1966 …2020

Research output per year

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Article
2020

Meeting report on the 2019 international symposium of molecular design breeding in animals (Yangling, China) with the consensus on genome-editing agricultural animals and their regulation

Wang, X., Chen, Y., Sonstegard, T. S., Hackett, P. B., Fan, Z. & Li, K., Apr 1 2020, In : Transgenic Research. 29, 2, p. 263-265 3 p.

Research output: Contribution to journalArticle

2019

Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution

Phillips, H. R., Tolstyka, Z. P., Hall, B. C., Hexum, J. K., Hackett, P. B. & Reineke, T. M., Apr 8 2019, In : Biomacromolecules. 20, 4, p. 1530-1544 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Aquaculture genomics, genetics and breeding in the United States: Current status, challenges, and priorities for future research

Abdelrahman, H., ElHady, M., Alcivar-Warren, A., Allen, S., Al-Tobasei, R., Bao, L., Beck, B., Blackburn, H., Bosworth, B., Buchanan, J., Chappell, J., Daniels, W., Dong, S., Dunham, R., Durland, E., Elaswad, A., Gomez-Chiarri, M., Gosh, K., Guo, X., Hackett, P. & 31 others, Hanson, T., Hedgecock, D., Howard, T., Holland, L., Jackson, M., Jin, Y., Kahlil, K., Kocher, T., Leeds, T., Li, N., Lindsey, L., Liu, S., Liu, Z., Martin, K., Novriadi, R., Odin, R., Palti, Y., Peatman, E., Proestou, D., Qin, G., Reading, B., Rexroad, C., Roberts, S., Salem, M., Severin, A., Shi, H., Shoemaker, C., Stiles, S., Tan, S., Tang, K. F. J. & The Aquaculture Genomics, Genetics and Breeding Workshop, Hisham Abdelrahmaßn, Feb 20 2017, In : BMC Genomics. 18, 1, 191.

Research output: Contribution to journalArticle

50 Scopus citations

Prolonged Expression of Secreted Enzymes in Dogs after Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease

Aronovich, E. L., Hyland, K. A., Hall, B. C., Bell, J. B., Olson, E. R., Rusten, M. U., Hunter, D. W., Matthew Ellinwood, N., Scott McIvor, R. & Hackett, P. B., Jul 2017, In : Human gene therapy. 28, 7, p. 551-564 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Transgene Expression in Dogs after Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters

Hyland, K. A., Aronovich, E. L., Olson, E. R., Bell, J. B., Rusten, M. U., Gunther, R., Hunter, D. W., Hackett, P. B. & Scott Mcivor, R., Jul 2017, In : Human gene therapy. 28, 7, p. 541-550 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2016

N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery

Dhande, Y. K., Wagh, B. S., Hall, B. C., Sprouse, D., Hackett, P. B. & Reineke, T. M., Mar 14 2016, In : Biomacromolecules. 17, 3, p. 830-840 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Phase i trials using sleeping beauty to generate CD19-specific CAR T cells

Kebriaei, P., Singh, H., Huls, M. H., Figliola, M. J., Bassett, R., Olivares, S., Jena, B., Dawson, M. J., Kumaresan, P. R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M. A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R. N., Moyes, J. S. & 19 others, Rondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E. J., Kantarjian, H., Keating, M., Wierda, W., Do, K. A., Largaespada, D. A., Lee, D. A., Hackett, P. B., Champlin, R. E. & Cooper, L. J. N., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3363-3376 14 p.

Research output: Contribution to journalArticle

161 Scopus citations

Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery

Tolstyka, Z. P., Phillips, H., Cortez, M., Wu, Y., Ingle, N., Bell, J. B., Hackett, P. B. & Reineke, T. M., Jan 11 2016, In : ACS Biomaterials Science and Engineering. 2, 1, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Editing livestock genomes with site-specific nucleases

Carlson, D. F., Tan, W., Hackett, P. B. & Fahrenkrug, S. C., Jan 1 2014, In : Reproduction, Fertility and Development. 26, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

NMR structural analysis of Sleeping Beauty transposase binding to DNA

Carpentier, C. E., Schreifels, J. M., Aronovich, E. L., Carlson, D. F., Hackett, P. B. & Nesmelova, I. V., Jan 2014, In : Protein Science. 23, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

Tan, W., Carlson, D. F., Lancto, C. A., Garbe, J. R., Webster, D. A., Hackett, P. B. & Fahrenkrug, S. C., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16526-16531 6 p.

Research output: Contribution to journalArticle

180 Scopus citations
15 Scopus citations

Sleeping beauty system to redirect T-cell specificity for human applications

Maiti, S. N., Huls, H., Singh, H., Dawson, M., Figliola, M., Olivares, S., Rao, P., Zhao, Y. J., Multani, A., Yang, G., Zhang, L., Crossland, D., Ang, S., Torikai, H., Rabinovich, B., Lee, D. A., Kebriaei, P., Hackett, P., Champlin, R. E. & Cooper, L. J. N., Feb 1 2013, In : Journal of Immunotherapy. 36, 2, p. 112-123 12 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon

Song, G., Li, Q., Long, Y., Hackett, P. B. & Cui, Z., Sep 20 2012, In : Journal of Genetics and Genomics. 39, 9, p. 503-520 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effective Gene Trapping Mediated by Sleeping Beauty Transposon

Song, G., Li, Q., Long, Y., Gu, Q., Hackett, P. B. & Cui, Z., Aug 31 2012, In : PloS one. 7, 8, e44123.

Research output: Contribution to journalArticle

8 Scopus citations

Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies

Kebriaei, P., Huls, H., Jena, B., Munsell, M., Jackson, R., Lee, D. A., Hackett, P. B., Rondon, G., Shpall, E., Champlin, R. E. & Cooper, L. J. N., May 1 2012, In : Human gene therapy. 23, 5, p. 444-450 7 p.

Research output: Contribution to journalArticle

80 Scopus citations
2011

Characterization of the human artemis promoter by heterologous gene expression in vitro and in vivo

Multhaup, M. M., Gurram, S., Podetz-Pedersen, K. M., Karlen, A. D., Swanson, D. L., Somia, N. V., Hackett, P. B., Cowan, M. J. & Mc Ivor, R. S., Oct 1 2011, In : DNA and Cell Biology. 30, 10, p. 751-761 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Efficacy and safety of sleeping beauty transposon-mediated gene transfer in preclinical animal studies

Hackett, P. B., Aronovich, E. L., Hunter, D., Urness, M., Bell, J. B., Kass, S. J., Cooper, L. J. N. & Mc Ivor, R. S., Oct 1 2011, In : Current gene therapy. 11, 5, p. 341-349 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells

Castilho-Fernandes, A., de Almeida, D. C., Fontes, A. M., Melo, F. U. F., Picanço-Castro, V., Freitas, M. C., Orellana, M. D., Palma, P. V. B., Hackett, P. B., Friedman, S. L. & Covas, D. T., Dec 1 2011, In : Experimental and Molecular Pathology. 91, 3, p. 664-672 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Sleeping Beauty-mediated correction of Fanconi anemia type C

Hyland, K. A., Olson, E. R., Clark, K. J., Aronovich, E. L., Hackett, P. B., Blazar, B. R., Tolar, J. & Scott Mcivor, R., Sep 1 2011, In : Journal of Gene Medicine. 13, 9, p. 462-469 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system

Carlson, D. F., Garbe, J. R., Tan, W., Martin, M. J., Dobrinsky, J. R., Hackett, P. B., Clark, K. J. & Fahrenkrug, S. C., Oct 1 2011, In : Transgenic Research. 20, 5, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Sleeping Beauty transposon system: A non-viral vector for gene therapy

Aronovich, E. L., McIvor, R. S. & Hackett, P. B., Apr 1 2011, In : Human molecular genetics. 20, p. R14-R20 ddr140.

Research output: Contribution to journalArticle

91 Scopus citations
2010

Duration of expression and activity of sleeping beauty transposase in mouse liver following hydrodynamic DNA delivery

Bell, J. B., Aronovich, E. L., Schreifels, J. M., Beadnell, T. C. & Hackett, P. B., Oct 2010, In : Molecular Therapy. 18, 10, p. 1796-1802 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons

Podetz-Pedersen, K. M., Bell, J. B., Steele, T. W. J., Wilber, A., Shier, W. T., Belur, L., Mc Ivor, R. S. & Hackett, P. B., Feb 1 2010, In : Human gene therapy. 21, 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

Wang, Y., Kaiser, M. S., Larson, J. D., Nasevicius, A., Clark, K. J., Wadman, S. A., Roberg-Perez, S. E., Ekker, S. C., Hackett, P. B., McGrail, M. & Essner, J. J., Sep 15 2010, In : Development. 137, 18, p. 3119-3128 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Precision genetics for complex objectives in animal agriculture

Fahrenkrug, S. C., Blake, A., Carlson, D. F., Doran, T., Eenennaam, V. A., Faber, D., Galli, C., Gao, Q., Hackett, P. B., Li, N., Maga, E. A., Muir, W. M., Murray, J. D., Shi, D., Stotish, R., Sullivan, E., Taylor, J. F., Walton, M., Wheeler, M., Whitelaw, B. & 1 others, Glennfff, B. P., Jun 25 2010, In : Journal of animal science. 88, 7, p. 2530-2539 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

Combination of Reverse and Chemical Genetic Screens Reveals Angiogenesis Inhibitors and Targets

Kalén, M., Wallgard, E., Asker, N., Nasevicius, A., Athley, E., Billgren, E., Larson, J. D., Wadman, S. A., Norseng, E., Clark, K. J., He, L., Karlsson-Lindahl, L., Häger, A. K., Weber, H., Augustin, H., Samuelsson, T., Kemmet, C. K., Utesch, C. M., Essner, J. J., Hackett, P. B. & 1 others, Hellström, M., Apr 24 2009, In : Chemistry and Biology. 16, 4, p. 432-441 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system

Aronovich, E. L., Bell, J. B., Khan, S. A., Belur, L. R., Gunther, R., Koniar, B., Schachern, P. A., Parker, J. B., Carlson, C. S., Whitley, C. B., McIvor, R. S., Gupta, P. & Hackett, P. B., Apr 22 2009, In : Molecular Therapy. 17, 7, p. 1136-1144 9 p.

Research output: Contribution to journalArticle

69 Scopus citations
2008

Redirecting specificity of T-cell populations for CD19 using the sleeping beauty system

Singh, H., Manuri, P. R., Olivares, S., Dara, N., Dawson, M. J., Huls, H., Hackett, P. B., Kohn, D. B., Shpall, E. J., Champlin, R. E. & Cooper, L. J. N., Apr 15 2008, In : Cancer Research. 68, 8, p. 2961-2971 11 p.

Research output: Contribution to journalArticle

181 Scopus citations

Transgene expression and silencing in a tick cell line: A model system for functional tick genomics

Kurtti, T. J., Mattila, J. T., Herron, M. J., Felsheim, R. F., Baldridge, G. D., Burkhardt, N. Y., Blazar, B. R., Hackett, P. B., Meyer, J. M. & Munderloh, U. G., Oct 1 2008, In : Insect Biochemistry and Molecular Biology. 38, 10, p. 963-968 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: Implications for non-viral gene therapy of mucopolysaccharidoses

Aronovich, E. L., Bell, J. B., Belur, L. R., Gunther, R., Koniar, B., Erickson, D. C. C., Schachern, P. A., Matise, I., Mclvor, R. S., Whitley, C. B. & Hackett, P. B., May 1 2007, In : Journal of Gene Medicine. 9, 5, p. 403-415 13 p.

Research output: Contribution to journalArticle

88 Scopus citations
2006

Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon

Geurts, A. M., Wilber, A., Carlson, C. M., Lobitz, P. D., Clark, K. J., Hackett, P. B., Mc Ivor, R. S. & Largaespada, D. A., Jun 26 2006, In : BMC Biotechnology. 6, 30.

Research output: Contribution to journalArticle

34 Scopus citations

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates

Balciunas, D., Wangensteen, K. J., Wilber, A., Bell, J., Geurts, A., Sivasubbu, S., Wang, X., Hackett, P. B., Largaespada, D. A., McIvor, R. S. & Ekker, S. C., Nov 1 2006, In : PLoS genetics. 2, 11, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

200 Scopus citations

RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues

Wilber, A., Frandsen, J. L., Geurts, J. L., Largaespada, D. A., Hackett, P. B. & McIvor, R. S., Mar 2006, In : Molecular Therapy. 13, 3, p. 625-630 6 p.

Research output: Contribution to journalArticle

91 Scopus citations
26 Scopus citations

Structure-based prediction of insertion-site preferences of transposons into chromosomes

Geurts, A. M., Hackett, C. S., Bell, J. B., Bergemann, T. L., Collier, L. S., Carlson, C. M., Largaespada, D. A. & Hackett, P. B., Jul 10 2006, In : Nucleic acids research. 34, 9, p. 2803-2811 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2005

Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

Ohlfest, J. R., Frandsen, J. L., Fritz, S., Lobitz, P. D., Perkinson, S. G., Clark, K. J., Nelsestuen, G., Key, N. S., McIvor, R. S., Hackett, P. B. & Largaespada, D. A., Apr 1 2005, In : Blood. 105, 7, p. 2691-2698 8 p.

Research output: Contribution to journalArticle

116 Scopus citations

Target-site preferences of Sleeping Beauty transposons

Liu, G., Geurts, A. M., Yae, K., Srinivasan, A. R., Fahrenkrug, S. C., Largaespada, D. A., Takeda, J., Horie, K., Olson, W. K. & Hackett, P. B., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 161-173 13 p.

Research output: Contribution to journalArticle

110 Scopus citations
2004

Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells

Converse, A. D., Belur, L. R., Gori, J. L., Liu, G., Amaya, F., Aguilar-Cordova, E., Hackett, P. B. & McIvor, R. S., Dec 1 2004, In : Bioscience Reports. 24, 6, p. 577-594 18 p.

Research output: Contribution to journalArticle

16 Scopus citations

Excision of Sleeping Beauty transposons: Parameters and applications to gene therapy

Liu, G., Aronovich, E. L., Cui, Z., Whitley, C. B. & Hackett, P. B., May 1 2004, In : Journal of Gene Medicine. 6, 5, p. 574-583 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Transposon vectors for gene-trap insertional mutagenesis in vertebrates

Clark, K. J., Geurts, A. M., Bell, J. B. & Hackett, P. B., Aug 1 2004, In : Genesis. 39, 4, p. 225-233 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
2003

Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon

Davidson, A. E., Balciunas, D., Mohn, D., Shaffer, J., Hermanson, S., Sivasubbu, S., Cliff, M. P., Hackett, P. B. & Ekker, S. C., Nov 15 2003, In : Developmental Biology. 263, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

181 Scopus citations

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

Belur, L., Frandsen, J. L., Dupuy, A. J., Ingbar, D. H., Largaespada, D. A., Hackett, P. B. & Mc Ivor, R. S., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

96 Scopus citations

Gene transfer into genomes of human cells by the Sleeping Beauty transposon system

Geurts, A. M., Yang, Y., Clark, K. J., Liu, G., Cui, Z., Dupuy, A. J., Bell, J. B., Largaespada, D. A. & Hackett, P. B., Jul 1 2003, In : Molecular Therapy. 8, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

272 Scopus citations

RecA-mediated, targeted mutagenesis in zebrafish

Cui, Z., Yang, Y., Kaufman, C. D., Agalliu, D. & Hackett, P. B., Mar 1 2003, In : Marine Biotechnology. 5, 2, p. 174-184 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

Mammalian germ-line transgenesis by transposition

Dupuy, A. J., Clark, K., Carlson, C. M., Fritz, S., Davidson, A. E., Markley, K. M., Finley, K., Fletcher, C. F., Ekker, S. C., Hackett, P. B., Horn, S. & Largaespada, D. A., Apr 2 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4495-4499 5 p.

Research output: Contribution to journalArticle

168 Scopus citations

Structure-function analysis of the inverted terminal repeats of the Sleeping Beauty transposon

Cui, Z., Geurts, A. M., Liu, G., Kaufman, C. D. & Hackett, P. B., Jan 1 2002, In : Journal of Molecular Biology. 318, 5, p. 1221-1235 15 p.

Research output: Contribution to journalArticle

173 Scopus citations
2001

Effects of insert size on transposition efficiency of the Sleeping Beauty transposon in mouse cells

Karsi, A., Moav, B., Hackett, P. & Liu, Z., Oct 20 2001, In : Marine Biotechnology. 3, 3, p. 241-245 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

Inhibition of skiA and skiB gene expression ventralizes zebrafish embryos

Cui, Z., Clark, K. J., Kaufman, C. D. & Hackett, P. B., Aug 20 2001, In : Genesis. 30, 3, p. 149-153 5 p.

Research output: Contribution to journalArticle

12 Scopus citations