Robert J Schumacher

Scientific Director, Center for Translational Medicine

Research Director, Center for Translational Medicine
Adjunct Assistant Professor, Experimental and Clinical Pharmacology

Emailrschumac@umn.edu

Research activity per year

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20 Article
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2021
A preclinical safety study of thyroid hormone instilled into the lungs of healthy rats—an investigational therapy for ARDS
Flory, C. M., Norris, B. J., Larson, N. A., Coicou, L. G., Koniar, B. L., Mysz, M. A., Rich, T. P., Ingbar, D. H. & Schumacher, R. J., Jan 1 2021, In: Journal of Pharmacology and Experimental Therapeutics. 376, 1, p. 74-83 10 p.
Research output: Contribution to journal › Article › peer-review
2019
Clinical and microbiologic investigation of an expedited peri-implantitis dog model: An animal study
Seong, W. J., Kotsakis, G., Huh, J. K., Jeong, S. C., Nam, K. Y., Kim, J. R., Heo, Y. C., Kim, H. C., Zhang, L., Evans, M. D., Conrad, H. & Schumacher, R. J., Jul 15 2019, In: BMC Oral Health. 19, 1, 150.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K
Gorr, S. U., Flory, C. M. & Schumacher, R. J., May 2019, In: PloS one. 14, 5, e0216669.
Research output: Contribution to journal › Article › peer-review

Open Access
15 Scopus citations
Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity
Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Apr 15 2019, In: Investigational New Drugs. 37, 2, p. 378-383 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
2018

Engraftment of Reprogrammed Human Bile Duct Cells Transiently Rescues Diabetes in Mice
Banga, A., Dutton, J. R., Mysz, M. A., Norris, B., Flory, C. M., Ogle, B. M., Tolar, J. & Schumacher, R. J., 2018, In: Journal of Stem Cell Research and Therapy. 8, 7
Research output: Contribution to journal › Article › peer-review

Open Access
2017
A completely biological "off-the-shelf" arteriovenous graft that recellularizes in baboons
Syedain, Z. H., Graham, M. L., Dunn, T. B., O'Brien, T., Johnson, S. L., Schumacher, R. J. & Tranquillo, R. T., Nov 1 2017, In: Science Translational Medicine. 9, 414, eaan4209.
Research output: Contribution to journal › Article › peer-review

Open Access
47 Scopus citations
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In: Cell Chemical Biology. 24, 10, p. 1259-1275.e6
Research output: Contribution to journal › Article › peer-review

Open Access
13 Scopus citations
2015
Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts
Patil, S., Lis, L. G., Schumacher, R. J., Norris, B. J., Morgan, M. L., Cuellar, R. A. D., Blazar, B. R., Suryanarayanan, R., Gurvich, V. J. & Georg, G. I., Dec 10 2015, In: Journal of medicinal chemistry. 58, 23, p. 9334-9344 11 p.
Research output: Contribution to journal › Article › peer-review
36 Scopus citations
2012
A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer
Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In: Science Translational Medicine. 4, 156, 156ra139.
Research output: Contribution to journal › Article › peer-review
174 Scopus citations
2009
Steady-state pharmacokinetics following application of a novel transdermal estradiol spray in healthy postmenopausal women
Morton, T. L., Gattermeir, D. J., Petersen, C. A., Day, W. W. & Schumacher, R. J., Sep 2009, In: Journal of Clinical Pharmacology. 49, 9, p. 1037-1046 10 p.
Research output: Contribution to journal › Article › peer-review
10 Scopus citations
The effects of skin-to-skin contact, application site washing, and sunscreen use on the pharmacokinetics of estradiol from a metered-dose transdermal spray
Schumacher, R. J., Gattermeir, D. J., Peterson, C. A., Wisdom, C. & Day, W. W., Jan 2009, In: Menopause. 16, 1, p. 177-183 7 p.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations
2007
The effects of intravaginal clindamycin and metronidazole therapy on vaginal Mobiluncus morphotypes in patients with bacterial vaginosis
Nyirjesy, P., McIntosh, M. J., Steinmetz, J. I., Schumacher, R. J. & Joffrion, J. L., Apr 1 2007, In: Sexually Transmitted Diseases. 34, 4, p. 197-202 6 p.
Research output: Contribution to journal › Article › peer-review
18 Scopus citations
2006
The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis
Nyirjesy, P., McIntosh, M. J., Gattermeir, D. J., Schumacher, R. J., Steinmetz, J. I. & Joffrion, J. L., May 2006, In: American journal of obstetrics and gynecology. 194, 5, p. 1277-1282 6 p.
Research output: Contribution to journal › Article › peer-review
16 Scopus citations
2005
An open-label, two-period, crossover study of the systemic bioavailability in healthy women of clindamycin phosphate from two vaginal cream formulations
Saul Levinson, R., Mitan, S. J., Steinmetz, J. I., Gattermeir, D. J., Schumacher, R. J. & Joffrion, J. L., Dec 2005, In: Clinical Therapeutics. 27, 12, p. 1894-1900 7 p.
Research output: Contribution to journal › Article › peer-review
9 Scopus citations
1998
Hop modulates hsp70/hsp90 interactions in protein folding
Johnson, B. D., Schumacher, R. J., Ross, E. D. & Toft, D. O., Feb 6 1998, In: Journal of Biological Chemistry. 273, 6, p. 3679-3686 8 p.
Research output: Contribution to journal › Article › peer-review
270 Scopus citations
Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT
Won, K. A., Schumacher, R. J., Farr, G. W., Horwich, A. L. & Reed, S. I., Dec 1998, In: Molecular and cellular biology. 18, 12, p. 7584-7589 6 p.
Research output: Contribution to journal › Article › peer-review
122 Scopus citations
1997
Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms
Farr, G. W., Scharl, E. C., Schumacher, R. J., Sondek, S. & Horwich, A. L., Jun 13 1997, In: Cell. 89, 6, p. 927-937 11 p.
Research output: Contribution to journal › Article › peer-review
150 Scopus citations
1996
Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation
Schumacher, R. J., Hansen, W. J., Freeman, B. C., Alnemri, E., Litwack, G. & Toft, D. O., Nov 26 1996, In: Biochemistry. 35, 47, p. 14889-14898 10 p.
Research output: Contribution to journal › Article › peer-review
138 Scopus citations
1995
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1
Freeman, B. C., Myers, M. P., Schumacher, R. & Morimoto, R. I., 1995, In: EMBO Journal. 14, 10, p. 2281-2292 12 p.
Research output: Contribution to journal › Article › peer-review
374 Scopus citations
1994
ATP-dependent chaperoning activity of reticulocyte lysate
Schumacher, R. J., Hurst, R., Sullivan, W. P., McMahon, N. J., Toft, D. O. & Matts, R. L., Apr 1 1994, In: Journal of Biological Chemistry. 269, 13, p. 9493-9499 7 p.
Research output: Contribution to journal › Article › peer-review
120 Scopus citations

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