1991 …2023
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Research Output 1991 2019

  • 96 Article
  • 4 Review article
  • 3 Comment/debate
  • 1 Conference contribution
2019
1 Citation (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

Bioanalytical and mass spectrometric methods for aldehyde profiling in biological fluids

Dator, R. P., Solivio, M. J., Villalta, P. W. & Balbo, S., Jan 1 2019, In : Toxics. 7, 2, 32.

Research output: Contribution to journalReview article

Open Access
Aldehydes
Fluids
Mass spectrometry
Mass Spectrometry
Biomarkers
Aldehydes
Fluids
Mass spectrometry
Mass Spectrometry
Biomarkers

Reactivity of an Unusual Amidase May Explain Colibactin's DNA Cross-Linking Activity

Jiang, Y., Stornetta, A., Villalta, P. W., Wilson, M. R., Boudreau, P. D., Zha, L., Balbo, S. & Balskus, E. P., Jul 24 2019, In : Journal of the American Chemical Society. 141, 29, p. 11489-11496 8 p.

Research output: Contribution to journalArticle

amidase
DNA
Enzymes
Substrates
Amides
12 Citations (Scopus)

The human gut bacterial genotoxin colibactin alkylates DNA

Wilson, M. R., Jiang, Y., Villalta, P. W., Stornetta, A., Boudreau, P. D., Carrá, A., Brennan, C. A., Chun, E., Ngo, L., Samson, L. D., Engelward, B. P., Garrett, W. S., Balbo, S. & Balskus, E. P., Feb 15 2019, In : Science. 363, 6428, eaar7785.

Research output: Contribution to journalArticle

Open Access
Mutagens
DNA
Escherichia coli
DNA Adducts
colibactin
2018
6 Citations (Scopus)
Open Access
Tobacco
Enantiomers
DNA Adducts
Metabolites
Carcinogens
6 Citations (Scopus)
Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
2 Citations (Scopus)

In Vivo Stable Isotope Labeling and Mass Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats

Dator, R., von Weymarn, L. B., Villalta, P. W., Hooyman, C. J., Maertens, L. A., Upadhyaya, P., Murphy, S. E. & Balbo, S., Oct 16 2018, In : Analytical Chemistry. 90, 20, p. 11863-11872 10 p.

Research output: Contribution to journalArticle

Tobacco
Metabolites
Isotopes
Carcinogens
Labeling
7 Citations (Scopus)
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
4 Citations (Scopus)
DNA Adducts
High performance liquid chromatography
Carcinogens
Amines
Mass spectrometry
2017
5 Citations (Scopus)
Open Access
Carbonyl compounds
Saliva
Screening
Electrospray ionization
Physiological Phenomena
9 Citations (Scopus)

Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts

Guo, J., Villalta, P. W. & Turesky, R., Nov 7 2017, In : Analytical chemistry. 89, 21, p. 11728-11736 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Mass spectrometry
Screening
Ions
Deoxyribose
6 Citations (Scopus)

DNA adduct profiles predict in vitro cell viability after treatment with the experimental anticancer prodrug PR104A

Stornetta, A., Villalta, P. W., Gossner, F., Wilson, W. R., Balbo, S. & Sturla, S. J., Jan 1 2017, In : Chemical Research in Toxicology. 30, 3, p. 830-839 10 p.

Research output: Contribution to journalArticle

DNA Adducts
Prodrugs
Cell Survival
Cells
Isotopes
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
4 Citations (Scopus)

Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans

Wang, Y., Villalta, P. W., Peng, L., Dingley, K., Malfatti, M. A., Turteltaub, K. W. & Turesky, R., Feb 20 2017, In : Chemical research in toxicology. 30, 2, p. 705-714 10 p.

Research output: Contribution to journalArticle

Open Access
Albumins
Acids
Mass spectrometry
Mass Spectrometry
Metabolites
7 Citations (Scopus)

Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells

Ming, X., Groehler, A., Michaelson-Richie, E. D., Villalta, P. W., Campbell, C. R. & Tretyakova, N. Y., Apr 17 2017, In : Chemical research in toxicology. 30, 4, p. 980-995 16 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Proteomics
Cisplatin
Mass spectrometry
Mass Spectrometry
7 Citations (Scopus)
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
11 Citations (Scopus)

Targeting NF-κB p65 with a helenalin inspired bis-electrophile

Widen, J. C., Kempema, A. M., Villalta, P. W. & Harki, D. A., Jan 1 2017, In : ACS Chemical Biology. 12, 1, p. 102-113 12 p.

Research output: Contribution to journalArticle

Open Access
Transcription Factor RelA
DNA
Proteins
Molecules
Sesquiterpenes
9 Citations (Scopus)

The future of DNA adductomic analysis

Villalta, P. W. & Balbo, S., Sep 1 2017, In : International Journal of Molecular Sciences. 18, 9, 1870.

Research output: Contribution to journalArticle

DNA
deoxyribonucleic acid
Mass spectrometry
Mass Spectrometry
DNA Adducts
7 Citations (Scopus)
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
18 Citations (Scopus)
Deoxyguanosine
DNA Adducts
Meats
Liquid chromatography
Carcinogens
25 Citations (Scopus)
nornitrogen mustard
Cells
DNA
Proteins
Brain Neoplasms
9 Citations (Scopus)
Macular Degeneration
Tandem Mass Spectrometry
Liquid Chromatography
DNA
Retinal Pigment Epithelium
3 Citations (Scopus)

Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling

Zhou, B., Yu, X., Zhuang, C., Villalta, P., Lin, Y., Lu, J. & Xing, C., Jan 1 2016, In : ChemMedChem. 11, 13, p. 1436-1445 10 p.

Research output: Contribution to journalArticle

Chalcone
Tubulin
Cytotoxicity
Labeling
Chalcones
2015
16 Citations (Scopus)
Tobacco
DNA Adducts
Carcinogens
Phosphates
Lung
18 Citations (Scopus)

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS3 Adductomic Approach

Stornetta, A., Villalta, P. W., Hecht, S. S., Sturla, S. J. & Balbo, S., Oct 28 2015, In : Analytical chemistry. 87, 23, p. 11706-11713 8 p.

Research output: Contribution to journalArticle

Alkylation
Screening
DNA Adducts
DNA
Alkylating Agents
2014
10 Citations (Scopus)
Deoxyguanosine
Liquid chromatography
Tandem Mass Spectrometry
Malondialdehyde
Liquid Chromatography
5 Citations (Scopus)
DNA Adducts
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Ionization
33 Citations (Scopus)
DNA Adducts
Complex Mixtures
Mass spectrometry
DNA
Nitrosamines
17 Citations (Scopus)

Covalent modification of cytochrome c by reactive metabolites of Furan

Phillips, M. B., Sullivan, M. M., Villalta, P. W. & Peterson, L. A., Jan 21 2014, In : Chemical research in toxicology. 27, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

Metabolites
Cytochromes c
Lysine
Proteins
Poisons
70 Citations (Scopus)

DNA adductomics

Balbo, S., Turesky, R. & Villalta, P. W., Mar 17 2014, In : Chemical Research in Toxicology. 27, 3, p. 356-366 11 p.

Research output: Contribution to journalReview article

Toxicology
DNA
DNA Damage
Metabolomics
DNA Adducts
DNA Adducts
Mass Spectrometry
1,3-butadiene
5 Citations (Scopus)

NanoLC/ESI+ HRMS3 quantitation of DNA adducts induced by 1,3-butadiene

Sangaraju, D., Villalta, P. W., Wickramaratne, S. S., Swenberg, J. & Tretyakova, N. Y., Jan 1 2014, In : Journal of the American Society for Mass Spectrometry. 25, 7, p. 1124-1135 12 p.

Research output: Contribution to journalArticle

DNA Adducts
DNA
Rats
Liver
Nucleotides
2013
27 Citations (Scopus)

1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells

Gherezghiher, T. B., Ming, X., Villalta, P. W., Campbell, C. R. & Tretyakova, N. Y., May 3 2013, In : Journal of Proteome Research. 12, 5, p. 2151-2164 14 p.

Research output: Contribution to journalArticle

Fibrosarcoma
DNA
Proteins
Nitrogen Mustard Compounds
High Mobility Group Proteins
22 Citations (Scopus)
Electrospray ionization
DNA Adducts
Electrospray Ionization Mass Spectrometry
Liquid chromatography
Mouth Mucosa
11 Citations (Scopus)

Capillary HPLC-accurate mass MS/MS quantitation of N7-(2,3,4-trihydroxybut- 1-yl)-guanine adducts of 1,3-butadiene in human leukocyte DNA

Sangaraju, D., Villalta, P. W., Goggin, M., Agunsoye, M. O., Campbell, C. R. & Tretyakova, N. Y., Nov 4 2013, In : Chemical Research in Toxicology. 26, 10, p. 1486-1497 12 p.

Research output: Contribution to journalArticle

Leukocytes
High Pressure Liquid Chromatography
Epoxy Compounds
DNA
DNA Adducts
7 Citations (Scopus)
Aldehyde Dehydrogenase
Tobacco
DNA Adducts
Stem cells
Carcinogens
2 Citations (Scopus)
Sodium Nitrite
Rats
Liver
DNA
Nitrosation
68 Citations (Scopus)

Mass spectrometry of structurally modified DNA

Tretyakova, N. Y., Villalta, P. W. & Kotapati, S., Apr 10 2013, In : Chemical Reviews. 113, 4, p. 2395-2436 42 p.

Research output: Contribution to journalReview article

Mass spectrometry
DNA
DNA Adducts
Biotechnology
Nucleosides
18 Citations (Scopus)

Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities

Pietsch, K. E., Van Midwoud, P. M., Villalta, P. W. & Sturla, S. J., Jan 18 2013, In : Chemical Research in Toxicology. 26, 1, p. 146-155 10 p.

Research output: Contribution to journalArticle

DNA Adducts
Oxidoreductases
Prostaglandins
Cytotoxicity
Toxicity
23 Citations (Scopus)
N'-nitrosonornicotine
DNA Adducts
Rats
Tissue
Nasal Mucosa
28 Citations (Scopus)

Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy

Wickramaratne, S. S., Mukherjee, S., Villalta, P. W., Schärer, O. D. & Tretyakova, N. Y., Sep 18 2013, In : Bioconjugate Chemistry. 24, 9, p. 1496-1506 11 p.

Research output: Contribution to journalArticle

Amination
DNA
Proteins
Guanine
Ultraviolet Rays
2012
16 Citations (Scopus)

Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model

Siddique, H. R., Liao, D. J., Mishra, S. K., Schuster, T., Wang, L., Matter, B., Campbell, P. M., Villalta, P. W., Nanda, S., Deng, Y. & Bhat, M. S., Oct 1 2012, In : International Journal of Cancer. 131, 7, p. 1720-1731 12 p.

Research output: Contribution to journalArticle

Pancreatic Ductal Carcinoma
Catechin
Polyphenols
Growth
Adenocarcinoma
15 Citations (Scopus)

Translesion synthesis across 1,N6-(2-hydroxy-3- hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N6-γ- HMHP-dA) adducts by human and archebacterial DNA polymerases

Kotapati, S., Maddukuri, L., Wickramaratne, S. S., Seneviratne, U., Goggin, M., Pence, M. G., Villalta, P. W., Guengerich, F. P., Marnett, L. & Tretyakova, N. Y., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 38800-38811 12 p.

Research output: Contribution to journalArticle

Adenine
DNA-Directed DNA Polymerase
Nucleotides
Mutagenesis
Frameshift Mutation
2011
19 Citations (Scopus)
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Leukocytes
2010
52 Citations (Scopus)
Smokeless Tobacco
Polycyclic Aromatic Hydrocarbons
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Smokeless Tobacco
Polycyclic Aromatic Hydrocarbons
Gas Chromatography-Mass Spectrometry
Toxicology
Research
15 Citations (Scopus)

Detection of 7-(2′-Carboxyethyl)guanine but not 7- carboxymethylguanine in human liver DNA

Cheng, G., Wang, M., Villalta, P. W. & Hecht, S. S., Jun 21 2010, In : Chemical research in toxicology. 23, 6, p. 1089-1096 8 p.

Research output: Contribution to journalArticle

Liver
DNA
Esters
Solid Phase Extraction
Nitrosation