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Research Output 1982 2019

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Article
2019
Mycophenolic Acid
Leukopenia
Logistic Models
mycophenolic acid glucuronide
Pharmacokinetics
2018

A Gallbladder-Based Enterohepatic Circulation Model for Pharmacokinetic Studies

Okour, M. & Brundage, R., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics. 44, 4, p. 493-504 12 p.

Research output: Contribution to journalArticle

Enterohepatic Circulation
Gallbladder
Pharmacokinetics
Gallbladder Emptying
Meals

Amikacin pharmacokinetic-pharmacodynamic analysis in pediatric cancer patients

Alhadab, A. A., Ahmed, M. A. & Brundage, R., Apr 1 2018, In : Antimicrobial agents and chemotherapy. 62, 4, e01781-17.

Research output: Contribution to journalArticle

Open Access
Amikacin
Pharmacokinetics
Pediatrics
Neoplasms
Safety

Iron supplements in nursing home patients associated with reduced carbamazepine absorption

Ahn, J. E., Bathena, S. P. R., Brundage, R., Conway, J. M., Leppik, I. E. & Birnbaum, A. K., Nov 1 2018, In : Epilepsy Research. 147, p. 115-118 4 p.

Research output: Contribution to journalArticle

Carbamazepine
Nursing Homes
Iron
Pharmacokinetics
Internship and Residency
2 Citations (Scopus)

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Polepally, A. R., Brundage, R., Remmel, R. P., Leppik, I. E., Pennell, P. B., White, J. R., Ramsay, R. E., Kistner, B. M. & Birnbaum, A. K., Sep 1 2018, In : Epilepsia. 59, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Intravenous Administration
Young Adult
Epilepsy
Pharmacokinetics
Biological Availability
3 Citations (Scopus)
Enterohepatic Circulation
Mycophenolic Acid
Kidney
Single Nucleotide Polymorphism
Hepatocyte Nuclear Factor 1
2017
9 Citations (Scopus)

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites

Flora, D. R., Rettie, A. E., Brundage, R. & Tracy, T. S., Jan 1 2017, In : Journal of Clinical Pharmacology. 57, 3, p. 382-393 12 p.

Research output: Contribution to journalArticle

Warfarin
Cytochrome P-450 Enzyme System
Pharmacokinetics
Genotype
Alleles
22 Citations (Scopus)

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

Sanghavi, K., Brundage, R. C., Miller, M. B., Schladt, D. P., Israni, A. K., Guan, W., Oetting, W. S., Mannon, R. B., Remmel, R. P., Matas, A. J. & Jacobson, P. A., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Tacrolimus
African Americans
Genotype
Kidney
Cytochrome P-450 CYP3A
5 Citations (Scopus)

Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients

Ahmed, G. F., Bathena, S. P. R., Brundage, R., Leppik, I. E., Conway, J. M., Schwartz, J. B. & Birnbaum, A. K., Mar 1 2017, In : AAPS Journal. 19, 2, p. 551-556 6 p.

Research output: Contribution to journalArticle

Nursing Homes
Pharmacokinetics
gabapentin
Body Weights and Measures
Independent Living
2016
4 Citations (Scopus)
Orphan Drug Production
Adrenoleukodystrophy
Pharmacodynamics
Bayes Theorem
Pharmacokinetics
3 Citations (Scopus)

A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy

Ahmed, M. A., Kartha, R. V., Brundage, R. C., Cloyd, J., Basu, C., Carlin, B. P., Jones, R. O., Moser, A. B., Fatemi, A. & Raymond, G. V., Jun 1 2016, In : British Journal of Clinical Pharmacology. 81, 6, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Erucic Acids
Fatty Acids
Peroxisomal Disorders
Brain

Epstein-Barr virus dynamics in asymptomatic immunocompetent adults: An intensive 6-month study

Johnson, K. H., Webb, C. H., Schmeling, D. O., Brundage, R. C. & Balfour, H. H., May 13 2016, In : Clinical and Translational Immunology. 5, e81.

Research output: Contribution to journalArticle

Human Herpesvirus 4
DNA
Membrane Proteins
Antibodies
Virus Shedding
14 Citations (Scopus)

Operational Characteristics of Linear Concentration-QT Models for Assessing QTc Interval in the Thorough QT and Phase I Clinical Studies

Garnett, C., Needleman, K., Liu, J., Brundage, R. & Wang, Y., Aug 1 2016, In : Clinical Pharmacology and Therapeutics. p. 170-178 9 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Sensitivity and Specificity
Clinical Studies
6 Citations (Scopus)

Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning

Sanghavi, K. J., Wiseman, A., Kirstein, M. N., Cao, Q., Brundage, R., Jensen, K., Rogosheske, J., Kurtzweil, A., Long-Boyle, J., Wagner, J. E., Warlick, E. D., Brunstein, C. G., Weisdorf, D. J. & Jacobson, P. A., Sep 1 2016, In : Translational Research. 175, p. 103-115.e4

Research output: Contribution to journalArticle

Transplants
Hematopoietic Stem Cells
Stem cells
Mortality
Cell Transplantation
2 Citations (Scopus)
Healthy Volunteers
Pharmacokinetics
Neuropsychological Tests
Migraine Disorders
Short-Term Memory
2 Citations (Scopus)
Brain Natriuretic Peptide
Doxorubicin
Breast Neoplasms
Troponin
Enalapril

Prospective studies of infectious mononucleosis in university students

Grimm, J. M., Schmeling, D. O., Dunmire, S. K., Knight, J. A., Mullan, B. D., Ed, J. A., Brundage, R. C., Hogquist, K. A. & Balfour, H. H., Aug 12 2016, In : Clinical and Translational Immunology. 5, 8, e94.

Research output: Contribution to journalArticle

Infectious Mononucleosis
Human Herpesvirus 4
Epstein-Barr Virus Infections
Prospective Studies
Students
2015
1 Citation (Scopus)

Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension VS. Commercial tablets

Sarafoglou, K. M., Gonzalez-Bolanos, M. T., Zimmerman, C. L., Boonstra, T., Yaw Addo, O. & Brundage, R., Jan 1 2015, In : Journal of Clinical Pharmacology. 55, 4, p. 452-457 6 p.

Research output: Contribution to journalArticle

Tablets
Hydrocortisone
Suspensions
Steroids
Congenital Adrenal Hyperplasia
5 Citations (Scopus)

Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia

Sarafoglou, K. M., Zimmerman, C. L., Gonzalez-Bolanos, M. T., Willis, B. A. & Brundage, R., Jan 1 2015, In : Journal of Investigative Medicine. 63, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

17-alpha-Hydroxyprogesterone
Congenital Adrenal Hyperplasia
Hydrocortisone
Androstenedione
Area Under Curve
5 Citations (Scopus)
Healthy Volunteers
Pharmacokinetics
Oral Administration
Word Association Tests
Poisson Distribution
7 Citations (Scopus)
Isotopes
Biological Availability
Epilepsy
Pharmacokinetics
lamotrigine
2014
2 Citations (Scopus)

Bayesian approach to estimate AUC, partition coefficient and drug targeting index for studies with serial sacrifice design

Wang, T., Baron, K., Zhong, W., Brundage, R. & Elmquist, W. F., Jan 1 2014, In : Pharmaceutical research. 31, 3, p. 649-659 11 p.

Research output: Contribution to journalArticle

Bayes Theorem
Drug Delivery Systems
Area Under Curve
Tissue
Plasmas
14 Citations (Scopus)

Ethnic and genetic factors in methadone pharmacokinetics: A population pharmacokinetic study

Bart, G., Lenz, S., Straka, R. J. & Brundage, R., Dec 1 2014, In : Drug and alcohol dependence. 145, p. 185-193 9 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Methadone
Population
Opiate Alkaloids
Enantiomers
21 Citations (Scopus)

Model-based lamotrigine clearance changes during pregnancy: Clinical implication

Polepally, A. R., Pennell, P. B., Brundage, R. C., Stowe, Z. N., Newport, D. J., Viguera, A. C., Ritchie, J. C. & Birnbaum, A. K., Jan 1 2014, In : Annals of Clinical and Translational Neurology. 1, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

Pregnancy
Postpartum Period
Gestational Age
Half-Life
lamotrigine
19 Citations (Scopus)

Pharmacometric characterization of efavirenz developmental pharmacokinetics and pharmacogenetics in HIV-Infected children

Salem, A. H., Fletcher, C. V. & Brundage, R., Jan 1 2014, In : Antimicrobial agents and chemotherapy. 58, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

efavirenz
Pharmacogenetics
Pharmacokinetics
HIV
Sigmoid Colon
8 Citations (Scopus)
Ganciclovir
Pharmacokinetics
Pediatrics
Transplants
Kidney
12 Citations (Scopus)

SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours

Khatri, A., Williams, B. W., Fisher, J., Brundage, R., Gurvich, V. J., Lis, L. G., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A., Lamba, J. K. & Kirstein, M. N., Jan 21 2014, In : British Journal of Cancer. 110, 2, p. 304-312 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacokinetics
Genotype
Neoplasms
Cytidine Deaminase
2013
22 Citations (Scopus)

A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers

Agarwal, S. K., Kriel, R. L., Brundage, R., Ivaturi, V. D. & Cloyd, J. C., Aug 1 2013, In : Epilepsy Research. 105, 3, p. 362-367 6 p.

Research output: Contribution to journalArticle

Intranasal Administration
Diazepam
Intravenous Administration
Biological Availability
Healthy Volunteers
30 Citations (Scopus)

Bioavailability of Intranasal vs. Rectal Diazepam

Ivaturi, V., Kriel, R., Brundage, R., Loewen, G., Mansbach, H. & Cloyd, J. C., Feb 1 2013, In : Epilepsy Research. 103, 2-3, p. 254-261 8 p.

Research output: Contribution to journalArticle

Diazepam
Biological Availability
Gels
Nose
Pharmacokinetics
17 Citations (Scopus)

Intravenous topiramate: Safety and pharmacokinetics following a single dose in patients with epilepsy or migraines taking oral topiramate

Clark, A. M., Kriel, R. L., Leppik, I. E., White, J. R., Henry, T. R., Brundage, R. C. & Cloyd, J. C., Jun 1 2013, In : Epilepsia. 54, 6, p. 1106-1111 6 p.

Research output: Contribution to journalArticle

Migraine Disorders
Epilepsy
Pharmacokinetics
Safety
Half-Life
19 Citations (Scopus)

Intravenous topiramate: Comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers

Clark, A. M., Kriel, R. L., Leppik, I. E., Marino, S. E., Mishra, U., Brundage, R. & Cloyd, J. C., Jun 1 2013, In : Epilepsia. 54, 6, p. 1099-1105 7 p.

Research output: Contribution to journalArticle

Healthy Volunteers
Pharmacokinetics
Safety
Seizures
topiramate
14 Citations (Scopus)

Population pharmacokinetics of rifampicin in Mexican patients with tuberculosis

Milán Segovia, R. C., Domínguez Ramírez, A. M., Jung Cook, H., Magaña Aquino, M., Vigna Pérez, M., Brundage, R. C. & Romano Moreno, S., Feb 1 2013, In : Journal of Clinical Pharmacy and Therapeutics. 38, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

Rifampin
Tuberculosis
Pharmacokinetics
Drug Compounding
Population
8 Citations (Scopus)
Carbamazepine
Young Adult
Epilepsy
Pharmacokinetics
Pharmaceutical Preparations
2012
8 Citations (Scopus)

Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine

Khatri, A., Brundage, R., Hull, J. M., Williams, B. W., Yee, D. & Kirstein, M. N., Mar 1 2012, In : AAPS Journal. 14, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

gemcitabine
Somatomedins
Cell Line
Bayes Theorem
Receptor Protein-Tyrosine Kinases
11 Citations (Scopus)

Population pharmacokinetics of carbamazepine in elderly patients

Punyawudho, B., Ramsay, E. R., Brundage, R., MacIas, F. M., Collins, J. F. & Birnbaum, A. K., Apr 1 2012, In : Therapeutic Drug Monitoring. 34, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

Carbamazepine
Pharmacokinetics
Population
Independent Living
Phenytoin
13 Citations (Scopus)
Mycophenolic Acid
Cell Transplantation
Young Adult
Pharmacokinetics
Pediatrics
32 Citations (Scopus)

Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder

Holman, C. J., Karger, A., Mullan, B. D., Brundage, R. & Balfour, H. H., Sep 1 2012, In : Clinical Transplantation. 26, 5, p. 741-747 7 p.

Research output: Contribution to journalArticle

Virus Shedding
Lymphoproliferative Disorders
Human Herpesvirus 4
Transplants
Polymerase Chain Reaction
28 Citations (Scopus)

Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: Effects of race and sex

Marino, S. E., Birnbaum, A. K., Leppik, I. E., Conway, J. M., Musib, L. C., Brundage, R., Ramsay, R. E., Pennell, P. B., White, J. R., Gross, C. R., Rarick, J. O., Mishra, U. & Cloyd, J. C., Mar 1 2012, In : Clinical pharmacology and therapeutics. 91, 3, p. 483-488 6 p.

Research output: Contribution to journalArticle

Carbamazepine
Intravenous Administration
Epilepsy
Pharmacokinetics
African Americans
2011
14 Citations (Scopus)

Atazanavir and atazanavir/ritonavir pharmacokinetics in HIV-infected infants, children, and adolescents

Kiser, J. J., Rutstein, R. M., Samson, P., Graham, B., Aldrovandi, G., Mofenson, L. M., Smith, E., Schnittman, S., Fenton, T., Brundage, R. & Fletcher, C. V., Jul 31 2011, In : AIDS. 25, 12, p. 1489-1496 8 p.

Research output: Contribution to journalArticle

Ritonavir
Pharmacokinetics
HIV
Capsules
Powders
85 Citations (Scopus)

Dosing equation for tacrolimus using genetic variants and clinical factors

Passey, C., Birnbaum, A. K., Brundage, R., Oetting, W. S., Israni, A. K. & Jacobson, P. A., Dec 1 2011, In : British Journal of Clinical Pharmacology. 72, 6, p. 948-957 10 p.

Research output: Contribution to journalArticle

Tacrolimus
Cytochrome P-450 CYP3A
Genotype
Single Nucleotide Polymorphism
Transplants
9 Citations (Scopus)

Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid

Khatri, A., Gaber, M. W., Brundage, R., Naimark, M. D., Hanna, S. K., Stewart, C. F. & Kirstein, M. N., Sep 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

irinotecan
Cerebrospinal fluid
Radiation Effects
Cerebrospinal Fluid
Rats
4 Citations (Scopus)
Phenytoin
Isotopes
Biological Availability
Epilepsy
Anticonvulsants
110 Citations (Scopus)

Population pharmacokinetic and concentration-QTc models for moxifloxacin: Pooled analysis of 20 thorough QT studies

Florian, J. A., Tornøe, C. W., Brundage, R., Parekh, A. & Garnett, C. E., Aug 1 2011, In : Journal of Clinical Pharmacology. 51, 8, p. 1152-1162 11 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Population
Tablets
Meta-Analysis
Linear Models
25 Citations (Scopus)

Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine ® ) in cancer patients

Kolesar, J., Brundage, R., Pomplun, M., Alberti, D., Holen, K., Traynor, A., Ivy, P. & Wilding, G., Feb 1 2011, In : Cancer chemotherapy and pharmacology. 67, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Plasmas
Population
Neoplasms
Erythrocytes
2010
34 Citations (Scopus)

Effect of antacids on the pharmacokinetics of raltegravir in human immunodeficiency virus-seronegative volunteers

Kiser, J. J., Bumpass, J. B., Meditz, A. L., Anderson, P. L., Bushman, L., Ray, M., Predhomme, J. A., Rower, J., MaWhinney, S. & Brundage, R., Dec 1 2010, In : Antimicrobial agents and chemotherapy. 54, 12, p. 4999-5003 5 p.

Research output: Contribution to journalArticle

Antacids
Volunteers
Pharmacokinetics
HIV
Divalent Cations
3 Citations (Scopus)
Virus Diseases
Human Herpesvirus 4
Ganciclovir
Pharmacokinetics
Pediatrics
9 Citations (Scopus)

Valacyclovir pharmacokinetics and exploratory pharmacodynamics in young adults with epstein-barr virus infectious mononucleosis

Vezina, H. E., Balfour, H. H., Weller, D. R., Anderson, B. J. & Brundage, R., Jul 1 2010, In : Journal of Clinical Pharmacology. 50, 7, p. 734-742 9 p.

Research output: Contribution to journalArticle

valacyclovir
Infectious Mononucleosis
Acyclovir
Human Herpesvirus 4
Young Adult
2009
15 Citations (Scopus)

Population pharmacokinetics of albendazole in patients with neurocysticercosis

Castro, N., Márquez-Caraveo, C., Brundage, R., González-Esquivel, D., Suárez, A. M., Góngora, F., Jara, A., Urizar, J., Lanao, J. M. & Jung, H., Nov 17 2009, In : International Journal of Clinical Pharmacology and Therapeutics. 47, 11, p. 679-685 7 p.

Research output: Contribution to journalArticle

Neurocysticercosis
Albendazole
Pharmacokinetics
Biological Availability
Population
2008
35 Citations (Scopus)

Differential genotype dependent inhibition of CYP2C9 in humans

Kumar, V., Brundage, R. C., Oetting, W. S., Leppik, I. E. & Tracy, T. S., Jan 1 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1242-1248 7 p.

Research output: Contribution to journalArticle

Flurbiprofen
Fluconazole
Genotype
Drug Interactions
Alleles
23 Citations (Scopus)

Estrogen elevates the peak overnight production rate of acylated ghrelin

Paulo, R. C., Brundage, R., Cosma, M., Mielke, K. L., Bowers, C. Y. & Veldhuis, J. D., Jan 1 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 11, p. 4440-4447 8 p.

Research output: Contribution to journalArticle

Ghrelin
Estrogens
Metabolic Clearance Rate
Plasmas
Acylation