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Research Output 1966 2019

199 Citations (Scopus)

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates

Balciunas, D., Wangensteen, K. J., Wilber, A., Bell, J., Geurts, A., Sivasubbu, S., Wang, X., Hackett, P. B., Largaespada, D. A., McIvor, R. S. & Ekker, S. C., Nov 1 2006, In : PLoS genetics. 2, 11, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

cargo
transposons
Vertebrates
vertebrate
vertebrates
91 Citations (Scopus)

RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues

Wilber, A., Frandsen, J. L., Geurts, J. L., Largaespada, D. A., Hackett, P. B. & McIvor, R. S., Mar 2006, In : Molecular Therapy. 13, 3, p. 625-630 6 p.

Research output: Contribution to journalArticle

Transposases
Beauty
Insertional Mutagenesis
RNA
Gene Expression
26 Citations (Scopus)
Beauty
Transposases
Plasmids
Erythropoietin
Genetic Recombination
55 Citations (Scopus)

Structure-based prediction of insertion-site preferences of transposons into chromosomes

Geurts, A. M., Hackett, C. S., Bell, J. B., Bergemann, T. L., Collier, L. S., Carlson, C. M., Largaespada, D. A. & Hackett, P. B., Jul 10 2006, In : Nucleic acids research. 34, 9, p. 2803-2811 9 p.

Research output: Contribution to journalArticle

Beauty
Plasmids
Chromosomes
Interspersed Repetitive Sequences
Aptitude
2005
34 Citations (Scopus)

Awakening gene therapy with Sleeping Beauty transposons

Essner, J. J., McIvor, R. S. & Hackett, P. B., Oct 2005, In : Current Opinion in Pharmacology. 5, 5 SPEC.ISS., p. 513-519 7 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Junctional Epidermolysis Bullosa
Tyrosinemias
Inborn Genetic Diseases
16 Citations (Scopus)

Fishing for answers with transposons

Wadman, S. A., Clark, K. J. & Hackett, P. B., Jun 1 2005, In : Marine Biotechnology. 7, 3, p. 135-141 7 p.

Research output: Contribution to journalReview article

Beauty
Chromosomes
transposons
Gene Transfer Techniques
chromosome
116 Citations (Scopus)

Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

Ohlfest, J. R., Frandsen, J. L., Fritz, S., Lobitz, P. D., Perkinson, S. G., Clark, K. J., Nelsestuen, G., Key, N. S., McIvor, R. S., Hackett, P. B. & Largaespada, D. A., Apr 1 2005, In : Blood. 105, 7, p. 2691-2698 8 p.

Research output: Contribution to journalArticle

Gene transfer
Beauty
Factor VIII
Hemophilia A
Genes
113 Citations (Scopus)

Sleeping Beauty Transposon-Mediated Gene Therapy for Prolonged Expression

Hackett, P. B., Ekker, S. C., Largaespada, D. A. & McIvor, R. S., Dec 1 2005, In : Advances in Genetics. 54, p. 189-232 44 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Base Pairing
Plasmids
Chromosomes
109 Citations (Scopus)

Target-site preferences of Sleeping Beauty transposons

Liu, G., Geurts, A. M., Yae, K., Srinivasan, A. R., Fahrenkrug, S. C., Largaespada, D. A., Takeda, J., Horie, K., Olson, W. K. & Hackett, P. B., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 161-173 13 p.

Research output: Contribution to journalArticle

Beauty
Consensus Sequence
Genes
Intergenic DNA
Base Pairing
2004
16 Citations (Scopus)

Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells

Converse, A. D., Belur, L. R., Gori, J. L., Liu, G., Amaya, F., Aguilar-Cordova, E., Hackett, P. B. & McIvor, R. S., Dec 1 2004, In : Bioscience Reports. 24, 6, p. 577-594 18 p.

Research output: Contribution to journalArticle

Transposases
Beauty
Cultured Cells
Genes
Cells
63 Citations (Scopus)

Excision of Sleeping Beauty transposons: Parameters and applications to gene therapy

Liu, G., Aronovich, E. L., Cui, Z., Whitley, C. B. & Hackett, P. B., May 1 2004, In : Journal of Gene Medicine. 6, 5, p. 574-583 10 p.

Research output: Contribution to journalArticle

Beauty
Genetic Therapy
Transposases
Plasmids
Mammalian Chromosomes
50 Citations (Scopus)

Transposon vectors for gene-trap insertional mutagenesis in vertebrates

Clark, K. J., Geurts, A. M., Bell, J. B. & Hackett, P. B., Aug 1 2004, In : Genesis. 39, 4, p. 225-233 9 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Vertebrates
Beauty
Genes
DNA Transposable Elements
2003

Antisense for high-throughput genomic studies

Hackett, P. B. & Essner, J. J., Mar 1 2003, In : Genetic Engineering News. 23, 5, p. 34+44

Research output: Contribution to journalComment/debate

180 Citations (Scopus)

Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon

Davidson, A. E., Balciunas, D., Mohn, D., Shaffer, J., Hermanson, S., Sivasubbu, S., Cliff, M. P., Hackett, P. B. & Ekker, S. C., Nov 15 2003, In : Developmental Biology. 263, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

Beauty
Gene Transfer Techniques
Zebrafish
Gene Expression
Transposases
96 Citations (Scopus)

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

Belur, L., Frandsen, J. L., Dupuy, A. J., Ingbar, D. H., Largaespada, D. A., Hackett, P. B. & Mc Ivor, R. S., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Lung
Transgenes
Transposases
271 Citations (Scopus)

Gene transfer into genomes of human cells by the Sleeping Beauty transposon system

Geurts, A. M., Yang, Y., Clark, K. J., Liu, G., Cui, Z., Dupuy, A. J., Bell, J. B., Largaespada, D. A. & Hackett, P. B., Jul 1 2003, In : Molecular Therapy. 8, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

Beauty
Human Genome
Transposases
Genes
Chromosomes
19 Citations (Scopus)

RecA-mediated, targeted mutagenesis in zebrafish

Cui, Z., Yang, Y., Kaufman, C. D., Agalliu, D. & Hackett, P. B., Mar 1 2003, In : Marine Biotechnology. 5, 2, p. 174-184 11 p.

Research output: Contribution to journalArticle

site-directed mutagenesis
Zebrafish
Danio rerio
green fluorescent protein
Mutagenesis
2002
3 Citations (Scopus)

Genetic engineering: What are we fearing?

Hackett, P. B., May 28 2002, In : Transgenic Research. 11, 2, p. 97-99 3 p.

Research output: Contribution to journalComment/debate

Genetically Modified Organisms
information dissemination
Genetic Engineering
Information Dissemination
genetic engineering
168 Citations (Scopus)

Mammalian germ-line transgenesis by transposition

Dupuy, A. J., Clark, K., Carlson, C. M., Fritz, S., Davidson, A. E., Markley, K. M., Finley, K., Fletcher, C. F., Ekker, S. C., Hackett, P. B., Horn, S. & Largaespada, D. A., Apr 2 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4495-4499 5 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Germ Cells
Embryonic Structures
Transposases
Beauty
173 Citations (Scopus)

Structure-function analysis of the inverted terminal repeats of the Sleeping Beauty transposon

Cui, Z., Geurts, A. M., Liu, G., Kaufman, C. D. & Hackett, P. B., Jan 1 2002, In : Journal of Molecular Biology. 318, 5, p. 1221-1235 15 p.

Research output: Contribution to journalArticle

Beauty
Terminal Repeat Sequences
Nucleic Acid Repetitive Sequences
Transposases
Insertional Mutagenesis
2001
51 Citations (Scopus)

Effects of insert size on transposition efficiency of the Sleeping Beauty transposon in mouse cells

Karsi, A., Moav, B., Hackett, P. B. & Liu, Z., Oct 20 2001, In : Marine Biotechnology. 3, 3, p. 241-245 5 p.

Research output: Contribution to journalArticle

Beauty
transposition (genetics)
transposons
Efficiency
mice
12 Citations (Scopus)

Inhibition of skiA and skiB gene expression ventralizes zebrafish embryos

Cui, Z., Clark, K. J., Kaufman, C. D. & Hackett, P. B., Aug 20 2001, In : Genesis. 30, 3, p. 149-153 5 p.

Research output: Contribution to journalArticle

Developmental Gene Expression Regulation
Zebrafish Proteins
Body Patterning
Antisense Oligonucleotides
DNA-Binding Proteins
2000
3 Citations (Scopus)

Alternative transcriptional initiation and splicing define the translational efficiencies of zebrafish mRNAs encoding eukaryotic initiation factor 4E

Fahrenkrug, S. C., Hackett, P. B., Joshi, B. & Jagus, R., Jan 1 2000, In : Differentiation. 66, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Zebrafish
Messenger RNA
Exons
Stored Messenger RNA
20 Citations (Scopus)

Ectopic expression of c-ski disrupts gastrulation and neural patterning in zebrafish

Kaufman, C. D., Martínez-Rodriguez, G. & Hackett, P. B., Jul 1 2000, In : Mechanisms of Development. 95, 1-2, p. 147-162 16 p.

Research output: Contribution to journalArticle

Gastrulation
Mesoderm
Zebrafish
Neural Plate
Phenotype
1999
15 Citations (Scopus)

Dicistronic gene expression in developing zebrafish

Fahrenkrug, S. C., Clark, K. J., Dahlquist, M. O. & Hackett, P. B., Jan 1 1999, In : Marine Biotechnology. 1, 6, p. 552-561 10 p.

Research output: Contribution to journalArticle

Zebrafish
ribosomes
Danio rerio
gene expression
virus
14 Citations (Scopus)

Dynamic and tissue-specific expression of eIF4E during zebrafish embryogenesis

Fahrenkrug, S. C., Dahlquist, M. O., Clark, K. J. & Hackett, P. B., Jan 1 1999, In : Differentiation. 65, 4, p. 191-201 11 p.

Research output: Contribution to journalArticle

Zebrafish
Embryonic Development
RNA Cap-Binding Proteins
Gene Expression
Oogenesis
16 Citations (Scopus)

Genetic applications of transposons and other repetitive elements in zebrafish

Ivics, Z., Izsvák, Z. & Hackett, P. B., Dec 1 1999, In : Methods in Cell Biology. 60, p. 99-131 33 p.

Research output: Contribution to journalArticle

Transposases
Nucleic Acid Repetitive Sequences
Zebrafish
30 Citations (Scopus)
Thyroid Hormone Receptors
Rhombencephalon
Retinoic Acid Receptors
Homeobox Genes
Zebrafish
13 Citations (Scopus)

Position-independent expression of transgenes in zebrafish

Caldovic, L., Agalliu, D. & Hackett, P. B., Oct 1 1999, In : Transgenic Research. 8, 5, p. 321-334 14 p.

Research output: Contribution to journalArticle

Zebrafish
Transgenes
Danio rerio
transgenes
position effect (genetics)
84 Citations (Scopus)

Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification

Izsvák, Z., Ivics, Z., Shimoda, N., Mohn, D., Okamoto, H. & Hackett, P. B., Jan 28 1999, In : Journal of Molecular Evolution. 48, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

miniature inverted repeat transposable elements
DNA Transposable Elements
teleost
transposons
amplification
1997
972 Citations (Scopus)

Molecular reconstruction of sleeping beauty, a Tc1-like transposon from fish, and its transposition in human cells

Ivics, Z., Hackett, P. B., Plasterk, R. H. & Izsvák, Z., Nov 14 1997, In : Cell. 91, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

Beauty
Fish
Transposases
Fishes
Cells
25 Citations (Scopus)

Repetitive elements and their genetic applications in zebrafish

Izsvák, Z., Ivics, Z. & Hackett, P. B., Jan 1 1997, In : Biochemistry and Cell Biology. 75, 5, p. 507-523 17 p.

Research output: Contribution to journalArticle

Zebrafish
Genes
Genome
Chromosome Mapping
Genetic Research
61 Citations (Scopus)

The zebrafish thyroid hormone receptor α1 is expressed during early embryogenesis and can function in transcriptional repression

Essner, J. J., Breuer, J. J., Essner, R. D., Fahrenkrug, S. C. & Hackett, P. B., Jan 1 1997, In : Differentiation. 62, 3, p. 107-117 11 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
Zebrafish
Embryonic Development
Tretinoin
erbA Genes
1996
38 Citations (Scopus)

Autogenous regulation of RNA translation and packaging by Rous sarcoma virus Pr76(gag)

Sonstegard, T. S. & Hackett, P. B., Oct 1 1996, In : Journal of virology. 70, 10, p. 6642-6652 11 p.

Research output: Contribution to journalArticle

Rous sarcoma virus
Product Packaging
translation (genetics)
packaging
gag Gene Products
58 Citations (Scopus)

DANA elements: A family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio)

Izsvák, Z., Ivics, Z., Garcia-Estefania, D., Fahrenkrug, S. C. & Hackett, P. B., Feb 6 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 3, p. 1077-1081 5 p.

Research output: Contribution to journalArticle

Zebrafish
Transfer RNA
Short Interspersed Nucleotide Elements
DNA
Genome
48 Citations (Scopus)

Expression of zebrafish connexin43.4 in the notochord and tail bud of wild-type and mutant no tail embryos

Essner, J. J., Laing, J. G., Beyer, E. C., Johnson, R. G. & Hackett, P. B., Aug 1 1996, In : Developmental Biology. 177, 2, p. 449-462 14 p.

Research output: Contribution to journalArticle

Notochord
Zebrafish
Tail
Embryonic Structures
Gap Junctions
1 Citation (Scopus)

Genetic engineering of Minnesota superfish.

Hackett, P. B., 1996, In : SAAS bulletin, biochemistry and biotechnology. 9, p. 69-76 8 p.

Research output: Contribution to journalArticle

Genetic Engineering
Fishes
Transgenes
Aquaculture
Mosaicism
121 Citations (Scopus)

Identification of functional domains and evolution of Tc1-like transposable elements

Ivics, Z., Izsvák, Z., Minter, A. & Hackett, P. B., May 14 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 10, p. 5008-5013 6 p.

Research output: Contribution to journalArticle

Transposases
DNA Transposable Elements
Fishes
Leucine Zippers
Nuclear Localization Signals
1995
79 Citations (Scopus)

Characterization of a Tc1-like transposable element in zebrafish (Danio rerio)

Izsvák, Z., Ivics, Z. & Hackett, P. B., May 1 1995, In : MGG Molecular & General Genetics. 247, 3, p. 312-322 11 p.

Research output: Contribution to journalArticle

DNA Transposable Elements
Zebrafish
Genome
Transposases
Fishes
5 Citations (Scopus)

Development of cellular resistance to pp60(v-src) kinase-induced cell death

Wu, L. W. & Hackett, P. B., Jan 1 1995, In : Oncogene. 11, 8, p. 1459-1468 10 p.

Research output: Contribution to journalArticle

Oncogene Protein pp60(v-src)
src Genes
src-Family Kinases
Cell Death
Protein-Tyrosine Kinases
30 Citations (Scopus)

Development of position-independent expression vectors and their transfer into transgenic fish

Caldovic, L. & Hackett, P. B., Mar 1 1995, In : Molecular Marine Biology and Biotechnology. 4, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Genetic Transcription
Gene Transfer Techniques
Genetic Vectors
Genetically Modified Animals
23 Citations (Scopus)

Regulation of fish growth hormone transcription

Farchi-Pisanty, O., Hackett, P. B. & Moav, B., Sep 1 1995, In : Molecular Marine Biology and Biotechnology. 4, 3, p. 215-223 9 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Genetic Transcription
Retinaldehyde
Chloramphenicol O-Acetyltransferase
Carps
1993

[5] Reverse Cloning Procedure for Generation of Subclones for DNA Sequencing

Liu, Z. & Hackett, P. B., Jan 1 1993, In : Methods in enzymology. 218, C, p. 47-58 12 p.

Research output: Contribution to journalArticle

Cloning
DNA Sequence Analysis
Organism Cloning
DNA
DNA-Directed DNA Polymerase
22 Citations (Scopus)

Alterations of the three short open reading frames in the Rous sarcoma virus leader RNA modulate viral replication and gene expression

Moustakas, A., Sonstegard, T. S. & Hackett, P. B., Jan 1 1993, In : Journal of virology. 67, 7, p. 4337-4349 13 p.

Research output: Contribution to journalArticle

Rous sarcoma virus
Viral Genes
codons
Codon
Open Reading Frames
11 Citations (Scopus)

Effects of the open reading frames in the Rous sarcoma virus leader RNA on translation

Moustakas, A., Sonstegard, T. S. & Hackett, P. B., Jan 1 1993, In : Journal of virology. 67, 7, p. 4350-4357 8 p.

Research output: Contribution to journalArticle

Rous sarcoma virus
translation (genetics)
Open Reading Frames
open reading frames
RNA
20 Citations (Scopus)

Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.

Ivics, Z., Izsvák, Z. & Hackett, P. B., Jun 1 1993, In : Molecular Marine Biology and Biotechnology. 2, 3, p. 162-173 12 p.

Research output: Contribution to journalArticle

Zebrafish
Danio rerio
chromosome
Chromosomes
genetically modified organisms
24 Citations (Scopus)

Regulation of expression of transgenes in developing fish

Moav, B., Liu, Z., Caldovic, L. D., Gross, M. L., Faras, A. J. & Hackett, P. B., May 1 1993, In : Transgenic Research. 2, 3, p. 153-161 9 p.

Research output: Contribution to journalArticle

Goldfish
Zebrafish
goldfish
Transgenes
Danio rerio
1992
28 Citations (Scopus)

Characterization of AluI repeats of zebrafish (Brachydanio rerio).

He, L., Zhu, Z., Faras, A. J., Guise, K. S., Hackett, P. B. & Kapuscinski, A. R., Apr 1992, In : Molecular Marine Biology and Biotechnology. 1, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

Zebrafish
Danio rerio
genome
Genome
Nucleic Acid Repetitive Sequences
33 Citations (Scopus)

Molecular analysis and growth evaluation of northern pike (Esox Iucius) microinjected with growth hormone genes

Gross, M. L., Schneider, J. F., Moav, N., Moav, B., Alvarez, C., Myster, S. H., Liu, Z., Hallerman, E. M., Hackett, P. B., Guise, K. S., Faras, A. J. & Kapuscinski, A. R., May 15 1992, In : Aquaculture. 103, 3-4, p. 253-273 21 p.

Research output: Contribution to journalArticle

Esox
Esox lucius
molecular analysis
somatotropin
hormone