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Kidney Medicine & Life Sciences
Genes Medicine & Life Sciences
Cysts Medicine & Life Sciences
Hepatocyte Nuclear Factor 1-beta Medicine & Life Sciences
Proteins Medicine & Life Sciences
Polycystic Kidney Diseases Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Complementary DNA Medicine & Life Sciences

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Projects 2015 2021

gene expression
gene expression

Research Output 1983 2017

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

Wang, Q., Cobo-Stark, P., Patel, V., Somlo, S., Han, P. L. & Igarashi, P. 2017 (Accepted/In press) In : Kidney International.

Research output: Research - peer-reviewArticle

Polycystic Kidney Diseases
Cyclic AMP
1 Citations

Hepatocyte nuclear factor-1β regulates urinary concentration and response to hypertonicity

Aboudehen, K., Noureddine, L., Cobo-Stark, P., Avdulov, S., Farahani, S., Gearhart, M. D., Bichet, D. G., Pontoglio, M., Patel, V. & Igarashi, P. Oct 1 2017 In : Journal of the American Society of Nephrology. 28, 10, p. 2887-2900 14 p.

Research output: Research - peer-reviewArticle

Hepatocyte Nuclear Factor 1-beta
Transcription Factors
Kidney Tubules
6 Citations

MicroRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Hajarnis, S. , Lakhia, R. , Yheskel, M. , Williams, D. , Sorourian, M. , Liu, X. , Aboudehen, K. , Zhang, S. , Kersjes, K. , Galasso, R. , Li, J. , Kaimal, V. , Lockton, S. , Davis, S. , Flaten, A. , Johnson, J. A. , Holland, W. L. , Kusminski, C. M. , Scherer, P. E. , Harris, P. C. & 6 others Trudel, M., Wallace, D. P., Igarashi, P., Lee, E. C., Androsavich, J. R. & Patel, V. Feb 16 2017 In : Nature Communications. 8, 14395

Research output: Research - peer-reviewArticle

kidney diseases
Autosomal Dominant Polycystic Kidney
4 Citations

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease

Lu, D., Rauhauser, A., Li, B., Ren, C., McEnery, K., Zhu, J., Chaki, M., Vadnagara, K., Elhadi, S., Jetten, A. M., Igarashi, P. & Attanasio, M. 2016 In : Kidney International. 89, 6, p. 1307-1323 17 p.

Research output: Research - peer-reviewArticle

Cystic Kidney Diseases
Cell Aging
DNA Damage
Epithelial Cells

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease

Kompatscher, A., de Baaij, J. H. F., Aboudehen, K., Hoefnagels, A. P. W. M., Igarashi, P., Bindels, R. J. M., Veenstra, G. J. C. & Hoenderop, J. G. J. Oct 8 2016 (Accepted/In press) In : Kidney International.

Research output: Research - peer-reviewArticle

Potassium Channels
Kidney Diseases
Transcriptional Activation