Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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Article
1997
5 Citations (Scopus)

Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss webster mice

Rady, J. J., Baemmert, D., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Feb 1 1997, In : Pharmacology Biochemistry and Behavior. 56, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Enkephalins
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
Endorphins
46 Citations (Scopus)

The FEMA GRAS assessment of furfural used as a flavour ingredient

Adams, T. B., Doull, J., Goodman, J. I., Munro, I. C., Newberne, P., Portoghese, P. S., Smith, R. L., Wagner, B. M., Weil, C. S., Woods, L. A. & Ford, R. A., Jan 1 1997, In : Food and Chemical Toxicology. 35, 8, p. 739-751 13 p.

Research output: Contribution to journalArticle

Furaldehyde
furfural
Flavors
ingredients
flavor
1998
9 Citations (Scopus)

14-desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: The role of the 14-hyroxy group at δ opioid receptors

Kshirsagar, T. A., Fang, X. & Portoghese, P. S., Jul 2 1998, In : Journal of Medicinal Chemistry. 41, 14, p. 2657-2660 4 p.

Research output: Contribution to journalArticle

naltrindole
Opioid Receptors
Ligands
Opioid Analgesics
7-spiroindanyloxymorphone
8 Citations (Scopus)

7-Arylidenenaltrexones as selective δ1 opioid receptor antagonists

Ohkawa, S. & Portoghese, P. S., Oct 8 1998, In : Journal of Medicinal Chemistry. 41, 21, p. 4177-4180 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Ligands
Enkephalins
Morphine
Smooth Muscle
52 Citations (Scopus)

Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists

Subramanian, G., Germana Paterlini, M., Larson, D. L., Portoghese, P. S. & Ferguson, D. M., Nov 19 1998, In : Journal of Medicinal Chemistry. 41, 24, p. 4777-4789 13 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Ligands
Molecular Dynamics Simulation
Opiate Alkaloids
Space Flight
59 Citations (Scopus)

Contribution of the opioid system to alcohol aversion and alcohol drinking behavior

Froehlich, J. C., Badia-Elder, N. E., Zink, R. W., McCullough, D. E. & Portoghese, P. S., Dec 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 287, 1, p. 284-292 9 p.

Research output: Contribution to journalArticle

Drinking Behavior
Alcohol Drinking
naltrindole
Opioid Analgesics
Alcohols
91 Citations (Scopus)

Effect of Mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking

Krishnan-Sarin, S., Wand, G. S., Li, X. W., Portoghese, P. S. & Froehlich, J. C., Mar 1 1998, In : Pharmacology Biochemistry and Behavior. 59, 3, p. 627-635 9 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Alcohol Drinking
Rats
beta-funaltrexamine
Alcohols
17 Citations (Scopus)

GRAS flavoring substances 18

Newberne, P., Smith, R. L., Doull, J., Goodman, J. I., Munro, I. C., Portoghese, P. S., Wagner, B. M., Weil, C. S., Woods, L. A., Adams, T. B., Hallagan, J. B. & Ford, R. A., Sep 1998, In : Food Technology. 52, 9, p. 58-76 19 p.

Research output: Contribution to journalArticle

Food additives
Food Additives
Flavors
flavorings
food additives
11 Citations (Scopus)

NTI4F: A non-peptide fluorescent probe selective for functional delta opioid receptors

Kshirsagar, T., Nakano, A. H., Law, P-Y., Elde, R. & Portoghese, P. S., Jun 19 1998, In : Neuroscience Letters. 249, 2-3, p. 83-86 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Opioid Receptors
Fluorescent Dyes
naltrindole
Ethylketocyclazocine
15 Citations (Scopus)

Synthesis of 7-arylmorphinans. Probing the 'address' requirements for selectivity at opioid δ receptors

Gao, P., Larson, D. L. & Portoghese, P. S., Jul 30 1998, In : Journal of Medicinal Chemistry. 41, 16, p. 3091-3098 8 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
naltrindole
Opioid Receptors
Morphinans
Oxymorphone
52 Citations (Scopus)

The FEMA GRAS assessment of lactones used as flavour ingredients

Adams, T. B., Greer, D. B., Doull, J., Munro, I. C., Newberne, P., Portoghese, P. S., Smith, R. L., Wagner, B. M., Weil, C. S., Woods, L. A. & Ford, R. A., Apr 6 1998, In : Food and Chemical Toxicology. 36, 4, p. 249-278 30 p.

Research output: Contribution to journalArticle

Flavors
Lactones
8 Citations (Scopus)

The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Linner, K. M., Stickney, B. J., Quist, H. E., Sharp, B. M. & Portoghese, P. S., Jul 31 1998, In : European Journal of Pharmacology. 354, 1

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Allografts
Kidney
Opioid Receptors
1999
54 Citations (Scopus)

Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: Implication of an atypical μ-opoid receptor

Peterson, P. K., Gekker, G., Hu, S., Lokensgard, J. R., Portoghese, P. S. & Chao, C. C., Feb 1 1999, In : Neuropharmacology. 38, 2, p. 273-278 6 p.

Research output: Contribution to journalArticle

HIV-1
Cell Culture Techniques
Opioid Receptors
Brain
Opioid Peptides
6 Citations (Scopus)
activity structure
Recombinant DNA
Pharmaceutical Chemistry
Opioid Analgesics
chemistry
64 Citations (Scopus)

The δ2-opioid receptor antagonist naltriben reduces motivated responding for ethanol

June, H. L., McCane, S. R., Zink, R. W., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Dec 1 1999, In : Psychopharmacology. 147, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Saccharin
Ethanol
Naloxone
Alcohols
2000
71 Citations (Scopus)

5'-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonist

Jones, R. M. & Portoghese, P. S., May 12 2000, In : European Journal of Pharmacology. 396, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Smooth Muscle
Opioid Receptors
Cricetulus
Opioid Analgesics
39 Citations (Scopus)
kappa Opioid Receptor
mu Opioid Receptor
Narcotic Antagonists
COS Cells
norbinaltorphimine
18 Citations (Scopus)

Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone

McCurdy, C. R., Jones, R. M. & Portoghese, P. S., Mar 23 2000, In : Organic Letters. 2, 6, p. 819-821 3 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Oxymorphone
Naltrexone
Sulfonamides
analogs
75 Citations (Scopus)

Molecular docking reveals a novel binding site model for fentanyl at the μ-opioid receptor

Subramanian, G., Paterlini, M. G., Portoghese, P. S. & Ferguson, D. M., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

Opioid Receptors
Fentanyl
Binding Sites
Ligands
Opiate Alkaloids
11 Citations (Scopus)

Morphine tolerance in mice changes response of heroin from μ to δ opioid receptors

Rady, J. J., Holmes, B. B., Portoghese, P. S. & Fujimoto, J. M., Jun 1 2000, In : Proceedings of the Society for Experimental Biology and Medicine. 224, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

Heroin
Opioid Receptors
Morphine
Brain
naltrindole
83 Citations (Scopus)

Potent and selective indolomorphinan antagonists of the kappa-opioid receptor

Stevens, W. C., Jones, R. M., Subramanian, G., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Guanidines
naltrindole
Guanidine
Amines
77 Citations (Scopus)

Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1

Paterlini, M. G., Avitabile, F., Ostrowski, B. G., Ferguson, D. M. & Portoghese, P. S., Jan 1 2000, In : Biophysical journal. 78, 2, p. 590-599 10 p.

Research output: Contribution to journalArticle

Opioid Peptides
Peptides
Enkephalins
Ileum
Proline
2001
11 Citations (Scopus)

Affinity labels as tools for the identification of opioid receptor recognition sites

Portoghese, P. S., El Kouhen, R., Law, P-Y., Loh, H. H. & Le Bourdonnec, B., Apr 1 2001, In : Farmaco. 56, 3, p. 191-196 6 p.

Research output: Contribution to journalArticle

Affinity Labels
Opioid Receptors
Opioid Analgesics
Isoindoles
Narcotic Antagonists
32 Citations (Scopus)
Opioid Receptors
Muscle Contraction
Ileum
Swine
Neurons
167 Citations (Scopus)
Opioid Receptors
Ligands
Narcotic Antagonists
Opioid Analgesics
Lipid Bilayers
77 Citations (Scopus)
Oxymorphone
Naltrexone
Opioid Receptors
Site-Directed Mutagenesis
naltrindole
4 Citations (Scopus)

Molecular recognition at kappa opioid receptors

Portoghese, P. S., Jan 1 2001, In : Pure and Applied Chemistry. 73, 9, p. 1387-1391 5 p.

Research output: Contribution to journalArticle

Molecular recognition
kappa Opioid Receptor
Mutagenesis
naltrindole
Narcotic Antagonists
19 Citations (Scopus)
D-Penicillamine (2,5)-Enkephalin
Ion Transport
Opioid Receptors
Opioid Analgesics
Mucous Membrane
2 Citations (Scopus)
Immunologic Adjuvants
Central Nervous System Infections
Psychotropic Drugs
Narcotics
Microglia
34 Citations (Scopus)
Butorphanol
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Narcotic Antagonists
Neuropeptide Y
kappa Opioid Receptor
45 Citations (Scopus)

Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole

Kumar Sharma, S., Jones, R. M., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jun 21 2001, In : Journal of Medicinal Chemistry. 44, 13, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Guanidine
Opioid Receptors
Site-Directed Mutagenesis
42 Citations (Scopus)

κ-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes

Peterson, P. K., Gekker, G., Lokensgard, J. R., Bidlack, J. M., Chang, A. C., Fang, X. & Portoghese, P. S., May 1 2001, In : Biochemical Pharmacology. 61, 9, p. 1145-1151 7 p.

Research output: Contribution to journalArticle

Lymphocytes
Opioid Receptors
HIV-1
Ligands
Antiviral Agents
2002
40 Citations (Scopus)

Kappa opioid antagonist effects of the novel kappa antagonist 5′-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys

Negus, S. S., Mello, N. K., Linsenmayer, D. C., Jones, R. & Portoghese, P. S., Oct 16 2002, In : Psychopharmacology. 163, 3-4, p. 412-419 8 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Macaca mulatta
Appointments and Schedules
Morphine
kappa Opioid Receptor
15 Citations (Scopus)

Methadone and heroin antinociception: Predominant δ-opioid-receptor responses in methadone-tolerant mice

Rady, J. J., Portoghese, P. S. & Fujimoto, J. M., Apr 23 2002, In : Japanese Journal of Pharmacology. 88, 3, p. 319-331 13 p.

Research output: Contribution to journalArticle

Methadone
Heroin
Opioid Receptors
Morphine
Methysergide
11 Citations (Scopus)

Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: Application to opioid receptor affinity labels with greatly improved fluorogenic properties

McCurdy, C. R., Le Bourdonnec, B., Metzger, T. G., El Kouhen, R., Zhang, Y., Law, P-Y. & Portoghese, P. S., Jul 4 2002, In : Journal of Medicinal Chemistry. 45, 14, p. 2887-2890 4 p.

Research output: Contribution to journalArticle

Affinity Labels
Opioid Receptors
Opiate Alkaloids
Isoindoles
Fluorescence
2003
347 Citations (Scopus)

Antidepressant-like effects of κ-opioid receptor antagonists in the forced swim test in rats

Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S. & Carlezon, W. A., Apr 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 1, p. 323-330 8 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Cyclic AMP Response Element-Binding Protein
Antidepressive Agents
Nucleus Accumbens
Dynorphins
1 Citation (Scopus)
Vas Deferens
Opioid Receptors
Knockout Mice
Ligands
Morphine
44 Citations (Scopus)

Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord

Portoghese, P. S. & Lunzer, M. M., Apr 25 2003, In : European Journal of Pharmacology. 467, 1-3, p. 233-234 2 p.

Research output: Contribution to journalArticle

Opioid Receptors
Spinal Cord
Ants
Narcotic Antagonists
Enkephalins
2004
117 Citations (Scopus)

A bivalent ligand (KDN-21) reveals spinal δ and κ opioid receptors are organized as heterodimers that give rise to δ1 and δ2 phenotypes. Selective targeting of δ-κ heterodimers

Bhushan, R. G., Sharma, S. K., Xie, Z., Daniels, D. J. & Portoghese, P. S., Jun 3 2004, In : Journal of Medicinal Chemistry. 47, 12, p. 2969-2972 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Pharmacology
Ligands
Phenotype
Spinal Cord
9 Citations (Scopus)
Myenteric Plexus
Opioid Receptors
Opioid Analgesics
Small Intestine
Diprenorphine
192 Citations (Scopus)

Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

Todtenkopf, M. S., Marcus, J. F., Portoghese, P. S. & Carlezon, W. A., Apr 1 2004, In : Psychopharmacology. 172, 4, p. 463-470 8 p.

Research output: Contribution to journalArticle

Self Stimulation
Opioid Receptors
Reward
Ligands
Cyclic AMP Response Element-Binding Protein
23 Citations (Scopus)

Safety evaluation of natural flavour complexes

Smith, R. L., Adams, T. B., Cohen, S. M., Doull, J., Feron, V. J., Goodman, J. I., Hall, R. L., Marnett, L. J., Portoghese, P. S., Waddell, W. J. & Wagner, B. M., Apr 1 2004, In : Toxicology Letters. 149, 1-3, p. 197-207 11 p.

Research output: Contribution to journalArticle

Flavors
Safety
Toxicology
Poisons
Metabolic Networks and Pathways
2005
92 Citations (Scopus)

A bivalent ligand (KDAN-18) containing δ-antagonist and κ-agonist pharmacophores bridges δ2 and κ1 opioid receptor phenotype

Daniels, D. J., Kulkarni, A., Xie, Z., Bhushan, R. G. & Portoghese, P. S., Mar 24 2005, In : Journal of Medicinal Chemistry. 48, 6, p. 1713-1716 4 p.

Research output: Contribution to journalArticle

naltrindole
Opioid Receptors
Ligands
Phenotype
Tail
270 Citations (Scopus)

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

Waldhoer, M., Fong, J., Jones, R. M., Lunzer, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S. & Whistler, J. L., Jun 21 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 25, p. 9050-9055 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Opioid Receptors
Opioid Analgesics
Analgesics
Drug Delivery Systems
15 Citations (Scopus)

Comparison of peptidic and nonpeptidic δ-opioid agonists on guanosine 5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding in brain slices from Sprague-Dawley rats

Jutkiewicz, E. M., Walker, N. P., Folk, J. E., Rice, K. C., Portoghese, P. S., Woods, J. H. & Traynor, J. R., Mar 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 1314-1320 7 p.

Research output: Contribution to journalArticle

Guanosine 5'-O-(3-Thiotriphosphate)
Opioid Analgesics
Sprague Dawley Rats
Brain
naltrindole
51 Citations (Scopus)

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system

Zhang, Y., Sham, Y. Y., Rajamani, R., Gao, J. & Portoghese, P. S., May 1 2005, In : ChemBioChem. 6, 5, p. 853-859 7 p.

Research output: Contribution to journalArticle

Rhodopsin
mu Opioid Receptor
Molecular Dynamics Simulation
Molecular dynamics
Membranes
75 Citations (Scopus)

Interaction of bivalent ligand KDN21 with heterodimeric δ-κ opioid receptors in human embryonic kidney 293 cells

Xie, Z., Bhushan, R. G., Daniels, D. J. & Portoghese, P. S., Oct 1 2005, In : Molecular Pharmacology. 68, 4, p. 1079-1086 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
naltrindole
Ligands
Kidney
Mitogen-Activated Protein Kinase 3
214 Citations (Scopus)

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

Daniels, D. J., Lenard, N. R., Etienne, C. L., Law, P-Y., Roerig, S. C. & Portoghese, P. S., Dec 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 52, p. 19208-19213 6 p.

Research output: Contribution to journalArticle

naltrindole
Opioid Receptors
Opioid Analgesics
Ligands
Morphine
7 Citations (Scopus)

Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label

Zhang, Y., McCurdy, C. R., Metzger, T. G. & Portoghese, P. S., Feb 22 2005, In : Biochemistry. 44, 7, p. 2271-2275 5 p.

Research output: Contribution to journalArticle

Affinity Labels
mu Opioid Receptor
Opioid Receptors
Isoindoles
Fluorophores
2006
9 Citations (Scopus)
naltrindole
delta Opioid Receptor
Imaging techniques
D-Penicillamine (2,5)-Enkephalin
Vas Deferens