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Research Output 2003 2019

2019
1 Citation (Scopus)

Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma

Rahrmann, E. P., Wolf, N. K., Otto, G. M., Heltemes Harris, L. M., Ramsey, L. B., Shu, J., LaRue, R. S., Linden, M. A., Rathe, S., Starr, T., Farrar, M. A., Moriarity, B. S. & Largaespada, D. A., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 567-582 16 p.

Research output: Contribution to journalArticle

Beauty
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Carrier Proteins
Follicular Lymphoma
3 Citations (Scopus)

Thymic regulatory T cells arise via two distinct developmental programs

Owen, D. L., Mahmud, S., Sjaastad, L. E., Williams, J. B., Spanier, J. A., Simeonov, D. R., Ruscher, R., Huang, W., Proekt, I., Miller, C. N., Hekim, C., Jeschke, J. C., Aggarwal, P., Broeckel, U., LaRue, R. S., Henzler, C. M., Alegre, M. L., Anderson, M. S., August, A., Marson, A. & 3 othersZheng, Y., Williams, C. B. & Farrar, M. A., Feb 1 2019, In : Nature immunology. 20, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoantigens
Stem Cells
T-Cell Antigen Receptor
Transcriptome
2018
9 Citations (Scopus)
Gene Expression Profiling
Osteosarcoma
Survival
Multigene Family
Neoplasms
2017
2 Citations (Scopus)

Data Descriptor: Transcriptomic analysis of gene signatures associated with sickle pain

Paul, J. A., Aich, A., Abrahante, J. E., Wang, Y., LaRue, R. S., Rathe, S. K., Kalland, K., Mittal, A., Jha, R., Peng, F., Largaespada, D. A., Bagchi, A. & Gupta, K., May 16 2017, In : Scientific Data. 4, 170051.

Research output: Contribution to journalArticle

Pain
Descriptors
pain
Signature
Genes
2016
Beauty
Mutagenesis
Adenocarcinoma
Genes
Mutation
2015
95 Citations (Scopus)

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 othersGorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

Beauty
Osteosarcoma
Neoplasm Metastasis
Genes
Oncogenes
2014
3 Citations (Scopus)

Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy

Litterman, A. J., Zellmer, D. M., LaRue, R. S., Jameson, S. C. & Largaespada, D. A., Sep 1 2014, In : Cancer Immunology Research. 2, 9, p. 839-845 7 p.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
T-Lymphocytes
Phenotype
Antigens
Interleukin-2
14 Citations (Scopus)

CD200 in CNS tumor-induced immunosuppression: The role for CD200 pathway blockade in targeted immunotherapy

Moertel, C. L., Xia, J., LaRue, R. S., Waldron, N. N., Andersen, B. M., Prins, R. M., Okada, H., Donson, A. M., Foreman, N. K., Hunt, M., Pennell, C. A. & Olin, M. R., Dec 16 2014, In : Journal for ImmunoTherapy of Cancer. 2, 1, 46.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Immunotherapy
Immunosuppression
Brain Neoplasms
Glioblastoma
14 Citations (Scopus)

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Sachs, Z., LaRue, R. S., Nguyen, H. T., Sachs, K., Noble, K. E., Hassan, N. A. M., Diaz-Flores, E., Rathe, S. K., Sarver, A. L., Bendall, S. C., Ha, N. A., Diers, M. D., Nolan, G. P., Shannon, K. M. & Largaespada, D. A., Nov 20 2014, In : Blood. 124, 22, p. 3274-3283 10 p.

Research output: Contribution to journalArticle

Oncogenes
Acute Myeloid Leukemia
Gene expression
Leukemia
Stem cells
2012
207 Citations (Scopus)

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

Jäger, S., Kim, D. Y., Hultquist, J. F., Shindo, K., LaRue, R. S., Kwon, E., Li, M., Anderson, B. D., Yen, L., Stanley, D., Mahon, C., Kane, J., Franks-Skiba, K., Cimermancic, P., Burlingame, A., Sali, A., Craik, C. S., Harris, R., Gross, J. D. & Krogan, N. J., Jan 19 2012, In : Nature. 481, 7381, p. 371-375 5 p.

Research output: Contribution to journalArticle

Virus Diseases
HIV-1
Ligases
Ubiquitin
Antiviral Agents
56 Citations (Scopus)

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

Hultquist, J. F., Binka, M., LaRue, R. S., Simon, V. & Harris, R., Mar 1 2012, In : Journal of virology. 86, 5, p. 2874-2877 4 p.

Research output: Contribution to journalArticle

vif Gene Products
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus
HIV
2011
194 Citations (Scopus)

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-Deficient HIV-1

Hultquist, J. F., Lengyel, J. A., Refsland, E. W., LaRue, R. S., Lackey, L., Brown, W. L. & Harris, R., Nov 1 2011, In : Journal of Virology. 85, 21, p. 11220-11234 15 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
pathogenicity
T-lymphocytes
T-Lymphocytes
2010
39 Citations (Scopus)

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif

Albin, J. S., LaRue, R. S., Weaver, J. A., Brown, W. L., Shindo, K., Harjes, E., Matsuo, H. & Harris, R., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. 40785-40792 8 p.

Research output: Contribution to journalArticle

Virion
HIV-1
Viral Regulatory and Accessory Proteins
Amino Acids
Degradation
69 Citations (Scopus)

Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity

LaRue, R. S., Lengyel, J., Jónsson, S. R., Andrésdóttir, V. & Harris, R. S., Aug 1 2010, In : Journal of Virology. 84, 16, p. 8193-8201 9 p.

Research output: Contribution to journalArticle

vif Gene Products
Proteins
proteins
Lentivirus
Macaca

Retrovirus restriction factors

Harris, R., LaRue, R. S. & Hope, T. J., Jan 1 2010, Recent Advances in Human Retroviruses: Principles of Replication and Pathogenesis: Advances in Retroviral Research. World Scientific Publishing Co., p. 407-437 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retroviridae
Viruses
Interferons
Proteins
Research
2009

Erratum: Pathogenesis of coxsackievirus-B5 acquired from intra-renal porcine islet cell xenografts in diabetic mice (Xenotransplantation 16 (91-98))

Myers, S. E., LaRue, R., Njenga, M. K., Shaw, D. P. & Love, B. C., May 1 2009, In : Xenotransplantation. 16, 3, 1 p.

Research output: Contribution to journalComment/debate

Heterologous Transplantation
Enterovirus
Islets of Langerhans
Heterografts
Swine
147 Citations (Scopus)

Guidelines for naming nonprimate APOBEC3 genes and proteins

LaRue, R. S., Andrésdóttir, V., Blanchard, Y., Conticello, S. G., Derse, D., Emerman, M., Greene, W. C., Jónsson, S. R., Landau, N. R., Löchelt, M., Malik, H. S., Malim, M. H., Münk, C., O'Brien, S. J., Pathak, V. K., Strebel, K., Wain-Hobson, S., Yu, X. F., Yuhki, N. & Harris, R. S., Jan 1 2009, In : Journal of virology. 83, 2, p. 494-497 4 p.

Research output: Contribution to journalComment/debate

Host factors that restrict retrovirus replication

Stenglein, M. D., Schumacher, A. J., LaRue, R. S. & Harris, R., Jan 1 2009, Viral Genome Replication. Springer US, p. 297-334 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retroviridae
Retroviridae Infections
Viral DNA
Antiviral Agents
Proteins
4 Citations (Scopus)

Pathogenesis of coxsackievirus-B5 acquired from intra-renal porcine islet cell xenografts in diabetic mice

Myers, S. E., LaRue, R. S., Njenga, M. K., Shaw, D. P. & Love, B. C., Mar 1 2009, In : Xenotransplantation. 16, 2, p. 91-98 8 p.

Research output: Contribution to journalArticle

Enterovirus
Islets of Langerhans
Heterografts
Swine
Kidney
2008
126 Citations (Scopus)

The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals

LaRue, R. S., Jónsson, S. R., Silverstein, K. A. T., Lajoie, M., Bertrand, D., El-Mabrouk, N., Hötzel, I., Andrésdóttir, V., Smith, T. P. L. & Harris, R. S., Nov 18 2008, In : BMC Molecular Biology. 9, 104.

Research output: Contribution to journalArticle

Mammals
Genes
Sheep
Swine
Genetic Recombination
2007
41 Citations (Scopus)

The restriction of zoonotic PERV transmission by human APOBEC3G

Jónsson, S. R., LaRue, R. S., Stenglein, M. D., Fahrenkrug, S. C., Andrésdóttir, V. & Harris, R. S., Sep 12 2007, In : PloS one. 2, 9, e893.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Zoonoses
Swine
Viruses
2005
21 Citations (Scopus)

A wild goose metapneumovirus containing a large attachment glycoprotein is avirulent but immunoprotective in domestic turkeys

Bennett, R. S., LaRue, R. S., Shaw, D., Yu, Q., Nagaraja, K. V., Halvorson, D. A. & Njenga, M. K., Dec 1 2005, In : Journal of virology. 79, 23, p. 14834-14842 9 p.

Research output: Contribution to journalArticle

Metapneumovirus
Avian metapneumovirus
Geese
geese
glycoproteins
2004
9 Citations (Scopus)

Transplanting encephalomyocarditis virus-infected porcine islet cells reverses diabetes in recipient mice but also transmits the virus

Brewer, L., LaRue, R. S., Hering, B. J., Brown, C. & Njenga, M. K., Mar 1 2004, In : Xenotransplantation. 11, 2, p. 160-170 11 p.

Research output: Contribution to journalArticle

Encephalomyocarditis virus
Islets of Langerhans
Swine
Viruses
Virus Diseases
2003
47 Citations (Scopus)

A wild-type porcine Encephalomyocarditis virus containing a short poly(C) tract is pathogenic to mice, pigs, and cynomolgus macaques

LaRue, R. S., Myers, S., Brewer, L., Shaw, D. P., Brown, C., Seal, B. S. & Njenga, M. K., Sep 1 2003, In : Journal of virology. 77, 17, p. 9136-9146 11 p.

Research output: Contribution to journalArticle

Encephalomyocarditis virus
Poly C
Macaca fascicularis
Macaca
Swine