Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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Article
2003
1 Citation (Scopus)

Effect of opioid receptor ligands on the μ-S196A knock-in and μ knockout mouse vas deferens

Portoghese, P. S., Law, P-Y. & Loh, H. H., Oct 8 2003, In : European Journal of Pharmacology. 478, 2-3, p. 207-210 4 p.

Research output: Contribution to journalArticle

Vas Deferens
Opioid Receptors
Knockout Mice
Ligands
Morphine
16 Citations (Scopus)

Gras flavoring substances 21

Smith, R. L., Cohen, S. M., Doull, J., Feron, V. J., Goodman, J. I., Marnett, L. J., Portoghese, P. S., Waddell, W. J., Wagner, B. M. & Adams, T. B., May 1 2003, Food Technology, 57, 5, p. 46-53 8 p.

Research output: Contribution to specialist publicationArticle

Food additives
Food Additives
Flavors
flavorings
food additives
44 Citations (Scopus)

Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord

Portoghese, P. S. & Lunzer, M. M., Apr 25 2003, In : European Journal of Pharmacology. 467, 1-3, p. 233-234 2 p.

Research output: Contribution to journalArticle

Opioid Receptors
Spinal Cord
Ants
Narcotic Antagonists
Enkephalins
2002
40 Citations (Scopus)

Kappa opioid antagonist effects of the novel kappa antagonist 5′-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys

Negus, S. S., Mello, N. K., Linsenmayer, D. C., Jones, R. & Portoghese, P. S., Oct 16 2002, In : Psychopharmacology. 163, 3-4, p. 412-419 8 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Macaca mulatta
Appointments and Schedules
Morphine
kappa Opioid Receptor
15 Citations (Scopus)

Methadone and heroin antinociception: Predominant δ-opioid-receptor responses in methadone-tolerant mice

Rady, J. J., Portoghese, P. S. & Fujimoto, J. M., Apr 23 2002, In : Japanese Journal of Pharmacology. 88, 3, p. 319-331 13 p.

Research output: Contribution to journalArticle

Methadone
Heroin
Opioid Receptors
Morphine
gamma-Aminobutyric Acid
11 Citations (Scopus)

Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: Application to opioid receptor affinity labels with greatly improved fluorogenic properties

McCurdy, C. R., Le Bourdonnec, B., Metzger, T. G., El Kouhen, R., Zhang, Y., Law, P-Y. & Portoghese, P. S., Jul 4 2002, In : Journal of Medicinal Chemistry. 45, 14, p. 2887-2890 4 p.

Research output: Contribution to journalArticle

Affinity Labels
Opioid Receptors
Opiate Alkaloids
Isoindoles
Fluorescence
2001
11 Citations (Scopus)

Affinity labels as tools for the identification of opioid receptor recognition sites

Portoghese, P. S., El Kouhen, R., Law, P-Y., Loh, H. H. & Le Bourdonnec, B., Apr 1 2001, In : Farmaco. 56, 3, p. 191-196 6 p.

Research output: Contribution to journalArticle

Affinity Labels
Opioid Receptors
Opioid Analgesics
Isoindoles
Narcotic Antagonists
32 Citations (Scopus)
Opioid Receptors
Muscle Contraction
Ileum
Swine
Neurons
166 Citations (Scopus)
Opioid Receptors
Ligands
Narcotic Antagonists
Opioid Analgesics
Lipid Bilayers
23 Citations (Scopus)

GRAS flavoring substances 20

Smith, R. L., Doull, J., Feron, V. J., Goodman, J. I., Munro, I. C., Newberne, P. M., Portoghese, P. S., Waddell, W. J., Wagner, B. M., Adams, T. B. & McGowen, M. M., Jan 1 2001, Food Technology, 55, 12 1 p.

Research output: Contribution to specialist publicationArticle

77 Citations (Scopus)
Oxymorphone
Naltrexone
Opioid Receptors
Site-Directed Mutagenesis
naltrindole
4 Citations (Scopus)

Molecular recognition at kappa opioid receptors

Portoghese, P. S., Jan 1 2001, In : Pure and Applied Chemistry. 73, 9, p. 1387-1391 5 p.

Research output: Contribution to journalArticle

Molecular recognition
kappa Opioid Receptor
Mutagenesis
naltrindole
Narcotic Antagonists
19 Citations (Scopus)
D-Penicillamine (2,5)-Enkephalin
Ion Transport
Opioid Receptors
Opioid Analgesics
Mucous Membrane
2 Citations (Scopus)
Immunologic Adjuvants
Central Nervous System Infections
Psychotropic Drugs
Narcotics
Microglia
34 Citations (Scopus)
Butorphanol
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Narcotic Antagonists
Neuropeptide Y
kappa Opioid Receptor
45 Citations (Scopus)

Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole

Kumar Sharma, S., Jones, R. M., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jun 21 2001, In : Journal of Medicinal Chemistry. 44, 13, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Guanidine
Opioid Receptors
Site-Directed Mutagenesis
42 Citations (Scopus)

κ-opioid receptor agonist suppression of HIV-1 expression in CD4 + lymphocytes

Peterson, P. K., Gekker, G., Lokensgard, J. R., Bidlack, J. M., Chang, A. C., Fang, X. & Portoghese, P. S., May 1 2001, In : Biochemical Pharmacology. 61, 9, p. 1145-1151 7 p.

Research output: Contribution to journalArticle

Lymphocytes
Opioid Receptors
HIV-1
Ligands
Antiviral Agents
2000
71 Citations (Scopus)

5'-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonist

Jones, R. M. & Portoghese, P. S., May 12 2000, In : European Journal of Pharmacology. 396, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Smooth Muscle
Opioid Receptors
Cricetulus
Opioid Analgesics
39 Citations (Scopus)
kappa Opioid Receptor
mu Opioid Receptor
Narcotic Antagonists
COS Cells
norbinaltorphimine
33 Citations (Scopus)

GRAS flavoring substances 19

Newberne, P., Smith, R. L., Doull, J., Feron, V. J., Goodman, J. I., Munro, I. C., Portoghese, P. S., Waddell, W. J., Wagner, B. M., Weil, C. S., Adams, T. B. & Hallagan, J. B., Jun 1 2000, Food Technology, 54, 6.

Research output: Contribution to specialist publicationArticle

flavorings
18 Citations (Scopus)

Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone

McCurdy, C. R., Jones, R. M. & Portoghese, P. S., Mar 23 2000, In : Organic Letters. 2, 6, p. 819-821 3 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Oxymorphone
Naltrexone
Sulfonamides
analogs
74 Citations (Scopus)

Molecular docking reveals a novel binding site model for fentanyl at the μ-opioid receptor

Subramanian, G., Paterlini, M. G., Portoghese, P. S. & Ferguson, D. M., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

Opioid Receptors
Fentanyl
Binding Sites
Ligands
Opiate Alkaloids
11 Citations (Scopus)

Morphine tolerance in mice changes response of heroin from μ to δ opioid receptors

Rady, J. J., Holmes, B. B., Portoghese, P. S. & Fujimoto, J. M., Jun 1 2000, In : Proceedings of the Society for Experimental Biology and Medicine. 224, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

Heroin
Opioid Receptors
Morphine
Brain
naltrindole
83 Citations (Scopus)

Potent and selective indolomorphinan antagonists of the kappa-opioid receptor

Stevens, W. C., Jones, R. M., Subramanian, G., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Guanidines
naltrindole
Guanidine
Amines
77 Citations (Scopus)

Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1

Paterlini, M. G., Avitabile, F., Ostrowski, B. G., Ferguson, D. M. & Portoghese, P. S., Jan 1 2000, In : Biophysical journal. 78, 2, p. 590-599 10 p.

Research output: Contribution to journalArticle

Opioid Peptides
Peptides
Enkephalins
Ileum
Proline
1999
53 Citations (Scopus)

Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: Implication of an atypical μ-opoid receptor

Peterson, P. K., Gekker, G., Hu, S., Lokensgard, J. R., Portoghese, P. S. & Chao, C. C., Feb 1 1999, In : Neuropharmacology. 38, 2, p. 273-278 6 p.

Research output: Contribution to journalArticle

HIV-1
Cell Culture Techniques
Opioid Receptors
Brain
Opioid Peptides
6 Citations (Scopus)
activity structure
Recombinant DNA
Pharmaceutical Chemistry
Opioid Analgesics
chemistry
64 Citations (Scopus)

The δ2-opioid receptor antagonist naltriben reduces motivated responding for ethanol

June, H. L., McCane, S. R., Zink, R. W., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Dec 1 1999, In : Psychopharmacology. 147, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Saccharin
Ethanol
Naloxone
Alcohols
1998
9 Citations (Scopus)

14-desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: The role of the 14-hyroxy group at δ opioid receptors

Kshirsagar, T. A., Fang, X. & Portoghese, P. S., Jul 2 1998, In : Journal of Medicinal Chemistry. 41, 14, p. 2657-2660 4 p.

Research output: Contribution to journalArticle

naltrindole
Opioid Receptors
Ligands
Opioid Analgesics
7-spiroindanyloxymorphone
8 Citations (Scopus)

7-Arylidenenaltrexones as selective δ1 opioid receptor antagonists

Ohkawa, S. & Portoghese, P. S., Oct 8 1998, In : Journal of Medicinal Chemistry. 41, 21, p. 4177-4180 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Ligands
Enkephalins
Morphine
Smooth Muscle
52 Citations (Scopus)

Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists

Subramanian, G., Germana Paterlini, M., Larson, D. L., Portoghese, P. S. & Ferguson, D. M., Nov 19 1998, In : Journal of Medicinal Chemistry. 41, 24, p. 4777-4789 13 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Ligands
Molecular Dynamics Simulation
Opiate Alkaloids
Space Flight
59 Citations (Scopus)

Contribution of the opioid system to alcohol aversion and alcohol drinking behavior

Froehlich, J. C., Badia-Elder, N. E., Zink, R. W., McCullough, D. E. & Portoghese, P. S., Dec 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 287, 1, p. 284-292 9 p.

Research output: Contribution to journalArticle

Drinking Behavior
Alcohol Drinking
naltrindole
Opioid Analgesics
Alcohols
91 Citations (Scopus)

Effect of Mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking

Krishnan-Sarin, S., Wand, G. S., Li, X. W., Portoghese, P. S. & Froehlich, J. C., Mar 1 1998, In : Pharmacology Biochemistry and Behavior. 59, 3, p. 627-635 9 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Alcohol Drinking
Rats
beta-funaltrexamine
Alcohols
17 Citations (Scopus)

GRAS flavoring substances 18

Newberne, P., Smith, R. L., Doull, J., Goodman, J. I., Munro, I. C., Portoghese, P. S., Wagner, B. M., Weil, C. S., Woods, L. A., Adams, T. B., Hallagan, J. B. & Ford, R. A., Sep 1998, In : Food Technology. 52, 9, p. 58-76 19 p.

Research output: Contribution to journalArticle

Food additives
Food Additives
Flavors
flavorings
food additives
11 Citations (Scopus)

NTI4F: A non-peptide fluorescent probe selective for functional delta opioid receptors

Kshirsagar, T., Nakano, A. H., Law, P-Y., Elde, R. & Portoghese, P. S., Jun 19 1998, In : Neuroscience Letters. 249, 2-3, p. 83-86 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Opioid Receptors
Fluorescent Dyes
naltrindole
Ethylketocyclazocine
15 Citations (Scopus)

Synthesis of 7-arylmorphinans. Probing the 'address' requirements for selectivity at opioid δ receptors

Gao, P., Larson, D. L. & Portoghese, P. S., Jul 30 1998, In : Journal of Medicinal Chemistry. 41, 16, p. 3091-3098 8 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
naltrindole
Opioid Receptors
Morphinans
Oxymorphone
50 Citations (Scopus)

The FEMA GRAS assessment of lactones used as flavour ingredients

Adams, T. B., Greer, D. B., Doull, J., Munro, I. C., Newberne, P., Portoghese, P. S., Smith, R. L., Wagner, B. M., Weil, C. S., Woods, L. A. & Ford, R. A., Apr 6 1998, In : Food and Chemical Toxicology. 36, 4, p. 249-278 30 p.

Research output: Contribution to journalArticle

Lactones
lactones
ingredients
flavor
8 Citations (Scopus)

The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Linner, K. M., Stickney, B. J., Quist, H. E., Sharp, B. M. & Portoghese, P. S., Jul 31 1998, In : European Journal of Pharmacology. 354, 1

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Allografts
Kidney
Opioid Receptors
1997
11 Citations (Scopus)

7-Spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands

Fang, X., Larson, D. L. & Portoghese, P. S., Sep 26 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3064-3070 7 p.

Research output: Contribution to journalArticle

Oxymorphone
Hydromorphone
Naltrexone
naltrindole
Opioid Receptors
18 Citations (Scopus)

7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for δ opioid receptors

Ohkawa, S., DiGiacomo, B., Larson, D. L., Takemori, A. E. & Portoghese, P. S., May 23 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1720-1725 6 p.

Research output: Contribution to journalArticle

Oxymorphone
Naltrexone
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
Ligands
4 Citations (Scopus)

A guinea pig ileum preparation devoid of functional κ receptors: A new in vitro pharmacologic assay for μ-opioid ligands

Schwartz, R. W., Chang, A. C., Portoghese, P. S. & Berzetei-Gurske, I. P., Mar 7 1997, In : Life Sciences. 60, 15

Research output: Contribution to journalArticle

Opioid Receptors
Ileum
Opioid Analgesics
Assays
Guinea Pigs
124 Citations (Scopus)

Effects of kappa opioids on cocaine self-administration by rhesus monkeys

Negus, S. S., Mello, N. K., Portoghese, P. S. & Lin, C. E., Jul 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 1, p. 44-55 12 p.

Research output: Contribution to journalArticle

Self Administration
Macaca mulatta
Cocaine
Ethylketocyclazocine
Opioid Analgesics
8 Citations (Scopus)

Fluorescent N-benzylnaltrindole analogues as potential delta opioid receptor selective probes

Korlipara, V., Ells, J., Wang, J., Tam, S., Elde, R. & Portoghese, P. S., Jan 1 1997, In : European Journal of Medicinal Chemistry. 32, 2, p. 171-174 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Fluorescent Dyes
N-benzylnaltrindole
15 Citations (Scopus)
Capsaicin
Substance P
Spinal Cord
substance P (1-7)

Medicinal chemistry as we start the next millennium

Portoghese, P. S., Dec 1 1997, In : Pharmacochemistry Library. 28, C, p. 409-419 11 p.

Research output: Contribution to journalArticle

Pharmaceutical Chemistry
Technology
Genetic engineering
Paint
Recombinant DNA
72 Citations (Scopus)
Dynorphins
Chemical activation
Opioid Analgesics
Opioid Receptors
Ligands
47 Citations (Scopus)

Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor

Clark, M. J., Emmerson, P. J., Mansour, A., Akil, H., Woods, J. H., Portoghese, P. S., Remmers, A. E. & Medzihradsky, F., Nov 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 283, 2, p. 501-510 10 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Glioma
Opioid Analgesics
Ligands
23 Citations (Scopus)

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

Farouz-Grant, F. & Portoghese, P. S., Jun 20 1997, In : Journal of Medicinal Chemistry. 40, 13, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Smooth Muscle
Muscle
Substitution reactions
5 Citations (Scopus)

Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss webster mice

Rady, J. J., Baemmert, D., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Feb 1 1997, In : Pharmacology Biochemistry and Behavior. 56, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Enkephalins
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
Endorphins
46 Citations (Scopus)

The FEMA GRAS assessment of furfural used as a flavour ingredient

Adams, T. B., Doull, J., Goodman, J. I., Munro, I. C., Newberne, P., Portoghese, P. S., Smith, R. L., Wagner, B. M., Weil, C. S., Woods, L. A. & Ford, R. A., Jan 1 1997, In : Food and Chemical Toxicology. 35, 8, p. 739-751 13 p.

Research output: Contribution to journalArticle

Furaldehyde
furfural
Flavors
ingredients
flavor