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  • 16 Similar Profiles
Ryanodine Receptor Calcium Release Channel Medicine & Life Sciences
Calmodulin Medicine & Life Sciences
Fluorescence Resonance Energy Transfer Medicine & Life Sciences
Tacrolimus Binding Proteins Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Sarcoplasmic Reticulum Medicine & Life Sciences
Calcium Medicine & Life Sciences

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Projects 2008 2021

Ryanodine Receptor Calcium Release Channel
Heart Failure
Therapeutics
Heart Failure
Calcium
Therapeutics

Research Output 1994 2019

1 Citation (Scopus)

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Walweel, K., Gomez-Hurtado, N., Rebbeck, R. T., Oo, Y. W., Beard, N. A., Molenaar, P., dos Remedios, C., van Helden, D. F., Cornea, R. L., Knollmann, B. C. & Laver, D. R., May 1 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 96-106 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Calmodulin
Phosphorylation
Calcium-Calmodulin-Dependent Protein Kinases
1 Citation (Scopus)

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Batiste, S. M., Blackwell, D. J., Kim, K., Kryshtal, D. O., Gomez-Hurtado, N., Rebbeck, R. T., Cornea, R. L., Johnston, J. N. & Knollmann, B. C., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4810-4815 6 p.

Research output: Contribution to journalArticle

Open Access
Ryanodine Receptor Calcium Release Channel
Calcium
Biological Products
Cardiac Arrhythmias
Cardiac Myocytes

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

Ceholski, D. K., Turnbull, I. C., Kong, C. W., Koplev, S., Mayourian, J., Gorski, P. A., Stillitano, F., Skodras, A. A., Nonnenmacher, M., Cohen, N., Björkegren, J. L. M., Stroik, D., Cornea, R. L., Thomas, D. D., Li, R. A., Costa, K. D. & Hajjar, R. J., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 147-154 8 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Cardiac Myocytes
Mutation
Clustered Regularly Interspaced Short Palindromic Repeats
phospholamban

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells

Stroik, D., Yuen, S. L., Janicek, K. A., Schaaf, T. M., Li, J., Ceholski, D. K., Hajjar, R. J., Cornea, R. L. & Thomas, D. D., Dec 1 2018, In : Scientific reports. 8, 1, 12560.

Research output: Contribution to journalArticle

Protein Transport
Proteins
Calcium
High-Throughput Screening Assays
Small Molecule Libraries
8 Citations (Scopus)

High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels

Rebbeck, R. T., Essawy, M. M., Nitu, F. R., Grant, B. D., Gillispie, G. D., Thomas, D. D., Bers, D. M. & Cornea, R. L., Jan 1 2017, In : SLAS Discovery. 22, 2, p. 176-186 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Modulators
Throughput
Fluorescence Resonance Energy Transfer
Molecules