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Personal profile

Research interests

Early-life environment (i.e., micronutrient deficiency, hypoglycemia, intrauterine growth restriction, hypoxic-ischemic encephalopathy) can have long-term impact on adult health by increased risk of obesity, diabetes, hypertension, cardiovascular disease, neurocognitive decline. Utilizing preclinical models, we investigate how early-life environment causes permanent change in expression of molecules (e.g., proteins, hormones) that maintain physiological homeostasis, including stress responses, fear and anxiety, and learning and memory. In particular, we focus on growth factors that play critical roles in the neuroendocrine system, a major regulatory system that can be influenced by early-life environment. With this knowledge we hope to uncover molecules that can be targeted for therapeutic development and provide insights into how fetal/neonatal conditions contribute to the risk of adult diseases. These will be essential in developing strategies for treatment and prevention of adulthood pathophysiologies.

Research interests

  • developmental origins of adult diseases

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 3 Similar Profiles
Iron Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
Brain-Derived Neurotrophic Factor Medicine & Life Sciences
Brain Medicine & Life Sciences
Hypoglycemia Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
Iron-Deficiency Anemias Medicine & Life Sciences
Choline Medicine & Life Sciences

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Projects 2009 2023

Research Output 2003 2019

Cord blood-derived exosomal CNTN2 and BDNF: Potential molecular markers for brain health of neonates at risk for iron deficiency

Marell, P. S., Blohowiak, S. E., Evans, M. D., Georgieff, M. K., Kling, P. J. & Tran, P. V., Oct 2019, In : Nutrients. 11, 10, 2478.

Research output: Contribution to journalArticle

Open Access
Contactin 2
Brain-Derived Neurotrophic Factor
Fetal Blood
1 Citation (Scopus)

Dysregulation of neuronal genes by fetal-neonatal iron deficiency anemia is associated with altered DNA methylation in the rat hippocampus

Lien, Y. C., Condon, D. E., Georgieff, M. K., Simmons, R. A. & Tran, P. V., May 2019, In : Nutrients. 11, 5, 1191.

Research output: Contribution to journalArticle

Open Access
Neonatal Anemia
iron deficiency anemia
Iron-Deficiency Anemias
DNA methylation
DNA Methylation
Cell Death
Nerve Growth Factors
Nicotinic Receptors
Neuroprotective Agents
1 Citation (Scopus)

Iron as a model nutrient for understanding the nutritional origins of neuropsychiatric disease

Barks, A., Hall, A. M., Tran, P. V. & Georgieff, M. K., Jan 1 2019, In : Pediatric Research. 85, 2, p. 176-182 7 p.

Research output: Contribution to journalReview article

Open Access

Perinatal Ischemia Alters Global Expression of Synaptosomal Proteins Critical for Neural Plasticity in the Developing Mouse Brain

Barks, A. K., Beeson, M. M., Matveeva, T., Gale, J. J., Rao, R. & Tran, P. V., Jul 1 2019, In : Developmental Neuroscience. 40, 5-6, p. 638-650 13 p.

Research output: Contribution to journalArticle

Open Access
Neuronal Plasticity