1982 …2020

Research output per year

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Research Output

2020

Measuring Lipid Transfer Protein Activity Using Bicelle-Dilution Model Membranes

Gao, Y-G., Le, T. M. L., Zhai, X., Boldyrev, I. A., Mishra, S. K., Tischer, A., Murayama, T., Nishida, A., Molotkovsky, J. G., Alam, A. & Brown, R. E., Feb 18 2020, In : Analytical Chemistry. 92, 4, p. 3417-3425 9 p.

Research output: Contribution to journalArticle

2019

In Vitro Measurement of Sphingolipid Intermembrane Transport Illustrated by GLTP Superfamily Members

Kenoth, R., Brown, R. E. & Kamlekar, R. K., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1949, p. 237-256 20 p.

Research output: Contribution to journalArticle

Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α

Hirano, Y., Gao, Y-G., Stephenson, D. J., Vu, N. T., Malinina, L., Simanshu, D. K., Chalfant, C. E., Patel, D. J. & Brown, R. E., May 3 2019, In : eLife. 8, 28 p., e44760.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair

MacKnight, H. P., Stephenson, D. J., Hoeferlin, L. A., Benusa, S. D., DeLigio, J. T., Maus, K. D., Ali, A. N., Wayne, J. S., Park, M. A., Hinchcliffe, E. H., Brown, R. E., Ryan, J. J., Diegelmann, R. F. & Chalfant, C. E., Dec 3 2019, In : Science Signaling. 12, 610, 17 p., eaav5918.

Research output: Contribution to journalArticle

1 Scopus citations

Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells

Mishra, S. K., Stephenson, D. J., Chalfant, C. E. & Brown, R. E., Feb 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 2, p. 158-167 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation

Mishra, S. K., Gao, Y-G., Deng, Y., Chalfant, C. E., Hinchcliffe, E. H. & Brown, R. E., May 4 2018, In : Autophagy. 14, 5

Research output: Contribution to journalArticle

9 Scopus citations

Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein

Kenoth, R., Zou, X., Simanshu, D. K., Pike, H. M., Malinina, L., Patel, D. J., Brown, R. E. & Kamlekar, R. K., May 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 5, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family

Ochoa-Lizarralde, B., Gao, Y. G., Popov, A. N., Samygina, V. R., Zhai, X., Mishra, S. K., Boldyrev, I. A., Molotkovsky, J. G., Simanshu, D. K., Patel, D. J., Brown, R. E. & Malinina, L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 43, p. 16709-16723 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

The many roles of CPTPs

Brown, R. E., Dec 1 2018, In : ASBMB TODAY. December, p. 12-14 2 p.

Research output: Contribution to journalArticle

Open Access
2017

How α-helical motifs form functionally diverse lipid-binding compartments

Malinina, L., Patel, D. J. & Brown, R. E., Jun 20 2017, In : Annual Review of Biochemistry. 86, p. 609-636 28 p.

Research output: Contribution to journalArticle

8 Scopus citations

Phosphatidylserine stimulates ceramide 1-phosphate (C1P) intermembrane transfer by C1P transfer proteins

Zhai, X., Gao, Y. G., Mishra, S. K., Simanshu, D. K., Boldyrev, I. A., Benson, L. M., Bergen, H. R., Malinina, L., Mundy, J., Molotkovsky, J. G., Patel, D. J. & Brown, R. E., Feb 10 2017, In : Journal of Biological Chemistry. 292, 6, p. 2531-2541 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Catalytic Mechanism of Eukaryotic Neutral Ceramidase

Malinina, L. & Brown, R. E., Aug 7 2015, In : Structure. 23, 8, p. 1371-1372 2 p., 3236.

Research output: Contribution to journalShort survey

2 Scopus citations

Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding protein

Rao, E., Singh, P., Zhai, X., Li, Y., Zhu, G., Zhang, Y., Hao, J., Chi, Y-I., Brown, R. E., Cleary, M. P. & Li, B., Jan 1 2015, In : Oncotarget. 6, 10, p. 7815-7827 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Sphingolipid transfer proteins defined by the GLTP-fold

Malinina, L., Simanshu, D. K., Zhai, X., Samygina, V. R., Kamlekar, R., Kenoth, R., Ochoa-Lizarralde, B., Malakhova, M. L., Molotkovsky, J. G., Patel, D. J. & Brown, R. E., Mar 23 2015, In : Quarterly Reviews of Biophysics. 48, 3, p. 281-322 42 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Arabidopsis accelerated cell death 11, ACD11, Is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels

Simanshu, D. K., Zhai, X., Munch, D., Hofius, D., Markham, J. E., Bielawski, J., Bielawska, A., Malinina, L., Molotkovsky, J. G., Mundy, J. W., Patel, D. J. & Brown, R. E., Jan 10 2014, In : Cell reports. 6, 2, p. 388-399 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Nanoscale packing differences in sphingomyelin and phosphatidylcholine revealed by bodipy fluorescence in monolayers: Physiological implications

Zhai, X., Boldyrev, I. A., Mizuno, N. K., Momsen, M. M., Molotkovsky, J. G., Brockman, H. L. & Brown, R. E., Mar 25 2014, In : Langmuir. 30, 11, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

An expedient synthesis of fluorescent labeled ceramide-1-phosphate analogues

Boldyrev, I. A., Brown, R. E. & Molotkovsky, J. G., Sep 1 2013, In : Russian Journal of Bioorganic Chemistry. 39, 5, p. 539-542 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine

Zhai, X., Momsen, W. E., Malakhov, D. A., Boldyrev, I. A., Momsen, M. M., Molotkovsky, J. G., Brockman, H. L. & Brown, R. E., Apr 1 2013, In : Journal of Lipid Research. 54, 4, p. 1103-1113 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

Simanshu, D. K., Kamlekar, R. K., Wijesinghe, D. S., Zou, X., Zhai, X., Mishra, S. K., Molotkovsky, J. G., Malinina, L., Hinchcliffe, E. H., Chalfant, C. E., Brown, R. E. & Patel, D. J., Jul 19 2013, In : Nature. 500, 7463, p. 463-467 5 p.

Research output: Contribution to journalArticle

93 Scopus citations

Structural insights into lipid-dependent reversible dimerization of human GLTP

Samygina, V. R., Ochoa-Lizarralde, B., Popov, A. N., Cabo-Bilbao, A., Goni-De-Cerio, F., Molotkovsky, J. G., Patel, D. J., Brown, R. E. & Malinina, L., Apr 1 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 4, p. 603-616 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): Structure drives preference for simple neutral glycosphingolipids

Kamlekar, R. K., Simanshu, D. K., Gao, Y-G., Kenoth, R., Pike, H. M., Prendergast, F. G., Malinina, L., Molotkovsky, J. G., Venyaminov, S. Y., Patel, D. J. & Brown, R. E., Feb 1 2013, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1831, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: Does a molten globule-like state regulate activity?

Kenoth, R., Kamlekar, R. K., Simanshu, D. K., Gao, Y-G., Malinina, L., Prendergast, F. G., Molotkovsky, J. G., Patel, D. J., Venyaminov, S. Y. & Brown, R. E., Jun 14 2011, In : Biochemistry. 50, 23, p. 5163-5171 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein

Samygina, V. R., Popov, A. N., Cabo-Bilbao, A., Ochoa-Lizarralde, B., Goni-De-Cerio, F., Zhai, X., Molotkovsky, J. G., Patel, D. J., Brown, R. E. & Malinina, L., Nov 9 2011, In : Structure. 19, 11, p. 1644-1654 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Human glycolipid transfer protein (GLTP) expression modulates cell shape

Gao, Y., Chung, T., Zou, X., Pike, H. M. & Brown, R. E., May 24 2011, In : PloS one. 6, 5, e19990.

Research output: Contribution to journalArticle

9 Scopus citations

Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: Involvement of the bioactive sphingolipid ceramide

Zou, X., Gao, Y-G., Ruvolo, V. R., Gardner, T. L., Ruvolo, P. P. & Brown, R. E., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1301-1311 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

Characterization of the lateral distribution of fluorescent lipid in binary-constituent lipid monolayers by principal component analysis

Brown, R. E., Sugár, I. P., Zhai, X., Boldyrev, I. A., Molotkovsky, J. G. & Brockman, H. L., May 26 2010, In : International Journal of Biomedical Imaging. 2010, 125850.

Research output: Contribution to journalArticle

2 Scopus citations

Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold

Kamlekar, R. K., Gao, Y-G., Kenoth, R., Molotkovsky, J. G., Prendergast, F. G., Malinina, L., Patel, D. J., Wessels, W. S., Venyaminov, S. Y. & Brown, R. E., Oct 20 2010, In : Biophysical journal. 99, 8, p. 2626-2635 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold

Kenoth, R., Simanshu, D. K., Kamlekar, R. K., Pike, H. M., Molotkovsky, J. G., Benson, L. M., Bergen, H. R., Prendergast, F. G., Malinina, L., Venyaminov, S. Y., Patel, D. J. & Brown, R. E., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13066-13078 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: Insights into glycolipid binding affinity

Zhai, X., Malakhova, M. L., Pike, H. M., Benson, L. M., Bergen, H. R., Sugár, I. P., Malinina, L., Patel, D. J. & Brown, R. E., May 15 2009, In : Journal of Biological Chemistry. 284, 20, p. 13620-13628 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions

Gale, S. E., Westover, E. J., Dudley, N., Krishnan, K., Merlin, S., Scherrer, D. E., Han, X., Zhai, X., Brockman, H. L., Brown, R. E., Covey, D. F., Schaffer, J. E., Schlesinger, P. & Ory, D. S., Jan 16 2009, In : Journal of Biological Chemistry. 284, 3, p. 1755-1764 10 p.

Research output: Contribution to journalArticle

53 Scopus citations
2008

Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant

Petersen, N. H. T., McKinney, L. V., Pike, H., Hofius, D., Zakaria, A., Brodersen, P., Petersen, M., Brown, R. E. & Mundy, J., Sep 1 2008, In : FEBS Journal. 275, 17, p. 4378-4388 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Human glycolipid transfer protein (GLTP) genes: Organization, transcriptional status and evolution

Zou, X., Chung, T., Lin, X., Malakhova, M. L., Pike, H. M. & Brown, R. E., Feb 8 2008, In : BMC Genomics. 9, 72.

Research output: Contribution to journalArticle

16 Scopus citations

Phase diagrams of lipid mixtures relevant to the study of membrane rafts

Goñi, F. M., Alonso, A., Bagatolli, L. A., Brown, R. E., Marsh, D., Prieto, M. & Thewalt, J. L., Nov 1 2008, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1781, 11-12, p. 665-684 20 p.

Research output: Contribution to journalReview article

149 Scopus citations
2007

Glycolipid transfer proteins

Brown, R. E. & Mattjus, P., Jun 1 2007, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1771, 6, p. 746-760 15 p.

Research output: Contribution to journalReview article

58 Scopus citations

New BODIPY lipid probes for fluorescence studies of membranes

Boldyrev, I. A., Zhai, X., Momsen, M. M., Brockman, H. L., Brown, R. E. & Molotkovsky, J. G., Jul 1 2007, In : Journal of Lipid Research. 48, 7, p. 1518-1532 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

Using monomolecular films to characterize lipid lateral interactions

Brown, R. E. & Brockman, H. L., Dec 1 2007, Lipid Rafts. McIntosh, T. J. (ed.). p. 41-58 18 p. (Methods in Molecular Biology; vol. 398).

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations
2006

Lactosylceramide: Lateral Interactions with cholesterol

Zhai, X., Li, X. M., Momsen, M. M., Brockman, H. L. & Brown, R. E., Oct 2006, In : Biophysical journal. 91, 7, p. 2490-2500 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure

Malinina, L., Malakhova, M. L., Kanack, A. T., Lu, M., Abagyan, R., Brown, R. E. & Patel, D. J., Nov 1 2006, In : PLoS biology. 4, 11, p. 1996-2011 16 p.

Research output: Contribution to journalArticle

43 Scopus citations
2005

Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by αB-crystallin through inhibition of RAS activation

Li, D. W. C., Liu, J. P., Mao, Y. W., Xiang, H., Wang, J., Ma, W-Y., Dong, Z., Pike, H. M., Brown, R. E. & Reed, J. C., Sep 1 2005, In : Molecular biology of the cell. 16, 9, p. 4437-4453 17 p.

Research output: Contribution to journalArticle

142 Scopus citations

Glycolipid transfer protein interaction with bilayer vesicles: Modulation by changing lipid composition

Rao, C. S., Chung, T., Pike, H. M. & Brown, R. E., Dec 2005, In : Biophysical journal. 89, 6, p. 4017-4028 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Point mutational analysis of the liganding site in human glycolipid transfer protein: Functionality of the complex

Malakhova, M. L., Malinina, L., Pike, H. M., Kanack, A. T., Patel, D. J. & Brown, R. E., Jul 15 2005, In : Journal of Biological Chemistry. 280, 28, p. 26312-26320 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

The 3-hydroxy group and 4,5-trans double bond of sphingomyelin are essential for modulation of galactosylceramide transmembrane asymmetry

Malewicz, B., Valiyaveettil, J. T., Jacob, K., Byun, H. S., Mattjus, P., Baumann, W. J., Bittman, R. & Brown, R. E., Apr 2005, In : Biophysical journal. 88, 4, p. 2670-2680 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: A model for action based on kinetic and thermodynamic analyses

Rao, C. S., Lin, X., Pike, H. M., Molotkovsky, J. G. & Brown, R. E., Nov 2 2004, In : Biochemistry. 43, 43, p. 13805-13815 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Human glycolipid transfer protein: Probing conformation using fluorescence spectroscopy

Li, X. M., Malakhova, M. L., Lin, X., Pike, H. M., Chung, T., Molotkovsky, J. G. & Brown, R. E., Aug 10 2004, In : Biochemistry. 43, 31, p. 10285-10294 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Structural basis for glycosphingolipid transfer specificity

Malinina, L., Malakhova, M. L., Teplov, A., Brown, R. E. & Patel, D. J., Aug 26 2004, In : Nature. 430, 7003, p. 1048-1053 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior

Brockman, H. L., Momsen, M. M., Brown, R. E., He, L., Chun, J., Byun, H. S. & Bittman, R., Sep 2004, In : Biophysical journal. 87, 3, p. 1722-1731 10 p.

Research output: Contribution to journalArticle

70 Scopus citations
2003

Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects: Studies with cholesterol enantiomers

Westover, E. J., Covey, D. F., Brockman, H. L., Brown, R. E. & Pike, L. J., Dec 19 2003, In : Journal of Biological Chemistry. 278, 51, p. 51125-51133 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Glycolipid intermembrane transfer is accelerated by HET-C2, a filamentous fungus gene product involved in the cell-cell incompatibility response

Mattjus, P., Turcq, B., Pike, H. M., Molotkovsky, J. G. & Brown, R. E., Jan 21 2003, In : Biochemistry. 42, 2, p. 535-542 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Sterol Structure and Sphingomyelin Acyl Chain Length Modulate Lateral Packing Elasticity and Detergent Solubility in Model Membranes

Li, X. M., Momsen, M. M., Brockman, H. L. & Brown, R. E., Dec 2003, In : Biophysical journal. 85, 6, p. 3788-3801 14 p.

Research output: Contribution to journalArticle

59 Scopus citations
2002

Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense

Brodersen, P., Petersen, M., Pike, H. M., Olszak, B., Skov, S., Ødum, N., Jørgensen, L. B., Brown, R. E. & Mundy, J., Feb 15 2002, In : Genes and Development. 16, 4, p. 490-502 13 p.

Research output: Contribution to journalArticle

290 Scopus citations