1996 …2022

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Article
2020

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Wilkinson, P. E., Merkourea, S., Gopalakrishnan, R. & Argyris, P. P., Jan 1 2020, (Accepted/In press) In : Head and Neck Pathology.

Research output: Contribution to journalArticle

Regulation of osteoclast differentiation at multiple stages by protein kinase D family kinases

Leightner, A. C., Meyers, C. M. G., Evans, M. D., Mansky, K. C., Gopalakrishnan, R. & Jensen, E. D., Feb 1 2020, In : International journal of molecular sciences. 21, 3, 1056.

Research output: Contribution to journalArticle

Open Access
2019

A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma

Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Jan 1 2019, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journalArticle

Intraoral Cutaneous Hamartomas - Clinicopathologic and Immunohistochemical Characteristics of 3 Cases

Wilkinson, P. E., Gopalakrishnan, R. & Argyris, P. P., Nov 1 2019, In : American Journal of Dermatopathology. 41, 11, p. 794-798 5 p.

Research output: Contribution to journalArticle

2018

Clinicopathologic and Molecular Characteristics of Familial Cherubism with Associated Odontogenic Tumorous Proliferations

Argyris, P. P., Gopalakrishnan, R., Hu, Y., Reichenberger, E. J. & Koutlas, I. G., Mar 1 2018, In : Head and Neck Pathology. 12, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors

Tasca, A., Astleford, K., Blixt, N. C., Jensen, E. D., Gopalakrishnan, R. & Mansky, K. C., Sep 2018, In : PloS one. 13, 9, e0203404.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Class II and IV HDACs function as inhibitors of osteoclast differentiation

Blixt, N. C., Faulkner, B. K., Astleford, K., Lelich, R., Schering, J., Spencer, E., Gopalakrishnan, R., Jensen, E. D. & Mansky, K. C., Sep 2017, In : PloS one. 12, 9, e0185441.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Li, H., Reksten, T. R., Ice, J. A., Kelly, J. A., Adrianto, I., Rasmussen, A., Wang, S., He, B., Grundahl, K. M., Glenn, S. B., Miceli-Richard, C., Bowman, S., Lester, S., Eriksson, P., Eloranta, M. L., Brun, J. G., Gøransson, L. G., Harboe, E., Guthridge, J. M., Kaufman, K. M. & 31 others, Kvarnström, M., Cunninghame Graham, D. S., Patel, K., Adler, A. J., Farris, A. D., Brennan, M. T., Chodosh, J., Gopalakrishnan, R., Weisman, M. H., Venuturupalli, S., Wallace, D. J., Hefner, K. S., Houston, G. D., Huang, A. J. W., Hughes, P. J., Lewis, D. M., Radfar, L., Vista, E. S., Edgar, C. E., Rohrer, M. D., Stone, D. U., Vyse, T. J., Harley, J. B., Gaffney, P. M., James, J. A., Turner, S., Alevizos, I., Anaya, J. M., Rhodus, N. L., Segal, B. M. & for UK Primary Sjögren's Syndrome Registry, Jan 1 2017, In : PLoS genetics. 13, 6, e1006820.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Regulation of osteoclast differentiation by myosin X

Tasca, A., Astleford, K., Lederman, A., Jensen, E. D., Lee, B. S., Gopalakrishnan, R. & Mansky, K. C., Dec 1 2017, In : Scientific reports. 7, 1, 7603.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2016

Methionine restriction alters bone morphology and affects osteoblast differentiation

Ouattara, A., Cooke, D., Gopalakrishnan, R., Huang, T. H. & Ables, G. P., Dec 1 2016, In : Bone Reports. 5, p. 33-42 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
8 Scopus citations

Patients with Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity

Wolska, N., Rybakowska, P., Rasmussen, A., Brown, M., Montgomery, C., Klopocki, A., Grundahl, K., Scofield, R. H., Radfar, L., Stone, D. U., Anaya, J. M., Ice, J. A., Lessard, C. J., Lewis, D. M., Rhodus, N. L., Gopalakrishnan, R., Huang, A. J. W., Hughes, P. J., Rohrer, M. D., Weisman, M. H. & 6 others, Venuturupalli, S., Guthridge, J. M., James, J. A., Sivils, K. L., Bagavant, H. & Deshmukh, U. S., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 724-729 6 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
4 Scopus citations

Serum Markers of Bone Turnover and Angiogenesis in Patients with Bisphosphonate-Related Osteonecrosis of the Jaw after Discontinuation of Long-Term Intravenous Bisphosphonate Therapy

Thumbigere-Math, V., Michalowicz, B. S., Hughes, P. J., Basi, D. L., Tsai, M. L., Swenson, K. K., Rockwell, L. & Gopalakrishnan, R., Apr 1 2016, In : Journal of Oral and Maxillofacial Surgery. 74, 4, p. 738-746 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

Liu, K., Kurien, B. T., Zimmerman, S. L., Kaufman, K. M., Taft, D. H., Kottyan, L. C., Lazaro, S., Weaver, C. A., Ice, J. A., Adler, A. J., Chodosh, J., Radfar, L., Rasmussen, A., Stone, D. U., Lewis, D. M., Li, S., Koelsch, K. A., Igoe, A., Talsania, M., Kumar, J. & 58 others, Maier-Moore, J. S., Harris, V. M., Gopalakrishnan, R., Jonsson, R., Lessard, J. A., Lu, X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang, A. J. W., Brennan, M. T., Hughes, P., Illei, G. G., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Xie, G., Ng, W. F., Nordmark, G., Eriksson, P., Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Segal, B. M., Vyse, T. J., Wahren-Herlenius, M., Witte, T., Pons-Estel, B., Alarcón-Riquelme, M. E., Guthridge, J. M., James, J. A., Lessard, C. J., Kelly, J. A., Thompson, S. D., Gaffney, P. M., Montgomery, C. G., Edberg, J. C., Kimberly, R. P., Alarcón, G. S., Langefeld, C. L., Gilkeson, G. S., Kamen, D. L., Tsao, B. P., Joseph McCune, W., Salmon, J. E., Merrill, J. T., Weisman, M. H., Wallace, D. J., Utset, T. O., Bottinger, E. P., Amos, C. I., Siminovitch, K. A., Mariette, X., Sivils, K. L., Harley, J. B. & Hal Scofield, R., May 1 2016, In : Arthritis and Rheumatology. 68, 5, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations
2015

Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF

Stemig, M., Astelford, K., Emery, A., Cho, J. J., Allen, B., Huang, T. H., Gopalakrishnan, R., Mansky, K. C. & Jensen, E. D., Apr 15 2015, In : PloS one. 10, 4, e0123843.

Research output: Contribution to journalArticle

10 Scopus citations

Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice

Billington, C. J., Schmidt, B., Marcucio, R. S., Hallgrimsson, B., Gopalakrishnan, R. & Petryk, A., Feb 1 2015, In : DMM Disease Models and Mechanisms. 8, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Recurrent Ameloblastoma of the Mandible With Unusual Granular Cell Component

Argyris, P. P., McBeain, M. J. T., Rake, A., Pambuccian, S. E., Gopalakrishnan, R. & Koutlas, I. G., Jun 3 2015, In : International Journal of Surgical Pathology. 23, 4, p. 298-304 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw

Thumbigere-Math, V., Michalowicz, B. S., de Jong, E. P., Griffin, T. J., Basi, D. L., Hughes, P. J., Tsai, M. L., Swenson, K. K., Rockwell, L. & Gopalakrishnan, R., Jan 1 2015, In : Oral Diseases. 21, 1, p. 46-56 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Smad1/5 and Smad4 expression are important for osteoclast differentiation

Tasca, A. W., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E. D., Gopalakrishnan, R. & Mansky, K., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding

Huntley, R., Davydova, J., Petryk, A., Billington, C. J., Jensen, E. D., Mansky, K. C. & Gopalakrishnan, R., Oct 1 2015, In : Journal of Cellular Biochemistry. 116, 10, p. 2239-2246 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014
2 Scopus citations

Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw

Thumbigere-Math, V., Michalowicz, B. S., Hodges, J. S., Tsai, M. L., Swenson, K. K., Rockwell, L. & Gopalakrishnan, R., Feb 1 2014, In : Journal of Periodontology. 85, 2, p. 226-233 8 p.

Research output: Contribution to journalArticle

Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw

Thumbigere-Math, V., Michalowicz, B. S., Hodges, J. S., Tsai, M. L., Swenson, K. K., Rockwell, L. & Gopalakrishnan, R., Feb 2014, In : Journal of periodontology. 85, 2, p. 226-233 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa

Argyris, P., Gopalakrishnan, R., Pambuccian, S. E., Tosios, K. I. & Koutlas, I. G., Jun 2014, In : Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 117, 6, p. e441-e448

Research output: Contribution to journalArticle

4 Scopus citations
17 Scopus citations
2013

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization

Forsman, C. L., Ng, B. C., Heinze, R. K., Kuo, C., Sergi, C., Gopalakrishnan, R., Yee, D., Graf, D., Schwertfeger, K. L. & Petryk, A., Jan 1 2013, In : Developmental Biology. 373, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M., Mansky, K. & Gopalakrishnan, R., Dec 27 2013, In : Journal of Biological Chemistry. 288, 52, p. 37230-37240 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
11 Scopus citations
4 Scopus citations

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Lessard, C. J., Li, H., Adrianto, I., Ice, J. A., Rasmussen, A., Grundahl, K. M., Kelly, J. A., Dozmorov, M. G., Miceli-Richard, C., Bowman, S., Lester, S., Eriksson, P., Eloranta, M. L., Brun, J. G., Gøransson, L. G., Harboe, E., Guthridge, J. M., Kaufman, K. M., Kvarnström, M., Jazebi, H. & 40 others, Graham, D. S. C., Grandits, M. E., Nazmul-Hossain, A. N. M., Patel, K., Adler, A. J., Maier-Moore, J. S., Farris, A. D., Brennan, M. T., Lessard, J. A., Chodosh, J., Gopalakrishnan, R., Hefner, K. S., Houston, G. D., Huang, A. J. W., Hughes, P. J., Lewis, D. M., Radfar, L., Rohrer, M. D., Stone, D. U., Wren, J. D., Vyse, T. J., Gaffney, P. M., James, J. A., Omdal, R., Wahren-Herlenius, M., Illei, G. G., Witte, T., Jonsson, R., Rischmueller, M., Rönnblom, L., Nordmark, G., Ng, W. F., Mariette, X., Anaya, J. M., Rhodus, N. L., Segal, B. M., Scofield, R. H., Montgomery, C. G., Harley, J. B. & Sivils, K. L., Nov 1 2013, In : Nature Genetics. 45, 11, p. 1284-1294 11 p.

Research output: Contribution to journalArticle

221 Scopus citations
2012

A retrospective study evaluating frequency and risk factors of osteonecrosis of the jaw in 576 cancer patients receiving intravenous bisphosphonates

Thumbigere-Math, V., Tu, L., Huckabay, S., Dudek, A. Z., Lunos, S., Basi, D. L., Hughes, P. J., Leach, J. W., Swenson, K. K. & Gopalakrishnan, R., Aug 1 2012, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 35, 4, p. 386-392 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Metastasizing pleomorphic adenoma presents intraorally: A case report and review of the literature

Reiland, M. D., Koutlas, I. G., Gopalakrishnan, R., Pearson, A. G. & Basi, D. L., Oct 2012, In : Journal of Oral and Maxillofacial Surgery. 70, 10, p. e531-e540

Research output: Contribution to journalArticle

15 Scopus citations
2011

Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation

Pham, L., Beyer, K., Jensen, E. D., Sotillo Rodriguez, J. E., Davydova, J., Yamamoto, M., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2011, In : Journal of Cellular Biochemistry. 112, 3, p. 793-803 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Glycosylation oftwisted gastrulation is required for BMP binding and activity during craniofacial development

Billington, C. J., Fiebig, J. E., Forsman, C., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O'Connor, M. B., Mueller, T. D. & Petryk, A., Dec 1 2011, In : Frontiers in Physiology. 2 SEP, Article 59.

Research output: Contribution to journalArticle

6 Scopus citations

HDAC3 and HDAC7 have opposite effects on osteoclast differentiation

Pham, L., Kaiser, B., Romsa, A., Schwarz, T., Gopalakrishnan, R., Jensen, E. D. & Mansky, K., Apr 8 2011, In : Journal of Biological Chemistry. 286, 14, p. 12056-12065 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Matrix metalloproteinase-9 expression in alveolar extraction sockets of zoledronic acid-treated rats

Basi, D. L., Hughes, P. J., Thumbigere-Math, V., Sabino, MA., Mariash, A., Lunos, S. A., Jensen, E. & Gopalakrishnan, R., Nov 1 2011, In : Journal of Oral and Maxillofacial Surgery. 69, 11, p. 2698-2707 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice

Billington, C. J., Ng, B., Forsman, C., Schmidt, B., Bagchi, A., Symer, D. E., Schotta, G., Gopalakrishnan, R., Sarver, A. L. & Petryk, A., Jul 1 2011, In : Developmental Biology. 355, 1, p. 21-31 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors

Jensen, E. D., Pham, L., Billington, C. J., Espe, K., Carlson, A. E., Westendorf, J. J., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2010, In : Journal of Cellular Biochemistry. 109, 4, p. 672-682 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts

Grigsby, I. F., Pham, L., Gopalakrishnan, R., Mansky, L. M. & Mansky, K. C., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1324-1329 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects

Samaan, G., Yugo, D., Rajagopalan, S., Wall, J., Donnell, R., Goldowitz, D., Gopalakrishnan, R. & Venkatachalam, S., Sep 1 2010, In : Biochemical and Biophysical Research Communications. 400, 1, p. 60-65 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
49 Scopus citations

The expression of twisted gastrulation in postnatal mouse brain and functional implications

Sun, M., Forsman, C., Sergi, C., Gopalakrishnan, R., O'Connor, M. B. & Petryk, A., Aug 1 2010, In : Neuroscience. 169, 2, p. 920-931 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009

Bisphosphonate-Related Osteonecrosis of the Jaw: Clinical Features, Risk Factors, Management, and Treatment Outcomes of 26 Patients

Thumbigere-Math, V., Sabino, MA. C., Gopalakrishnan, R., Huckabay, S., Dudek, A. Z., Basu, S., Hughes, P. J., Michalowicz, B. S., Leach, J. W., Swenson, K. K., Swift, J. Q., Adkinson, C. & Basi, D. L., Sep 1 2009, In : Journal of Oral and Maxillofacial Surgery. 67, 9, p. 1904-1913 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
49 Scopus citations

Co-activator activator (CoAA) prevents the transcriptional activity of runt domain transcription factors

Li, X., Hoeppner, L. H., Jensen, E. D., Gopalakrishnan, R. & Westendorf, J. J., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dental (Odontogenic) Choristoma of the Tongue

Gopalakrishnan, R., Koutlas, I. G., Schauer, G. M. & Schnitker, G., May 1 2009, In : Journal of Oral and Maxillofacial Surgery. 67, 5, p. 1135-1138 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling

Sotillo Rodriguez, J. E., Mansky, K., Jensen, E. D., Carlson, A. E., Schwarz, T., Pham, L., MacKenzie, B., Prasad, H., Rohrer, M. D., Petryk, A. & Gopalakrishnan, R., Nov 1 2009, In : Journal of Bone and Mineral Research. 24, 11, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone

Suttamanatwong, S., Jensen, E. D., Schilling, J., Franceschi, R. T., Carlson, A. E., Mansky, K. & Gopalakrishnan, R., May 15 2009, In : Journal of Cellular Biochemistry. 107, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice

MacKenzie, B. A., Wolff, R., Lowe, N., Billington, C. J., Peterson, A., Schmidt, B., Graf, D., Mina, M., Gopalakrishnan, R. & Petryk, A., Apr 1 2009, In : Developmental Biology. 328, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

25 Scopus citations