Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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1997
47 Citations (Scopus)

Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor

Clark, M. J., Emmerson, P. J., Mansour, A., Akil, H., Woods, J. H., Portoghese, P. S., Remmers, A. E. & Medzihradsky, F., Nov 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 283, 2, p. 501-510 10 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Glioma
Opioid Analgesics
Ligands
23 Citations (Scopus)

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

Farouz-Grant, F. & Portoghese, P. S., Jun 20 1997, In : Journal of Medicinal Chemistry. 40, 13, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Smooth Muscle
Muscle
Substitution reactions
5 Citations (Scopus)

Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss webster mice

Rady, J. J., Baemmert, D., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Feb 1 1997, In : Pharmacology Biochemistry and Behavior. 56, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Enkephalins
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
Endorphins
46 Citations (Scopus)

The FEMA GRAS assessment of furfural used as a flavour ingredient

Adams, T. B., Doull, J., Goodman, J. I., Munro, I. C., Newberne, P., Portoghese, P. S., Smith, R. L., Wagner, B. M., Weil, C. S., Woods, L. A. & Ford, R. A., Jan 1 1997, In : Food and Chemical Toxicology. 35, 8, p. 739-751 13 p.

Research output: Contribution to journalArticle

Furaldehyde
furfural
Flavors
ingredients
flavor
1996
14 Citations (Scopus)
G-Protein-Coupled Receptors
Proteins
Bacteriorhodopsins
Proline
Mutagenesis
81 Citations (Scopus)
Naltrexone
Narcotic Antagonists
Opioid Receptors
Ligands
naltrindole
12 Citations (Scopus)
Opioid Receptors
Aspartic Acid
Central Nervous System
Acute Pain
Opioid Analgesics
4 Citations (Scopus)
Boron
Ketones
Protons
Hydrogen
Carbon
20 Citations (Scopus)

GRAS flavoring substances 17

Smith, R. L., Newberne, P., Adams, T. B., Ford, R. A., Hallagan, J. B., Doull, J., Goodman, J. I., Munro, I. C., Portoghese, P. S., Wagner, B. M., Weil, C. S. & Woods, L. A., Oct 1 1996, Food Technology, 50, 10, p. 72-77+81.

Research output: Contribution to specialist publicationArticle

Food additives
Food Additives
Flavors
flavorings
food additives
17 Citations (Scopus)

Opioid antagonist activity of naltrexone-derived bivalent ligands: Importance of a properly oriented molecular scaffold to guide "address" recognition at κ opioid receptors

Bolognesi, M. L., Ojala, W. H., Gleason, W. B., Griffin, J. F., Farouz-Grant, F., Larson, D. L., Takemori, A. E. & Portoghese, P. S., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1816-1822 7 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Opioid Receptors
Ligands
Biological Availability
1 Citation (Scopus)

Selective nonpeptide ligands as probes to explore δ opioid receptor architecture

Portoghese, P. S., Dec 1 1996, In : Pharmacochemistry Library. 24, C, p. 303-312 10 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Ligands
1995
17 Citations (Scopus)
naltrindole
Opioid Receptors
Central Nervous System
Amino Acids
Ligands
27 Citations (Scopus)

Cold water swim stress- and delta-2 opioid-induced analgesia are modulated by spinal γ-aminobutyric acid(A) receptors

Killian, P., Holmes, B. B., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Jan 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 274, 2, p. 730-734 5 p.

Research output: Contribution to journalArticle

Aminobutyrates
delta Opioid Receptor
Dehydration
Analgesia
Opioid Analgesics
20 Citations (Scopus)

Electrophilic N-Benzylnaltrindoles as δ Opioid Receptor-Selective Antagonists

Korlipara, V. L., Takemori, A. E. & Portoghese, P. S., Apr 1 1995, In : Journal of Medicinal Chemistry. 38, 8, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Vas Deferens
Affinity Labels
Isothiocyanates
Inhibitory Concentration 50
14 Citations (Scopus)
Monocyte-Macrophage Precursor Cells
Opioid Peptides
Opioid Analgesics
HIV-1
Up-Regulation

Franklin Robinson memorial symposium on medicinal chemistry in drug abuse research

Newman, A. H., Portoghese, P. S., Calderon, S., Lewis, J., Kline, R. H., Anderson, P., Rice, K. C. & Portoghese, K. C., Aug 24 1995, In : NIDA Research Monograph Series. 152, p. 65-70 6 p.

Research output: Contribution to journalArticle

Pharmaceutical Chemistry
Substance-Related Disorders
Research
43 Citations (Scopus)

Monophenylation of Morphinan-6-ones with Diphenyliodonium Iodide

Gao, P. & Portoghese, P. S., Apr 1 1995, In : Journal of Organic Chemistry. 60, 7, p. 2276-2278 3 p.

Research output: Contribution to journalArticle

Morphinans
diphenyliodonium
43 Citations (Scopus)

Role of delta opioid receptors in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys

Negus, S. S., Mello, N. K., Portoghese, P. S., Lukas, S. E. & Mendelson, J. H., Jan 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 3, p. 1245-1256 12 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
naltrindole
Macaca mulatta
Cocaine
Haplorhini
21 Citations (Scopus)
Endorphins
Opioid Receptors
Pentobarbital
Tail
Narcotic Antagonists
2 Citations (Scopus)

Synthesis of [3H]DIPPA: A potent irreversible antagonist selective for the κ opioid receptor

Chang, AC. C., Trometer, J. D. & Portoghese, P. S., Jan 1 1995, In : Journal of Labelled Compounds and Radiopharmaceuticals. 36, 6, p. 553-557 5 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Receptors
Affinity Labels
Halogenation
2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide
95 Citations (Scopus)

The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference

Krishnan-Sarin, S., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Jan 1 1995, In : Pharmacology, Biochemistry and Behavior. 52, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Rats
Alcohols
naltrindole
Opioid Receptors
120 Citations (Scopus)

The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference

Krishnan-Sarin, S., Jing, S. L., Kurtz, D. L., Zweifel, M., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Jul 1 1995, In : Psychopharmacology. 120, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

naltrindole
Saccharin
delta Opioid Receptor
Narcotic Antagonists
Alcohols
50 Citations (Scopus)

Upregulation of HIV-1 expression in cocultures of chronically infected promonocytes and human brain cells by dynorphin

Chao, C. C., Gekker, G., Hu, S., Sheng, W. S., Portoghese, P. S. & Peterson, P. K., Aug 25 1995, In : Biochemical Pharmacology. 50, 5, p. 715-722 8 p.

Research output: Contribution to journalArticle

Monocyte-Macrophage Precursor Cells
Dynorphins
Coculture Techniques
Viruses
HIV-1
1994
25 Citations (Scopus)
Affinity Labels
Opioid Receptors
Opioid Analgesics
Assays
Tail
45 Citations (Scopus)

Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain

Búzás, B., Izenwasser, S., Portoghese, P. S. & Cox, B. M., Jan 1 1994, In : Life Sciences. 54, 7

Research output: Contribution to journalArticle

delta Opioid Receptor
Adenylyl Cyclases
Rats
Brain
enkephalin, Ser(2), Leu(5), Thr(6)-
52 Citations (Scopus)

Interaction of [d-Pen2, d-Pen5]enkephalin and [d-Ala2, Glu4]deltorphin with δ-opioid receptor subtypes in vivo

Vanderah, T., Takemori, A. E., Sultana, M., Portoghese, P. S., Mosberg, H. I., Hruby, V. J., Haaseth, R. C., Matsunaga, T. O. & Porreca, F., Feb 3 1994, In : European Journal of Pharmacology. 252, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

Enkephalins
Opioid Receptors
naltrindole
Narcotic Antagonists
deltorphin
12 Citations (Scopus)

INTERAKTION VON S-(+)-KETAMIN MIT OPIATREZEPTOREN

Translated title of the contribution: Interaction of S-(+)-ketamine with opiate receptorsFreye, E., Latasch, L., Schmidhammer, H. & Portoghese, P., Jan 1 1994, In : Anaesthesist. 43, SUPPL. 2

Research output: Contribution to journalArticle

Ketamine
Opioid Receptors
Hypnotics and Sedatives
naltrindole
Respiratory Insufficiency
23 Citations (Scopus)

Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice

Miyamoto, Y., Bowen, W. D., Portoghese, P. S. & Takemori, A. E., Jan 1 1994, In : Journal of Pharmacology and Experimental Therapeutics. 270, 1, p. 37-39 3 p.

Research output: Contribution to journalArticle

Morphine Dependence
delta Opioid Receptor
Morphine
Opioid-Related Disorders
Narcotic Antagonists
12 Citations (Scopus)

Molecular modeling of the conformational and sodium ion binding properties of the oligosaccharide component of ganglioside GM1

Rodgers, J. C. & Portoghese, P. S., Jan 1 1994, In : Biopolymers. 34, 10, p. 1311-1326 16 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Oligosaccharides
Molecular modeling
Binding sites
Sugars
95 Citations (Scopus)

Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells

Peterson, P. K., Gekker, G., Hu, S., Anderson, W. R., Kravitz, F., Portoghese, P. S., Balfour, H. H. & Chao, C. C., Mar 1994, In : Journal of Neuroimmunology. 50, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Monocyte-Macrophage Precursor Cells
Morphine
HIV-1
Brain
Coculture Techniques
25 Citations (Scopus)

N-Benzylnaltrindoles as Long-Acting δ-Opioid Receptor Antagonists

Korlipara, V. L., Takemori, A. E. & Portoghese, P. S., Jun 1 1994, In : Journal of Medicinal Chemistry. 37, 12, p. 1882-1885 4 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Enkephalins
Nitrogen
N-benzylnaltrindole
35 Citations (Scopus)
Opioid Receptors
Structure-Activity Relationship
Nitrogen
Acidic Amino Acids
Narcotic Antagonists
25 Citations (Scopus)

Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss webster mice

Rady, J. J., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Jan 1 1994, In : Life Sciences. 55, 8, p. 603-609 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Heroin
naltrindole
Tail
Opioid Receptors
44 Citations (Scopus)

Synthesis of Naltrexone-Derived δ-Opioid Antagonists. Role of Conformation of the δ Address Moiety

Portoghese, P. S., Sultana, M., Moe, S. T. & Takemori, A. E., Mar 1 1994, In : Journal of Medicinal Chemistry. 37, 5, p. 579-585 7 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Benzene
naltrindole
Opioid Receptors
25 Citations (Scopus)

The effect of selective opioid antagonists on butorphanol-induced feeding

Levine, A. S., Grace, M., Portoghese, P. S. & Billington, C. J., Feb 21 1994, In : Brain Research. 637, 1-2, p. 242-248 7 p.

Research output: Contribution to journalArticle

Butorphanol
Narcotic Antagonists
naltrindole
Opioid Receptors
beta-funaltrexamine
62 Citations (Scopus)

κ Opioid Receptor Selective Affinity Labels: Electrophilic Benzeneacetamides as κ Selective Opioid Antagonists

Chang, A. C., Takemori, A. E., Ojala, W. H., Gleason, W. B. & Portoghese, P. S., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 26, p. 4490-4498 9 p.

Research output: Contribution to journalArticle

Benzeneacetamides
Affinity Labels
Narcotic Antagonists
Opioid Receptors
Opioid Analgesics
1993
84 Citations (Scopus)

7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord

Sofuoglu, M., Portoghese, P. S. & Takemori, A. E., 1993, In : Life Sciences. 52, 8, p. 769-775 7 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
Narcotic Antagonists
Opioid Receptors
Spinal Cord
naltrindole
delta Opioid Receptor
7-benzylidenenaltrexone
167 Citations (Scopus)

A single residue, aspartic acid 95, in the δ opioid receptor specifies selective high affinity agonist binding

Kong, H., Raynor, K., Yasuda, K., Moe, S. T., Portoghese, P. S., Bell, G. I. & Reisine, T., Jan 1 1993, In : Journal of Biological Chemistry. 268, 31, p. 23055-23058 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Aspartic Acid
D-Penicillamine (2,5)-Enkephalin
naltrindole
Enkephalins
12 Citations (Scopus)

Differential antagonism by naltrindole-5′-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice

Chakrabarti, S., Sultana, M., Portoghese, P. S. & Takemori, A. E., 1993, In : Life Sciences. 53, 23, p. 1761-1765 5 p.

Research output: Contribution to journalArticle

enkephalin, Ser(2), Leu(5), Thr(6)-
D-Penicillamine (2,5)-Enkephalin
Corpus Striatum
Binding Sites
Opioid Receptors
116 Citations (Scopus)

Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats

Negus, S. S., Henriksen, S. J., Mattox, A., Pasternak, G. W., Portoghese, P. S., Takemori, A. E., Weinger, M. B. & Koob, G. F., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 3, p. 1245-1252 8 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
delta Opioid Receptor
mu Opioid Receptor
Heroin
naltrindole

Effects of naltriben (NTB) on the development and expression of chronic dependence on morphine

Miyamoto, Y., Portoghese, P. S. & Takemori, A. E., Jan 1 1993, In : NIDA Research Monograph Series. 132, 1 p.

Research output: Contribution to journalArticle

Morphine Dependence
naltrindole benzofuran
45 Citations (Scopus)
Enkephalins
Opioid Receptors
Spinal Cord
Brain
Endorphins
28 Citations (Scopus)

Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens

Wild, K. D., Carlisi, V. J., Mosberg, H. I., Bowen, W. D., Portoghese, P. S., Sultana, M., Takemori, A. E., Hruby, V. J. & Porreca, F., Dec 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 264, 2, p. 831-838 8 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Vas Deferens
Enkephalins
Opioid Receptors
76 Citations (Scopus)

Involvement of delta2 opioid receptors in the development of morphine dependence in mice

Miyamoto, Y., Portoghese, P. S. & Takemori, A. E., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 264, 3, p. 1141-1145 5 p.

Research output: Contribution to journalArticle

Morphine Dependence
Opioid Receptors
Morphine
Naloxone
Diarrhea
33 Citations (Scopus)

Involvement of δ2 opioid receptors in acute dependence on morphine in mice

Miyamoto, Y., Portoghese, P. S. & Takemori, A. E., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 3, p. 1325-1327 3 p.

Research output: Contribution to journalArticle

Morphine Dependence
Opioid Receptors
Naloxone
Morphine
Injections
37 Citations (Scopus)

Modulation of morphine antinociception by swim-stress in the mouse: Involvement of supraspinal opioid delta-2 receptors

Vanderah, T. W., Wild, K. D., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D., Hruby, V. J., Mosberg, H. I. & Porreca, F., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 267, 1, p. 449-455 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Morphine
Dehydration
Enkephalins
Antibodies
40 Citations (Scopus)

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Reid, L. D., Hubbell, C. L., Glaccum, M. B., Bilsky, E. J., Portoghese, P. S. & Porreca, F., Jan 1 1993, In : Life Sciences. 52, 9

Research output: Contribution to journalArticle

naltrindole
delta Opioid Receptor
Narcotic Antagonists
Cocaine
Medial Forebrain Bundle
12 Citations (Scopus)

Possible Contribution of a Glutathione Conjugate to the Long-Duration Action of β-Funaltrexamine

Larson, D. L., Hua, M., Takemori, A. E. & Portoghese, P. S., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 23, p. 3669-3673 5 p.

Research output: Contribution to journalArticle

Glutathione
Naltrexone
Narcotic Antagonists
Opioid Receptors
Morphine
23 Citations (Scopus)

Spinal δ2 but not δ1 opioid receptors are involved in intracereboventricular β-endorphin-induced antinociception in the mouse

Tseng, L. F., Collins, K. A. & Portoghese, P. S., 1993, In : Life Sciences. 52, 19, p. PL211-PL215

Research output: Contribution to journalArticle

Endorphins
Opioid Receptors
Tail
Spinal Cord
Ala(2)-MePhe(4)-Gly(5)-enkephalin