Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Targeting N-Myc with Selective Aurora Kinase A Degraders for Neuroblastoma Therapy
Harki, D. A. (PI), Harris, R. (CoI) & Levinson, N. M. (CoI)
7/15/21 → 7/14/25
Project: Research project
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Midwest AViDD Center - Project 5 Admin Supplement
Harris, R. (PI) & Li, F. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
9/1/22 → 4/30/25
Project: Research project
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Midwest AViDD Center
Harris, R. (PI), Aihara, H. (CoI), Aliota, M. T. (CoI), Harki, D. A. (CoI), Langlois, R. A. (CoI), Li, F. (CoI), Liang, Y. (CoI) & Ly, H. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
5/16/22 → 4/30/25
Project: Research project
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APOBEC3B and DNA Repair as Synthetic Lethal Combinations in CCOC
Harris, R. (PI)
THE OVARIAN CANCER RESEARCH FUND INC
3/1/21 → 6/5/22
Project: Research project
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Implications and Vulnerabilities of APOBEC Mutagenesis in Breast Cancer
Harris, R. (PI)
MEMORIAL SLOAN-KETTERING CANCER CENTER, NIH NATIONAL CANCER INSTITUTE (NCI)
8/13/20 → 7/31/22
Project: Research project
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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
Tang, J., Moorthy, R., Hirsch, L. E., Demir, Ö., Baker, Z. D., Naumann, J. A., Jones, K. F. M., Grillo, M. J., Haefner, E. S., Shi, K., Levy, M. J., Gupta, H. B., Aihara, H., Harris, R. S., Amaro, R. E., Levinson, N. M. & Harki, D. A., Feb 20 2025, In: Cell Chemical Biology. 32, 2, p. 352-362.e10Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes
Wyllie, M. K., Morris, C. K., Moeller, N. H., Schares, H. A. M., Moorthy, R., Belica, C. A., Grillo, M. J., Demir, Ö., Ayoub, A. M., Carpenter, M. A., Aihara, H., Harris, R. S., Amaro, R. E. & Harki, D. A., Jan 17 2025, In: ACS Chemical Biology. 20, 1, p. 117-127 11 p.Research output: Contribution to journal › Article › peer-review
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A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain
Esler, M. A., Belica, C. A., Rollie, J. A., Brown, W. L., Moghadasi, S. A., Shi, K., Harki, D. A., Harris, R. S. & Aihara, H., Nov 27 2024, In: Nucleic acids research. 52, 21, p. 13138-13151 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination
Belica, C. A., Carpenter, M. A., Chen, Y., Brown, W. L., Moeller, N. H., Boylan, I. T., Harris, R. S. & Aihara, H., Jun 2024, In: Journal of Biological Chemistry. 300, 6, 107410.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
Sanchez, A., Ortega, P., Sakhtemani, R., Manjunath, L., Oh, S., Bournique, E., Becker, A., Kim, K., Durfee, C., Temiz, N. A., Chen, X. S., Harris, R. S., Lawrence, M. S. & Buisson, R., Dec 2024, In: Nature communications. 15, 1, 2370.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations
Datasets
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The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism
Harris, R. & Shaban, N., Mendeley Data, 2017
DOI: 10.17632/6mdtnv4kjb.1, https://data.mendeley.com/datasets/6mdtnv4kjb
Dataset