Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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Letter
2001
10 Citations (Scopus)
naltrindole
Affinity Labels
Naltrexone
delta Opioid Receptor
Molecular Models
2000
17 Citations (Scopus)
Dynorphins
kappa Opioid Receptor
Peptide Fragments
Polymerase chain reaction
Opioid Receptors
12 Citations (Scopus)

Reporter affinity labels: An o-phthalaldehyde derivative of β- naltrexamine as a fluorogenic ligand for opioid receptors

Le Bourdonnec, B., El Kouhen, R., Lunzer, M. M., Law, P. Y., Loh, H. H. & Portoghese, P. S., Jun 29 2000, In : Journal of Medicinal Chemistry. 43, 13, p. 2489-2492 4 p.

Research output: Contribution to journalLetter

Affinity Labels
o-Phthalaldehyde
kappa Opioid Receptor
Naltrexone
delta Opioid Receptor
1998
83 Citations (Scopus)

Mutational evidence for a common κ antagonist binding pocket in the wild-type κ and mutant μ[K303E] opioid receptors [1]

Jones, R. M., Hjorth, S. A., Schwartz, T. W. & Portoghese, P. S., Dec 3 1998, In : Journal of Medicinal Chemistry. 41, 25, p. 4911-4914 4 p.

Research output: Contribution to journalLetter

Molecular Sequence Data
Molecular Conformation
kappa Opioid Receptor
Naltrexone
Molecular Models
1987
125 Citations (Scopus)

Bimorphinans as Highly Selective, Potent k opioid Receptor Antagonists

Portoghese, P. S., Lipkowski, A. W. & Takemori, A. E., Feb 1 1987, In : Journal of Medicinal Chemistry. 30, 2, p. 238-239 2 p.

Research output: Contribution to journalLetter

Morphinans
kappa Opioid Receptor
Narcotic Antagonists
Opioid Receptors
Structure-Activity Relationship
1 Citation (Scopus)

Could DAA modulate norepinephrine storage function?

Portoghese, P. S., Jan 1 1987, In : Trends in Pharmacological Sciences. 8, 1, p. 18-19 2 p.

Research output: Contribution to journalLetter

Norepinephrine
1978
54 Citations (Scopus)
Nitrogen Mustard Compounds
Naltrexone
Competitive Binding
Narcotic Antagonists
Alkylating Agents
1976
8 Citations (Scopus)

A circular Dichroism Study of the Interaction of Sodium and Potassium Ions with Methionine Enkephalin

Poupaert, J. H., Portoghese, P. S. & Garsky, V., Nov 1 1976, In : Journal of Medicinal Chemistry. 19, 11, p. 1354-1356 3 p.

Research output: Contribution to journalLetter

Molecular Conformation
Methionine Enkephalin
Oligopeptides
Circular Dichroism
Methionine
1971
9 Citations (Scopus)

Correlation of analgesic potencies of N‐substituted normeperidines and in vitroN‐dealkylation

Abdel‐Monem, M. M. & Portoghese, P. S., Jan 1 1971, In : Journal of Pharmacy and Pharmacology. 23, 11, p. 875-876 2 p.

Research output: Contribution to journalLetter

Dealkylation
Meperidine
Structure-Activity Relationship
Intravenous Injections
Gas Chromatography
1968
8 Citations (Scopus)

Absolute stereochemistry and analgesic potency of prodine enantiomers

Portoghese, P. S. & Larson, D. L., Jan 1 1968, In : Journal of Pharmaceutical Sciences. 57, 4, p. 711-713 3 p.

Research output: Contribution to journalLetter

Alphaprodine
Piperidines
Physical Chemistry
Optical Rotatory Dispersion
Infrared Rays
1966
7 Citations (Scopus)

Stereochemistry of methadol diastereomers

Portoghese, P. S. & Williams, D. A., Jan 1 1966, In : Journal of Pharmaceutical Sciences. 55, 9, p. 990-991 2 p.

Research output: Contribution to journalLetter

Methadyl Acetate
Pharmaceutical Chemistry
Methadone
1965
7 Citations (Scopus)
Drug Synergism
Piperidines
Analgesics
1964
1 Citation (Scopus)

Resolution and absolute configuration of (+)‐α‐anilinopropionic acid

Portoghese, P. S., Jan 1 1964, In : Journal of Pharmaceutical Sciences. 53, 2, p. 228-229 2 p.

Research output: Contribution to journalLetter

Aniline Compounds
Anilides
Non-Narcotic Analgesics
Pharmaceutical Chemistry
Propionates
1962

The absolute antipodal activity of analgesics in the basic anilide series

Portoghese, P. S., Jan 1 1962, In : Journal of Pharmaceutical Sciences. 51, 12, p. 1197-1198 2 p.

Research output: Contribution to journalLetter

Anilides
Non-Narcotic Analgesics
Analgesics
1 Citation (Scopus)

The absolute configuration of (‐)‐N‐[2‐(methylbenzylamino)‐propyl]‐propionanilide

Portoghese, P. S. & Larson, D. L., Jan 1 1962, In : Journal of Pharmaceutical Sciences. 51, 11, p. 1115-1116 2 p.

Research output: Contribution to journalLetter