Philip S Portoghese

1961 …2019
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Research Output 1961 2019

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1985

Selectivity of opioid agonists and antagonists for the various opioid receptor types

Takemori, A. E. & Portoghese, P. S., Dec 1 1985, In : Psychopharmacology bulletin. 21, 3, p. 464-465 2 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Narcotics
Opioid Receptors
62 Citations (Scopus)

Stereostructure-Activity Relationship of Opioid Agonist and Antagonist Bivalent Ligands. Evidence for Bridging between Vicinal Opioid Receptors

Portoghese, P. S., Larson, D. L., Yim, C. B., Sayre, L. M., Ronsisvalle, G., Lipkowski, A. W., Takemori, A. E., Rice, K. C. & Tam, S. W., Jan 1 1985, In : Journal of Medicinal Chemistry. 28, 9, p. 1140-1141 2 p.

Research output: Contribution to journalArticle

Oxymorphone
Endorphins
Naltrexone
Stereoisomerism
Narcotic Antagonists
57 Citations (Scopus)

Synthesis and Biological Evaluation of Phosphonamidate Peptide Inhibitors of Enkephalinase and Angiotensin-Converting Enzyme

Elliott, R. L., Marks, N., Berg, M. J. & Portoghese, P. S., Jan 1 1985, In : Journal of Medicinal Chemistry. 28, 9, p. 1208-1216 9 p.

Research output: Contribution to journalArticle

Neprilysin
Angiotensin-Converting Enzyme Inhibitors
Leucine Enkephalin
Peptides
Endopeptidases
10 Citations (Scopus)

Synthesis and physico‐chemical properties of (R, S)‐6‐ditrideuteriomethylamino‐4,4‐diphenylheptan‐3‐one hydrochloride (methadone‐d6)

Gérardy, B. M., Poupaert, J. H., Vandervorst, D., Dumont, P., Declerq, JP. P., Van Meerssche, M. & Portoghese, P. S., Jan 1 1985, In : Journal of Labelled Compounds and Radiopharmaceuticals. 22, 1, p. 5-22 18 p.

Research output: Contribution to journalArticle

Methadone
Hydrophilicity
Chemical shift
Alkalinity
Hydrophobic and Hydrophilic Interactions
51 Citations (Scopus)

TENA, a selective kappa opioid receptor antagonist

Portoghese, P. S. & Takemori, A. E., Feb 25 1985, In : Life Sciences. 36, 8, p. 801-805 5 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Ethylketocyclazocine
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Vas Deferens

β-FNA-insensitive, opioid peptide preferring receptors in the guinea pig ileum (GPI)

Takemori, A. E. & Portoghese, P. S., Jan 1 1985, In : Federation Proceedings. 44, 4

Research output: Contribution to journalArticle

beta-funaltrexamine
Peptide Receptors
Opioid Peptides
Ileum
Guinea Pigs
13 Citations (Scopus)

β-funaltrexamine (β-FNA) and neural tumor response in mice

Zagon, I. S., McLaughlin, P. J., Takemori, A. E. & Portoghese, P. S., Oct 8 1985, In : European Journal of Pharmacology. 116, 1-2, p. 165-169 5 p.

Research output: Contribution to journalArticle

Neoplasms
Narcotic Antagonists
Incidence
Neuroblastoma
Analgesia
1986
10 Citations (Scopus)

Activity of N-Methyl-a- and -β-funaltrexamine at Opioid Receptors

Mohamed, M. S., Larson, D. L., Portoghese, P. S. & Takemori, A. E., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 8, p. 1551-1553 3 p.

Research output: Contribution to journalArticle

Opioid Receptors
Narcotic Antagonists
Ileum
Opioid Analgesics
Cysteine
8 Citations (Scopus)

Affinity labels as probes for opioid receptor types and subtypes

Portoghese, P. S. & Takemori, A. E., Jan 1 1986, In : NIDA Research Monograph Series. No. 69, p. 157-168 12 p.

Research output: Contribution to journalArticle

Affinity Labels
Naltrexone
Opioid Receptors
Structure-Activity Relationship
24 Citations (Scopus)

A novel pyrrole synthesis via reaction of ketones with N-aminoimides

Lipkowski, A. W., Nagase, H. & Portoghese, P. S., Jan 1 1986, In : Tetrahedron Letters. 27, 36, p. 4257-4260 4 p.

Research output: Contribution to journalArticle

Pyrroles
Ketones
Morphinans
Imides
19 Citations (Scopus)
Naltrexone
Ships
Opioid Receptors
Molecular Structure
X-Ray Diffraction
36 Citations (Scopus)

Effects of β-funaltrexamine (β-FNA) on morphine dependence in rats and monkeys

Aceto, M. D., Dewey, W. L., Portoghese, P. S. & Takemori, A. E., Apr 29 1986, In : European Journal of Pharmacology. 123, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

Morphine Dependence
Morphine
Haplorhini
Narcotic Antagonists
Naloxone
39 Citations (Scopus)

Efficient Preparation of Polyfunctional a-Diketones from Carboxylic Acids

Conrow, R. & Portoghese, P. S., Jan 1 1986, In : Journal of Organic Chemistry. 51, 6, p. 938-940 3 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Enzyme Inhibitors
Enzymes
Arginine
8 Citations (Scopus)
Opioid Analgesics
Acids
Vas Deferens
Protons
Spectrum Analysis
12 Citations (Scopus)
Narcotic Antagonists
Nitrogen
Opiate Alkaloids
Ileum
Opioid Analgesics
11 Citations (Scopus)

Irreversible Blockage of Opioid Receptor Types by Ester Homologues of β-Funaltrexamine

Schoenecker, J. W., Takemori, A. E. & Portoghese, P. S., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 10, p. 1868-1871 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Esters
Vas Deferens
Ileum
Guinea Pigs
2 Citations (Scopus)

Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor.

Lovett, J. A. & Portoghese, P. S., Dec 1 1986, In : NIDA research monograph. 75, p. 185-188 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Melphalan
Peptides
Leucine-2-Alanine Enkephalin
Leucine Enkephalin
91 Citations (Scopus)

Opioid Agonist and Antagonist Bivalent Ligands. The Relationship between Spacer Length and Selectivity at Multiple Opioid Receptors

Portoghese, P. S., Larson, D. L., Sayre, L. M., Yim, C. B., Ronsisvalle, G., Tam, S. W. & Takemori, A. E., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 10, p. 1855-1861 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Receptors
Ligands
Guinea Pigs
Ethylketocyclazocine
59 Citations (Scopus)

Peptides as Receptor Selectivity Modulators of Opiate Pharmacophores

Lipkowski, A. W., Tam, S. W. & Portoghese, P. S., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 7, p. 1222-1225 4 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Peptide Receptors
Alkaloids
Opioid Receptors
Oxymorphone
11 Citations (Scopus)

Stereoselectivity of the Reduction of Naltrexone Oxime with Borane

Mohamed, M. S. & Portoghese, P. S., Jan 1 1986, In : Journal of Organic Chemistry. 51, 1, p. 105-106 2 p.

Research output: Contribution to journalArticle

Boranes
Stereoselectivity
Naltrexone
Oximes
Opiate Alkaloids
5 Citations (Scopus)

Synthesis and Biological Activity of Analogues of β-Chlornaltrexamine and β-Funaltrexamine at Opioid Receptors

Portoghese, P. S., Rein, M. D. & Takemori, A. E., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 10, p. 1861-1864 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Affinity Labels
Vas Deferens
Alkylation
Ileum
35 Citations (Scopus)

Synthesis and Opioid Antagonist Potencies of Naltrexamine Bivalent Ligands with Conformationally Restricted Spacers

Portoghese, P. S., Ronsisvalle, G., Larson, D. L. & Takemori, A. E., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 9, p. 1650-1653 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Ligands
Opioid Receptors
Occupations
Guinea Pigs
49 Citations (Scopus)

The μ, κ and δ properties of various opioid agonists

Takemori, A. E., Ikeda, M. & Portoghese, P. S., Apr 29 1986, In : European Journal of Pharmacology. 123, 3, p. 357-361 5 p.

Research output: Contribution to journalArticle

Buprenorphine
Vas Deferens
Opioid Receptors
Opioid Analgesics
Guinea Pigs
1987
473 Citations (Scopus)

Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

Portoghese, P. S., Lipkowski, A. W. & Takemori, A. E., Mar 30 1987, In : Life Sciences. 40, 13, p. 1287-1292 6 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Receptors
Ligands
Molecular Probes
Smooth Muscle
92 Citations (Scopus)
kappa Opioid Receptor
delta Opioid Receptor
Analgesia
Morphine
mu Opioid Receptor
16 Citations (Scopus)

Hybrid Bivalent Ligands with Opiate and Enkephalin Pharmacophores

Portoghese, P. S., Larson, D. L., Ronsisvalle, G., Schiller, P. W., Nguyen, T. M. D., Lemieux, C. & Takemori, A. E., Nov 1 1987, In : Journal of Medicinal Chemistry. 30, 11, p. 1991-1994 4 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Enkephalins
Opioid Receptors
Ligands
Ileum
14 Citations (Scopus)

N,N-Dialkylated Leucine Enkephalins as Potential δ Opioid Receptor Antagonists

Lovett, J. A. & Portoghese, P. S., Jul 1 1987, In : Journal of Medicinal Chemistry. 30, 7, p. 1144-1149 6 p.

Research output: Contribution to journalArticle

Leucine Enkephalin
Vas Deferens
Narcotic Antagonists
Enkephalins
Opioid Receptors
7 Citations (Scopus)

Nonequilibrium Opioid Antagonist Activity of 6,14-Dideoxynaltrexone Derivatives

Schoenecker, J. W., Takemori, A. E. & Portoghese, P. S., Jun 1 1987, In : Journal of Medicinal Chemistry. 30, 6, p. 1040-1044 5 p.

Research output: Contribution to journalArticle

Fumarates
Vas Deferens
Narcotic Antagonists
Ileum
Guinea Pigs
3 Citations (Scopus)

Opioid Agonist and Antagonist Activities of Monofunctional Nitrogen Mustard Analogues of β-chlornaltrexamine

Schoenecker, J. W., Takemori, A. E. & Portoghese, P. S., May 1 1987, In : Journal of Medicinal Chemistry. 30, 5, p. 933-935 3 p.

Research output: Contribution to journalArticle

Mechlorethamine
Narcotic Antagonists
Opioid Receptors
Ileum
Guinea Pigs
1 Citation (Scopus)

Role of the spinal cord in the development of opiate tolerance and dependence.

Takemori, A. E., DeLander, G. E. & Portoghese, P. S., Dec 1 1987, In : NIDA research monograph. 76, p. 42-45 4 p.

Research output: Contribution to journalArticle

Drug Tolerance
Opioid-Related Disorders
Naltrexone
Narcotic Antagonists
Narcotics
13 Citations (Scopus)
Melphalan
Narcotic Antagonists
Leucine Enkephalin
Opioid Receptors
Smooth Muscle
15 Citations (Scopus)

The crystal structure of a bimorphinan with highly selective kappa opioid receptor antagonist activity

Urbańczyk-Lipkowska, Z., Etter, M. C., Lipkowski, A. W. & Portoghese, P. S., Jan 1 1987, In : Journal of Molecular Structure. 159, 3-4, p. 287-295 9 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Morphinans
Crystal structure
Pyrroles
9 Citations (Scopus)

X-ray Crystal Structure of the Opioid Ligand Naltrexonazine

Urbanczyk-Lipkowska, Z., Lipkowski, A. W., Etter, M. C., Hahn, E. F., Pasternak, G. W. & Portoghese, P. S., Aug 1 1987, In : Journal of Medicinal Chemistry. 30, 8, p. 1489-1494 6 p.

Research output: Contribution to journalArticle

Opioid Receptors
Opioid Analgesics
X-Rays
Ligands
X Ray Crystallography
43 Citations (Scopus)

κ-Selective Opiate Antagonist Nor-Binaltorphimine Improves Outcome After Traumatic Spinal Cord Injury in Rats

Faden, A. I., Takemori, A. E. & Portoghese, P. S., Jan 1 1987, In : Central Nervous System Trauma. 4, 4, p. 227-234 8 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Spinal Cord Injuries
Opioid Receptors
Wounds and Injuries
Opioid Analgesics
1988
2 Citations (Scopus)

Additions and Corrections: Binaltorphimine-related bivalent ligands and their. kappa. opioid receptor antagonist selectivity (J. Med. Chem. (1988) 31(10) (2056–2056))

Portoghese, P. S., Nagase, H., Lipkowski, A. W., Larson, D. L. & Takemori, A. E., Oct 1 1988, In : Journal of Medicinal Chemistry. 31, 10, 1 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Ligands
binaltorphimine
138 Citations (Scopus)

Binaltorphimine-Related Bivalent Ligands and their κ Opioid Receptor Antagonist Selectivity

Portoghese, P. S., Nagase, H., Lipkowski, A. W., Larson, D. L. & Takemori, A. E., Apr 1 1988, In : Journal of Medicinal Chemistry. 31, 4, p. 836-841 6 p.

Research output: Contribution to journalArticle

Morphinans
Narcotic Antagonists
Ligands
Naltrexone
Pyrroles
239 Citations (Scopus)

Communications to the Editor

Portoghese, P. S., Sultana, M., Nagase, H. & Takemori, A. E., Dec 1 1988, In : Journal of Medicinal Chemistry. 31, 2, p. 281-282 2 p.

Research output: Contribution to journalArticle

Molecular Conformation
delta Opioid Receptor
Narcotic Antagonists
Opioid Receptors
Structure-Activity Relationship
3 Citations (Scopus)

Irreversible binding of [3H]β-funaltremaxine to brain slices of morphine-tolerant and -dependent mice

Takahashi, M., Portoghese, P. S. & Takemori, A. E., May 10 1988, In : European Journal of Pharmacology. 149, 3, p. 205-212 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Mesencephalon
Corpus Striatum
Morphine
Narcotic Antagonists
151 Citations (Scopus)

Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs

Werling, L. L., Frattali, A., Portoghese, P. S., Takemori, A. E. & Cox, B. M., Jan 1 1988, In : Journal of Pharmacology and Experimental Therapeutics. 246, 1, p. 282-286 5 p.

Research output: Contribution to journalArticle

(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
kappa Opioid Receptor
Dopamine
Guinea Pigs
Naloxone
491 Citations (Scopus)

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

Portoghese, P. S., Sultana, M. & Takemori, A. E., Jan 27 1988, In : European Journal of Pharmacology. 146, 1, p. 185-186 2 p.

Research output: Contribution to journalArticle

naltrindole
Morphinans
Indoles
delta Opioid Receptor
Vas Deferens
393 Citations (Scopus)

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays

Takemori, A. E., Ho, G. Y., Naeseth, J. S. & Portoghese, P. S., Jan 1 1988, In : Journal of Pharmacology and Experimental Therapeutics. 246, 1, p. 255-258 4 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Analgesics
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Ethylketocyclazocine
46 Citations (Scopus)

Only One Pharmacophore Is Required for the k Opioid Antagonist Selectivity of Norbinaltorphimine

Portoghese, P. S., Nagase, H. & Takemori, A. E., Jul 1 1988, In : Journal of Medicinal Chemistry. 31, 7, p. 1344-1347 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Opioid Receptors
Dynorphins
Naltrexone
Smooth Muscle
44 Citations (Scopus)

Spinal κ-opiate receptor involvement in the analgesia of pregnancy: effects of intrathecal nor-binaltorphimine, a κ-selective antagonist

Sander, H. W., Portoghese, P. S. & Gintzler, A. R., Dec 6 1988, In : Brain Research. 474, 2, p. 343-347 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Analgesia
Pregnancy
Opioid Analgesics
Mothers
39 Citations (Scopus)

Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats

Takemori, A. E., Schwartz, M. M. & Portoghese, P. S., Dec 1 1988, In : Journal of Pharmacology and Experimental Therapeutics. 247, 3, p. 971-974 4 p.

Research output: Contribution to journalArticle

Diuresis
Opioid Analgesics
Diuretics
Ethylketocyclazocine
Narcotic Antagonists
1989
28 Citations (Scopus)

Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat

Carr, K. D., Bak, T. H., Simon, E. J. & Portoghese, P. S., Jan 1 1989, In : Life Sciences. 45, 19, p. 1787-1792 6 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Naloxone
Rats
Injections
21 Citations (Scopus)
delta Opioid Receptor
mu Opioid Receptor
D-Penicillamine (2,5)-Enkephalin
Adenylyl Cyclases
Sulpiride
8 Citations (Scopus)

Nonbonded13C-14N dipole-dipole interactions

Moreland, C. G., Stejskal, E. O., Sumner, S. C. J., Memory, J. D., Ivy Carroll, F., Brine, G. A. & Portoghese, P. S., Jun 1 1989, In : Journal of Magnetic Resonance (1969). 83, 1, p. 173-176 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Opioid Agonist and Antagonist Activities of Peripherally Selective Derivatives of Naltrexamine and Oxymorphamine

Botros, S., Lipkowski, A. W., Larson, D. L., Stark, P. A., Takemori, A. E. & Portoghese, P. S., Sep 1 1989, In : Journal of Medicinal Chemistry. 32, 9, p. 2068-2071 4 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Morphine
Central Nervous System
Ligands
Naltrexone
17 Citations (Scopus)

Reactivity of glutathione with α,β-unsaturated ketone flavouring substances

Portoghese, P. S., Kedziora, G. S., Larson, D. L., Bernard, B. K. & Hall, R. L., Jan 1 1989, In : Food and Chemical Toxicology. 27, 12, p. 773-776 4 p.

Research output: Contribution to journalArticle

flavorings
ketones
Ketones
Glutathione
glutathione
53 Citations (Scopus)

Selective kappa antagonist properties of nor-binaltorphimine in the rat mes seizure model

Tortella, F. C., Echevarria, E., Lipkowski, A. W., Takemori, A. E., Portoghese, P. S. & Holaday, J. W., Jan 1 1989, In : Life Sciences. 44, 10, p. 661-665 5 p.

Research output: Contribution to journalArticle

Rats
Seizures
Anticonvulsants
Electroshock
Opioid Analgesics