Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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1961
15 Citations (Scopus)

Relative hydrolytic rates of certain alkyl (b) dl‐α‐(2‐piperidyl)‐phenylacetates

Portoghese, P. S. & Malspeis, L., Jan 1 1961, In : Journal of Pharmaceutical Sciences. 50, 6, p. 494-501 8 p.

Research output: Contribution to journalArticle

Phenylacetates
Esters
Hydrolysis
Hydroxyl Radical

Stereochemistry of the Cyclization of the Half-Esters of Diarylitaeonic Acid

Smissman, E. E., Portoghese, P. S. & Mode, R. A., Jan 1 1961, In : Journal of Organic Chemistry. 26, 10, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

Stereochemistry
Cyclization
Condensation
Esters
Acids
1962
6 Citations (Scopus)

Stereoaspects of the Prins Reaction of Anethole

Portoghese, P. S. & Smissman, E. E., Mar 1 1962, In : Journal of Organic Chemistry. 27, 3, p. 719-722 4 p.

Research output: Contribution to journalArticle

Stereochemistry
Formaldehyde
Condensation
Hydrogen bonds
Ions

β-Terpinene and β-Phellandrene from the Pyrolysis of Sabinene

Portoghese, P. S., Sep 1 1962, In : Journal of Organic Chemistry. 27, 9, 1 p.

Research output: Contribution to journalArticle

Pyrolysis
beta-phellandrene
gamma-terpinene
sabinene
1964
3 Citations (Scopus)
Analgesics
Alanine
3-chloro-4,4-dimethyl-2-oxazolidinone
1965
188 Citations (Scopus)

A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

Portoghese, P. S., Sep 1 1965, In : Journal of Medicinal Chemistry. 8, 5, p. 609-616 8 p.

Research output: Contribution to journalArticle

Narcotics
Analgesics
26 Citations (Scopus)

Mechanism of the Prins Reaction. Stereoaspects of the Formation of 1,3-Dioxanes

Smissman, E. E., Schnettler, R. A. & Portoghese, P. S., Mar 1 1965, In : Journal of Organic Chemistry. 30, 3, p. 797-801 5 p.

Research output: Contribution to journalArticle

Dioxanes
Alkenes
Formaldehyde
3 Citations (Scopus)

Stereochemical Studies on Medicinal Agents. II. Absolute Configuration of (-)-Phenampromide

Portoghese, P. S., Mar 1 1965, In : Journal of Medicinal Chemistry. 8, 2, p. 147-150 4 p.

Research output: Contribution to journalArticle

Phenylalanine
aniline
1966
45 Citations (Scopus)

Bicyclic Bases. Synthesis of 2,5-Diazabicyclo[2.2.1]heptanes

Portoghese, P. S. & Mikhail, A. A., Apr 1 1966, In : Journal of Organic Chemistry. 31, 4, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

Heptanes
Proline
Derivatives
benzylamine
prolinol
5 Citations (Scopus)

Stereochemistry of isomethadol isomers

Portoghese, P. S. & Williams, D. A., Jan 1 1966, In : Tetrahedron Letters. 7, 50, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

1967
95 Citations (Scopus)
Ephedrine
Hydrogen
Structure-Activity Relationship
Epinephrine
Amines
1968
31 Citations (Scopus)

Stereochemical Studies on Medicinal Agents. V.1 Synthesis, Configuration, and Pharmacological Activity of Pipradrol Enantiomers

Portoghese, P. S., Pazdernik, T. L., Kuhn, W. L., Hite, G. & Shafi’ee, A., Jan 1 1968, In : Journal of Medicinal Chemistry. 11, 1, p. 12-15 4 p.

Research output: Contribution to journalArticle

Central Nervous System Stimulants
Pharmacology
Amphetamine
Anticonvulsants
pipradrol
33 Citations (Scopus)
Heptanes
Meperidine
Pharmacology
Brain
1969
4 Citations (Scopus)

Chemical and nuclear magnetic resonance studies of 3,3‐diphenyltetrahydrofuran derivatives

Portoghese, P. S. & Williams, D. A., Jan 1 1969, In : Journal of Heterocyclic Chemistry. 6, 3, p. 307-312 6 p.

Research output: Contribution to journalArticle

Isomers
Conformations
Methadyl Acetate
Nuclear magnetic resonance
Derivatives
25 Citations (Scopus)
Methadyl Acetate
Methadone
1970
19 Citations (Scopus)

Stereochemical studies on medicinal agents. 8. Absolute stereochemistries of isomethadol isomers.

Portoghese, P. S. & Williams, D. A., Jul 1 1970, In : Journal of Medicinal Chemistry. 13, 4, p. 626-630 5 p.

Research output: Contribution to journalArticle

Stereochemistry
Isomers
Isomerism
Enantiomers
Methadone
1971
17 Citations (Scopus)

Bicyclic bases. Synthesis, configuration, and NMR analysis of N-tosyl-2-thia-5-azabicyclo[2.2.1]heptane-2-oxides

Portoghese, P. S. & Telang, V. G., Jan 1 1971, In : Tetrahedron. 27, 10, p. 1823-1829 7 p.

Research output: Contribution to journalArticle

sulfoxide
Heptanes
Sulfones
Oxides
Anions
20 Citations (Scopus)

Bicyclic bases. Synthesis and nuclear magnetic resonance investigation of some chiral 2-oxa-5-azabicyclo[2.2.1]Heptane derivatives

Portoghese, P. S. & Turcotte, J. G., Jan 1 1971, In : Tetrahedron. 27, 5, p. 961-967 7 p.

Research output: Contribution to journalArticle

Heptanes
Proline
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Derivatives
6 Citations (Scopus)

Bieyclic bases . Synthesis and stereochemical studies of chiral 5‐substituted N‐tosyl‐2‐azabicyclo[2.2.1[ heptanes

Portoghese, P. S., Lattin, D. L. & Telang, V. G., Dec 1971, In : Journal of Heterocyclic Chemistry. 8, 6, p. 993-998 6 p.

Research output: Contribution to journalArticle

Heptanes
Geometry
7 Citations (Scopus)

Interaction between an amide nitrogen lone pair and a noncontiguous carbonyl carbon and its effect on amide rotation

Portoghese, P. S. & Turcotte, J. G., Dec 1 1971, In : Nature. 230, 5294, p. 457-459 3 p.

Research output: Contribution to journalArticle

Amides
Nitrogen
Carbon
Carbon Monoxide
Magnetic Resonance Spectroscopy
18 Citations (Scopus)

Potential Nonequilibrium Analgetic Receptor Inactivators. Synthesis and Biological Activities of N-Acylanileridines

Portoghese, P. S., Telang, V. G., Takemoei, A. E. & Hayashi, G., Feb 1 1971, In : Journal of Medicinal Chemistry. 14, 2, p. 144-148 5 p.

Research output: Contribution to journalArticle

Naloxone
Narcotic Antagonists
18 Citations (Scopus)
Phenoxybenzamine
Alanine
Adrenergic Agents
Adrenergic Receptors
10 Citations (Scopus)
Heptanes
Cholinergic Antagonists
Ileum
Guinea Pigs
7 Citations (Scopus)
Isomerism
Drug Receptors
Energy Transfer
Structure-Activity Relationship
Theoretical Models
1972
73 Citations (Scopus)

N-Demethylation of Morphine and Structurally Related Compounds with Chloroformate Estersf

Abdel-Monem, M. M. & Portoghese, P. S., Feb 1 1972, In : Journal of Medicinal Chemistry. 15, 2, p. 208-210 3 p.

Research output: Contribution to journalArticle

Morphinans
Formates
Infrared Rays
Carbon Isotopes
Dealkylation
6 Citations (Scopus)

Pharmacokinetics, Metabolism, and Urinary Excretion of [3H]Alphaprodine in Dogsf

Abdel-Monem, M. M., Harris, P. A. & Portoghese, P. S., Jul 1 1972, In : Journal of Medicinal Chemistry. 15, 7, p. 706-708 3 p.

Research output: Contribution to journalArticle

Alphaprodine
Pharmacokinetics
Plasma Volume
Narcotics
Urine

Prostaglandins: the once-a-month birth control pill of the future.

Portoghese, P. S., Mar 1 1972, In : Minnesota pharmacist. 26, 6, p. 8-9 2 p.

Research output: Contribution to journalArticle

Contraception
Prostaglandins
Dinoprost
Umbilical Cord
Dinoprostone
25 Citations (Scopus)

Stereochemical Studies on Medicinal Agents. 11.†, 1 Metabolism and Distribution of Prodine Isomers in Mice

Abdel-Monem, M. M., Larson, D. L., Kupferberg, H. J. & Portoghese, P. S., May 1 1972, In : Journal of Medicinal Chemistry. 15, 5, p. 494-500 7 p.

Research output: Contribution to journalArticle

Alphaprodine
Amides
Blood Proteins
Brain
1973
23 Citations (Scopus)

2-azatricyclo[2.2.1.01,6]heptane: Synthesis and conversion to 2-azabicyclo[2.2.1]heptanes

Portoghese, P. S. & Sepp, D. T., Jan 1 1973, In : Tetrahedron. 29, 15, p. 2253-2256 4 p.

Research output: Contribution to journalArticle

Heptanes
Acetates
Nitrogen
Oxidation
5 Citations (Scopus)
Nipecotic Acids
Isotope Labeling
Nitrosamines
Meperidine
Tritium
23 Citations (Scopus)
Alphaprodine
Isomerism
Morphine
4-propionyloxy-4-phenyl-N-methylpiperidine
1974
12 Citations (Scopus)

Potential Nonequilibrium Analgetic Receptor inactIvators. Further Pharmacologic Studies of N-Acylanileridines

Takemori, A. E., Ward, A., Portoghese, P. S. & Telang, V. G., Oct 1 1974, In : Journal of Medicinal Chemistry. 17, 10, p. 1051-1054 4 p.

Research output: Contribution to journalArticle

Ileum
Analgesia
Morphine
Analgesics
Guinea Pigs
18 Citations (Scopus)
Methadone
Circular Dichroism
Protons
Magnetic Resonance Spectroscopy
Salts
17 Citations (Scopus)
Alphaprodine
Morphine
4-propionyloxy-4-phenyl-N-methylpiperidine
15 Citations (Scopus)
Promedol
Alphaprodine
Drug Receptors
Drug Interactions
Morphine
4-phenylpiperidine
1975
15 Citations (Scopus)

Oxidation of oxyphenbutazone by sheep vesicular gland microsomes and lipoxygenase

Portoghese, P. S., Svanborg, K. & Samuelsson, B., Apr 7 1975, In : Biochemical and Biophysical Research Communications. 63, 3, p. 748-755 8 p.

Research output: Contribution to journalArticle

Oxyphenbutazone
Prostaglandin Antagonists
Lipoxygenase
Biosynthesis
Liquid chromatography
1976
9 Citations (Scopus)

A simple, stereoselective synthesis of a prostaglandin endoperoxide analog

Abatjoglou, A. G. & Portoghese, P. S., Jan 1 1976, In : Tetrahedron Letters. 17, 18, p. 1457-1460 4 p.

Research output: Contribution to journalArticle

Synthetic Prostaglandin Endoperoxides
25 Citations (Scopus)

Correlation of Opiate Receptor Affinity with Analgetic Effects of Meperidine Homologs

Pert, C. B., Snyder, S. H. & Portoghese, P. S., Oct 1 1976, In : Journal of Medicinal Chemistry. 19, 10, p. 1248-1250 3 p.

Research output: Contribution to journalArticle

Meperidine
Opioid Receptors
Drug Receptors
Brain
Carbon
11 Citations (Scopus)

Relation between Analgetic ED50 Dose and Time-Course Brain Levels of N-Alkylnormeperidine Homologs

Larson, D. L. & Portoghese, P. S., Jan 1 1976, In : Journal of Medicinal Chemistry. 19, 1, p. 16-19 4 p.

Research output: Contribution to journalArticle

Dealkylation
Brain
Meperidine
Liver
Lipid Metabolism
14 Citations (Scopus)
Methadone
Stereoisomerism
Hydrogen
5-methylmethadone
isomethadone
17 Citations (Scopus)

Synthesis and Adrenoreceptor Blocking Action of Aziridinium Ions Derived from Phenoxybenzamine and Dibenamine

Henkel, J. G., Portoghese, P. S., Miller, J. W. & Lewis, P., Jan 1 1976, In : Journal of Medicinal Chemistry. 19, 1, p. 6-10 5 p.

Research output: Contribution to journalArticle

Dibenzylchlorethamine
Phenoxybenzamine
Ions
Adrenergic Agents
Vas Deferens
1977
11 Citations (Scopus)

3-Hydroxy-17-aralkylmorphinans as Potential Opiate Receptor-Site-Directed Alkylating Agents

Portoghese, P. S., Hanson, R. N., Telang, V. G., Winger, J. L. & Takemori, A. E., Aug 1 1977, In : Journal of Medicinal Chemistry. 20, 8, p. 1020-1024 5 p.

Research output: Contribution to journalArticle

Alkylating Agents
Opioid Receptors
Opiate Alkaloids
Analgesia
Morphine
10 Citations (Scopus)

A Novel Prostaglandin Endoperoxide Mimic, Prostaglandin F Acetal

Portoghese, P. S., Larson, D. L., Abatjoglou, A. G., Dunham, E. W., Gerrard, J. M. & White, J. G., Feb 1 1977, In : Journal of Medicinal Chemistry. 20, 2, p. 320-321 2 p.

Research output: Contribution to journalArticle

Prostaglandin Endoperoxides
Synthetic Prostaglandins
Acetals
Dinoprost
Gerbillinae