Philip S Portoghese

1961 …2019
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Projects 1982 2017

Research Output 1961 2019

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In : Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journalArticle

Loperamide
Opioid Receptors
Analgesics
Opioid Analgesics
Analgesia
2 Citations (Scopus)

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance

Akgun, E., Lunzer, M. M. & Portoghese, P. S., Apr 17 2019, In : ACS Chemical Neuroscience. 10, 4, p. 2004-2011 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Neuroglia
Astrocytes
Neurons
Analgesics
1 Citation (Scopus)

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., Hutchinson, M. R. & Wang, X., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9577-9587 11 p.

Research output: Contribution to journalArticle

Stereochemistry
Toll-Like Receptor 4
Naltrexone
Proteins
Stereoselectivity

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Shueb, S. S., Erb, S. J., Lunzer, M. M., Speltz, R., Harding-Rose, C., Akgün, E., Simone, D. A. & Portoghese, P. S., Dec 1 2019, In : Neuropharmacology. 160, 107690.

Research output: Contribution to journalArticle

Bone Neoplasms
Opioid Analgesics
Calcaneus
Inbred C3H Mouse
Fibrosarcoma

The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward

Cataldo, G., Erb, S. J., Lunzer, M. M., Luong, N., Akgün, E., Portoghese, P. S., Olson, J. K. & Simone, D. A., Nov 1 2019, In : Neuropharmacology. 158, 107598.

Research output: Contribution to journalArticle

Hyperalgesia
Neuralgia
Peripheral Nervous System Diseases
Reward
Cisplatin