants
Fibrin
17 Citations (Scopus)

Engineered microvessels with strong alignment and high lumen density via cell-induced fibrin gel compaction and interstitial flow

Morin, K. T., Dries-Devlin, J. L. & Tranquillo, R. T., Feb 1 2014, In : Tissue Engineering - Part A. 20, 3-4, p. 553-565 13 p.

Research output: Contribution to journalArticle

Microvessels
Fibrin
Compaction
Gels
Cell Count
41 Citations (Scopus)

Functional consequences of a tissue-engineered myocardial patch for cardiac repair in a rat infarct model

Wendel, J. S., Ye, L., Zhang, P., Tranquillo, R. T. & Zhang, J. J., Apr 1 2014, In : Tissue Engineering - Part A. 20, 7-8, p. 1325-1335 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Rats
Repair
Tissue
Fibrin
60 Citations (Scopus)

Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery

Syedain, Z. H., Meier, L. A., Lahti, M. T., Johnson, S. L. & Tranquillo, R. T., Jun 1 2014, In : Tissue Engineering - Part A. 20, 11-12, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

Femoral Artery
Grafts
Sheep
Transplants
Allografts
2013
16 Citations (Scopus)

Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction

Morin, K. T., Smith, A. O., Davis, G. E. & Tranquillo, R. T., Nov 1 2013, In : Microvascular Research. 90, p. 12-22 11 p.

Research output: Contribution to journalArticle

Microvessels
Fibrin
Gels
Tissue engineering
Compaction
17 Citations (Scopus)
Cytoskeleton
Military electronic countermeasures
Tissue
Fibers
Stiffness
5 Citations (Scopus)

Combating adaptation to cyclic stretching by prolonging activation of extracellular signal-regulated kinase

Weinbaum, J. S., Schmidt, J. B. & Tranquillo, R. T., Sep 1 2013, In : Cellular and Molecular Bioengineering. 6, 3, p. 279-286 8 p.

Research output: Contribution to journalArticle

Collagen
Extracellular Signal-Regulated MAP Kinases
Stretching
Activation
Chemical activation
61 Citations (Scopus)

Decellularized tissue-engineered heart valve leaflets with recellularization potential

Syedain, Z. H., Bradee, A. R., Kren, S., Taylor, D. A. & Tranquillo, R. T., Mar 1 2013, In : Tissue Engineering - Part A. 19, 5-6, p. 759-769 11 p.

Research output: Contribution to journalArticle

Heart Valves
Tissue
Tensile properties
Detergents
Stem cells
29 Citations (Scopus)
Fibroblasts
Collagen
Tissue
Silicones
Stretching
32 Citations (Scopus)

Tubular heart valves from decellularized engineered tissue

Syedain, Z. H., Meier, L. A., Reimer, J. M. & Tranquillo, R. T., Jul 30 2013, In : Annals of Biomedical Engineering. 41, 12, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

Tissue
Pressure gradient
Mechanical properties
Fatigue testing
Struts
2012
12 Citations (Scopus)

Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue

Bjork, J. W., Meier, L. A., Johnson, S. L., Syedain, Z. H. & Tranquillo, R. T., Apr 1 2012, In : Tissue Engineering - Part A. 18, 7-8, p. 785-795 11 p.

Research output: Contribution to journalArticle

Insulin
Fibrin
Collagen
Tissue
Tensile Strength
51 Citations (Scopus)
Fibrin
Collagen
Gels
Biopolymers
Mechanical testing
21 Citations (Scopus)

Microstructural and mechanical differences between digested collagen-fibrin co-gels and pure collagen and fibrin gels

Lai, V., Frey, C. R., Kerandi, A. M., Lake, S. P., Tranquillo, R. T. & Barocas, V. H., Jan 1 2012, In : Acta Biomaterialia. 8, 11, p. 4031-4042 12 p.

Research output: Contribution to journalArticle

Fibrin
Collagen
Gels
Proteins
Biopolymers
2011
29 Citations (Scopus)

Guided sprouting from endothelial spheroids in fibrin gels aligned by magnetic fields and cell-induced gel compaction

Morin, K. T. & Tranquillo, R. T., Sep 1 2011, In : Biomaterials. 32, 26, p. 6111-6118 8 p.

Research output: Contribution to journalArticle

Magnetic Fields
Fibrin
Compaction
Gels
Magnetic fields
120 Citations (Scopus)

Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring

Syedain, Z. H., Meier, L. A., Bjork, J. W., Lee, A. & Tranquillo, R. T., Jan 1 2011, In : Biomaterials. 32, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

Pulsatile flow
Bioreactors
Fibroblasts
Fibrin
Grafts
33 Citations (Scopus)

Implantation of a Tissue-engineered Heart Valve from Human Fibroblasts Exhibiting Short Term Function in the Sheep Pulmonary Artery

Syedain, Z. H., Lahti, M. T., Johnson, S. L., Robinson, P. S., Ruth, G. R., Bianco, R. W. & Tranquillo, R. T., Jun 1 2011, In : Cardiovascular Engineering and Technology. 2, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Heart Valves
Fibroblasts
Pulmonary Artery
Sheep
Echocardiography
41 Citations (Scopus)
Fibroblasts
Gels
Collagen
Geometry
Fibers
32 Citations (Scopus)

Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue

Bjork, J. W., Johnson, S. L. & Tranquillo, R. T., Apr 1 2011, In : Biomaterials. 32, 10, p. 2479-2488 10 p.

Research output: Contribution to journalArticle

Ruthenium
Fibrin
Tissue
Chemical Phenomena
Stiffness
22 Citations (Scopus)
Collagen
Connective Tissue
Elastin
Stretching
Tissue
2010
52 Citations (Scopus)

Fibrin degradation enhances vascular smooth muscle cell proliferation and matrix deposition in fibrin-based tissue constructs fabricated in vitro

Ahmann, K. A., Weinbaum, J. S., Johnson, S. L. & Tranquillo, R. T., Oct 1 2010, In : Tissue Engineering - Part A. 16, 10, p. 3261-3270 10 p.

Research output: Contribution to journalArticle

Cell proliferation
Fibrin
Fibrin Fibrinogen Degradation Products
Vascular Smooth Muscle
Smooth Muscle Myocytes
16 Citations (Scopus)

Fusion of concentrically layered tubular tissue constructs increases burst strength

Huynh, T. N. & Tranquillo, R. T., Jun 1 2010, In : Annals of Biomedical Engineering. 38, 6, p. 2226-2236 11 p.

Research output: Contribution to journalArticle

Fusion reactions
Tissue
Collagen
Fibroblasts
Tensile strength
9 Citations (Scopus)

Monitoring collagen transcription by vascular smooth muscle cells in fibrin-based tissue constructs

Weinbaum, J. S., Qi, J. & Tranquillo, R. T., Jun 1 2010, In : Tissue Engineering - Part C: Methods. 16, 3, p. 459-467 9 p.

Research output: Contribution to journalArticle

Transcription
Fibrin
Vascular Smooth Muscle
Collagen
Smooth Muscle Myocytes
7 Citations (Scopus)
Connective Tissue Growth Factor
Glycoproteins
Fibroblasts
Extracellular Matrix
Tissue
2009
104 Citations (Scopus)

Cell-Induced Alignment Augments Twitch Force in Fibrin Gel-Based Engineered Myocardium via Gap Junction Modification

Black, L. D., Meyers, J. D., Weinbaum, J. S., Shvelidze, Y. A. & Tranquillo, R. T., Oct 1 2009, In : Tissue Engineering - Part A. 15, 10, p. 3099-3108 10 p.

Research output: Contribution to journalArticle

Gap Junctions
Fibrin
Myocardium
Gels
Tissue
23 Citations (Scopus)

Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue

Syedain, Z. H., Bjork, J., Sando, L. & Tranquillo, R. T., Dec 1 2009, In : Biomaterials. 30, 35, p. 6695-6701 7 p.

Research output: Contribution to journalArticle

Ruthenium
Fibrin
Connective Tissue
Compaction
Gels
66 Citations (Scopus)

Controlled cyclic stretch bioreactor for tissue-engineered heart valves

Syedain, Z. H. & Tranquillo, R. T., Sep 1 2009, In : Biomaterials. 30, 25, p. 4078-4084 7 p.

Research output: Contribution to journalArticle

Heart Valves
Bioreactors
Latex
Latexes
Tissue
32 Citations (Scopus)

Image-based biomechanics of collagen-based tissue equivalents

Sander, E., Stylianopoulos, T., Tranquillo, R. & Barocas, V., May 1 2009, In : IEEE Engineering in Medicine and Biology Magazine. 28, 3, p. 10-18 9 p., 4939184.

Research output: Contribution to journalArticle

Fibrillar Collagens
Biomedical Engineering
Biological Models
Finite Element Analysis
Mechanical Stress
104 Citations (Scopus)
Extracellular Matrix
Collagen
Gels
Anisotropy
Homeostasis
31 Citations (Scopus)

Planar biaxial behavior of fibrin-based tissue-engineered heart valve leaflets

Robinson, P. S. & Tranquillo, R. T., Oct 1 2009, In : Tissue Engineering - Part A. 15, 10, p. 2763-2772 10 p.

Research output: Contribution to journalArticle

Heart Valves
Fibrin
Tissue
Aortic Valve
Fibers
36 Citations (Scopus)

Planar biaxial mechanical behavior of bioartificial tissues possessing prescribed fiber alignment

Jhun, C. S., Evans, M. C., Barocas, V. H. & Tranquillo, R. T., Aug 1 2009, In : Journal of Biomechanical Engineering. 131, 8, 81006-1.

Research output: Contribution to journalArticle

Fungi
Tissue
Fibers
Anisotropy
Molds
20 Citations (Scopus)

Transmural flow bioreactor for vascular tissue engineering

Bjork, J. W. & Tranquillo, R. T., Dec 15 2009, In : Biotechnology and Bioengineering. 104, 6, p. 1197-1206 10 p.

Research output: Contribution to journalArticle

Bioreactors
Tissue Engineering
Tissue engineering
Blood Vessels
Tissue
2008
128 Citations (Scopus)
Fibrin
Connective Tissue
Collagen
Tensile Strength
Growth