Philip S Portoghese

1961 …2019
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Projects 1982 2017

Research Output 1961 2019

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In : Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journalArticle

Opioid Receptors
Opioid Analgesics
2 Citations (Scopus)

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance

Akgun, E., Lunzer, M. M. & Portoghese, P. S., Apr 17 2019, In : ACS Chemical Neuroscience. 10, 4, p. 2004-2011 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
1 Citation (Scopus)

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., Hutchinson, M. R. & Wang, X., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9577-9587 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Shueb, S. S., Erb, S. J., Lunzer, M. M., Speltz, R., Harding-Rose, C., Akgün, E., Simone, D. A. & Portoghese, P. S., Dec 1 2019, In : Neuropharmacology. 160, 107690.

Research output: Contribution to journalArticle

Bone Neoplasms
Opioid Analgesics
Inbred C3H Mouse

The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward

Cataldo, G., Erb, S. J., Lunzer, M. M., Luong, N., Akgün, E., Portoghese, P. S., Olson, J. K. & Simone, D. A., Nov 1 2019, In : Neuropharmacology. 158, 107598.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases