Projects per year
Personal profile
Research interests
Dr. Rajasingham an Infectious Diseases physician and Assistant Professor of Medicine at the University of Minnesota. Her primary research interest is to maximize the public health impact of screening HIV-infected persons for opportunistic infections in order to decrease HIV/AIDS-related mortality. She particularly interested in the evaluation of cost-effective diagnostics and treatment algorithms to care of persons with advanced HIV disease.
Dr. Rajasingham received formal training from the Harvard School of Public Health in Global Health Delivery, and has spent one year in Uganda working as a clinical research coordinator for an NIH-sponsored clinical trial investigating the optimal timing of antiretroviral therapy in HIV-infected persons with cryptococcal meningitis (COAT Trial). Over the past twelve years, she has worked closely with the Ugandan and American collaborative research team at the Infectious Disease Institute (IDI) in Kampala, Uganda. Dr. Rajasingham has led an international consortium to estimate the global burden of cryptococcal infection. She has evaluated the cost-effectiveness of a Ugandan national CRAG screening program, and performed a budgetary impact analysis for funders to estimate costs and diagnostics tests required for persons with advanced HIV disease in sub Saharan Africa. She has consulted for the Pan American Health Organization (PAHO) and UNITAID for health economics evaluations of novel point-of-care diagnostics among persons with advanced HIV disease. She is the co-PI of a phase III randomized clinical trial in Uganda evaluating the efficacy of high dose AmBisome to prevent cryptococcal meningitis in persons with advanced HIV disease, and PI for an R01 cluster-randomized trial evaluating point-of-care diagnostics in persons with advanced HIV disease, funded by NIAID.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Determining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis
Bahr, N. (PI), Boulware, D. R. (CoI) & Rajasingham, R. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
1/1/24 → 5/31/27
Project: Research project
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Development, Clinical Validation, and Assessment for Implementation of a Novel Mp1p D4 Point-of-Care
Rajasingham, R. (PI)
DUKE UNIVERSITY, NIH Nat'l Inst of Allergy & Infect Dis
5/11/23 → 4/30/25
Project: Research project
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Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection
Rajasingham, R. (PI), Boulware, D. R. (CoI) & Huppler Hullsiek, K. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
4/21/23 → 3/31/25
Project: Research project
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An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease
Rajasingham, R. (PI), Boulware, D. R. (CoI) & Huppler Hullsiek, K. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
8/23/21 → 7/31/26
Project: Research project
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Determining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis
Rajasingham, R. (PI) & Boulware, D. R. (CoI)
UNIVERSITY OF KANSAS MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
6/21/22 → 5/31/24
Project: Research project
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Resolving the CD4-testing crisis to help end AIDS-related deaths
Syarif, O., Oladele, R., Gils, T., Rajasingham, R., Falconer, J., Achii, P., Tembo, E., Tobaiwa, D. D., Mwehonge, K., Schutz, C., Govender, N. P., Meintjes, G., Meya, D. B. & Loyse, A., Jan 2025, In: The Lancet Global Health. 13, 1, p. e16-e18Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Baseline C-reactive Protein as a Risk Factor for Cryptococcal Meningitis and Death in HIV-associated Cryptococcal Antigenemia With CrAg Titer as an Effect Modifier
Skipper, C. P., Kirumira, P., Dai, B., Wele, A., Naluyima, R., Namuli, T., Turya, F., Muhumuza, P., Kibengo, F., Boulware, D. R., Meya, D. B., Nalintya, E. & Rajasingham, R., Aug 1 2024, In: Open Forum Infectious Diseases. 11, 8, ofae392.Research output: Contribution to journal › Article › peer-review
Open Access -
Progress toward realizing the promise of decentralized clinical trials
McCarthy, M. W., Lindsell, C. J., Rajasingham, R., Stewart, T. G., Boulware, D. R. & Naggie, S., Jan 29 2024, In: Journal of Clinical and Translational Science. 8, 1, e19.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa
Sekar, P., Hale, G., Gakuru, J., Meya, D. B., Boulware, D. R., Ellis, J., Nalintya, E., Bahr, N. C. & Rajasingham, R., Aug 2024, In: Emerging infectious diseases. 30, 8, p. 1523-1530 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Diagnostic Performance of the Visitect Advanced Disease Point-Of-Care CD4 Platform: A Pragmatic, Mixed-Methods, Multisite Validation, Costing, and Qualitative Analysis
Nalintya, E., Sekar, P., Namakula, O. L., Tadeo, K. K., Kwizera, R., Apeduno, L., Naluyima, D. R., Nanano, R., Mujungu, L., Lehman, A., Adzemovic, T., Amperiize, M., Kavuma, P., Kasone, V., Fieberg, A., Nerima, P., Dai, B., Meya, D. B., Boulware, D. R. & Rajasingham, R., Dec 1 2024, In: Journal of Acquired Immune Deficiency Syndromes. 97, 4, p. 387-396 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Press/Media
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UMN study finds hydroxychloroquine fails to protect first responders from COVID-19
10/21/20
1 item of Media coverage
Press/Media: Research
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‘Desperation science’ slows the hunt for coronavirus drugs
Rajasingham, R. & Boulware, D. R.
7/8/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Ups and downs of Hydroxychloroquine has slowed enrollment of U of M trials
5/25/20
1 item of Media coverage
Press/Media: Research
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Hydroxychloroquine and the Coronavirus: What Studies Actually Say
5/19/20
1 item of Media coverage
Press/Media: Research