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Research Output 1978 2019

2007
82 Citations (Scopus)

Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer

Wilber, A., Linehan, J. L., Tian, X., Woll, P. S., Morris, J. K., Belur, L., Mc Ivor, R. S. & Kaufman, D. S., Nov 1 2007, In : Stem Cells. 25, 11, p. 2919-2927 9 p.

Research output: Contribution to journalArticle

Transgenes
Beauty
Transposases
Genes
RNA
54 Citations (Scopus)

Messenger RNA as a source of transposase for Sleeping Beauty transposon-mediated correction of hereditary tyrosinemia type I

Wilber, A., Wangensteen, K. J., Chen, Y., Zhuo, L., Frandsen, J. L., Bell, J. B., Chen, Z. J., Ekker, S. C., Mc Ivor, R. S. & Wang, X., Jul 1 2007, In : Molecular Therapy. 15, 7, p. 1280-1287 8 p.

Research output: Contribution to journalArticle

Tyrosinemias
Transposases
Beauty
Messenger RNA
RNA
78 Citations (Scopus)

Preferential delivery of the sleeping beauty transposon system to livers of mice by hydrodynamic injection

Hackett, Podetz-Pedersen, K. M., Aronovich, E. L., Belur, L. & Mc Ivor, R. S., Dec 13 2007, In : Nature Protocols. 2, 12, p. 3153-3165 13 p.

Research output: Contribution to journalArticle

Beauty
Hydrodynamics
Liver
Injections
DNA
16 Citations (Scopus)

Protection of mice from methotrexate toxicity by ex vivo transduction using lentivirus vectors expressing drug-resistant dihydrofolate reductase

Gori, J. L., Podetz-Pedersen, K., Swanson, D., Karlen, A. D., Gunther, R., Somia, N. V. & Mc Ivor, R. S., Sep 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 3, p. 989-997 9 p.

Research output: Contribution to journalArticle

Lentivirus
Tetrahydrofolate Dehydrogenase
Methotrexate
Green Fluorescent Proteins
Bone Marrow
487 Citations (Scopus)

Sarcoma derived from cultured mesenchymal stem cells

Tolar, J., Nauta, A. J., Osborn, M. J., Mortari, A. P., McElmurry, R. T., Bell, S., Xia, L., Zhou, N., Riddle, M., Schroeder, T. M., Westendorf, J. J., McIvor, R. S., Hogendoorn, P. C. W., Szuhai, K., Oseth, L., Hirsch, B., Yant, S. R., Kay, M. A., Peister, A., Prockop, D. J. & 2 others, Fibbe, W. E. & Blazar, B. R., Feb 1 2007, In : STEM CELLS. 25, 2, p. 371-379 9 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Sarcoma
Luciferases
Chromosome Aberrations
Bone Marrow
2006
27 Citations (Scopus)

17β-Hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells

Seth, G., McIvor, R. S. & Hu, W. S., Jan 24 2006, In : Journal of Biotechnology. 121, 2, p. 241-252 12 p.

Research output: Contribution to journalArticle

Cholesterol
Biosynthesis
Cells
Cell Line
Mammals
6 Citations (Scopus)
uracil phosphoribosyltransferase
Cytosine Deaminase
Flucytosine
Nerve Growth Factor Receptor
Gene Fusion
34 Citations (Scopus)

Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon

Geurts, A. M., Wilber, A., Carlson, C. M., Lobitz, P. D., Clark, K. J., Hackett, P. B., Mc Ivor, R. S. & Largaespada, D. A., Jun 26 2006, In : BMC Biotechnology. 6, 30.

Research output: Contribution to journalArticle

Beauty
Gene Expression
Genes
Response Elements
Doxycycline
161 Citations (Scopus)

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates

Balciunas, D., Wangensteen, K. J., Wilber, A., Bell, J., Geurts, A., Sivasubbu, S., Wang, X., Hackett, P. B., Largaespada, D. A., Mc Ivor, R. S. & Ekker, S. C., Nov 1 2006, In : PLoS Genetics. 2, 11, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

cargo
transposons
Vertebrates
vertebrate
vertebrates
64 Citations (Scopus)

Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells

Tolar, J., O'Shaughnessy, M. J., Panoskaltsis-Mortari, A., McElmurry, R. T., Bell, S., Riddle, M., McIvor, R. S., Yant, S. R., Kay, M. A., Krause, D., Verfaillie, C. M. & Blazar, B. R., May 15 2006, In : Blood. 107, 10, p. 4182-4188 7 p.

Research output: Contribution to journalArticle

Stem Cells
T-cells
Cells
Bioluminescence
Histocompatibility Antigens Class I
14 Citations (Scopus)
Severe Combined Immunodeficiency
Mutation
DNA-Activated Protein Kinase
Homologous Recombination
Point Mutation
91 Citations (Scopus)

RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues

Wilber, A., Frandsen, J. L., Geurts, J. L., Largaespada, D. A., Hackett, P. B. & Mc Ivor, R. S., Jan 1 2006, In : Molecular Therapy. 13, 3, p. 625-630 6 p.

Research output: Contribution to journalArticle

Transposases
Beauty
Insertional Mutagenesis
RNA
Gene Expression
26 Citations (Scopus)

Sleeping beauty-mediated transposition and long-term expression in vivo: Use of the LoxP/Cre recombinase system to distinguish transposition-specific expression

Score, P. R., Belur, L., Frandsen, J. L., Guerts, J. L., Yamaguchi, T., Somia, N. V., Hackett, P. B., Largaespada, D. A. & Mc Ivor, R. S., Jan 1 2006, In : Molecular Therapy. 13, 3, p. 617-624 8 p.

Research output: Contribution to journalArticle

Beauty
Transposases
Plasmids
Erythropoietin
Genetic Recombination
86 Citations (Scopus)

Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

Huang, X., Wilber, A. C., Bao, L., Tuong, D., Tolar, J., Orchard, P. J., Levine, B. L., June, C. H., McIvor, R. S., Blazar, B. R. & Zhou, X., Jan 15 2006, In : Blood. 107, 2, p. 483-491 9 p.

Research output: Contribution to journalArticle

Gene transfer
Beauty
T-cells
Gene expression
Lymphocytes
2005
53 Citations (Scopus)
Iduronidase
Picornaviridae
Firefly Luciferases
Gene Expression
Luciferases
34 Citations (Scopus)

Awakening gene therapy with Sleeping Beauty transposons

Essner, J. J., Mc Ivor, R. S. & Hackett, P. B., Jan 1 2005, In : Current Opinion in Pharmacology. 5, 5 SPEC.ISS., p. 513-519 7 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Junctional Epidermolysis Bullosa
Tyrosinemias
Inborn Genetic Diseases
32 Citations (Scopus)

Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging

Wilber, A., Frandsen, J. L., Wangensteen, K. J., Ekker, S. C., Wang, X. & Mc Ivor, R. S., Nov 1 2005, In : Human Gene Therapy. 16, 11, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

Luciferases
Plasmids
Gene Expression
DNA
Genetic Therapy
4 Citations (Scopus)

Long-term transgene expression and survival of transgene-expressing grafts following lentivirus transduction of bone marrow side population cells

Zhang, J. L., Cai, J., Jackson, J. D., Kuszynski, C. A., Walls, S., Mc Ivor, R. S. & Fox, I. J., Apr 27 2005, In : Transplantation. 79, 8, p. 882-888 7 p.

Research output: Contribution to journalArticle

Side-Population Cells
Lentivirus
Transgenes
Bone Marrow Cells
Transplants
9 Citations (Scopus)
Tetrahydrofolate Dehydrogenase
Drug Resistance
Methotrexate
Bone Marrow
Pharmaceutical Preparations
117 Citations (Scopus)

Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

Ohlfest, J. R., Frandsen, J. L., Fritz, S., Lobitz, P. D., Perkinson, S. G., Clark, K. J., Nelsestuen, G., Key, N. S., Mc Ivor, R. S., Hackett, P. B. & Largaespada, D. A., Apr 1 2005, In : Blood. 105, 7, p. 2691-2698 8 p.

Research output: Contribution to journalArticle

Gene transfer
Beauty
Factor VIII
Hemophilia A
Genes
32 Citations (Scopus)

Real-time in vivo imaging of stem cells following transgenesis by transposition

Tolar, J., Osborn, M., Bell, S., McElmurry, R., Xia, L., Riddle, M., Panoskaltsis-Mortari, A., Jiang, Y., McIvor, R. S., Contag, C. H., Yant, S. R., Kay, M. A., Verfaillie, C. M. & Blazar, B. R., Jul 1 2005, In : Molecular Therapy. 12, 1, p. 42-48 7 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Stem Cells
Beauty
Clone Cells
Firefly Luciferases
111 Citations (Scopus)

Sleeping Beauty Transposon-Mediated Gene Therapy for Prolonged Expression

Hackett, P. B., Ekker, S. C., Largaespada, D. A. & Mc Ivor, R. S., Dec 1 2005, In : Advances in Genetics. 54, p. 189-232 44 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Base Pairing
Plasmids
Chromosomes
72 Citations (Scopus)
Beauty
Oncogenes
Transposases
Liver
Neoplasms
2004
73 Citations (Scopus)

Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human α-L-iduronidase gene

Hartung, S. D., Frandsen, J. L., Pan, D., Koniar, B. L., Graupman, P., Gunther, R., Low, W. C., Whitley, C. B. & Mc Ivor, R. S., Jan 1 2004, In : Molecular Therapy. 9, 6, p. 866-875 10 p.

Research output: Contribution to journalArticle

Iduronidase
Craniofacial Abnormalities
Nervous System Malformations
Dependovirus
Parturition
15 Citations (Scopus)

Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells

Converse, A. D., Belur, L. R., Gori, J. L., Liu, G., Amaya, F., Aguilar-Cordova, E., Hackett, P. B. & McIvor, R. S., Dec 1 2004, In : Bioscience Reports. 24, 6, p. 577-594 18 p.

Research output: Contribution to journalArticle

Transposases
Beauty
Cultured Cells
Genes
Cells
8 Citations (Scopus)

Craniofacial abnormalities in a murine knock-out model of mucopolysaccharidosis i h: a computed tomography and anatomic study

Graupman, P., Pan, D., Konair, B., Hartung, S., Mc Ivor, R. S., Whitley, C. B., Low, W. C. & Lam, C. H., Jan 1 2004, In : Journal of Craniofacial Surgery. 15, 3, 1 p.

Research output: Contribution to journalArticle

Craniofacial Abnormalities
Mucopolysaccharidosis I
Tomography
Mucopolysaccharidoses
Mandibular Condyle
Polyethyleneimine
Gene Transfer Techniques
DNA Transposable Elements
Luciferases
Inbred C57BL Mouse
2003
26 Citations (Scopus)

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Dimerization
Ligands
Methotrexate
Proteins
10 Citations (Scopus)

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Methotrexate
Folic Acid Antagonists
Genetic Therapy
96 Citations (Scopus)

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

Belur, L., Frandsen, J. L., Dupuy, A. J., Ingbar, D. H., Largaespada, D. A., Hackett, P. B. & Mc Ivor, R. S., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Lung
Transgenes
Transposases
11 Citations (Scopus)

Human nerve growth factor receptor and cytosine deaminase fusion genes

Lewis, V. A., Basso, L. M., Blake, N., Salo, J., Lund, T. C., Mc Ivor, R. S. & Orchard, P. J., Jul 1 2003, In : Human Gene Therapy. 14, 10, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Nerve Growth Factor Receptor
Gene Fusion
Flucytosine
Flow Cytometry
6 Citations (Scopus)

Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase

Sweeney, C. L., Frandsen, J. L., Verfaillie, C. M. & Mc Ivor, R. S., Mar 15 2003, In : Cancer Research. 63, 6, p. 1304-1310 7 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Ribose
Bone Marrow
2002
34 Citations (Scopus)
Nerve Growth Factor Receptor
Thymidine Kinase
Simplexvirus
T-Lymphocytes
Product Packaging
15 Citations (Scopus)
Trimetrexate
Folic Acid Antagonists
Ribose
Hematopoietic Stem Cells
Tetrahydrofolate Dehydrogenase
6 Citations (Scopus)

Methotrexate exacerbates tumor progression in a murine model of chronic myeloid leukemia

Sweeney, C. L., Diers, M. D., Frandsen, J. L., Gunther, R., Verfaillie, C. M. & Mc Ivor, R. S., Mar 4 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 3, p. 1075-1084 10 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Methotrexate
Tetrahydrofolate Dehydrogenase
Drug Resistance
Neoplasms
2001
7 Citations (Scopus)

Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow

Belur, L., Boelk-Galvan, D., Diers, M. D., Mc Ivor, R. S. & Zimmerman, C. L., Feb 15 2001, In : Cancer Research. 61, 4, p. 1522-1526 5 p.

Research output: Contribution to journalArticle

Methotrexate
Bone Marrow
Pharmaceutical Preparations
Tetrahydrofolate Dehydrogenase
Folic Acid Antagonists
2000
4 Citations (Scopus)

Department of health and human services national institutes of health recombinant DNA advisory committee: Minutes of meeting March 8-10, 2000

Estuardo Aguilar-Cordova, C., Levi-Pearl, S. L., Macklin, R., Markert, M. L., Mc Ivor, R. S., Mickelson, C. A., Wolff, J. A., Ando, D. G., Breakefield, X. O., Chow, L. T., Friedmann, T., Gordon, J. W., Greenblatt, J. J., Juengst, E. T. & King, N. M. P., Oct 10 2000, In : Human Gene Therapy. 11, 15, p. 2159-2192 34 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

In vivo transduction of cerebellar Purkinje cells using adeno-associated virus vectors

Kaemmerer, W. F., Reddy, R. G., Warlick, C. A., Hartung, S. D., Mc Ivor, R. S. & Low, W. C., Jan 1 2000, In : Molecular Therapy. 2, 5, p. 446-457 12 p.

Research output: Contribution to journalArticle

Dependovirus
Purkinje Cells
Adenoviridae
Cerebellar Nuclei
Injections
19 Citations (Scopus)
Tetrahydrofolate Dehydrogenase
Nucleosides
Methotrexate
Toxicity
Cells
20 Citations (Scopus)

Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity

James, R. I., Warlick, C. A., Diers, M. D., Gunther, R. & Mc Ivor, R. S., Aug 15 2000, In : Blood. 96, 4, p. 1334-1341 8 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Whole-Body Irradiation
Methotrexate
Bone Marrow
Irradiation
41 Citations (Scopus)

Prenatal gene transfer: Scientific, medical, and ethical issues: A report of the recombinant DNA advisory committee

Mc Ivor, R. S., Ando, D., Breakefield, X. O., Buckley, R., Chow, L., Deisseroth, A., Greenblatt, J., Mickelson, C., Markert, M. L., Aguilar-Cordova, E., Cohen, A. R., Fletcher, J. C., Karson, E., Mickelson, C., Parkman, R., Wolff, J. A., Zallen, D., King, N. M. P., Macklin, R., Andrews, L. & 8 others, Friedmann, T., Gordon, J., Juengst, E. T., Levi-Pearl, S. L., Lin, M. H., Markert, M. L., McIvor, R. S. & Noguchi, P., May 20 2000, In : Human gene therapy. 11, 8, p. 1211-1229 19 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)
Iduronidase
Mucopolysaccharidoses
Mucopolysaccharidosis I
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
8 Citations (Scopus)

'Supercharged cells' for delivery of recombinant human iduronate-2-sulfatase

Pan, D., Jonsson, J. J., Braun, S. E., Mc Ivor, R. S. & Whitley, C. B., Jan 1 2000, In : Molecular Genetics and Metabolism. 70, 3, p. 170-178 9 p.

Research output: Contribution to journalArticle

Iduronate Sulfatase
Iduronic Acid
Sulfatases
Lymphocytes
Enzymes
1999
15 Citations (Scopus)
Iduronidase
Mucopolysaccharidosis I
Dependovirus
Fibroblasts
Genes
10 Citations (Scopus)

Gene therapy of genetic diseases and cancer

Mc Ivor, R. S., Dec 15 1999, In : Pediatric Transplantation. 3, SUPPL. 1, p. 116-121 6 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Genetic Therapy
Neoplasms
Genes
Hematopoietic Stem Cells
2 Citations (Scopus)

Methotrexate resistance conferred by transplantation of drug-resistant transgenic marrow cells fractionated by counterflow elutriation

James, R. I., May, C., Diers, M. D., Wagner, J. E. & Mc Ivor, R. S., Jan 1 1999, In : Bone Marrow Transplantation. 24, 8, p. 815-821 7 p.

Research output: Contribution to journalArticle

Methotrexate
Transplantation
Bone Marrow
Drug Resistance
Oxidoreductases
1998

Gene therapy for chronic myelogenous leukemia

Verfaillie, C. M., Zhao, R. C. & Mc Ivor, R. S., Jan 1 1998, In : Hematology and Cell Therapy. 40, 5, 1 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic Therapy
13 Citations (Scopus)

Methotrexate-resistant form of dihydrofolate reductase protects transgenic murine embryos from teratogenic effects of methotrexate

Sutton, C., Mc Ivor, R. S., Vagt, M., Doggett, B. & Kapur, R. P., Jan 1 1998, In : Pediatric and Developmental Pathology. 1, 6, p. 503-512 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Methotrexate
Embryonic Structures
Transgenes
Fetal Diseases

Recombinant DNA Advisory Committee Meeting, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, March 10 1998: Department of Health and Human Services - National Institutes of Health

Mickelson, C. A., Gordon, J. W., Markert, M. L., Greenblatt, J. J., McIvor, R. S., Aguilar-Codova, C. E., Kumar, R., Tufaro, F., Osborne, S., Skirboll, Macklin, R., Fost, Lantos & Taylor, A., Nov 1 1998, In : Human Gene Therapy. 9, 16, p. 2427-2454 28 p.

Research output: Contribution to journalArticle