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Research Output 1983 2019

2019

Tissue-engineered transcatheter vein valve

Syedain, Z. H., Jenson, A. C., Patel, P. S., Feagler, C., Bahmer, L., Faizer, R. & Tranquillo, R. T., Sep 1 2019, In : Biomaterials. 216, 119229.

Research output: Contribution to journalArticle

Stents
Veins
Durability
Tissue
Hydrodynamics
2018
6 Citations (Scopus)

A cardiac patch from aligned microvessel and cardiomyocyte patches

Schaefer, J. A., Guzman, P. A., Riemenschneider, S. B., Kamp, T. J. & Tranquillo, R. T., Feb 1 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 2, p. 546-556 11 p.

Research output: Contribution to journalArticle

Microvessels
Stem cells
Cardiac Myocytes
Tissue
Endothelial cells
3 Citations (Scopus)

Shear Conditioning of Adipose Stem Cells for Reduced Platelet Binding to Engineered Vascular Grafts

La, A. & Tranquillo, R. T., Aug 1 2018, In : Tissue Engineering - Part A. 24, 15-16, p. 1242-1250 9 p.

Research output: Contribution to journalArticle

Platelets
Stem cells
Grafts
Blood Vessels
Shear stress
2017
15 Citations (Scopus)

A completely biological "off-the-shelf" arteriovenous graft that recellularizes in baboons

Syedain, Z. H., Graham, M. L., Dunn, T. B., O'Brien, T. D., Johnson, S. L., Schumacher, R. J. & Tranquillo, R. T., Nov 1 2017, In : Science Translational Medicine. 9, 414, eaan4209.

Research output: Contribution to journalArticle

Papio
Transplants
Renal Dialysis
Veins
Head

Corrigendum: Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

Syedain, Z. H., Reimer, J., Lahti, M., Berry, J., Johnson, S., Bianco, R. W. & Tranquillo, R. T., Jan 17 2017, In : Nature Communications. 8, 1 p.

Research output: Contribution to journalArticle

tissue engineering
Tissue Engineering
Tissue engineering
Grafts
Blood Vessels
17 Citations (Scopus)

Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs

Reimer, J., Syedain, Z. H., Haynie, B., Lahti, M., Berry, J. & Tranquillo, R. T., Feb 1 2017, In : Annals of Biomedical Engineering. 45, 2, p. 439-451 13 p.

Research output: Contribution to journalArticle

Pediatrics
Tissue
Elastin
Histology
Collagen
2016
23 Citations (Scopus)

Cells for tissue engineering of cardiac valves

Jana, S., Tranquillo, R. T. & Lerman, A., Oct 1 2016, In : Journal of Tissue Engineering and Regenerative Medicine. 10, 10, p. 804-824 21 p.

Research output: Contribution to journalReview article

Cell Engineering
Heart Valves
Tissue Engineering
Tissue engineering
Cell engineering
3 Citations (Scopus)

Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes

Schmidt, J. B. & Tranquillo, R. T., May 1 2016, In : Annals of Biomedical Engineering. 44, 5, p. 1785-1797 13 p.

Research output: Contribution to journalArticle

Bioreactors
Tissue
Latexes
Pulsatile flow
Fibroblasts
1 Citation (Scopus)

Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue

Schmidt, J. B., Chen, K. & Tranquillo, R. T., Mar 1 2016, In : Cellular and Molecular Bioengineering. 9, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

Collagen
Stretch
Stretching
Tissue
Fibroblasts
17 Citations (Scopus)

Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction

Riemenschneider, S. B., Mattia, D. J., Wendel, J. S., Schaefer, J. A., Ye, L., Guzman, P. A. & Tranquillo, R. T., Aug 1 2016, In : Biomaterials. 97, p. 51-61 11 p.

Research output: Contribution to journalArticle

Microvessels
Perfusion
Myocardial Infarction
Tissue
Rats
13 Citations (Scopus)

Swelling of Collagen-Hyaluronic Acid Co-Gels: An In Vitro Residual Stress Model

Lai, V., Nedrelow, D., Lake, S. P., Kim, B., Weiss, E. M., Tranquillo, R. T. & Barocas, V. H., Oct 1 2016, In : Annals of Biomedical Engineering. 44, 10, p. 2984-2993 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Collagen
Swelling
Residual stresses
Gels
7 Citations (Scopus)

Tissue Contraction Force Microscopy for Optimization of Engineered Cardiac Tissue

Schaefer, J. A. & Tranquillo, R. T., Jan 1 2016, In : Tissue Engineering - Part C: Methods. 22, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Polydimethylsiloxane
Microscopic examination
Tissue
Gels
38 Citations (Scopus)

Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

Syedain, Z. H., Reimer, J., Lahti, M., Berry, J., Johnson, S. & Tranquillo, R. T., Sep 27 2016, In : Nature communications. 7, 12951.

Research output: Contribution to journalArticle

tissue engineering
Tissue Engineering
Tissue engineering
Grafts
Blood Vessels
2015
38 Citations (Scopus)

6-Month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep

Syedain, Z., Reimer, J., Schmidt, J., Lahti, M., Berry, J., Bianco, R. & Tranquillo, R. T., Dec 1 2015, In : Biomaterials. 73, p. 175-184 10 p.

Research output: Contribution to journalArticle

Aortic Valve
Sheep
Tissue
Hemodynamics
Orifices
1 Citation (Scopus)

A mathematical model for understanding fluid flow through engineered tissues containing microvessels

Morin, K. T., Lenz, M. S., Labat, C. A. & Tranquillo, R. T., May 1 2015, In : Journal of Biomechanical Engineering. 137, 5, 051003.

Research output: Contribution to journalArticle

Microvessels
Flow of fluids
Theoretical Models
Tissue
Mathematical models
9 Citations (Scopus)

Automated image analysis programs for the quantification of microvascular network characteristics

Morin, K. T., Carlson, P. D. & Tranquillo, R. T., Aug 1 2015, In : Methods. 84, p. 76-83 8 p.

Research output: Contribution to journalReview article

Microvessels
Image analysis
Tissue

Cardiac tissue engineering for the treatment of heart failure post-infarction

Wendel, J. S. & Tranquillo, R. T., Jan 1 2015, Cardiac Fibrosis and Heart Failure: Cause or Effect?. Springer International Publishing, p. 405-418 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Military electronic countermeasures
Tissue Engineering
Treatment Failure
Tissue engineering
Infarction
16 Citations (Scopus)

Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

Kheradvar, A., Groves, E. M., Simmons, C. A., Griffith, B., Alavi, S. H., Tranquillo, R., Dasi, L. P., Falahatpisheh, A., Grande-Allen, K. J., Goergen, C. J., Mofrad, M. R. K., Baaijens, F., Canic, S. & Little, S. H., Apr 1 2015, In : Annals of Biomedical Engineering. 43, 4, p. 858-870 13 p.

Research output: Contribution to journalReview article

Catheters
Repair
Fabrication
16 Citations (Scopus)

Emerging Trends in Heart Valve Engineering: Part II. Novel and Standard Technologies for Aortic Valve Replacement

Kheradvar, A., Groves, E. M., Goergen, C. J., Alavi, S. H., Tranquillo, R., Simmons, C. A., Dasi, L. P., Grande-Allen, K. J., Mofrad, M. R. K., Falahatpisheh, A., Griffith, B., Baaijens, F., Little, S. H. & Canic, S., Apr 1 2015, In : Annals of Biomedical Engineering. 43, 4, p. 844-857 14 p.

Research output: Contribution to journalReview article

Medicine
Innovation
39 Citations (Scopus)

Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

Kheradvar, A., Groves, E. M., Dasi, L. P., Alavi, S. H., Tranquillo, R., Grande-Allen, K. J., Simmons, C. A., Griffith, B., Falahatpisheh, A., Goergen, C. J., Mofrad, M. R. K., Baaijens, F., Little, S. H. & Canic, S., Apr 1 2015, In : Annals of Biomedical Engineering. 43, 4, p. 833-843 11 p.

Research output: Contribution to journalReview article

Tissue
Artificial heart
Polymers
Costs
21 Citations (Scopus)

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies

Kheradvar, A., Groves, E. M., Falahatpisheh, A., Mofrad, M. K., Hamed Alavi, S., Tranquillo, R., Dasi, L. P., Simmons, C. A., Jane Grande-Allen, K., Goergen, C. J., Baaijens, F., Little, S. H., Canic, S. & Griffith, B., Oct 22 2015, In : Annals of Biomedical Engineering. 43, 10, p. 2314-2333 20 p.

Research output: Contribution to journalReview article

Computational methods
Fluids
Testing
30 Citations (Scopus)

Functional effects of a tissue-engineered cardiac patch from human induced pluripotent stem cell-derived cardiomyocytes in a rat infarct model

Wendel, J. S., Ye, L., Tao, R., Zhang, J., Zhang, J., Kamp, T. J. & Tranquillo, R. T., Nov 1 2015, In : Stem Cells Translational Medicine. 4, 11, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pericytes
Cardiac Myocytes
Infarction
Myocardium
1 Citation (Scopus)

Hydrogel scaffolds for regenerative medicine

Sander, E. A., Grassl, E. D. & Tranquillo, R. T., Jan 1 2015, Biomaterials and Regenerative Medicine. Cambridge University Press, p. 295-316 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Scaffolds (biology)
Collagen
Hydrogels
Tissue
Biopolymers
9 Citations (Scopus)

Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues

Weidenhamer, N. K., Moore, D. L., Lobo, F. L., Klair, N. T. & Tranquillo, R. T., May 1 2015, In : Journal of Tissue Engineering and Regenerative Medicine. 9, 5, p. 605-618 14 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Extracellular Matrix
Tissue
Ascorbic acid
16 Citations (Scopus)

Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes

Reimer, J. M., Syedain, Z. H., Haynie, B. H. T. & Tranquillo, R. T., Sep 1 2015, In : Biomaterials. 62, p. 88-94 7 p.

Research output: Contribution to journalArticle

Pulmonary Valve
Pediatrics
Heart Valves
Tissue
Pressure gradient
2014
19 Citations (Scopus)

Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery

Meier, L. A., Syedain, Z. H., Lahti, M. T., Johnson, S. S., Chen, M. H., Hebbel, R. P. & Tranquillo, R. T., Jan 1 2014, In : Journal of cardiovascular translational research. 7, 2, p. 242-249 8 p.

Research output: Contribution to journalArticle

Femoral Artery
Sheep
Endothelial Cells
Transplants
Fibrin
16 Citations (Scopus)

Engineered microvessels with strong alignment and high lumen density via cell-induced fibrin gel compaction and interstitial flow

Morin, K. T., Dries-Devlin, J. L. & Tranquillo, R. T., Feb 1 2014, In : Tissue Engineering - Part A. 20, 3-4, p. 553-565 13 p.

Research output: Contribution to journalArticle

Microvessels
Fibrin
Compaction
Gels
Cell Count
41 Citations (Scopus)

Functional consequences of a tissue-engineered myocardial patch for cardiac repair in a rat infarct model

Wendel, J. S., Ye, L., Zhang, P., Tranquillo, R. T. & Zhang, J. J., Apr 1 2014, In : Tissue Engineering - Part A. 20, 7-8, p. 1325-1335 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Rats
Repair
Tissue
Fibrin
56 Citations (Scopus)

Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery

Syedain, Z. H., Meier, L. A., Lahti, M. T., Johnson, S. L. & Tranquillo, R. T., Jun 1 2014, In : Tissue Engineering - Part A. 20, 11-12, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

Femoral Artery
Grafts
Sheep
Transplants
Allografts
2013
15 Citations (Scopus)

Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction

Morin, K. T., Smith, A. O., Davis, G. E. & Tranquillo, R. T., Nov 1 2013, In : Microvascular Research. 90, p. 12-22 11 p.

Research output: Contribution to journalArticle

Microvessels
Fibrin
Gels
Tissue engineering
Compaction
1 Citation (Scopus)

A multiscale approach to modeling the passive mechanical contribution of cells in tissues

Lai, V., Hadi, M. F., Tranquillo, R. T. & Barocas, V. H., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 B).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tissue
17 Citations (Scopus)
Cytoskeleton
Military electronic countermeasures
Tissue
Fibers
Stiffness
5 Citations (Scopus)

Combating adaptation to cyclic stretching by prolonging activation of extracellular signal-regulated kinase

Weinbaum, J. S., Schmidt, J. B. & Tranquillo, R. T., Sep 1 2013, In : Cellular and Molecular Bioengineering. 6, 3, p. 279-286 8 p.

Research output: Contribution to journalArticle

Collagen
Extracellular Signal-Regulated MAP Kinases
Stretching
Activation
Chemical activation
60 Citations (Scopus)

Decellularized tissue-engineered heart valve leaflets with recellularization potential

Syedain, Z. H., Bradee, A. R., Kren, S., Taylor, D. A. & Tranquillo, R. T., Mar 1 2013, In : Tissue Engineering - Part A. 19, 5-6, p. 759-769 11 p.

Research output: Contribution to journalArticle

Heart Valves
Tissue
Tensile properties
Detergents
Stem cells

Engineered microvessels subjected to interstitial flow

Morin, K. T., Dries-Devlin, J. L. & Tranquillo, R. T., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 A).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microvessels
26 Citations (Scopus)
Fibroblasts
Collagen
Tissue
Silicones
Stretching
60 Citations (Scopus)

In vitro models of angiogenesis and vasculogenesis in fibrin gel

Morin, K. T. & Tranquillo, R. T., Oct 1 2013, In : Experimental Cell Research. 319, 16, p. 2409-2417 9 p.

Research output: Contribution to journalReview article

Fibrin
Gels
Microvessels
In Vitro Techniques

Novel tissue-engineered heart valve

Syedain, Z. H., Meier, L. A., Reimer, J. & Tranquillo, R. T., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Heart Valves
Tissue

Swelling of collagen-hyaluronic acid tissue-equivalents: An experimental model to evaluate residual stress in soft tissues

Lai, V., Lake, S. P., Kim, B., Weiss, E. M., Tranquillo, R. T. & Barocas, V. H., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 B.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hyaluronic acid
Hyaluronic Acid
Collagen
Swelling
Residual stresses
3 Citations (Scopus)

Tissue-engineered heart valves

Schmidt, J. B. & Tranquillo, R. T., Jan 1 2013, Heart Valves: From Design to Clinical Implantation. Springer US, p. 261-280 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heart Valves
31 Citations (Scopus)

Tubular heart valves from decellularized engineered tissue

Syedain, Z. H., Meier, L. A., Reimer, J. M. & Tranquillo, R. T., Jul 30 2013, In : Annals of Biomedical Engineering. 41, 12, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

Tissue
Pressure gradient
Mechanical properties
Fatigue testing
Struts
2012

Collagen network architecture varies between pure collagen and collagen-fibrin co-gels

Lai, V., Kerandi, A. M., Lake, S. P., Tranquillo, R. T. & Barocas, V. H., Dec 1 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 1219-1220 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Network architecture
Collagen
Gels
12 Citations (Scopus)

Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue

Bjork, J. W., Meier, L. A., Johnson, S. L., Syedain, Z. H. & Tranquillo, R. T., Apr 1 2012, In : Tissue Engineering - Part A. 18, 7-8, p. 785-795 11 p.

Research output: Contribution to journalArticle

Insulin
Fibrin
Collagen
Tissue
Tensile Strength
50 Citations (Scopus)
Fibrin
Collagen
Gels
Biopolymers
Mechanical testing
20 Citations (Scopus)

Microstructural and mechanical differences between digested collagen-fibrin co-gels and pure collagen and fibrin gels

Lai, V., Frey, C. R., Kerandi, A. M., Lake, S. P., Tranquillo, R. T. & Barocas, V. H., Jan 1 2012, In : Acta Biomaterialia. 8, 11, p. 4031-4042 12 p.

Research output: Contribution to journalArticle

Fibrin
Collagen
Gels
Proteins
Biopolymers

Reply to the Letter to the Editor

Tranquillo, R. T. & Dickinson, R. B., Dec 1 2012, In : AICHE Journal. 58, 12, p. 3931-3932 2 p.

Research output: Contribution to journalLetter

2011

(336d) decellularization of tissue engineered leaflets with adult stem cell recellularization

Syedain, Z. H., Bradee, A. & Tranquillo, R. T., Jan 1 2011, Food, Pharmaceutical and Bioengineering Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, Vol. 1. p. 326-327 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

leaflet
Stem cells
Tissue

Collagen network topology is influenced by collagen concentration, but not by co-gelation with fibrin

Lai, V., Sander, E. A., Lake, S. P., Tranquillo, R. T. & Barocas, V. H., Dec 1 2011, ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. p. 1187-1188 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gelation
Fibrin
Collagen
Topology
3 Citations (Scopus)

Engineering of Small-Diameter Vessels

Isenberg, B. C., Williams, C. & Tranquillo, R. T., Dec 1 2011, Principles of Regenerative Medicine. Elsevier Inc., p. 853-875 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Scaffolds
Arteries
Transplants
Grafts
Tissue Scaffolds
28 Citations (Scopus)

Guided sprouting from endothelial spheroids in fibrin gels aligned by magnetic fields and cell-induced gel compaction

Morin, K. T. & Tranquillo, R. T., Sep 1 2011, In : Biomaterials. 32, 26, p. 6111-6118 8 p.

Research output: Contribution to journalArticle

Magnetic Fields
Fibrin
Compaction
Gels
Magnetic fields