1994 …2020

Research output per year

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Research Output

2020
Open Access
2019

Gene Correction of LGMD2A Patient-Specific iPSCs for the Development of Targeted Autologous Cell Therapy

Selvaraj, S., Dhoke, N. R., Kiley, J., Mateos-Aierdi, A. J., Tungtur, S., Mondragon-Gonzalez, R., Killeen, G., Oliveira, V. K. P., López de Munain, A. & Perlingeiro, R. C. R., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2147-2157 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Induced pluripotent stem cells for neuromuscular diseases: Potential for disease modeling, drug screening, and regenerative medicine

Selvaraj, S. & Perlingeiro, R. C. R., Jan 1 2019, Encyclopedia of Tissue Engineering and Regenerative Medicine. Elsevier, Vol. 1-3. p. 471-481 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification

Magli, A., Baik, J., Pota, P., Cordero, C. O., Kwak, I. Y., Garry, D. J., Love, P. E., Dynlacht, B. D. & Perlingeiro, R., Dec 1 2019, In : Nature communications. 10, 1, 2316.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies

Selvaraj, S., Kyba, M. & Perlingeiro, R. C. R., Sep 2019, In : Trends in Molecular Medicine. 25, 9, p. 803-816 14 p.

Research output: Contribution to journalReview article

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment

Incitti, T., Magli, A., Darabi, R., Yuan, C., Lin, K., Arpke, R. W., Azzag, K., Yamamoto, A., Stewart, R., Thomson, J. A., Kyba, M. & Perlingeiro, R. C. R., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4346-4351 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

Selvaraj, S., Mondragon-Gonzalez, R., Xu, B., Magli, A., Kim, H., Lainé, J., Kiley, J., McKee, H., Rinaldi, F., Aho, J., Tabti, N., Shen, W. & Perlingeiro, R. C., Nov 2019, In : eLife. 8, e47970.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Serial transplantation reveals a critical role for endoglin in hematopoietic stem cell quiescence

Borges, L., Oliveira, V. K. P., Baik, J., Bendall, S. C. & Perlingeiro, R. C. R., Feb 14 2019, In : Blood. 133, 7, p. 688-696 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity

Azuara-Medina, P. M., Sandoval-Duarte, A. M., Morales-Lázaro, S. L., Modragón-González, R., Vélez-Aguilera, G., Gómez-López, J. D. D., Jiménez-Gutiérrez, G. E., Tiburcio-Félix, R., Martínez-Vieyra, I., Suárez-Sánchez, R., Längst, G., Magaña, J. J., Winder, S. J., Ortega, A., Ramos Perlingeiro, R. D. C., Jacobs, L. A. & Cisneros, B., Mar 1 2019, In : Cell Death and Disease. 10, 3, 196.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm

Magli, A., Baik, J., Mills, L. J., Kwak, I., Dillon, B. S., Mondragon Gonzalez, R., Stafford, D. A., Swanson, S. A., Stewart, R., Thomson, J. A., Garry, D. J., Dynlacht, B. D., Perlingeiro, R. C. R. & Becker, P. B. (ed.), Feb 26 2019, In : PLoS Biology. 17, 2, e3000153.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Transplantation studies reveal internuclear transfer of toxic RNA in engrafted muscles of myotonic dystrophy 1 mice

Mondragon-Gonzalez, R., Azzag, K., Selvaraj, S., Yamamoto, A. & Perlingeiro, R., Sep 2019, In : EBioMedicine. 47, p. 553-562 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018
Open Access
8 Scopus citations
Open Access
7 Scopus citations

Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity

Chan, S., Arpke, R. W., Filareto, A., Xie, N., Pappas, M. P., Penaloza, J. S., Perlingeiro, R. & Kyba, M., Jul 5 2018, In : Cell Stem Cell. 23, 1, p. 74-85.e6

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2017

Endoglin: A novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models

Dourado, K. M. C., Baik, J., Oliveira, V. K. P., Beltrame, M., Yamamoto, A., Theuer, C. P., Figueiredo, C. A. V., Verneris, M. R. & Perlingeiro, R. C. R., May 4 2017, In : Blood. 129, 18, p. 2526-2536 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors

Kim, J., Magli, A., Chan, S. S. K., Oliveira, V. K. P., Wu, J., Darabi, R., Kyba, M. & Perlingeiro, R. C. R., Jul 11 2017, In : Stem Cell Reports. 9, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Generation of skeletal myogenic progenitors from human pluripotent stem cells using non-viral delivery of minicircle DNA

Kim, J., Oliveira, V. K. P., Yamamoto, A. & Perlingeiro, R. C. R., Aug 2017, In : Stem Cell Research. 23, p. 87-94 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Myogenic progenitor specification from pluripotent stem cells

Magli, A. & Perlingeiro, R. R. C., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 87-98 12 p.

Research output: Contribution to journalReview article

Open Access
11 Scopus citations

Pax7 remodels the chromatin landscape in skeletal muscle stem cells

Lilja, K. C., Zhang, N., Magli, A., Gunduz, V., Bowman, C. J., Arpke, R. W., Darabi, R., Kyba, M., Perlingeiro, R. & Dynlacht, B. D., Apr 2017, In : PloS one. 12, 4, e0176190.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors

Magli, A., Incitti, T., Kiley, J., Swanson, S. A., Darabi, R., Rinaldi, F., Selvaraj, S., Yamamoto, A., Tolar, J., Yuan, C., Stewart, R., Thomson, J. A. & Perlingeiro, R. C. R., Jun 27 2017, In : Cell reports. 19, 13, p. 2867-2877 11 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain

Bosnakovski, D., Toso, E. A., Hartweck, L. M., Magli, A., Lee, H. A., Thompson, E. R., Dandapat, A., Perlingeiro, R. C. R. & Kyba, M., Jan 1 2017, In : Journal of cell science. 130, 21, p. 3685-3697 13 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

Derivation of skeletal myogenic precursors from human pluripotent stem cells using conditional expression of PAX7

Darabi, R. & Perlingeiro, R. C. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 423-439 17 p. (Methods in Molecular Biology; vol. 1357).

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

Baik, J., Magli, A., Tahara, N., Swanson, S. A., Koyano-Nakagawa, N., Borges, L., Stewart, R., Garry, D. J., Kawakami, Y., Thomson, J. A. & Perlingeiro, R. C. R., Oct 7 2016, In : Nature communications. 7, 13101.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation

Carrió, E., Magli, A., Muñoz, M., Peinado, M. A., Perlingeiro, R. & Suelves, M., Apr 13 2016, In : BMC Biology. 14, 1, 30.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Myogenic progenitors from mouse pluripotent stem cells for muscle regeneration

Magli, A., Incitti, T. & Perlingeiro, R. C. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 191-208 18 p. (Methods in Molecular Biology; vol. 1460).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Treatment with rGDF11 does not improve the dystrophic muscle pathology of mdx mice

Rinaldi, F., Zhang, Y., Mondragon-Gonzalez, R., Harvey, J. & Perlingeiro, R. C. R., Jun 14 2016, In : Skeletal Muscle. 6, 1, 21.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2015

Coaxing stem cells for skeletal muscle repair

McCullagh, K. J. A. & Perlingeiro, R. C. R., Apr 1 2015, In : Advanced Drug Delivery Reviews. 84, p. 198-207 10 p.

Research output: Contribution to journalReview article

24 Scopus citations
19 Scopus citations
2014

Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene

Dandapat, A., Bosnakovski, D., Hartweck, L. M., Arpke, R. W., Baltgalvis, K. A., Vang, D., Baik, J., Darabi, R., Perlingeiro, R. C. R., Hamra, F. K., Gupta, K., Lowe, D. A. & Kyba, M., Jan 1 2014, In : Cell reports. 8, 5, p. 1484-1496 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells

Magli, A., Schnettler, E., Swanson, S. A., Borges, L., Hoffman, K., Stewart, R., Thomson, J. A., Keirstead, S. A. & Perlingeiro, R. C. R., Aug 2014, In : STEM CELLS. 32, 8, p. 2072-2083 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Stem cells for skeletal muscle regeneration: Therapeutic potential and roadblocks

Rinaldi, F. & Perlingeiro, R. C. R., Apr 2014, In : Translational Research. 163, 4, p. 409-417 9 p.

Research output: Contribution to journalReview article

38 Scopus citations
2013

A new immuno-, dystrophin-deficient model, the NSG-mdx4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation

Arpke, R. W., Darabi, R., Mader, T. L., Zhang, Y., Toyama, A., Lonetree, C. L., Nash, N., Lowe, D. A., Perlingeiro, R. C. R. & Kyba, M., Aug 1 2013, In : STEM CELLS. 31, 8, p. 1611-1620 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells

Filareto, A., Parker, S., Darabi, R., Borges, L., Iacovino, M., Schaaf, T., Mayerhofer, T., Chamberlain, J. S., Ervasti, J. M., McIvor, R. S., Kyba, M. & Perlingeiro, R. C. R., Apr 11 2013, In : Nature communications. 4, 1549.

Research output: Contribution to journalArticle

91 Scopus citations

Are we there yet? Navigating roadblocks to induced pluripotent stem cell therapy translation

Parker, S. L. & Perlingeiro, R. C., Jul 1 2013, In : Regenerative Medicine. 8, 4, p. 389-391 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

Etv2 rescues Flk1 mutant embryoid bodies

Rasmussen, T. L., Martin, C. M., Walter, C. A., Shi, X., Perlingeiro, R., Koyano-Nakagawa, N. & Garry, D. J., Jul 1 2013, In : Genesis. 51, 7, p. 471-480 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
12 Scopus citations

Functional dissection of Pax3 in paraxial mesoderm development and myogenesis

Magli, A., Schnettler, E., Rinaldi, F., Bremer, P. & Perlingeiro, R. C. R., Jan 2013, In : STEM CELLS. 31, 1, p. 59-70 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

A critical role for endoglin in the emergence of blood during embryonic development

Borges, L., Iacovino, M., Mayerhofer, T., Koyano-Nakagawa, N., Baik, J., Garry, D. J., Kyba, M., Letarte, M. & Perlingeiro, R. C. R., Jun 7 2012, In : Blood. 119, 23, p. 5417-5428 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effect of endoglin overexpression during embryoid body development

Baik, J., Borges, L., Magli, A., Thatava, T. & Perlingeiro, R. C. R., Oct 1 2012, In : Experimental Hematology. 40, 10, p. 837-846 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression

Koyano-Nakagawa, N., Kweon, J., Iacovino, M., Shi, X., Rasmussen, T. L., Borges, L., Zirbes, K. M., Li, T., Perlingeiro, R. C. R., Kyba, M. & Garry, D. J., Aug 1 2012, In : STEM CELLS. 30, 8, p. 1611-1623 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice

Darabi, R., Arpke, R. W., Irion, S., Dimos, J. T., Grskovic, M., Kyba, M. & Perlingeiro, R. C. R., May 4 2012, In : Cell Stem Cell. 10, 5, p. 610-619 10 p.

Research output: Contribution to journalArticle

238 Scopus citations

Regulation of vasculogenesis and angiogenesis

Perlingeiro, R. C. R., Jun 1 2012, Coronary Heart Disease: Clinical, Pathological, Imaging, and Molecular Profiles. Springer US, Vol. 9781461414759. p. 261-270 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Assessment of the myogenic stem cell compartment following transplantation of Pax3/Pax7-induced embryonic stem cell-derived progenitors

Darabi, R., Santos, F. N. C., Filareto, A., Pan, W., Koene, R., Rudnicki, M. A., Kyba, M. & Perlingeiro, R. C. R., May 1 2011, In : STEM CELLS. 29, 5, p. 777-790 14 p.

Research output: Contribution to journalArticle

82 Scopus citations

Functional Myogenic Engraftment from Mouse iPS Cells

Darabi, R., Pan, W., Bosnakovski, D., Baik, J., Kyba, M. & Perlingeiro, R. C. R., Nov 1 2011, In : Stem Cell Reviews and Reports. 7, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis

Zhang, L., Magli, A., Catanese, J., Xu, Z., Kyba, M. & Perlingeiro, R. C. R., Jul 7 2011, In : Blood. 118, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood

Ramos, A. L., Darabi, R., Akbarloo, N., Borges, L., Catanese, J., Dineen, S. P., Brekken, R. A. & Perlingeiro, R. C. R., Dec 10 2010, In : Circulation research. 107, 12, p. 1460-1469 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Engraftment of embryonic stem cell-derived myogenic progenitors in a dominant model of muscular dystrophy

Darabi, R., Baik, J., Clee, M., Kyba, M., Tupler, R. & Perlingeiro, R. C. R., Nov 1 2009, In : Experimental Neurology. 220, 1, p. 212-216 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

Gang, E. J., Darabi, R., Bosnakovski, D., Xu, Z., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Sep 10 2009, In : Experimental Cell Research. 315, 15, p. 2624-2636 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2008

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

Bosnakovski, D., Xu, Z., Ji Gang, E., Galindo, C. L., Liu, M., Simsek, T., Garner, H. R., Agha-Mohammadi, S., Tassin, A., Coppée, F., Belayew, A., Perlingeiro, R. R. & Kyba, M., Oct 22 2008, In : EMBO Journal. 27, 20, p. 2766-2779 14 p.

Research output: Contribution to journalArticle

170 Scopus citations