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Research Output 1966 2019

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Review article
2016
15 Citations (Scopus)

Engineered swine models of cancer

Watson, A. L., Carlson, D. F., Largaespada, D. A., Hackett, P. B. & Fahrenkrug, S. C., May 9 2016, In : Frontiers in Genetics. 7, MAY, 78.

Research output: Contribution to journalReview article

Swine
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
Technology
Endonucleases
2015
16 Citations (Scopus)

Gene therapy for neurologic manifestations of mucopolysaccharidoses

Wolf, D. A., Banerjee, S., Hackett, P. B., Whitley, C. B., McIvor, R. S. & Low, W. C., Feb 1 2015, In : Expert Opinion on Drug Delivery. 12, 2, p. 283-296 14 p.

Research output: Contribution to journalReview article

Mucopolysaccharidoses
Neurologic Manifestations
Genetic Therapy
Nervous System
Brain
28 Citations (Scopus)

Lysosomal storage disease: Gene therapy on both sides of the blood-brain barrier

Aronovich, E. L. & Hackett, P. B., Feb 1 2015, In : Molecular Genetics and Metabolism. 114, 2, p. 83-93 11 p.

Research output: Contribution to journalReview article

Lysosomal Storage Diseases
Gene therapy
Nervous System Diseases
Blood-Brain Barrier
Genetic Therapy
2013
58 Citations (Scopus)

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

Hackett, P. B., Largaespada, D. A., Switzer, K. C. & Cooper, L. J. N., Jan 1 2013, In : Translational Research. 161, 4, p. 265-283 19 p.

Research output: Contribution to journalReview article

Beauty
Gene therapy
Mutagenesis
DNA Transposable Elements
T-cells
2012
63 Citations (Scopus)

Targeting DNA with fingers and TALENs

Carlson, D. F., Fahrenkrug, S. C. & Hackett, P. B., Jan 1 2012, In : Molecular Therapy - Nucleic Acids. 1, 1, p. e3 e3.

Research output: Contribution to journalReview article

Fingers
DNA
Transcription Activator-Like Effector Nucleases
2010
149 Citations (Scopus)

A transposon and transposase system for human application

Hackett, P. B., Largaespada, D. A. & Cooper, L. J. N., Apr 1 2010, In : Molecular Therapy. 18, 4, p. 674-683 10 p.

Research output: Contribution to journalReview article

Transposases
Beauty
T-Cell Antigen Receptor Specificity
Viruses
Costs and Cost Analysis
37 Citations (Scopus)

DDE transposases: Structural similarity and diversity

Nesmelova, I. V. & Hackett, P. B., Sep 30 2010, In : Advanced Drug Delivery Reviews. 62, 12, p. 1187-1195 9 p.

Research output: Contribution to journalReview article

Transposases
Dichlorodiphenyl Dichloroethylene
DNA
Catalytic Domain
Ribonuclease H
77 Citations (Scopus)

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

Izsvák, Z., Hackett, P. B., Cooper, L. J. N. & Ivics, Z., Sep 1 2010, In : BioEssays. 32, 9, p. 756-767 12 p.

Research output: Contribution to journalReview article

Gene transfer
Beauty
Transgenes
Safety
DNA Transposable Elements
2007
49 Citations (Scopus)

Predicting preferential DNA vector insertion sites: Implications for functional genomics and gene therapy

Hackett, C. S., Geurts, A. M. & Hackett, P. B., Oct 31 2007, In : Genome biology. 8, SUPPL. 1, S12.

Research output: Contribution to journalReview article

gene therapy
Genomics
Genetic Therapy
genomics
DNA
2005
34 Citations (Scopus)

Awakening gene therapy with Sleeping Beauty transposons

Essner, J. J., Mc Ivor, R. S. & Hackett, P. B., Jan 1 2005, In : Current Opinion in Pharmacology. 5, 5 SPEC.ISS., p. 513-519 7 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Junctional Epidermolysis Bullosa
Tyrosinemias
Inborn Genetic Diseases
16 Citations (Scopus)

Fishing for answers with transposons

Wadman, S. A., Clark, K. J. & Hackett, P. B., Jun 1 2005, In : Marine Biotechnology. 7, 3, p. 135-141 7 p.

Research output: Contribution to journalReview article

Beauty
Chromosomes
transposons
Gene Transfer Techniques
chromosome
111 Citations (Scopus)

Sleeping Beauty Transposon-Mediated Gene Therapy for Prolonged Expression

Hackett, P. B., Ekker, S. C., Largaespada, D. A. & Mc Ivor, R. S., Dec 1 2005, In : Advances in Genetics. 54, p. 189-232 44 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Base Pairing
Plasmids
Chromosomes
1991
4 Citations (Scopus)

Gene transfer in fish.

Guise, K. S., Kapuscinski, A. A., Hackett, P. B. & Faras, A. J., Jan 1 1991, In : Biotechnology (Reading, Mass.). 16, p. 295-306 12 p.

Research output: Contribution to journalReview article

Genetically Modified Animals
Transfection
Fishes
Genes