Personal profile

Research interests

Early-life environment (i.e., micronutrient deficiency, hypoglycemia, intrauterine growth restriction, hypoxic-ischemic encephalopathy) can have long-term impact on adult health by increased risk of obesity, diabetes, hypertension, cardiovascular disease, neurocognitive decline. Utilizing preclinical models, we investigate how early-life environment causes permanent change in expression of molecules (e.g., proteins, hormones) that maintain physiological homeostasis, including stress responses, fear and anxiety, and learning and memory. In particular, we focus on growth factors that play critical roles in the neuroendocrine system, a major regulatory system that can be influenced by early-life environment. With this knowledge we hope to uncover molecules that can be targeted for therapeutic development and provide insights into how fetal/neonatal conditions contribute to the risk of adult diseases. These will be essential in developing strategies for treatment and prevention of adulthood pathophysiologies.

Keywords

  • developmental origins of adult diseases

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 5 Similar Profiles
Iron Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
Brain-Derived Neurotrophic Factor Medicine & Life Sciences
Hypoglycemia Medicine & Life Sciences
Choline Medicine & Life Sciences
Steroidogenic Factor 1 Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
Brain Medicine & Life Sciences

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Projects 2009 2022

Research Output 2003 2018

Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency

Kennedy, B. C., Tran, P. V., Kohli, M., Maertens, J. J., Gewirtz, J. C. & Georgieff, M. K. Jan 15 2018 In : Behavioural Brain Research. 336, p. 40-43 4 p.

Research output: Contribution to journalArticle

Choline
Iron
Neuronal Plasticity
Genes
Diet

Defiant: (DMRs: Easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus

Condon, D. E., Tran, P. V., Lien, Y. C., Schug, J., Georgieff, M. K., Simmons, R. A. & Won, K. J. Feb 5 2018 In : BMC Bioinformatics. 19, 1, 31

Research output: Contribution to journalArticle

Hippocampus
DNA Methylation
Iron
Annotation
Rats

Neonatal mouse hippocampus: Phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling

Wallin, D. J., Zamora, T. G., Alexander, M., Ennis, K. M., Tran, P. V. & Georgieff, M. K. Sep 1 2017 In : Pediatric Research. 82, 3, p. 501-508 8 p.

Research output: Contribution to journalArticle

Phlebotomy
Sirolimus
Erythropoietin
TOR Serine-Threonine Kinases
Anemia
3 Citations

Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice

Kennedy, B. C., Dimova, J. G., Dakoji, S., Yuan, L. L., Gewirtz, J. C. & Tran, P. V. Jul 1 2016 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 1, p. R166-R178

Research output: Contribution to journalArticle

Long-Term Memory
Knockout Mice
Hippocampus
Proteins
Long-Term Potentiation
3 Citations

Long-term brain and behavioral consequences of early-life iron deficiency

Kennedy, B. C., Wallin, D. J., Tran, P. V. & Georgieff, M. K. Jan 1 2016 Fetal Development: Research on Brain and Behavior, Environmental Influences, and Emerging Technologies. Springer International Publishing, p. 295-316 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Iron
Metabolome
Iron-Deficiency Anemias
Brain
Proteome