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Research Output 1998 2019

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2019

Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells

Song, J. M., Im, J., Nho, R. S., Han, Y. H., Upadhyaya, P. & Kassie, F., Mar 1 2019, In : Molecular Carcinogenesis. 58, 3, p. 321-333 13 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Lung Neoplasms
Cell Survival
Cell Proliferation
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)
N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA

NBGNU: A hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

Ge, Y., Lai, X., Li, J., Yu, R., Zhuang, Z., Sun, G., Cui, X., Zhang, N., Zhao, L., Upadhyaya, P. & Zhong, R., Feb 1 2019, In : Future Medicinal Chemistry. 11, 4, p. 269-284 16 p.

Research output: Contribution to journalArticle

Open Access
Prodrugs
DNA
O(6)-Methylguanine-DNA Methyltransferase
Guanine
Cell Death

Strain-specific altered nicotine metabolism in 3,3′-diindolylmethane (DIM) exposed mice

Bloom, A. J., Upadhyaya, P. & Kharasch, E. D., Jan 1 2019, In : Biopharmaceutics and Drug Disposition. 40, 5-6, p. 188-194 7 p.

Research output: Contribution to journalArticle

Nicotine
dimethylaniline monooxygenase (N-oxide forming)
Cytochromes
Liver Microsomes
Cotinine
2 Citations (Scopus)
Tobacco
Metabolites
Isotopes
Carcinogens
Labeling
4 Citations (Scopus)
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
3 Citations (Scopus)
Epidermal Growth Factor Receptor
Aspirin
Nitric Oxide
Carcinogenesis
Lung
2017
1 Citation (Scopus)
Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
5 Citations (Scopus)
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
2 Citations (Scopus)

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
2016
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
23 Citations (Scopus)
Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
2 Citations (Scopus)
Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
1 Citation (Scopus)
Aryl Hydrocarbon Receptors
Tobacco
Carcinogens
Nutrition
Lung
11 Citations (Scopus)
N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens
7 Citations (Scopus)

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical research in toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Nitrosamines
Tobacco
Metabolism
Cytochrome P-450 Enzyme System
12 Citations (Scopus)
Brassica
Vegetables
Biomarkers
3,3'-diindolylmethane
glucobrassicin
9 Citations (Scopus)

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

Song, J. M., Anandharaj, A., Upadhyaya, P., Kirtane, A. R., Kim, J. H., Hong, K. H., Panyam, J. & Kassie, F., Jan 1 2016, In : Oncotarget. 7, 36, p. 57752-57769 18 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Lung
Magnolia
Neoplasms
15 Citations (Scopus)
Deoxyguanosine
DNA Adducts
Liquid chromatography
Paraffin
Formaldehyde
2 Citations (Scopus)
N'-nitrosonornicotine
Gene Expression Profiling
Esophagus
Mouth
Carcinogenesis
2015
15 Citations (Scopus)

Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators

Song, J. M., Qian, X., Molla, K., Teferi, F., Upadhyaya, P., O'Sullivan, G., Luo, X. & Kassie, F., Jan 1 2015, In : Carcinogenesis. 36, 6, p. 666-675 10 p.

Research output: Contribution to journalArticle

Cell Cycle
Carcinogenesis
Inflammation
Lung
Cyclin D1
15 Citations (Scopus)
Tobacco
DNA Adducts
Carcinogens
Phosphates
Lung

Quantitative analysis of 3'-hydroxynorcotinine in human urine

Upadhyaya, P. & Hecht, S. S., May 1 2015, In : Nicotine and Tobacco Research. 17, 5, p. 524-529 6 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Urine
Nicotine
Erythrocebus patas
Biomarkers
3 Citations (Scopus)
RNA Sequence Analysis
Lipopolysaccharides
Pneumonia
Carcinogenesis
Lung
2014
31 Citations (Scopus)
DNA Adducts
Complex Mixtures
Mass spectrometry
DNA
Nitrosamines
24 Citations (Scopus)

Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanol in F-344 rats

Balbo, S., Johnson, C. S., Kovi, R. C., James-Yi, S. A., O'Sullivan, G., Wang, M., Le, C. T., Khariwala, S. S., Upadhyaya, P. & Hecht, S. S., Dec 1 2014, In : Carcinogenesis. 35, 12, p. 2798-2806 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Lung
Pancreas
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
13 Citations (Scopus)

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

Kava
Carcinogens
DNA Damage
Tobacco
Carcinogenesis
7 Citations (Scopus)

Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability

Song, J. M., Kirtane, A. R., Upadhyaya, P., Qian, X., Balbo, S., Teferi, F., Panyam, J. & Kassie, F., Dec 30 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 96-101 6 p.

Research output: Contribution to journalArticle

Biological Availability
Lung
Intranasal Administration
Carcinogens
Cytochrome P-450 Enzyme System
11 Citations (Scopus)

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing o6-methylguanine DNA adduct in A/J mice

Leitzman, P., Narayanapillai, S. C., Balbo, S., Zhou, B., Upadhyaya, P., Shaik, A. A., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jan 1 2014, In : Cancer Prevention Research. 7, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

Kava
DNA Adducts
Carcinogenesis
Lung
Adenoma
3 Citations (Scopus)
Electrospray ionization
Hydroxy Acids
Electrospray Ionization Mass Spectrometry
Liquid chromatography
Biomarkers
17 Citations (Scopus)
Brassica
Vegetables
Biomarkers
Glucosinolates
Urine
2013
34 Citations (Scopus)

(S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats

Balbo, S., James-Yi, S., Johnson, C. S., O'Sullivan, G., Stepanov, I., Wang, M., Bandyopadhyay, D., Kassie, F., Carmella, S. G., Upadhyaya, P. & Hecht, S. S., Sep 1 2013, In : Carcinogenesis. 34, 9, p. 2178-2183 6 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Smokeless Tobacco
Carcinogens
Mouth
Tobacco Products
9 Citations (Scopus)

Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice

Qian, X., Song, J. M., Melkamu, T., Upadhyaya, P. & Kassie, F., Apr 1 2013, In : Carcinogenesis. 34, 4, p. 841-849 9 p.

Research output: Contribution to journalArticle

Chemoprevention
Carcinogenesis
Lung
Lung Neoplasms
Neoplasms
1 Citation (Scopus)
bergapten
methoxsalen
Helix pomatia
Methoxsalen
Glucuronidase
7 Citations (Scopus)
Aldehyde Dehydrogenase
Tobacco
DNA Adducts
Stem cells
Carcinogens
17 Citations (Scopus)

Levels of (S)-N′-nitrosonornicotine in U.S. tobacco products

Stepanov, I., Yershova, K., Carmella, S. G., Upadhyaya, P. & Hecht, S. S., Jul 1 2013, In : Nicotine and Tobacco Research. 15, 7, p. 1305-1310 6 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Tobacco Products
Smokeless Tobacco
Tobacco
26 Citations (Scopus)

Lipopolysaccharide Enhances Mouse Lung Tumorigenesis: A Model for Inflammation-Driven Lung Cancer

Melkamu, T., Qian, X., Upadhyaya, P., O'Sullivan, G. & Kassie, F., Sep 1 2013, In : Veterinary pathology. 50, 5, p. 895-902 8 p.

Research output: Contribution to journalArticle

lung neoplasms
carcinogenesis
lipopolysaccharides
Lipopolysaccharides
Lung Neoplasms
23 Citations (Scopus)
N'-nitrosonornicotine
DNA Adducts
Rats
Tissue
Nasal Mucosa
2012
14 Citations (Scopus)

Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice

Urban, A. M., Upadhyaya, P., Cao, Q. & Peterson, L. A., Oct 15 2012, In : Chemical Research in Toxicology. 25, 10, p. 2167-2178 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Tumors
Repair
Neoplasms
Lung
8 Citations (Scopus)

Phenanthrene metabolism in smokers: Use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation

Wang, J., Zhong, Y., Carmella, S. G., Hochalter, J. B., Rauch, D., Oliver, A., Jensen, J., Hatsukami, D. K., Upadhyaya, P., Hecht, S. S. & Zimmerman, C. L., Sep 1 2012, In : Journal of Pharmacology and Experimental Therapeutics. 342, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

Polycyclic Aromatic Hydrocarbons
Epoxy Compounds
Lung Neoplasms
Smoking
Lung
14 Citations (Scopus)

The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA

Upadhyaya, P., Kumar, A., Byun, H. S., Bittman, R., Saba, J. D. & Hecht, S. S., Jul 20 2012, In : Biochemical and Biophysical Research Communications. 424, 1, p. 18-21 4 p.

Research output: Contribution to journalArticle

Sphingolipids
DNA Adducts
Degradation
Deoxyguanosine
DNA
2011
24 Citations (Scopus)

Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice

Dagne, A., Melkamu, T., Schutten, M. M., Qian, X., Upadhyaya, P., Luo, X. & Kassie, F., Apr 1 2011, In : Carcinogenesis. 32, 4, p. 561-567 7 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Lung Neoplasms
Diet
Lung
Poly(ADP-ribose) Polymerases
34 Citations (Scopus)

Immediate consequences of cigarette smoking: Rapid formation of polycyclic aromatic hydrocarbon diol epoxides

Zhong, Y., Carmella, S. G., Upadhyaya, P., Hochalter, J. B., Rauch, D., Oliver, A., Jensen, J., Hatsukami, D., Wang, J., Zimmerman, C. & Hecht, S. S., Feb 18 2011, In : Chemical Research in Toxicology. 24, 2, p. 246-252 7 p.

Research output: Contribution to journalArticle

Polycyclic Aromatic Hydrocarbons
Epoxy Compounds
Tobacco Products
Smoking
Plasmas
19 Citations (Scopus)
Smoke
Carcinogens
Tobacco
Carcinogenesis
Lung
15 Citations (Scopus)

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice

Johnson, T. E., Lampi Hermanson, D. L., Wang, L., Kassie, F., Upadhyaya, P., O'Sullivan, G., Hecht, S. S., Lu, J. & Xing, C., Jul 11 2011, In : American Journal of Chinese Medicine. 39, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

Kava
Carcinogenesis
Lung
Adenoma
Diet
14 Citations (Scopus)
Inhalation Administration
Polycyclic Aromatic Hydrocarbons
Lung Neoplasms
Epoxy Compounds
Tobacco Products
2010
7 Citations (Scopus)

Formation and distribution of NNK metabolites in an isolated perfused rat lung

Maertens, L. A., Upadhyaya, P., Hecht, S. S. & Zimmerman, C. L., May 1 2010, In : Drug Metabolism and Disposition. 38, 5, p. 752-760 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Lung
Deoxyguanosine
Guanine
Carcinogens