Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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Article
1993
33 Citations (Scopus)
Narcotic Antagonists
Nitrogen
Dynorphins
Guanidine
norbinaltorphimine
15 Citations (Scopus)

The design of δ-selective opioid receptor antagonists

Portoghese, P. S., Jan 1 1993, In : Farmaco. 48, 2, p. 243-251 9 p.

Research output: Contribution to journalArticle

naltrindole
Naltrexone
Narcotic Antagonists
Opioid Receptors
Conformations
8 Citations (Scopus)

The mixed antinociceptive agonist-antagonist activity of β-endorphin(1-27) in mice

Takemori, A. E. & Portoghese, P. S., Jan 1 1993, In : Life Sciences. 53, 13, p. 1049-1052 4 p.

Research output: Contribution to journalArticle

Endorphins
Narcotic Antagonists
Opioid Receptors
Methionine Enkephalin
Spinal Cord
35 Citations (Scopus)

δ-Opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine

Jones, D. N. C., Bowen, W. D., Portoghese, P. S. & Holtzman, S. G., Nov 9 1993, In : European Journal of Pharmacology. 249, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
naltrindole
Amphetamine
Cocaine
Motor Activity
1992
Narcotic Antagonists
81 Citations (Scopus)

Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone

Takemori, A. E., Sultana, M., Nagase, H. & Portoghese, P. S., Jan 1 1992, In : Life Sciences. 50, 20, p. 1491-1495 5 p.

Research output: Contribution to journalArticle

naltrindole
Oxymorphone
Naltrexone
enkephalin, Ser(2), Leu(5), Thr(6)-
Opioid Receptors
179 Citations (Scopus)

A highly selective δ1-opioid receptor antagonist: 7-benzylidenenaltrexone

Portoghese, P. S., Sultana, M., Nagase, H. & Takemori, A. E., Jul 21 1992, In : European Journal of Pharmacology. 218, 1, p. 195-196 2 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
Narcotic Antagonists
enkephalin, Ser(2), Leu(5), Thr(6)-
Enkephalins
Brain
Narcotic Antagonists

Chemical tools in opioid research.

Portoghese, P. S., Jan 1 1992, In : NIDA research monograph. 119, p. 27-33 7 p.

Research output: Contribution to journalArticle

Endorphins
Opioid Receptors
Opioid Analgesics
Research
97 Citations (Scopus)

Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Menkens, K., Bilsky, E. J., Wild, K. D., Portoghese, P. S., Reid, L. D. & Porreca, F., Aug 25 1992, In : European Journal of Pharmacology. 219, 2, p. 345-346 2 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Cocaine
Cocaine-Related Disorders
14 Citations (Scopus)

Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine

Sofuoglu, M., Portoghese, P. S. & Takemori, A. E., Jan 14 1992, In : European Journal of Pharmacology. 210, 2, p. 159-162 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Maintenance
Opioid Analgesics
norbinaltorphimine
54 Citations (Scopus)

Mediation of swim-stress antinociception by the opioid delta2 receptor in the mouse

Vanderah, T. W., Wild, K. D., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D., Mosberg, H. I. & Porreca, F., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 262, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Dehydration
Enkephalins
D-Penicillamine (2,5)-Enkephalin
Narcotic Antagonists
104 Citations (Scopus)

Modulation of Mu-mediated antinociception in the mouse involves opioid delta-2 receptors

Porreca, F., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D. & Mosberg, H. I., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 263, 1, p. 147-152 6 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Morphine
Enkephalins
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
27 Citations (Scopus)

Opioid Agonist and Antagonist Activities of Morphindoles Related to Naltrindole

Portoghese, P. S., Larson, D. L., Sultana, M. & Takemori, A. E., Nov 1 1992, In : Journal of Medicinal Chemistry. 35, 23, p. 4325-4329 5 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Vas Deferens
Opioid Receptors
Ligands
22 Citations (Scopus)

Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain

Schoffelmeer, A. N. M., De Vries, T. J., Hogenboom, F., Hruby, V. J., Portoghese, P. S. & Mulder, A. H., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 263, 1, p. 20-24 5 p.

Research output: Contribution to journalArticle

Presynaptic Receptors
delta Opioid Receptor
naltrindole
Narcotic Antagonists
mu Opioid Receptor
120 Citations (Scopus)

Spinal opioid delta antinociception in the mouse: Mediation by a 5'-NTII- sensitive delta receptor subtype

Mattia, A., Farmer, S. C., Takemori, A. E., Sultana, M., Portoghese, P. S., Mosberg, H. I., Bowen, W. D. & Porreca, F., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 260, 2, p. 518-525 8 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Enkephalins
Opioid Analgesics
glycyl-glycyl-glycyl-glycine
Opioid Receptors
26 Citations (Scopus)

The delta receptor is involved in sufentanil-induced respiratory depression-opioid subreceptors mediate different effects

Freye, E., Latasch, L. & Portoghese, P. S., Jan 1 1992, In : European Journal of Anaesthesiology. 9, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

naltrindole
Sufentanil
delta Opioid Receptor
Respiratory Insufficiency
Opioid Analgesics
110 Citations (Scopus)

The Role of Concepts in Structure-Activity Relationship Studies of Opioid Ligands

Portoghese, P. S., May 1 1992, In : Journal of Medicinal Chemistry. 35, 11, p. 1927-1937 11 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Structure-Activity Relationship
Opioid Analgesics
Ligands
Opioid Receptors
37 Citations (Scopus)

δ Opioid Antagonist Activity and Binding Studies of Regioisomeric Isothiocyanate Derivatives of Naltrindole: Evidence for δ Receptor Subtypes

Portoghese, P. S., Sultana, M., Nelson, W. L., Klein, P. & Takemori, A. E., Oct 1 1992, In : Journal of Medicinal Chemistry. 35, 22, p. 4086-4091 6 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Enkephalins
Opioid Receptors
Ligands
39 Citations (Scopus)

δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites

Sofuoglu, M., Portoghese, P. S. & Takemori, A. E., Jun 5 1992, In : European Journal of Pharmacology. 216, 2, p. 273-277 5 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
Opioid Receptors
Binding Sites
Enkephalins
Brain
1991
71 Citations (Scopus)
Molecular Sequence Data
Morphinans
Indoles
Protein Conformation
delta Opioid Receptor
48 Citations (Scopus)

Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes

Sofuoglu, M., Portoghese, P. S. & Takemori, A. E., Jan 1 1991, In : Life Sciences. 49, 19

Research output: Contribution to journalArticle

delta Opioid Receptor
D-Penicillamine (2,5)-Enkephalin
Leucine-2-Alanine Enkephalin
enkephalin, Ser(2), Leu(5), Thr(6)-
Spinal Cord
309 Citations (Scopus)
D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Enkephalins
Opioid Analgesics
naltrindole
288 Citations (Scopus)

Differential antagonism of opioid delta antinociception by [D-Ala 2 ,Leu 5 , Cys 6 ]enkephalin and naltrindole 5'-isothiocyanate: Evidence for delta receptor subtypes

Jiang, Q., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D., Mosberg, H. I. & Porreca, F., Jan 1 1991, In : Journal of Pharmacology and Experimental Therapeutics. 257, 3, p. 1069-1075 7 p.

Research output: Contribution to journalArticle

enkephalin, Ser(2), Leu(5), Thr(6)-
delta Opioid Receptor
Opioid Analgesics
Enkephalins
Narcotic Antagonists
2 Citations (Scopus)

Persistent Binding of Fatty Acyl Derivatives of Naltrexamine to Opioid Receptors

Portoghese, P. S., Garzon-Aburbeh, A. & Larson, D. L., Jul 1 1991, In : Journal of Medicinal Chemistry. 34, 7, p. 1966-1969 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Ligands
Membranes
Unsaturated Fatty Acids
Fatty Acids
99 Citations (Scopus)

Role of Spacer and Address Components in Peptidomimetic δ Opioid Receptor Antagonists Related to Naltrindole

Portoghese, P. S., Nagase, H., MaloneyHuss, K. E., Lin, C. E. & Takemori, A. E., May 1 1991, In : Journal of Medicinal Chemistry. 34, 5, p. 1715-1720 6 p.

Research output: Contribution to journalArticle

naltrindole
Peptidomimetics
Narcotic Antagonists
Leucine Enkephalin
Quinoxalines
43 Citations (Scopus)

Role of the Spacer in Conferring κ Opioid Receptor Selectivity to Bivalent Ligands Related to Norbinaltorphimine

Portoghese, P. S., Garzon-Aburbeh, A., Nagase, H., Lin, C. E. & Takemori, A. E., Apr 1 1991, In : Journal of Medicinal Chemistry. 34, 4, p. 1292-1296 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Thiophenes
Narcotic Antagonists
Ligands
Pyrans
362 Citations (Scopus)

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice

Abdelhamid, E. E., Sultana, M., Portoghese, P. S. & Takemori, A. E., Jan 1 1991, In : Journal of Pharmacology and Experimental Therapeutics. 258, 1, p. 299-303 5 p.

Research output: Contribution to journalArticle

Morphine Dependence
naltrindole
delta Opioid Receptor
Morphine
Opiate Alkaloids
40 Citations (Scopus)
Narcotic Antagonists
Energy Metabolism
Opioid Receptors
Phosphorylation
Percussion
1990

Dermorphin as lead in the design of highly potent and μ-specific morphine antagonists. Evidence for a third hydrophobic pocket in the μ receptor

Poupaert, J. H., Tulu Kimpansu, M., Barbas, D., Lybrand, T. & Portoghese, S., Dec 1 1990, In : Journal de Pharmacie de Belgique. 45, 6, 1 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Morphine
dermorphin
278 Citations (Scopus)

Design of Peptidomimetic 5 Opioid Receptor Antagonists Using the Message-Address Concept

Portoghese, P. S., Sultana, M. & Takemori, A. E., Jan 1 1990, In : Journal of Medicinal Chemistry. 33, 6, p. 1714-1720 7 p.

Research output: Contribution to journalArticle

Peptidomimetics
Narcotic Antagonists
Naltrexone
Guinea Pigs
naltrindole
3 Citations (Scopus)

Differential antagonism of DSLET and DPDPE by novel delta opioid receptor antagonists

Sofuoglu, M., Portoghese, P. S. & Takemori, A. E., Jan 1 1990, In : European Journal of Pharmacology. 183, 6, 1 p.

Research output: Contribution to journalArticle

enkephalin, Ser(2), Leu(5), Thr(6)-
D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Narcotic Antagonists
5 Citations (Scopus)

Facile Intramolecular O–14 C-7 Acetyl Transfer in Opiate 14-Acetate Esters

Nagase, H. N. & Portoghese, P. S., Jan 1 1990, In : Journal of Organic Chemistry. 55, 1, p. 365-367 3 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Esters
Acetates
Naltrexone
Naloxone

Isolation of kappa opioid receptor with an aminoethyl-nor-binaltorphimine (AE-norBNI) affinity column.

Song, Z. H., Barbas, D. P., Portoghese, P. S. & Takemori, A. E., Jan 1 1990, In : Progress in Clinical and Biological Research. 328, p. 69-72 4 p.

Research output: Contribution to journalArticle

Brain Chemistry
Diprenorphine
kappa Opioid Receptor
Naltrexone
Competitive Binding
6 Citations (Scopus)

Long-acting agonist and antagonist activities of naltrexamine bivalent ligands in mice

Takemori, A. E., Yim, C. B., Larson, D. L. & Portoghese, P. S., Sep 21 1990, In : European Journal of Pharmacology. 186, 2-3, p. 285-288 4 p.

Research output: Contribution to journalArticle

Ligands
Morphine
Central Nervous System
Injections
35 Citations (Scopus)

Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors

Quock, R. M., Best, J. A., Chen, D. C., Vaughn, L. K., Portoghese, P. S. & Takemori, A. E., Jan 3 1990, In : European Journal of Pharmacology. 175, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

Nitrous Oxide
Opioid Receptors
Analgesia
Naltrexone
219 Citations (Scopus)

Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures

Peterson, P. K., Sharp, B. M., Gekker, G., Portoghese, P. S., Sannerud, K. & Balfour, H. H., Sep 1 1990, In : AIDS. 4, 9, p. 869-873 5 p.

Research output: Contribution to journalArticle

Coculture Techniques
Morphine
HIV-1
Blood Cells
Growth
74 Citations (Scopus)

Naltrindole 5'-Isothiocyanate: A Nonequilibrium, Highly Selective δ Opioid Receptor Antagonist

Portoghese, P. S., Sultana, M. & Takemori, A. E., Jan 1 1990, In : Journal of Medicinal Chemistry. 33, 6, p. 1547-1548 2 p.

Research output: Contribution to journalArticle

Morphinans
Thiocyanates
Affinity Labels
delta Opioid Receptor
Narcotic Antagonists
76 Citations (Scopus)

Nor-binaltorphimine decreases deprivation and opioid-induced feeding

Levine, A. S., Grace, M., Billington, C. J. & Portoghese, P. S., Nov 26 1990, In : Brain Research. 534, 1-2, p. 60-64 5 p.

Research output: Contribution to journalArticle

enkephalin, Ser(2), Leu(5), Thr(6)-
Opioid Analgesics
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Ligands
128 Citations (Scopus)

Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex

Heijna, M. H., Padt, M., Hogenboom, F., Portoghese, P. S., Mulder, A. H. & Schoffelmeer, A. N. M., Jun 8 1990, In : European Journal of Pharmacology. 181, 3, p. 267-278 12 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
D-Penicillamine (2,5)-Enkephalin
Opioid Receptors
Frontal Lobe
Ala(2)-MePhe(4)-Gly(5)-enkephalin
13 Citations (Scopus)

Synthesis of Novel 6β,14-Epoxy-Bridged Opiates

MaloneyHuss, K. E. & Portoghese, P. S., Jan 1 1990, In : Journal of Organic Chemistry. 55, 9, p. 2957-2959 3 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Thebaine
Narcotic Antagonists
Cyclization
Ether
1989
28 Citations (Scopus)

Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat

Carr, K. D., Bak, T. H., Simon, E. J. & Portoghese, P. S., Jan 1 1989, In : Life Sciences. 45, 19, p. 1787-1792 6 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Naloxone
Rats
Injections
21 Citations (Scopus)
delta Opioid Receptor
mu Opioid Receptor
D-Penicillamine (2,5)-Enkephalin
Adenylyl Cyclases
Sulpiride
8 Citations (Scopus)

Nonbonded13C-14N dipole-dipole interactions

Moreland, C. G., Stejskal, E. O., Sumner, S. C. J., Memory, J. D., Ivy Carroll, F., Brine, G. A. & Portoghese, P. S., Jun 1 1989, In : Journal of Magnetic Resonance (1969). 83, 1, p. 173-176 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Opioid Agonist and Antagonist Activities of Peripherally Selective Derivatives of Naltrexamine and Oxymorphamine

Botros, S., Lipkowski, A. W., Larson, D. L., Stark, P. A., Takemori, A. E. & Portoghese, P. S., Sep 1 1989, In : Journal of Medicinal Chemistry. 32, 9, p. 2068-2071 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Morphine
Central Nervous System
Ligands
Naltrexone
17 Citations (Scopus)

Reactivity of glutathione with α,β-unsaturated ketone flavouring substances

Portoghese, P. S., Kedziora, G. S., Larson, D. L., Bernard, B. K. & Hall, R. L., Jan 1 1989, In : Food and Chemical Toxicology. 27, 12, p. 773-776 4 p.

Research output: Contribution to journalArticle

flavorings
ketones
Ketones
Glutathione
glutathione
53 Citations (Scopus)

Selective kappa antagonist properties of nor-binaltorphimine in the rat mes seizure model

Tortella, F. C., Echevarria, E., Lipkowski, A. W., Takemori, A. E., Portoghese, P. S. & Holaday, J. W., Jan 1 1989, In : Life Sciences. 44, 10, p. 661-665 5 p.

Research output: Contribution to journalArticle

Rats
Seizures
Anticonvulsants
Electroshock
Opioid Analgesics
22 Citations (Scopus)

Selective opioid antagonist effects on opioid-induced inhibition of release of norepinephrine in guinea pig cortex

Werling, L. L., McMahon, P. N., Portoghese, P. S., Takemori, A. E. & Cox, B. M., Feb 1989, In : Neuropharmacology. 28, 2, p. 103-107 5 p.

Research output: Contribution to journalArticle

alanylglycine
Narcotic Antagonists
Enkephalins
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Opioid Analgesics
28 Citations (Scopus)

The Facility of Formation of a Δ6Bond in Dihydromorphinone and Related Opiates

Nagase, H., Abe, A. & Portoghese, P. S., Aug 1 1989, In : Journal of Organic Chemistry. 54, 17, p. 4120-4125 6 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Hydromorphone
Naltrexone
Ketones
Stereochemistry
2 Citations (Scopus)

The use of μ opioid receptors in the mouse vas deferens for the study of opiate tolerance

Takemori, A. E. & Portoghese, P. S., Dec 19 1989, In : European Journal of Pharmacology. 174, 2-3, p. 267-271 5 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Vas Deferens
Opioid Receptors
Morphine
Ileum