Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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1993
33 Citations (Scopus)

Involvement of δ2 opioid receptors in acute dependence on morphine in mice

Miyamoto, Y., Portoghese, P. S. & Takemori, A. E., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 3, p. 1325-1327 3 p.

Research output: Contribution to journalArticle

Morphine Dependence
Opioid Receptors
Naloxone
Morphine
Injections
37 Citations (Scopus)

Modulation of morphine antinociception by swim-stress in the mouse: Involvement of supraspinal opioid delta-2 receptors

Vanderah, T. W., Wild, K. D., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D., Hruby, V. J., Mosberg, H. I. & Porreca, F., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 267, 1, p. 449-455 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Morphine
Dehydration
Enkephalins
Antibodies
40 Citations (Scopus)

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Reid, L. D., Hubbell, C. L., Glaccum, M. B., Bilsky, E. J., Portoghese, P. S. & Porreca, F., Jan 1 1993, In : Life Sciences. 52, 9

Research output: Contribution to journalArticle

naltrindole
delta Opioid Receptor
Narcotic Antagonists
Cocaine
Medial Forebrain Bundle
12 Citations (Scopus)

Possible Contribution of a Glutathione Conjugate to the Long-Duration Action of β-Funaltrexamine

Larson, D. L., Hua, M., Takemori, A. E. & Portoghese, P. S., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 23, p. 3669-3673 5 p.

Research output: Contribution to journalArticle

Glutathione
Naltrexone
Narcotic Antagonists
Opioid Receptors
Morphine
23 Citations (Scopus)

Spinal δ2 but not δ1 opioid receptors are involved in intracereboventricular β-endorphin-induced antinociception in the mouse

Tseng, L. F., Collins, K. A. & Portoghese, P. S., Jan 1 1993, In : Life Sciences. 52, 19

Research output: Contribution to journalArticle

Endorphins
Opioid Receptors
Tail
Spinal Cord
Ala(2)-MePhe(4)-Gly(5)-enkephalin
33 Citations (Scopus)
Narcotic Antagonists
Nitrogen
Dynorphins
Guanidine
norbinaltorphimine
15 Citations (Scopus)

The design of δ-selective opioid receptor antagonists

Portoghese, P. S., Jan 1 1993, In : Farmaco. 48, 2, p. 243-251 9 p.

Research output: Contribution to journalArticle

naltrindole
Naltrexone
Narcotic Antagonists
Opioid Receptors
Conformations
8 Citations (Scopus)

The mixed antinociceptive agonist-antagonist activity of β-endorphin(1-27) in mice

Takemori, A. E. & Portoghese, P. S., Jan 1 1993, In : Life Sciences. 53, 13, p. 1049-1052 4 p.

Research output: Contribution to journalArticle

Endorphins
Narcotic Antagonists
Opioid Receptors
Methionine Enkephalin
Spinal Cord
35 Citations (Scopus)

δ-Opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine

Jones, D. N. C., Bowen, W. D., Portoghese, P. S. & Holtzman, S. G., Nov 9 1993, In : European Journal of Pharmacology. 249, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
naltrindole
Amphetamine
Cocaine
Motor Activity
1994
25 Citations (Scopus)
Affinity Labels
Opioid Receptors
Opioid Analgesics
Assays
Tail
45 Citations (Scopus)

Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain

Búzás, B., Izenwasser, S., Portoghese, P. S. & Cox, B. M., Jan 1 1994, In : Life Sciences. 54, 7

Research output: Contribution to journalArticle

delta Opioid Receptor
Adenylyl Cyclases
Rats
Brain
enkephalin, Ser(2), Leu(5), Thr(6)-
52 Citations (Scopus)

Interaction of [d-Pen2, d-Pen5]enkephalin and [d-Ala2, Glu4]deltorphin with δ-opioid receptor subtypes in vivo

Vanderah, T., Takemori, A. E., Sultana, M., Portoghese, P. S., Mosberg, H. I., Hruby, V. J., Haaseth, R. C., Matsunaga, T. O. & Porreca, F., Feb 3 1994, In : European Journal of Pharmacology. 252, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

Enkephalins
Opioid Receptors
naltrindole
Narcotic Antagonists
deltorphin
12 Citations (Scopus)

INTERAKTION VON S-(+)-KETAMIN MIT OPIATREZEPTOREN

Translated title of the contribution: Interaction of S-(+)-ketamine with opiate receptorsFreye, E., Latasch, L., Schmidhammer, H. & Portoghese, P., Jan 1 1994, In : Anaesthesist. 43, SUPPL. 2

Research output: Contribution to journalArticle

Ketamine
Opioid Receptors
Hypnotics and Sedatives
naltrindole
Respiratory Insufficiency
23 Citations (Scopus)

Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice

Miyamoto, Y., Bowen, W. D., Portoghese, P. S. & Takemori, A. E., Jan 1 1994, In : Journal of Pharmacology and Experimental Therapeutics. 270, 1, p. 37-39 3 p.

Research output: Contribution to journalArticle

Morphine Dependence
delta Opioid Receptor
Morphine
Opioid-Related Disorders
Narcotic Antagonists
12 Citations (Scopus)

Molecular modeling of the conformational and sodium ion binding properties of the oligosaccharide component of ganglioside GM1

Rodgers, J. C. & Portoghese, P. S., Jan 1 1994, In : Biopolymers. 34, 10, p. 1311-1326 16 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Oligosaccharides
Molecular modeling
Binding sites
Sugars
95 Citations (Scopus)

Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells

Peterson, P. K., Gekker, G., Hu, S., Anderson, W. R., Kravitz, F., Portoghese, P. S., Balfour, H. H. & Chao, C. C., Jan 1 1994, In : Journal of Neuroimmunology. 50, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Monocyte-Macrophage Precursor Cells
Morphine
HIV-1
Brain
Coculture Techniques
25 Citations (Scopus)

N-Benzylnaltrindoles as Long-Acting δ-Opioid Receptor Antagonists

Korlipara, V. L., Takemori, A. E. & Portoghese, P. S., Jun 1 1994, In : Journal of Medicinal Chemistry. 37, 12, p. 1882-1885 4 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Enkephalins
Nitrogen
N-benzylnaltrindole
35 Citations (Scopus)
Opioid Receptors
Structure-Activity Relationship
Nitrogen
Acidic Amino Acids
Narcotic Antagonists
25 Citations (Scopus)

Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss webster mice

Rady, J. J., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Jan 1 1994, In : Life Sciences. 55, 8, p. 603-609 7 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Heroin
naltrindole
Tail
Opioid Receptors
44 Citations (Scopus)

Synthesis of Naltrexone-Derived δ-Opioid Antagonists. Role of Conformation of the δ Address Moiety

Portoghese, P. S., Sultana, M., Moe, S. T. & Takemori, A. E., Mar 1 1994, In : Journal of Medicinal Chemistry. 37, 5, p. 579-585 7 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Benzene
naltrindole
Opioid Receptors
24 Citations (Scopus)

The effect of selective opioid antagonists on butorphanol-induced feeding

Levine, A. S., Grace, M., Portoghese, P. S. & Billington, C. J., Feb 21 1994, In : Brain Research. 637, 1-2, p. 242-248 7 p.

Research output: Contribution to journalArticle

Butorphanol
Narcotic Antagonists
naltrindole
Opioid Receptors
beta-funaltrexamine
62 Citations (Scopus)

κ Opioid Receptor Selective Affinity Labels: Electrophilic Benzeneacetamides as κ Selective Opioid Antagonists

Chang, A. C., Takemori, A. E., Ojala, W. H., Gleason, W. B. & Portoghese, P. S., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 26, p. 4490-4498 9 p.

Research output: Contribution to journalArticle

Benzeneacetamides
Affinity Labels
Narcotic Antagonists
Opioid Receptors
Opioid Analgesics
1995
17 Citations (Scopus)
naltrindole
Opioid Receptors
Central Nervous System
Amino Acids
Ligands
27 Citations (Scopus)

Cold water swim stress- and delta-2 opioid-induced analgesia are modulated by spinal γ-aminobutyric acid(A) receptors

Killian, P., Holmes, B. B., Takemori, A. E., Portoghese, P. S. & Fujimoto, J. M., Jan 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 274, 2, p. 730-734 5 p.

Research output: Contribution to journalArticle

Aminobutyrates
delta Opioid Receptor
Dehydration
Analgesia
Opioid Analgesics
20 Citations (Scopus)

Electrophilic N-Benzylnaltrindoles as δ Opioid Receptor-Selective Antagonists

Korlipara, V. L., Takemori, A. E. & Portoghese, P. S., Apr 1 1995, In : Journal of Medicinal Chemistry. 38, 8, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Vas Deferens
Affinity Labels
Isothiocyanates
Inhibitory Concentration 50
13 Citations (Scopus)
Monocyte-Macrophage Precursor Cells
Opioid Peptides
Opioid Analgesics
HIV-1
Up-Regulation

Franklin Robinson memorial symposium on medicinal chemistry in drug abuse research

Newman, A. H., Portoghese, P. S., Calderon, S., Lewis, J., Kline, R. H., Anderson, P., Rice, K. C. & Portoghese, K. C., Aug 24 1995, In : NIDA Research Monograph Series. 152, p. 65-70 6 p.

Research output: Contribution to journalArticle

Pharmaceutical Chemistry
Substance-Related Disorders
Research
43 Citations (Scopus)

Monophenylation of Morphinan-6-ones with Diphenyliodonium Iodide

Gao, P. & Portoghese, P. S., Apr 1 1995, In : Journal of Organic Chemistry. 60, 7, p. 2276-2278 3 p.

Research output: Contribution to journalArticle

Morphinans
diphenyliodonium
43 Citations (Scopus)

Role of delta opioid receptors in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys

Negus, S. S., Mello, N. K., Portoghese, P. S., Lukas, S. E. & Mendelson, J. H., Jan 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 3, p. 1245-1256 12 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
naltrindole
Macaca mulatta
Cocaine
Haplorhini
21 Citations (Scopus)
Endorphins
Opioid Receptors
Pentobarbital
Tail
Narcotic Antagonists
2 Citations (Scopus)

Synthesis of [3H]DIPPA: A potent irreversible antagonist selective for the κ opioid receptor

Chang, AC. C., Trometer, J. D. & Portoghese, P. S., Jan 1 1995, In : Journal of Labelled Compounds and Radiopharmaceuticals. 36, 6, p. 553-557 5 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Receptors
Affinity Labels
Halogenation
2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide
95 Citations (Scopus)

The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference

Krishnan-Sarin, S., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Jan 1 1995, In : Pharmacology, Biochemistry and Behavior. 52, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Rats
Alcohols
naltrindole
Opioid Receptors
120 Citations (Scopus)

The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference

Krishnan-Sarin, S., Jing, S. L., Kurtz, D. L., Zweifel, M., Portoghese, P. S., Li, T. K. & Froehlich, J. C., Jul 1 1995, In : Psychopharmacology. 120, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

naltrindole
Saccharin
delta Opioid Receptor
Narcotic Antagonists
Alcohols
49 Citations (Scopus)

Upregulation of HIV-1 expression in cocultures of chronically infected promonocytes and human brain cells by dynorphin

Chao, C. C., Gekker, G., Hu, S., Sheng, W. S., Portoghese, P. S. & Peterson, P. K., Aug 25 1995, In : Biochemical Pharmacology. 50, 5, p. 715-722 8 p.

Research output: Contribution to journalArticle

Monocyte-Macrophage Precursor Cells
Dynorphins
Coculture Techniques
Viruses
HIV-1
1996
14 Citations (Scopus)
G-Protein-Coupled Receptors
Proteins
Bacteriorhodopsins
Proline
Mutagenesis
81 Citations (Scopus)
Naltrexone
Narcotic Antagonists
Opioid Receptors
Ligands
naltrindole
12 Citations (Scopus)
Opioid Receptors
Aspartic Acid
Central Nervous System
Acute Pain
Opioid Analgesics
4 Citations (Scopus)
Boron
Ketones
Protons
Hydrogen
Carbon
17 Citations (Scopus)

Opioid antagonist activity of naltrexone-derived bivalent ligands: Importance of a properly oriented molecular scaffold to guide "address" recognition at κ opioid receptors

Bolognesi, M. L., Ojala, W. H., Gleason, W. B., Griffin, J. F., Farouz-Grant, F., Larson, D. L., Takemori, A. E. & Portoghese, P. S., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1816-1822 7 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Opioid Receptors
Ligands
Biological Availability
1 Citation (Scopus)

Selective nonpeptide ligands as probes to explore δ opioid receptor architecture

Portoghese, P. S., Dec 1 1996, In : Pharmacochemistry Library. 24, C, p. 303-312 10 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Ligands
1997
11 Citations (Scopus)

7-Spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands

Fang, X., Larson, D. L. & Portoghese, P. S., Sep 26 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3064-3070 7 p.

Research output: Contribution to journalArticle

Oxymorphone
Hydromorphone
Naltrexone
naltrindole
Opioid Receptors
18 Citations (Scopus)

7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for δ opioid receptors

Ohkawa, S., DiGiacomo, B., Larson, D. L., Takemori, A. E. & Portoghese, P. S., May 23 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1720-1725 6 p.

Research output: Contribution to journalArticle

Oxymorphone
Naltrexone
Opioid Receptors
D-Penicillamine (2,5)-Enkephalin
Ligands
4 Citations (Scopus)

A guinea pig ileum preparation devoid of functional κ receptors: A new in vitro pharmacologic assay for μ-opioid ligands

Schwartz, R. W., Chang, A. C., Portoghese, P. S. & Berzetei-Gurske, I. P., Mar 7 1997, In : Life Sciences. 60, 15

Research output: Contribution to journalArticle

Opioid Receptors
Ileum
Opioid Analgesics
Assays
Guinea Pigs
125 Citations (Scopus)

Effects of kappa opioids on cocaine self-administration by rhesus monkeys

Negus, S. S., Mello, N. K., Portoghese, P. S. & Lin, C. E., Jul 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 1, p. 44-55 12 p.

Research output: Contribution to journalArticle

Self Administration
Macaca mulatta
Cocaine
Ethylketocyclazocine
Opioid Analgesics
8 Citations (Scopus)

Fluorescent N-benzylnaltrindole analogues as potential delta opioid receptor selective probes

Korlipara, V., Ells, J., Wang, J., Tam, S., Elde, R. & Portoghese, P. S., Jan 1 1997, In : European Journal of Medicinal Chemistry. 32, 2, p. 171-174 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Fluorescent Dyes
N-benzylnaltrindole
15 Citations (Scopus)
Capsaicin
Substance P
Spinal Cord
substance P (1-7)

Medicinal chemistry as we start the next millennium

Portoghese, P. S., Dec 1 1997, In : Pharmacochemistry Library. 28, C, p. 409-419 11 p.

Research output: Contribution to journalArticle

Pharmaceutical Chemistry
Technology
Genetic engineering
Paint
Recombinant DNA
72 Citations (Scopus)
Dynorphins
Chemical activation
Opioid Analgesics
Opioid Receptors
Ligands
47 Citations (Scopus)

Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor

Clark, M. J., Emmerson, P. J., Mansour, A., Akil, H., Woods, J. H., Portoghese, P. S., Remmers, A. E. & Medzihradsky, F., Nov 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 283, 2, p. 501-510 10 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
delta Opioid Receptor
Glioma
Opioid Analgesics
Ligands
23 Citations (Scopus)

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

Farouz-Grant, F. & Portoghese, P. S., Jun 20 1997, In : Journal of Medicinal Chemistry. 40, 13, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Smooth Muscle
Muscle
Substitution reactions