Projects per year
Personal profile
Research interests
Dr. Rajasingham an Infectious Diseases physician and Assistant Professor of Medicine at the University of Minnesota. Her primary research interest is to maximize the public health impact of screening HIV-infected persons for opportunistic infections in order to decrease HIV/AIDS-related mortality. She particularly interested in the evaluation of cost-effective diagnostics and treatment algorithms to care of persons with advanced HIV disease.
Dr. Rajasingham received formal training from the Harvard School of Public Health in Global Health Delivery, and has spent one year in Uganda working as a clinical research coordinator for an NIH-sponsored clinical trial investigating the optimal timing of antiretroviral therapy in HIV-infected persons with cryptococcal meningitis (COAT Trial). Over the past twelve years, she has worked closely with the Ugandan and American collaborative research team at the Infectious Disease Institute (IDI) in Kampala, Uganda. Dr. Rajasingham has led an international consortium to estimate the global burden of cryptococcal infection. She has evaluated the cost-effectiveness of a Ugandan national CRAG screening program, and performed a budgetary impact analysis for funders to estimate costs and diagnostics tests required for persons with advanced HIV disease in sub Saharan Africa. She has consulted for the Pan American Health Organization (PAHO) and UNITAID for health economics evaluations of novel point-of-care diagnostics among persons with advanced HIV disease. She is the co-PI of a phase III randomized clinical trial in Uganda evaluating the efficacy of high dose AmBisome to prevent cryptococcal meningitis in persons with advanced HIV disease, and PI for an R01 cluster-randomized trial evaluating point-of-care diagnostics in persons with advanced HIV disease, funded by NIAID.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 5 Gender Equality
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SDG 10 Reduced Inequalities
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SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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Understanding the causes of second episode cryptococcal meningitis to improve diagnosis and treatment
Bahr, N. (PI), Dai, B. (PI), Nicol, M. R. (PI), Selmecki, A. M. (PI), Boulware, D. R. (CoI) & Rajasingham, R. (CoI)
NIH NAT INST OF NEURO DISORDERS & STROKE
9/10/25 → 8/31/29
Project: Research project
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NIH Foreign Subaward for CON_90919
Rajasingham, R. (PI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
8/1/25 → 7/31/26
Project: Research project
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An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease
Dai, B. (PI), Rajasingham, R. (PI), Boulware, D. R. (CoI) & Huppler Hullsiek, K. (CoI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
8/23/21 → 7/31/26
Project: Research project
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NIH Foreign Subaward for CON_99631: Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection
Rajasingham, R. (PI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
4/1/25 → 3/31/26
Project: Research project
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Determining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis
Bahr, N. (PI), Dai, B. (PI), Boulware, D. R. (CoI) & Rajasingham, R. (CoI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
1/1/24 → 5/31/26
Project: Research project
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A cluster randomized trial of Visitect CD4 Advanced Disease platform among outpatients with advanced HIV disease in Uganda
the ENCORE team, Jan 2026, In: Journal of the International AIDS Society. 29, 1, e70075.Research output: Contribution to journal › Article › peer-review
Open Access -
Change in plasma cryptococcal antigen titers in Uganda among outpatients with advanced HIV disease from 2017 to 2022 with rollout of national cryptococcal screening
Poeschla, A., Wele, A., Nalintya, E., Dai, B., Meya, D. B., Boulware, D. R. & Rajasingham, R., Jun 2026, In: PloS one. 21, 6 June, e0349854.Research output: Contribution to journal › Article › peer-review
Open Access -
Headache as a Predictor of Cryptococcal Meningitis in Ambulatory Patients With Symptomatic HIV-associated Cryptococcal Antigenemia
Najjuka, S. M., Poeschla, A., Wele, A., Nalintya, E., Kirumira, P., Ayebale, P., Nakitto, G., Turya, F., Nankungu, L., Skipper, C. P., Fieberg, A., Dai, B., Boulware, D. R., Meya, D. B. & Rajasingham, R., Feb 1 2026, In: Open Forum Infectious Diseases. 13, 2, ofag027.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigation of human leukocyte antigen alleles as risk factors for cryptococcal disease in Ugandan individuals with HIV
Skipper, C. P., Dai, B., Borges, B., Augusto, D. G., Gerlach, E., Tukundane, A., Tadeo, K., Pastick, K. A., Williams, D. A., Kabahubya, M., Rajasingham, R., Nalintya, E., Meya, D. B., Boulware, D. R., Hollenbach, J. & Nielsen, K., Aug 2026, In: Human Immunology. 87, 8, 111788.Research output: Contribution to journal › Article › peer-review
Open Access -
Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis?
Bahr, N. C., Rajasingham, R. & Boulware, D. R., Jan 21 2026, In: JAMA Network Open. 9, 1, e2553489.Research output: Contribution to journal › Editorial
Open Access
Press/Media
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UMN study finds hydroxychloroquine fails to protect first responders from COVID-19
10/21/20
1 item of Media coverage
Press/Media: Research
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‘Desperation science’ slows the hunt for coronavirus drugs
Rajasingham, R. & Boulware, D. R.
7/8/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Ups and downs of Hydroxychloroquine has slowed enrollment of U of M trials
5/25/20
1 item of Media coverage
Press/Media: Research
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Hydroxychloroquine and the Coronavirus: What Studies Actually Say
5/19/20
1 item of Media coverage
Press/Media: Research