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Research Output 1978 2019

27 Citations (Scopus)

17β-Hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells

Seth, G., McIvor, R. S. & Hu, W. S., Jan 24 2006, In : Journal of Biotechnology. 121, 2, p. 241-252 12 p.

Research output: Contribution to journalArticle

Cholesterol
Biosynthesis
Cells
Cell Line
Mammals
2 Citations (Scopus)
Transposases
Beauty
Hydrodynamics
Luciferases
DNA Transposable Elements
5 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Dependovirus
Purkinje Cells
Cerebellar Diseases
Heparan Sulfate Proteoglycans
29 Citations (Scopus)

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

Wangensteen, K. J., Wilber, A., Keng, V. W., He, Z., Matise, I., Wangensteen, L., Carson, C. M., Chen, Y., Steer, C. J., Mc Ivor, R. S., Largaespada, D. A., Wang, X. & Ekker, S. C., May 1 2008, In : Hepatology. 47, 5, p. 1714-1724 11 p.

Research output: Contribution to journalArticle

Hydrolases
Hepatocytes
Liver
Genes
Gene Expression
37 Citations (Scopus)

A human purine nucleoside phosphorylase deficiency caused by a single base change

Williams, S. R., Gekeler, V., McIvor, R. S. & Martin, D. W., Jan 1 1987, In : Journal of Biological Chemistry. 262, 5, p. 2332-2338 7 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Genes
Exons
Mutation
Gels
9 Citations (Scopus)

An enhancer in the first intron of the human purine nucleoside phosphorylase-encoding gene

Jonsson, J. J., Converse, A. & Mclvor, R. S., Mar 25 1994, In : Gene. 140, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Introns
Genes
Thymidine Kinase
Cats
85 Citations (Scopus)

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells

Filareto, A., Parker, S., Darabi, R., Borges, L., Iacovino, M., Schaaf, T., Mayerhofer, T., Chamberlain, J. S., Ervasti, J. M., McIvor, R. S., Kyba, M. & Perlingeiro, R. C. R., Apr 11 2013, In : Nature Communications. 4, 1549.

Research output: Contribution to journalArticle

Utrophin
gene therapy
Gene therapy
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
5 Citations (Scopus)

An improved enzymatic radioassay for ribose 1-phosphate

Mc Ivor, R. S., Wohlhueter, R. M. & Plagemann, P. G. W., Nov 15 1982, In : Analytical Biochemistry. 127, 1, p. 150-154 5 p.

Research output: Contribution to journalArticle

Cell Extracts
Purine-Nucleoside Phosphorylase
Paper Chromatography
Inosine
Hypoxanthine
7 Citations (Scopus)
Spinocerebellar Ataxias
Trinucleotide Repeats
Antisense RNA
Gene therapy
Molecular Models
53 Citations (Scopus)
Iduronidase
Picornaviridae
Firefly Luciferases
Gene Expression
Luciferases
2 Citations (Scopus)

Assay for expression of methotrexate-resistant dihydrofolate reductase activity in the presence of drug-sensitive enzyme

Thompson, K., Vinh, D. B. N. & Mc Ivor, R. S., Jan 1 1992, In : Journal of Pharmacological and Toxicological Methods. 28, 3, p. 167-173 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Methotrexate
Assays
Enzymes
Pharmaceutical Preparations
34 Citations (Scopus)

Awakening gene therapy with Sleeping Beauty transposons

Essner, J. J., Mc Ivor, R. S. & Hackett, P. B., Jan 1 2005, In : Current Opinion in Pharmacology. 5, 5 SPEC.ISS., p. 513-519 7 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Junctional Epidermolysis Bullosa
Tyrosinemias
Inborn Genetic Diseases
50 Citations (Scopus)
Dependovirus
Green Fluorescent Proteins
Central Nervous System
Afferent Neurons
Sensory Receptor Cells
11 Citations (Scopus)

Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo

Podetz-Pedersen, K. M., Vezys, V., Somia, N. V., Russell, S. J. & Mc Ivor, R. S., Nov 1 2014, In : Human gene therapy. 25, 11, p. 955-965 11 p.

Research output: Contribution to journalArticle

Firefly Luciferases
Beauty
Luciferases
Cellular Immunity
Genes
3 Citations (Scopus)

Characterization of the human artemis promoter by heterologous gene expression in vitro and in vivo

Multhaup, M. M., Gurram, S., Podetz-Pedersen, K. M., Karlen, A. D., Swanson, D. L., Somia, N. V., Hackett, P. B., Cowan, M. J. & Mc Ivor, R. S., Oct 1 2011, In : DNA and Cell Biology. 30, 10, p. 751-761 11 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Gene Expression
V(D)J Recombination
Genes
Peptide Elongation Factor 1
34 Citations (Scopus)
Nerve Growth Factor Receptor
Thymidine Kinase
Simplexvirus
T-Lymphocytes
Product Packaging
12 Citations (Scopus)
Casein Kinase II
Cloning
Androgens
Rats
Organism Cloning
36 Citations (Scopus)

Cloning of human adenosine deaminase cDNA and expression in mouse cells

Valeric, D., Mc Ivor, R. S., Williams, S. R., Duyvesteyn, M. G. C., van Ormondt, H., van der Eb, A. J. & Martin, D. W., Jan 1 1984, In : Gene. 31, 1-3, p. 147-153 7 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
Organism Cloning
Plasmids
Complementary DNA
Metallothionein
6 Citations (Scopus)
uracil phosphoribosyltransferase
Cytosine Deaminase
Flucytosine
Nerve Growth Factor Receptor
Gene Fusion
11 Citations (Scopus)

Comparative methotrexate resistance of transgenic mice expressing two distinct dihydrofolate reductase variants

Morris, J. A., May, C., Kim, H. S., Ismail, R., Wagner, J. E., Gunther, R. & Mc Ivor, R. S., Jan 1 1996, In : Transgenics. 2, 1, p. 53-67 15 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Methotrexate
Genetic Therapy
Transgenic Mice
Gene Expression
34 Citations (Scopus)

Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon

Geurts, A. M., Wilber, A., Carlson, C. M., Lobitz, P. D., Clark, K. J., Hackett, P. B., Mc Ivor, R. S. & Largaespada, D. A., Jun 26 2006, In : BMC Biotechnology. 6, 30.

Research output: Contribution to journalArticle

Beauty
Gene Expression
Genes
Response Elements
Doxycycline
17 Citations (Scopus)

Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery

Zayed, H., Xia, L., Yerich, A., Yant, S. R., Kay, M. A., Puttaraju, M., McGarrity, G. J., Wiest, D. L., McIvor, R. S., Tolar, J. & Blazar, B. R., Jul 1 2007, In : Molecular Therapy. 15, 7, p. 1273-1279 7 p.

Research output: Contribution to journalArticle

Trans-Splicing
Polynucleotide 5'-Hydroxyl-Kinase
Spliceosomes
Beauty
Protein Deficiency
73 Citations (Scopus)

Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human α-L-iduronidase gene

Hartung, S. D., Frandsen, J. L., Pan, D., Koniar, B. L., Graupman, P., Gunther, R., Low, W. C., Whitley, C. B. & Mc Ivor, R. S., Jan 1 2004, In : Molecular Therapy. 9, 6, p. 866-875 10 p.

Research output: Contribution to journalArticle

Iduronidase
Craniofacial Abnormalities
Nervous System Malformations
Dependovirus
Parturition
14 Citations (Scopus)

Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression

Nelson, D. M., Butters, K. A., Markert, M. L., Reinsmoen, N. L. & Mc Ivor, R. S., Mar 21 1995, In : Journal of Immunology. 154, 6, p. 3006-3014 9 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
T-Lymphocytes
Gene Expression
Moloney murine leukemia virus
Terminal Repeat Sequences
8 Citations (Scopus)
Purine-Nucleoside Phosphorylase
T-Cell Lymphoma
Genetic Therapy
T-Lymphocytes
Genes
15 Citations (Scopus)

Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells

Converse, A. D., Belur, L. R., Gori, J. L., Liu, G., Amaya, F., Aguilar-Cordova, E., Hackett, P. B. & McIvor, R. S., Dec 1 2004, In : Bioscience Reports. 24, 6, p. 577-594 18 p.

Research output: Contribution to journalArticle

Transposases
Beauty
Cultured Cells
Genes
Cells
8 Citations (Scopus)

Craniofacial abnormalities in a murine knock-out model of mucopolysaccharidosis i h: a computed tomography and anatomic study

Graupman, P., Pan, D., Konair, B., Hartung, S., Mc Ivor, R. S., Whitley, C. B., Low, W. C. & Lam, C. H., Jan 1 2004, In : Journal of Craniofacial Surgery. 15, 3, 1 p.

Research output: Contribution to journalArticle

Craniofacial Abnormalities
Mucopolysaccharidosis I
Tomography
Mucopolysaccharidoses
Mandibular Condyle
19 Citations (Scopus)

Cytotoxicity associated with artemis overexpression after lentiviral vector-mediated gene transfer

Multhaup, M., Karlen, A. D., Swanson, D. L., Wilber, A., Somia, N. V., Cowan, M. J. & Mc Ivor, R. S., Jul 1 2010, In : Human Gene Therapy. 21, 7, p. 865-875 11 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Cell Survival
V(D)J Recombination
Phosphoglycerate Kinase
Genes
11 Citations (Scopus)
Moloney murine leukemia virus
Metallothionein
Proviruses
Purine-Nucleoside Phosphorylase
Genes
Polyethyleneimine
Gene Transfer Techniques
DNA Transposable Elements
Luciferases
Inbred C57BL Mouse
4 Citations (Scopus)

Department of health and human services national institutes of health recombinant DNA advisory committee: Minutes of meeting March 8-10, 2000

Estuardo Aguilar-Cordova, C., Levi-Pearl, S. L., Macklin, R., Markert, M. L., Mc Ivor, R. S., Mickelson, C. A., Wolff, J. A., Ando, D. G., Breakefield, X. O., Chow, L. T., Friedmann, T., Gordon, J. W., Greenblatt, J. J., Juengst, E. T. & King, N. M. P., Oct 10 2000, In : Human Gene Therapy. 11, 15, p. 2159-2192 34 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Dependency on intercellular adhesion molecule recognition and local interleukin-2 provision in generation of an in vivo CD8+ T-cell immune response to murine myeloid leukemia

Boyer, M. W., Orchard, P. J., Gorden, K. B., Anderson, P. M., McIvor, R. S. & Blazar, B. R., Jan 1 1995, In : Blood. 85, 9, p. 2498-2506 9 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
T-cells
Cell Adhesion Molecules
Interleukin-2
Leukemia
26 Citations (Scopus)

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Dimerization
Ligands
Methotrexate
Proteins
15 Citations (Scopus)

Differences in incorporation of nucleic acid bases and nucleosides by various Mycoplasma and Acholeplasma species

McIvor, R. S. & Kenny, G. E., Dec 1 1978, In : Journal of Bacteriology. 135, 2, p. 483-489 7 p.

Research output: Contribution to journalArticle

Acholeplasma
Nucleic Acid Precursors
Acholeplasma laidlawii
Mycoplasma pneumoniae
Thymine
60 Citations (Scopus)
Dependovirus
Spinal Puncture
Sensory Receptor Cells
Green Fluorescent Proteins
Genes
10 Citations (Scopus)

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Methotrexate
Folic Acid Antagonists
Genetic Therapy
45 Citations (Scopus)

Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I

Wolf, D. A., Lenander, A. W., Nan, Z., Belur, L. R., Whitley, C. B., Gupta, P., Low, W. C. & McIvor, R. S., Jul 1 2011, In : Neurobiology of Disease. 43, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

Mucopolysaccharidoses
Mucopolysaccharidosis I
Iduronidase
Nervous System Diseases
Central Nervous System
17 Citations (Scopus)

DNA transposons for modification of human primary T lymphocytes.

Huang, X., Wilber, A., Mc Ivor, R. S. & Zhou, X., Jan 1 2009, In : Methods in molecular biology (Clifton, N.J.). 506, p. 115-126 12 p.

Research output: Contribution to journalArticle

DNA Transposable Elements
T-Lymphocytes
Genes
HIV-1
X-Linked Combined Immunodeficiency Diseases
17 Citations (Scopus)

Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing

Laoharawee, K., DeKelver, R. C., Podetz-Pedersen, K. M., Rohde, M., Sproul, S., Nguyen, H. O., Nguyen, T., St. Martin, S. J., Ou, L., Tom, S., Radeke, R., Meyer, K. E., Holmes, M. C., Whitley, C. B., Wechsler, T. & Mc Ivor, R. S., Apr 4 2018, In : Molecular Therapy. 26, 4, p. 1127-1136 10 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis II
Zinc Fingers
Metabolic Diseases
Nervous System Diseases
Iduronate Sulfatase
13 Citations (Scopus)
Tetrahydrofolate Dehydrogenase
Methotrexate
Pharmaceutical Preparations
Therapeutics
Mutagenesis
32 Citations (Scopus)

Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging

Wilber, A., Frandsen, J. L., Wangensteen, K. J., Ekker, S. C., Wang, X. & Mc Ivor, R. S., Nov 1 2005, In : Human Gene Therapy. 16, 11, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

Luciferases
Plasmids
Gene Expression
DNA
Genetic Therapy
43 Citations (Scopus)

Efficacy and safety of sleeping beauty transposon-mediated gene transfer in preclinical animal studies

Hackett, P. B., Aronovich, E. L., Hunter, D., Urness, M., Bell, J. B., Kass, S. J., Cooper, L. J. N. & Mc Ivor, R. S., Oct 1 2011, In : Current gene therapy. 11, 5, p. 341-349 9 p.

Research output: Contribution to journalArticle

Beauty
Hydrodynamics
Safety
Genes
Humulus
82 Citations (Scopus)

Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer

Wilber, A., Linehan, J. L., Tian, X., Woll, P. S., Morris, J. K., Belur, L., Mc Ivor, R. S. & Kaufman, D. S., Nov 1 2007, In : Stem Cells. 25, 11, p. 2919-2927 9 p.

Research output: Contribution to journalArticle

Transgenes
Beauty
Transposases
Genes
RNA
5 Citations (Scopus)

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells

Wilber, A., Ulloa Montoya, F., Hammer, L., Moriarity, B. S., Geurts, A. M., Largaespada, D. A., Verfaillie, C. M., Mc Ivor, R. S. & Lakshmipathy, U., Dec 1 2011, In : Stem Cells International. 717069.

Research output: Contribution to journalArticle

Transposases
Beauty
Stem Cells
Gene Expression
Clone Cells
15 Citations (Scopus)
Iduronidase
Mucopolysaccharidosis I
Dependovirus
Fibroblasts
Genes
19 Citations (Scopus)

Expression of a cDNA sequence encoding human purine nucleoside phosphorylase in rodent and human cells

McIvor, R. S., Goddard, J. M., Simonsen, C. C. & Martin, D. W., Jan 1 1985, In : Molecular and Cellular Biology. 5, 6, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Facilitated transport of uracil and 5‐fluorouracil, and permeation of orotic acid into cultured mammalian cells

Wohlhueter, R. M., Mc Ivor, R. S. & Plagemann, P. G. W., Jan 1 1980, In : Journal of Cellular Physiology. 104, 3, p. 309-319 11 p.

Research output: Contribution to journalArticle

Orotic Acid
Uracil
Permeation
Cultured Cells
Nucleotides
27 Citations (Scopus)

Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons

Podetz-Pedersen, K. M., Bell, J. B., Steele, T. W. J., Wilber, A., Shier, W. T., Belur, L., Mc Ivor, R. S. & Hackett, P. B., Feb 1 2010, In : Human Gene Therapy. 21, 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Beauty
Intravenous Infusions
Gene Expression
Lung
96 Citations (Scopus)

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

Belur, L., Frandsen, J. L., Dupuy, A. J., Ingbar, D. H., Largaespada, D. A., Hackett, P. B. & Mc Ivor, R. S., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Lung
Transgenes
Transposases