1974 …2021

Research output per year

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Article
2020

The multifaceted role of ischemia/reperfusion in sickle cell anemia

Hebbel, R. P., Belcher, J. D. & Vercellotti, G. M., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1062-1072 11 p.

Research output: Contribution to journalArticle

2019
1 Scopus citations

Morphine promotes neovascularizing retinopathy in sickle transgeneic mice

Gupta, K., Chen, C., Lutty, G. A. & Hebbel, R. P., Apr 9 2019, In : Blood Advances. 3, 7, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Open Access

Reproducibility of endothelial microparticles in children and adolescents

Northrop, E. F., Milbauer, L. C., Rudser, K. D., Fox, C. K., Solovey, A. N., Kaizer, A. M., Hebbel, R. P., Kelly, A. S. & Ryder, J. R., Jan 1 2019, In : Biomarkers in Medicine. 14, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

2018
Open Access
2017

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

Solovey, A., Somani, A., Belcher, J. D., Milbauer, L., Vincent, L., Pawlinski, R., Nath, K. A., Kelm, R. J., Mackman, N., O'Sullivan, M. G., Gupta, K., Vercellotti, G. M. & Hebbel, R. P., Nov 2017, In : American Journal of Hematology. 92, 11, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Vascular function in breast cancer survivors on aromatase inhibitors: a pilot study

Blaes, A., Beckwith, H., Florea, N., Hebbel, R., Solovey, A., Potter, D., Yee, D., Vogel, R., Luepker, R. & Duprez, D., Nov 1 2017, In : Breast Cancer Research and Treatment. 166, 2, p. 541-547 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Reproducibility of circulating endothelial cell enumeration and activation in children and adolescents

Ryder, J. R., O'Connell, M. J., Rudser, K., Fox, C. K., Solovey, A., Hebbel, R. P. & Kelly, A. S., May 2016, In : Biomarkers in Medicine. 10, 5, p. 463-471 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Sickle cell disease: Renal manifestations and mechanisms

Nath, K. A. & Hebbel, R. P., Mar 27 2015, In : Nature Reviews Nephrology. 11, 3, p. 161-171 11 p.

Research output: Contribution to journalArticle

113 Scopus citations
2014

Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery

Meier, L. A., Syedain, Z. H., Lahti, M. T., Johnson, S. S., Chen, M. H., Hebbel, R. P. & Tranquillo, R. T., Mar 2014, In : Journal of cardiovascular translational research. 7, 2, p. 242-249 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Sparkenbaugh, E. M., Chantrathammachart, P., Mickelson, J., Van Ryn, J., Hebbel, R. P., Monroe, D. M., Mackman, N., Key, N. S. & Pawlinski, R., Mar 13 2014, In : Blood. 123, 11, p. 1747-1756 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

264 Scopus citations

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Age sensitizes the kidney to heme protein-induced acute kidney injury

Nath, K. A., Grande, J. P., Farrugia, G., Croatt, A. J., Belcher, J. D., Hebbel, R. P., Vercellotti, G. M. & Katusic, Z. S., Feb 8 2013, In : American Journal of Physiology - Renal Physiology. 304, 3, p. F317-F325

Research output: Contribution to journalArticle

19 Scopus citations

A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing

Shirodkar, A. V., Bernard, R. S., Gavryushova, A., Kop, A., Knight, B. J., Yan, M. S. C., Man, H. S. J., Sud, M., Hebbel, R. P., Oettgen, P., Aird, W. C. & Marsden, P. A., Apr 25 2013, In : Blood. 121, 17, p. 3531-3540 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
10 Scopus citations

Pilot study of vascular health in survivors of osteosarcoma

Mulrooney, D. A., Ness, K. K., Huang, S., Solovey, A., Hebbel, R. P., Neaton, J. D., Clohisy, D. R., Kelly, A. S. & Neglia, J. P., Oct 1 2013, In : Pediatric Blood and Cancer. 60, 10, p. 1703-1708 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Poly (lactic acid)-chitosan-collagen composite nanofibers as substrates for blood outgrowth endothelial cells

Swarnalatha, B., Nair, S. L., Shalumon, K. T., Milbauer, L. C., Jayakumar, R., Paul-Prasanth, B., Menon, K. K., Hebbel, R. P., Somani, A. & Nair, S. V., Jul 1 2013, In : International Journal of Biological Macromolecules. 58, p. 220-224 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012
9 Scopus citations

Establishment of outgrowth endothelial cells from peripheral blood

Martin-Ramirez, J., Hofman, M., Van Den Biggelaar, M., Hebbel, R. P. & Voorberg, J., Sep 1 2012, In : Nature Protocols. 7, 9, p. 1709-1715 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Morphine promotes renal pathology in sickle mice

Weber, M. L., Vang, D., Velho, P. E., Gupta, P., Crosson, J. T., Hebbel, R. P. & Gupta, K., Jul 19 2012, In : International Journal of Nephrology and Renovascular Disease. 5, p. 109-118 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mouse models for studying pain in sickle disease: Effects of strain, age, and acuteness

Cain, D. M., Vang, D., Simone, D. A., Hebbel, R. P. & Gupta, K., Feb 1 2012, In : British journal of haematology. 156, 4, p. 535-544 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Pilot study of vascular health in survivors of Hodgkin lymphoma

Mulrooney, D. A., Ness, K. K., Solovey, A., Hebbel, R. P., Neaton, J., Peterson, B. A., Lee, C. K., Kelly, A. S. & Neglia, J. P., Aug 1 2012, In : Pediatric Blood and Cancer. 59, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
2011
22 Scopus citations

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells

Sjeklocha, L. M., Park, C. W., Wong, P. Y. P., Roney, M. J., Belcher, J. D., Kaufman, D. S., Vercellotti, G. M., Hebbel, R. P. & Steer, C. J., Dec 28 2011, In : PloS one. 6, 12, e29110.

Research output: Contribution to journalArticle

13 Scopus citations

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

Gavins, F. N. E., Russell, J., Senchenkova, E. L., De Almeida Paula, L., Damazo, A. S., Esmon, C. T., Kirchhofer, D., Hebbel, R. P. & Granger, D. N., Apr 14 2011, In : Blood. 117, 15, p. 4125-4133 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula

Kang, L., Yamada, S., Hernandez, M. C., Croatt, A. J., Grande, J. P., Juncos, J. P., Vercellotti, G. M., Hebbel, R. P., Katusic, Z. S., Terzic, A. & Nath, K. A., Oct 1 2011, In : American Journal of Physiology - Renal Physiology. 301, 4, p. F845-F851

Research output: Contribution to journalArticle

16 Scopus citations

Selective enhancement of contractions to α1-adrenergic receptor activation in the aorta of mice with sickle cell disease

Juncos, R., Juncos, L., Hebbel, R. P., Vercellotti, G. M., Katusic, Z. S. & Nath, K. A., Feb 1 2011, In : Journal of Cardiovascular Pharmacology. 57, 2, p. 263-266 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2010

Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors

Bodempudi, V., Ohlfest, J. R., Terai, K., Zamora, E. A., Vogel, R. I., Gupta, K., Hebbel, R. P. & Dudek, A. Z., Dec 1 2010, In : Cancer gene therapy. 17, 12, p. 855-863 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane

Ueda, M., Alferiev, I. S., Simons, S. B., Hebbel, R. P., Levy, R. J. & Stachelek, S. J., Sep 1 2010, In : Biomaterials. 31, 25, p. 6394-6399 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Circulating activated endothelial cells in pediatric obesity

Kelly, A. S., Hebbel, R. P., Solovey, A., Schwarzenberg, S. J., Metzig, A. M., Moran, A., Sinaiko, A. R., Jacobs Jr, D. R. & Steinberger, J., Oct 1 2010, In : Journal of Pediatrics. 157, 4, p. 547-551 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease

Juncos, J. P., Grande, J. P., Croatt, A. J., Hebbel, R. P., Vercellotti, G. M., Katusic, Z. S. & Nath, K. A., Apr 1 2010, In : American Journal of Physiology - Renal Physiology. 298, 4, p. F892-F899

Research output: Contribution to journalArticle

20 Scopus citations

Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse

Solovey, A., Kollander, R., Milbauer, L., Abdulla, F., Chen, Y., Kelm, R. J. & Hebbel, R. P., Jan 2010, In : American Journal of Hematology. 85, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
29 Scopus citations

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids

Kohli, D. R., Li, Y., Khasabov, S. G., Gupta, P., Kehl, L. J., Ericson, M. E., Nguyen, J., Gupta, V., Hebbel, R. P., Simone, D. A. & Gupta, K., Jul 22 2010, In : Blood. 116, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

105 Scopus citations

Proinflammatory phenotype with imbalance of KLF2 and RelA: Risk of childhood stroke with sickle cell anemia

Enenstein, J., Milbauer, L., Domingo, E., Wells, A., Roney, M., Kiley, J., Wei, P. & Hebbel, R. P., Jan 1 2010, In : American Journal of Hematology. 85, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
14 Scopus citations

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

Hebbel, R. P., Vercellotti, G. M., Pace, B. S., Solovey, A. N., Kollander, R., Abanonu, C. F., Nguyen, J., Vineyard, J. V., Belcher, J. D., Abdulla, F., Osifuye, S., Eaton, J. W., Kelm, R. J. & Slungaard, A., Mar 25 2010, In : Blood. 115, 12, p. 2483-2490 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
2009

Activation of Endothelial and Coagulation Systems in Left Ventricular Assist Device Recipients

John, R., Panch, S., Hrabe, J., Wei, P., Solovey, A., Joyce, L. & Hebbel, R., Oct 1 2009, In : Annals of Thoracic Surgery. 88, 4, p. 1171-1179 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Blood outgrowth endothelial cell migration and trapping in vivo: a window into gene therapy

Milbauer, L. C., Enenstein, J. A., Roney, M., Solovey, A., Bodempudi, V., Nichols, T. C. & Hebbel, R. P., Apr 2009, In : Translational Research. 153, 4, p. 179-189 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cell adhesion molecule 1: A novel risk factor for venous thrombosis

Hasstedt, S. J., Bezemer, I. D., Callas, P. W., Vossen, C. Y., Trotman, W., Hebbel, R. P., Demers, C., Rosendaal, F. R. & Bovill, E. G., Nov 19 2009, In : Blood. 114, 14, p. 3084-3091 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice

Wang, H., Zhang, W., Tang, R., Hebbel, R. P., Kowalska, M. A., Zhang, C., Marth, J. D., Fukuda, M., Zhu, C. & Huo, Y., Jul 1 2009, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 7, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Core2 1-6-N-glucosaminyltransferase-i is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice

Wang, H., Tang, R., Zhang, W., Amirikian, K., Geng, Z., Geng, J., Hebbel, R. P., Xia, L., Marth, J. D., Fukuda, M., Katoh, S. & Huo, Y., Feb 1 2009, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 2, p. 180-187 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

Beckman, J. D., Belcher, J. D., Vineyard, J. V., Chen, C., Nguyen, J., Nwaneri, M. O., O'Sullivan, G., Gulbahce, E., Hebbel, R. P. & Vercellotti, G. M., Oct 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1243-H1253

Research output: Contribution to journalArticle

30 Scopus citations

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

Van Den Biggelaar, M., Bouwens, E. A. M., Kootstra, N. A., Hebbel, R. P., Voorberg, J. & Mertens, K., May 1 2009, In : Haematologica. 94, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

Kato, G. J., Hebbel, R. P., Steinberg, M. H. & Gladwin, M. T., Sep 1 2009, In : American Journal of Hematology. 84, 9, p. 618-625 8 p.

Research output: Contribution to journalArticle

184 Scopus citations
2008

Adhesion of sickle red cells to endothelium: Myths and future directions

Hebbel, R. P., Feb 1 2008, In : Transfusion Clinique et Biologique. 15, 1-2, p. 14-18 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Genetic endothelial systems biology of sickle stroke risk

Milbauer, L. C., Wei, P., Enenstein, J., Jiang, A., Hillery, C. A., Scott, J. P., Nelson, S. C., Bodempudi, V., Topper, J. N., Yang, R. B., Hirsch, B., Pan, W. & Hebbel, R. P., Apr 1 2008, In : Blood. 111, 7, p. 3872-3879 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases

Zwolak, P., Dudek, A. Z., Bodempudi, V. D., Nguyen, J., Hebbel, R. P., Gallus, N. J., Ericson, M. E., Goblirsch, M. J. & Clohisy, D. R., Feb 1 2008, In : International Journal of Cancer. 122, 3, p. 681-688 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Morphine induces mesangial cell proliferation and glomerulopathy via κ-opioid receptors

Weber, M. L., Farooqui, M., Nguyen, J., Ansonoff, M., Pintar, J. E., Hebbel, R. P. & Gupta, K., Jun 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 6, p. F1388-F1397

Research output: Contribution to journalArticle

29 Scopus citations