Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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1984
54 Citations (Scopus)

Comparative antagonism by naltrexone and naloxone of μ, κ, and δ agonists

Takemori, A. E. & Portoghese, P. S., Sep 3 1984, In : European Journal of Pharmacology. 104, 1-2, p. 101-104 4 p.

Research output: Contribution to journalArticle

Naltrexone
Naloxone
Ileum
Guinea Pigs
Vas Deferens
45 Citations (Scopus)
Affinity Labels
Naltrexone
Narcotic Antagonists
Ileum
Guinea Pigs
71 Citations (Scopus)

Role of spinal mu opioid receptors in the development of morphine tolerance and dependence

DeLander, G. E., Portoghese, P. S. & Takemori, A. E., Jan 1 1984, In : Journal of Pharmacology and Experimental Therapeutics. 231, 1, p. 91-96 6 p.

Research output: Contribution to journalArticle

Morphine Dependence
mu Opioid Receptor
Morphine
Spinal Injections
Spinal Cord
4 Citations (Scopus)

Synthesis and pharmacological evaluation of an 8/3-bis(2-chloroethyl)amino opiate as a nonequilibrium opioid receptor probe

Fang, S. N., Bell, K. H. & Portoghese, P. S., Jan 1984, In : Journal of Medicinal Chemistry. 27, 8, p. 1090-1092 3 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Codeine
Vas Deferens
Opioid Receptors
Ileum
1 Citation (Scopus)

The crystal structure and molecular conformation of threo 5-methylmetadone in relation to opioid receptor binding

Duax, W. L., Smith, G. D., Griffin, J. F., Strong, P. D. & Portoghese, P. S., Jan 1 1984, In : Tetrahedron. 40, 3, p. 467-471 5 p.

Research output: Contribution to journalArticle

Molecular Conformation
Opioid Receptors
Conformations
Crystal structure
Methadone
2 Citations (Scopus)

β-Funaltrexamine (β-FNA) and morphine dependence

Aceto, M. D., Dewey, W. L., Portoghese, P. C. & Takemori, A. E., Jan 1 1984, In : Federation Proceedings. 43, 3

Research output: Contribution to journalArticle

beta-funaltrexamine
Morphine Dependence
1983
24 Citations (Scopus)
Alkylation
Opioid Receptors
Affinity Labels
Vas Deferens
Ileum
19 Citations (Scopus)

Difference between μ-receptors in the guinea pig ileum and the mouse vas deferens

Sayre, L. M., Portoghese, P. S. & Takemori, A. E., May 20 1983, In : European Journal of Pharmacology. 90, 1, p. 159-160 2 p.

Research output: Contribution to journalArticle

Species Specificity
Organ Specificity
Vas Deferens
mu Opioid Receptor
Opioid Receptors
41 Citations (Scopus)

Different Receptor Sites Mediate Opioid Agonism and Antagonism

Portoghese, P. S. & Takemori, A. E., Jan 1 1983, In : Journal of Medicinal Chemistry. 26, 10, p. 1341-1343 3 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Narcotics
Opioid Receptors
Structure-Activity Relationship
42 Citations (Scopus)

Importance of C-6 Chirality in Conferring Irreversible Opioid Antagonism to Naltrexone-Derived Affinity Labels

Sayre, L. M., Larson, D. L., Fries, D. S., Takemori, A. E. & Portoghese, P. S., Jan 1 1983, In : Journal of Medicinal Chemistry. 26, 9, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

Affinity Labels
Naltrexone
Vas Deferens
Opioid Analgesics
Morphine
4 Citations (Scopus)

Methadone conformation and opioid activity

Duax, W. L., Smith, G. D., Griffin, J. F. & Portoghese, P. S., Jan 1 1983, In : Science. 220, 4595, p. 417-418 2 p.

Research output: Contribution to journalArticle

Methadone
Opioid Analgesics
Nitrogen
Carbon
Opioid Receptors
8 Citations (Scopus)

Stereochemistry of Cyanide Ion Addition to 3,4,5,6-Tetrahydropyridinium Derivatives

Essawi, M. Y. H. & Portoghese, P. S., Jan 1 1983, In : Journal of Organic Chemistry. 48, 13, p. 2138-2140 3 p.

Research output: Contribution to journalArticle

Nitriles
Stereochemistry
Cyanides
Salts
Nuclear magnetic resonance
21 Citations (Scopus)

Synthesis and Evaluation of 1- and 2-Substituted Fentanyl Analogues for Opioid Activity

Essawi, M. Y. H. & Portoghese, P. S., Jan 1 1983, In : Journal of Medicinal Chemistry. 26, 3, p. 348-352 5 p.

Research output: Contribution to journalArticle

Fentanyl
Opioid Analgesics
Opioid Peptides
Opioid Receptors
Vas Deferens
1982
9 Citations (Scopus)

Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators

Messing, R. B., Portoghese, P. S., Takemori, A. E. & Sparber, S. B., Jan 1 1982, In : Pharmacology, Biochemistry and Behavior. 16, 4, p. 621-626 6 p.

Research output: Contribution to journalArticle

Alkylating Agents
Opioid Receptors
Morphine
Amphetamine
Opiate Alkaloids
62 Citations (Scopus)

Improved assays for the assessment of κ{script}- and δ-properties of opioid ligands

Ward, S. J., Portoghese, P. S. & Takemori, A. E., Nov 19 1982, In : European Journal of Pharmacology. 85, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Ethylketocyclazocine
Morphine
Opioid Analgesics
Naloxone
Ligands
1 Citation (Scopus)

Improved screening methods for the assessment of κ and δ properties of opioid ligands

Ward, S. J., Portoghese, P. S. & Takemori, A. E., Jan 1 1982, In : Federation Proceedings. 41, 4

Research output: Contribution to journalArticle

Opioid Analgesics
Ligands
110 Citations (Scopus)
Narcotics
Vas Deferens
Ligands
Ethylketocyclazocine
Ileum
72 Citations (Scopus)

Opioid agonist and antagonist bivalent ligands as receptor probes

Portoghese, P. S., Ronsisvalle, G., Larson, D. L., Yim, C. B., Sayre, L. M. & Takemori, A. E., Jan 1 1982, In : Life Sciences. 31, 12-13, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Analgesics
Ligands
Morphine
Molecules
279 Citations (Scopus)

Pharmacological characterization in vivo of the novel opiate, β-funaltrexamine

Ward, S. J., Portoghese, P. S. & Takemori, A. E., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 220, 3, p. 494-498 5 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
kappa Opioid Receptor
Naltrexone
Opioid Receptors
Esters
120 Citations (Scopus)

Pharmacological profiles of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) on the mouse vas deferens preparation

Ward, S. J., Portoghese, P. S. & Takemori, A. E., Jun 4 1982, In : European Journal of Pharmacology. 80, 4, p. 377-384 8 p.

Research output: Contribution to journalArticle

Vas Deferens
Opioid Receptors
Pharmacology
chlornaltrexamine
10 Citations (Scopus)
Opioid Receptors
Esterification
Alcohols
X-Rays
Ligands
10 Citations (Scopus)

Synthesis, X-Ray Crystallographic Determination, and Opioid Activity of erythro-5-Methylmethadone Enantiomers. Evidence Which Suggests That μ and δ Opioid Receptors Possess Different Stereochemical Requirements

Portoghese, P. S., Poupaert, J. H., Larson, D. L., Groutas, W. C., Meitzner, G. D., Swenson, D. C., Smith, G. D. & Duax, W. L., Jan 1 1982, In : Journal of Medicinal Chemistry. 25, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Opioid Analgesics
X-Rays
Vas Deferens
Methadone
9 Citations (Scopus)
Tyramine
Opioid Peptides
Opiate Alkaloids
Vas Deferens
Opioid Receptors
1981
59 Citations (Scopus)
Opioid Receptors
Morphine
Ligands
Opiate Alkaloids
Endorphins
13 Citations (Scopus)
Sulfonamides
Chlorides
Peptides
aminomethanesulfonic acid
45 Citations (Scopus)

Antagonism by chlornaltrexamine of some effects of Δ9-tetrahydrocannabinol in rats

Tulunay, F. C., Ayhan, I. H., Portoghese, P. S. & Takemori, A. E., Mar 12 1981, In : European Journal of Pharmacology. 70, 2, p. 219-224 6 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Dronabinol
Cannabis
Hypothermia
Analgesia
1 Citation (Scopus)

Binding characteristics of the specific μ antagonist β-FNA, the fumaramate methyl ester derivative of naltrexone

Ward, S. J., Portoghese, P. S. & Takemori, A. E., Jan 1 1981, In : Federation Proceedings. 40, 3 I, 1 p.

Research output: Contribution to journalArticle

beta-funaltrexamine
Naltrexone
Esters
216 Citations (Scopus)

The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone

Takemori, A. E., Larson, D. L. & Portoghese, P. S., Apr 9 1981, In : European Journal of Pharmacology. 70, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotics
Morphine
Esters
Oxymorphone
1980
271 Citations (Scopus)

A Novel Opioid Receptor Site Directed Alkylating Agent with Irreversible Narcotic Antagonistic and Reversible Agonistic Activities

Portoghese, P. S., Larson, D. L., Sayre, L. M., Fries, D. S. & Takemori, A. E., Feb 1 1980, In : Journal of Medicinal Chemistry. 23, 3, p. 233-234 2 p.

Research output: Contribution to journalArticle

Alkylating Agents
Narcotics
Opioid Receptors
Structure-Activity Relationship
Ligands
5 Citations (Scopus)

A Novel Route for Functionalization of the Bridgehead C-2 Position of Benzomorphans1

Ramakrishnan, K. & Portoghese, P. S., Jan 1 1980, In : Journal of Organic Chemistry. 45, 21, p. 4240-4241 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice

Caruso, T. P., Larson, D. L., Portoghese, P. S. & Takemori, A. E., Dec 1 1980, In : Life Sciences. 27, 22, p. 2063-2069 7 p.

Research output: Contribution to journalArticle

Opioid Receptors
Brain
Trichloroacetic Acid
Narcotic Antagonists
Octoxynol
40 Citations (Scopus)

Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine

Caruso, T. P., Larson, D. L., Portoghese, P. S. & Takemori, A. E., Jan 1 1980, In : Journal of Pharmacology and Experimental Therapeutics. 213, 3, p. 539-544 6 p.

Research output: Contribution to journalArticle

Narcotics
Pharmacology
Analgesia
Naltrexone
Oxymorphone

Specificity of in vivo opiate antagonism by chlornaltrexamine

Messing, R. B., Portoghese, P. S., Takemori, A. E. & Sparber, S. B., Jan 1 1980, In : Federation Proceedings. 39, 3 II, 1 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Morphine
Naltrexone
Exploratory Behavior
Amphetamine
64 Citations (Scopus)

Stereospecific synthesis of the 6α- and 6β-amino derivatives of naltrexone and oxymorphone

Sayre, L. M. & Portoghese, P. S., Jan 1 1980, In : Journal of Organic Chemistry. 45, 16, p. 3366-3368 3 p.

Research output: Contribution to journalArticle

Oxymorphone
Naltrexone
Derivatives
5 Citations (Scopus)

Synthesis and biological evaluation of 2,3‐diazabicyclo[2.2.1]heptane derivatives as prostaglandin endoperoxide analogs

Kam, ST. T., Hanson, R. N. & Portoghese, P. S., Jan 1 1980, In : Journal of Pharmaceutical Sciences. 69, 9, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Synthetic Prostaglandin Endoperoxides
Heptanes
Platelet Aggregation
Skeleton
Human Activities
29 Citations (Scopus)

α-Cyanation Of -Tertiary Amtnes

Groutas, W. C., Essawi, M. & Portoghese, P. S., Jan 1 1980, In : Synthetic Communications. 10, 7, p. 495-502 8 p.

Research output: Contribution to journalArticle

1979
11 Citations (Scopus)

9,11-AZO-13-OXA-15-hydroxyprostanoic acid: A potent thromboxane synthetase inhibitor and a pgh2/txa2 receptor antagonist

Kam, S. T., Portoghese, P. S., Dunham, E. W. & Gerrard, J. M., Jan 1 1979, In : Prostaglandines and Medicine. 3, 5, p. 279-289 11 p.

Research output: Contribution to journalArticle

Thromboxane-A Synthase
Prostaglandin H2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Platelets
Inhibitory Concentration 50
42 Citations (Scopus)

Chloroxymorphamine, an opioid receptor site-directed alkylating agent having narcotic agonist activity

Caruso, T. P., Takemori, A. E., Larson, D. L. & Portoghese, P. S., Jan 1 1979, In : Science. 204, 4390, p. 316-318 3 p.

Research output: Contribution to journalArticle

Oxymorphone
Naltrexone
Alkylating Agents
Narcotics
Opioid Receptors
18 Citations (Scopus)

Synthesis and Biological Evaluation of 9,11-Azo-13-oxa-15-hydroxyprostanoic Acid, a Potent Inhibitor of Platelet Aggregation

Kam, S. T., Portoghese, P. S., Gerrard, J. M. & Dunham, E. W., Feb 1 1979, In : Journal of Medicinal Chemistry. 22, 11, p. 1402-1408 7 p.

Research output: Contribution to journalArticle

Prostaglandin H2
Platelet Aggregation Inhibitors
Platelet Aggregation
Synthetic Prostaglandin Endoperoxides
Thromboxane-A Synthase
102 Citations (Scopus)

Synthesis and Pharmacologic Characterization of an Alkylating Analog (Chlornaltrexamine), of Naltrexone with Ultralong-Lasting Narcotic Antagonist Properties

Portoghese, P. S., Larson, D. L., Jiang, J. B., Caruso, T. P. & Takemori, A. E., Feb 1 1979, In : Journal of Medicinal Chemistry. 22, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Narcotics
Opioid Receptors
chlornaltrexamine
1 Citation (Scopus)

Ultralong lasting single-dose tolerance to chloroxymorphamine (COA), an opioid receptor alkylating agonist

Caruso, T. P., Takemori, A. E., Larson, D. L. & Portoghese, P. S., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Oxymorphone
Naltrexone
Injections
1978

An ultra-long lasting narcotic antagonist, chlornaltrexamine: Effects in vitro and in vivo

Caruso, T. P., Takemori, A. E., Larson, D. L. & Portoghese, P. S., Jan 1 1978, In : Pharmacologist. 20, 3, 1 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
In Vitro Techniques
chlornaltrexamine
45 Citations (Scopus)

Stereoisomeric Ligands as Opioid Receptor Probes

Portoghese, P. S., Jan 1 1978, In : Accounts of Chemical Research. 11, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Ligands
Enantiomers
Conformations
Opioid Analgesics
1977
11 Citations (Scopus)

3-Hydroxy-17-aralkylmorphinans as Potential Opiate Receptor-Site-Directed Alkylating Agents

Portoghese, P. S., Hanson, R. N., Telang, V. G., Winger, J. L. & Takemori, A. E., Aug 1 1977, In : Journal of Medicinal Chemistry. 20, 8, p. 1020-1024 5 p.

Research output: Contribution to journalArticle

Alkylating Agents
Opioid Receptors
Opiate Alkaloids
Analgesia
Morphine
10 Citations (Scopus)

A Novel Prostaglandin Endoperoxide Mimic, Prostaglandin F Acetal

Portoghese, P. S., Larson, D. L., Abatjoglou, A. G., Dunham, E. W., Gerrard, J. M. & White, J. G., Feb 1 1977, In : Journal of Medicinal Chemistry. 20, 2, p. 320-321 2 p.

Research output: Contribution to journalArticle

Prostaglandin Endoperoxides
Synthetic Prostaglandins
Acetals
Dinoprost
Gerbillinae
53 Citations (Scopus)

Stereochemical Studies on Medicinal Agents. 23. Synthesis and Biological Evaluation of 6-Amino Derivatives of Naloxone and Naltrexone

Jiang, J. B., Hanson, R. N., Portoghese, P. S. & Takemori, A. E., Aug 1 1977, In : Journal of Medicinal Chemistry. 20, 8, p. 1100-1102 3 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Naloxone
In Vitro Techniques
1976
9 Citations (Scopus)

A simple, stereoselective synthesis of a prostaglandin endoperoxide analog

Abatjoglou, A. G. & Portoghese, P. S., Jan 1 1976, In : Tetrahedron Letters. 17, 18, p. 1457-1460 4 p.

Research output: Contribution to journalArticle

Synthetic Prostaglandin Endoperoxides
25 Citations (Scopus)

Correlation of Opiate Receptor Affinity with Analgetic Effects of Meperidine Homologs

Pert, C. B., Snyder, S. H. & Portoghese, P. S., Oct 1 1976, In : Journal of Medicinal Chemistry. 19, 10, p. 1248-1250 3 p.

Research output: Contribution to journalArticle

Meperidine
Opioid Receptors
Drug Receptors
Brain
Carbon
11 Citations (Scopus)

Relation between Analgetic ED50 Dose and Time-Course Brain Levels of N-Alkylnormeperidine Homologs

Larson, D. L. & Portoghese, P. S., Jan 1 1976, In : Journal of Medicinal Chemistry. 19, 1, p. 16-19 4 p.

Research output: Contribution to journalArticle

Dealkylation
Brain
Meperidine
Liver
Lipid Metabolism