Philip S Portoghese

1961 …2019
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Projects 1982 2017

Research Output 1961 2019

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance

Akgun, E., Lunzer, M. M. & Portoghese, P. S., Apr 17 2019, In : ACS Chemical Neuroscience. 10, 4, p. 2004-2011 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Neuroglia
Astrocytes
Neurons
Analgesics
1 Citation (Scopus)
Open Access
mu Opioid Receptor
Arthritis
Opioid Analgesics
Pain
Morphine
3 Citations (Scopus)

Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

Cataldo, G., Lunzer, M. M., Olson, J., Akgun, E., Belcher, J. D., Vercellotti, G. M., Portoghese, P. S. & Simone, D. A., Jul 1 2018, In : Pain. 159, 7, p. 1382-1391 10 p.

Research output: Contribution to journalArticle

Open Access
Nociception
Sickle Cell Anemia
Ligands
Pain
Morphine
7 Citations (Scopus)

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

Peterson, C. D., Kitto, K. F., Akgun, E., Lunzer, M. M., Riedl, M. S., Vulchanova, L., Wilcox, G. L., Portoghese, P. S. & Fairbanks, C. A., Jan 1 2017, In : Pain. 158, 12, p. 2431-2441 11 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Oxymorphone
mu Opioid Receptor
Neuralgia
Ligands
10 Citations (Scopus)

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese, P. S., Akgun, E. & Lunzer, M. M., Mar 15 2017, In : ACS Chemical Neuroscience. 8, 3, p. 426-428 3 p.

Research output: Contribution to journalArticle

Pharmacology
Ligands
Opioid Receptors
Opioid Analgesics