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Kidney Medicine & Life Sciences
Hepatocyte Nuclear Factor 1-beta Medicine & Life Sciences
Polycystic Kidney Diseases Medicine & Life Sciences
Cysts Medicine & Life Sciences
Genes Medicine & Life Sciences
Cilia Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Cystic Kidney Diseases Medicine & Life Sciences

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Projects 2015 2021

kidneys
gene expression
kidneys
gene expression

Research Output 1983 2018

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria

Wong, D. W. L., Yiu, W. H., Chan, K. W., Li, Y., Li, B., Lok, S. W. Y., Taketo, M. M., Igarashi, P., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N. & Tang, S. C. W. Jan 1 2018 (Accepted/In press) In : Kidney international.

Research output: Contribution to journalArticle

beta Catenin
Proteinuria
Inflammation
Kidney
Blood Urea Nitrogen

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

Wang, Q., Cobo-Stark, P., Patel, V., Somlo, S., Han, P. L. & Igarashi, P. Feb 1 2018 In : Kidney international. 93, 2, p. 375-389 15 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cyclic AMP
Cysts
Kidney
Growth
1 Citations

Hepatocyte nuclear factor-1β regulates urinary concentration and response to hypertonicity

Aboudehen, K., Noureddine, L., Cobo-Stark, P., Avdulov, S., Farahani, S., Gearhart, M. D., Bichet, D. G., Pontoglio, M., Patel, V. & Igarashi, P. Oct 1 2017 In : Journal of the American Society of Nephrology. 28, 10, p. 2887-2900 14 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1-beta
Kidney
Aquaporins
Transcription Factors
Kidney Tubules

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease

Kompatscher, A., de Baaij, J. H. F., Aboudehen, K., Hoefnagels, A. P. W. M., Igarashi, P., Bindels, R. J. M., Veenstra, G. J. C. & Hoenderop, J. G. J. Nov 1 2017 In : Kidney International. 92, 5, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Potassium Channels
Kidney Diseases
Transcriptional Activation
Kidney
Hypokalemia
10 Citations

MicroRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Hajarnis, S. , Lakhia, R. , Yheskel, M. , Williams, D. , Sorourian, M. , Liu, X. , Aboudehen, K. , Zhang, S. , Kersjes, K. , Galasso, R. , Li, J. , Kaimal, V. , Lockton, S. , Davis, S. , Flaten, A. , Johnson, J. A. , Holland, W. L. , Kusminski, C. M. , Scherer, P. E. , Harris, P. C. & 6 others Trudel, M., Wallace, D. P., Igarashi, P., Lee, E. C., Androsavich, J. R. & Patel, V. Feb 16 2017 In : Nature communications. 8, 14395

Research output: Contribution to journalArticle

kidney diseases
Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
metabolism
cysts