Projects per year
Personal profile
Research interests
Early-life environment (i.e., micronutrient deficiency, hypoglycemia, intrauterine growth restriction, hypoxic-ischemic encephalopathy) can have long-term impact on adult health by increased risk of obesity, diabetes, hypertension, cardiovascular disease, neurocognitive decline. Utilizing preclinical models, we investigate how early-life environment causes permanent change in expression of molecules (e.g., proteins, hormones) that maintain physiological homeostasis, including stress responses, fear and anxiety, and learning and memory. In particular, we focus on growth factors that play critical roles in the neuroendocrine system, a major regulatory system that can be influenced by early-life environment. With this knowledge we hope to uncover molecules that can be targeted for therapeutic development and provide insights into how fetal/neonatal conditions contribute to the risk of adult diseases. These will be essential in developing strategies for treatment and prevention of adulthood pathophysiologies.
Research interests
- developmental origins of adult diseases
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Projects
Newborn Iron Deficiency
Georgieff, M. K., Tran, P. V. & Lund, T. C.
NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV
8/13/18 → 7/31/23
Project: Research project
Detection and Correction of Iron Deficiency Induced Abno
Rao, R., Georgieff, M. K. & Tran, P. V.
NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV
9/22/17 → 6/30/22
Project: Research project
Roles of Iron-Dependent PHD and JARID in Early-Life Iron
Tran, P. V. & Georgieff, M. K.
NIH NAT INST OF NEURO DISORDERS & STROKE
7/1/17 → 6/30/22
Project: Research project
The Effect of Neonatal Anemia and Its Treatments on Brai
Georgieff, M. K., Gewirtz, J. C., Rao, R., Tran, P. V., Gisslen, T. A. & Tkac, I.
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
8/1/17 → 8/31/18
Project: Research project
Research Output
Cord blood-derived exosomal CNTN2 and BDNF: Potential molecular markers for brain health of neonates at risk for iron deficiency
Marell, P. S., Blohowiak, S. E., Evans, M. D., Georgieff, M. K., Kling, P. J. & Tran, P. V., Oct 2019, In : Nutrients. 11, 10, 2478.Research output: Contribution to journal › Article
Open Access
Dysregulation of neuronal genes by fetal-neonatal iron deficiency anemia is associated with altered DNA methylation in the rat hippocampus
Lien, Y. C., Condon, D. E., Georgieff, M. K., Simmons, R. A. & Tran, P. V., May 2019, In : Nutrients. 11, 5, 1191.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
In vitro evidence for post-insult neuroprotective activity of an evolutionarily conserved motif against excitotoxic neuronal cell death
Tran, P. V., Feb 6 2019, In : Neuroreport. 30, 3, p. 213-216 4 p.Research output: Contribution to journal › Article
Iron as a model nutrient for understanding the nutritional origins of neuropsychiatric disease
Barks, A., Hall, A. M., Tran, P. V. & Georgieff, M. K., Jan 1 2019, In : Pediatric Research. 85, 2, p. 176-182 7 p.Research output: Contribution to journal › Review article
Open Access
1
Scopus
citations
Perinatal Ischemia Alters Global Expression of Synaptosomal Proteins Critical for Neural Plasticity in the Developing Mouse Brain
Barks, A. K., Beeson, M. M., Matveeva, T., Gale, J. J., Rao, R. & Tran, P. V., Jul 1 2019, In : Developmental Neuroscience. 40, 5-6, p. 638-650 13 p.Research output: Contribution to journal › Article
Open Access