1966 …2020

Research output per year

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Research Output

2020

Meeting report on the 2019 international symposium of molecular design breeding in animals (Yangling, China) with the consensus on genome-editing agricultural animals and their regulation

Wang, X., Chen, Y., Sonstegard, T. S., Hackett, P. B., Fan, Z. & Li, K., Apr 1 2020, In : Transgenic Research. 29, 2, p. 263-265 3 p.

Research output: Contribution to journalArticle

2019

Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution

Phillips, H. R., Tolstyka, Z. P., Hall, B. C., Hexum, J. K., Hackett, P. B. & Reineke, T. M., Apr 8 2019, In : Biomacromolecules. 20, 4, p. 1530-1544 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Interspecies Organogenesis for Human Transplantation

Crane, A. T., Aravalli, R. N., Asakura, A., Grande, A. W., Krishna, V. D., Carlson, D. F., Cheeran, M. C. J., Danczyk, G., Dutton, J. R., Hackett, P. B., Hu, W. S., Li, L., Lu, W. C., Miller, Z. D., O’Brien, T. D., Panoskaltsis-Mortari, A., Parr, A. M., Pearce, C., Ruiz-Estevez, M., Shiao, M. & 6 others, Sipe, C. J., Toman, N. G., Voth, J., Xie, H., Steer, C. J. & Low, W. C., Sep 1 2019, In : Cell transplantation. 28, 9-10, p. 1091-1105 15 p.

Research output: Contribution to journalReview article

Open Access
2017

Acceptance and Access to Gene Editing: Science and Our Obligations to Mankind

Fong, Y. & Hackett, P. B., Jan 4 2017, In : Molecular Therapy. 25, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Open Access

Aquaculture genomics, genetics and breeding in the United States: Current status, challenges, and priorities for future research

Abdelrahman, H., ElHady, M., Alcivar-Warren, A., Allen, S., Al-Tobasei, R., Bao, L., Beck, B., Blackburn, H., Bosworth, B., Buchanan, J., Chappell, J., Daniels, W., Dong, S., Dunham, R., Durland, E., Elaswad, A., Gomez-Chiarri, M., Gosh, K., Guo, X., Hackett, P. & 31 others, Hanson, T., Hedgecock, D., Howard, T., Holland, L., Jackson, M., Jin, Y., Kahlil, K., Kocher, T., Leeds, T., Li, N., Lindsey, L., Liu, S., Liu, Z., Martin, K., Novriadi, R., Odin, R., Palti, Y., Peatman, E., Proestou, D., Qin, G., Reading, B., Rexroad, C., Roberts, S., Salem, M., Severin, A., Shi, H., Shoemaker, C., Stiles, S., Tan, S., Tang, K. F. J. & The Aquaculture Genomics, Genetics and Breeding Workshop, Hisham Abdelrahmaßn, Feb 20 2017, In : BMC Genomics. 18, 1, 191.

Research output: Contribution to journalArticle

50 Scopus citations

Erratum to: Aquaculture genomics, genetics and breeding in the United States: Current status, challenges, and priorities for future research. [BMC Genomics. 18, (2017), (191)] DOI: 10.1186/s12864-017-3557-1

Abdelrahman, H., ElHady, M., Alcivar-Warren, A., Allen, S., Al-Tobasei, R., Bao, L., Beck, B., Blackburn, H., Bosworth, B., Buchanan, J., Chappell, J., Daniels, W., Dong, S., Dunham, R., Durland, E., Elaswad, A., Gomez-Chiarri, M., Gosh, K., Guo, X., Hackett, P. & 31 others, Hanson, T., Hedgecock, D., Howard, T., Holland, L., Jackson, M., Jin, Y., Khalil, K., Kocher, T., Leeds, T., Li, N., Lindsey, L., Liu, S., Liu, Z., Martin, K., Novriadi, R., Odin, R., Palti, Y., Peatman, E., Proestou, D., Qin, G., Reading, B., Rexroad, C., Roberts, S., Salem, M., Severin, A., Shi, H., Shoemaker, C., Stiles, S., Tan, S., Tang, K. F. J. & The Aquaculture Genomics, Genetics and Breeding Workshop, Mar 16 2017, In : BMC Genomics. 18, 1, 235.

Research output: Contribution to journalComment/debate

Prolonged Expression of Secreted Enzymes in Dogs after Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease

Aronovich, E. L., Hyland, K. A., Hall, B. C., Bell, J. B., Olson, E. R., Rusten, M. U., Hunter, D. W., Matthew Ellinwood, N., Scott McIvor, R. & Hackett, P. B., Jul 2017, In : Human gene therapy. 28, 7, p. 551-564 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Transgene Expression in Dogs after Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters

Hyland, K. A., Aronovich, E. L., Olson, E. R., Bell, J. B., Rusten, M. U., Gunther, R., Hunter, D. W., Hackett, P. B. & Scott Mcivor, R., Jul 2017, In : Human gene therapy. 28, 7, p. 541-550 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2016

Engineered swine models of cancer

Watson, A. L., Carlson, D. F., Largaespada, D. A., Hackett, P. B. & Fahrenkrug, S. C., May 9 2016, In : Frontiers in Genetics. 7, MAY, 78.

Research output: Contribution to journalReview article

19 Scopus citations

N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery

Dhande, Y. K., Wagh, B. S., Hall, B. C., Sprouse, D., Hackett, P. B. & Reineke, T. M., Mar 14 2016, In : Biomacromolecules. 17, 3, p. 830-840 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Phase i trials using sleeping beauty to generate CD19-specific CAR T cells

Kebriaei, P., Singh, H., Huls, M. H., Figliola, M. J., Bassett, R., Olivares, S., Jena, B., Dawson, M. J., Kumaresan, P. R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M. A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R. N., Moyes, J. S. & 19 others, Rondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E. J., Kantarjian, H., Keating, M., Wierda, W., Do, K. A., Largaespada, D. A., Lee, D. A., Hackett, P. B., Champlin, R. E. & Cooper, L. J. N., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3363-3376 14 p.

Research output: Contribution to journalArticle

161 Scopus citations

Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery

Tolstyka, Z. P., Phillips, H., Cortez, M., Wu, Y., Ingle, N., Bell, J. B., Hackett, P. B. & Reineke, T. M., Jan 11 2016, In : ACS Biomaterials Science and Engineering. 2, 1, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2015

Gene therapy for neurologic manifestations of mucopolysaccharidoses

Wolf, D. A., Banerjee, S., Hackett, P. B., Whitley, C. B., McIvor, R. S. & Low, W. C., Feb 1 2015, In : Expert Opinion on Drug Delivery. 12, 2, p. 283-296 14 p.

Research output: Contribution to journalReview article

16 Scopus citations

Lysosomal storage disease: Gene therapy on both sides of the blood-brain barrier

Aronovich, E. L. & Hackett, P. B., Feb 1 2015, In : Molecular Genetics and Metabolism. 114, 2, p. 83-93 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Regulatory hurdles for agricult ure GMOs

Hackett, P. & Carroll, D., Mar 20 2015, In : Science. 347, 6228, 1 p.

Research output: Contribution to journalLetter

Risks of Insertional Mutagenesis by DNA Transposons in Cancer Gene Therapy

Hackett, P. B., Starr, T. K. & Cooper, L. J. N., Jan 1 2015, Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., p. 65-83 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Editing livestock genomes with site-specific nucleases

Carlson, D. F., Tan, W., Hackett, P. B. & Fahrenkrug, S. C., Jan 1 2014, In : Reproduction, Fertility and Development. 26, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

NMR structural analysis of Sleeping Beauty transposase binding to DNA

Carpentier, C. E., Schreifels, J. M., Aronovich, E. L., Carlson, D. F., Hackett, P. B. & Nesmelova, I. V., Jan 2014, In : Protein Science. 23, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rational design for enhanced gene therapy with DNA transposons

Hackett, P. B. & Aronovich, E. L., Sep 2014, In : Molecular Therapy. 22, 9, p. 1575-1577 3 p.

Research output: Contribution to journalComment/debate

2013

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

Tan, W., Carlson, D. F., Lancto, C. A., Garbe, J. R., Webster, D. A., Hackett, P. B. & Fahrenkrug, S. C., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16526-16531 6 p.

Research output: Contribution to journalArticle

180 Scopus citations

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

Hackett, P. B., Largaespada, D. A., Switzer, K. C. & Cooper, L. J. N., Apr 2013, In : Translational Research. 161, 4, p. 265-283 19 p.

Research output: Contribution to journalReview article

60 Scopus citations
15 Scopus citations

Sleeping beauty system to redirect T-cell specificity for human applications

Maiti, S. N., Huls, H., Singh, H., Dawson, M., Figliola, M., Olivares, S., Rao, P., Zhao, Y. J., Multani, A., Yang, G., Zhang, L., Crossland, D., Ang, S., Torikai, H., Rabinovich, B., Lee, D. A., Kebriaei, P., Hackett, P., Champlin, R. E. & Cooper, L. J. N., Feb 1 2013, In : Journal of Immunotherapy. 36, 2, p. 112-123 12 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon

Song, G., Li, Q., Long, Y., Hackett, P. B. & Cui, Z., Sep 20 2012, In : Journal of Genetics and Genomics. 39, 9, p. 503-520 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effective Gene Trapping Mediated by Sleeping Beauty Transposon

Song, G., Li, Q., Long, Y., Gu, Q., Hackett, P. B. & Cui, Z., Aug 31 2012, In : PloS one. 7, 8, e44123.

Research output: Contribution to journalArticle

8 Scopus citations

Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies

Kebriaei, P., Huls, H., Jena, B., Munsell, M., Jackson, R., Lee, D. A., Hackett, P. B., Rondon, G., Shpall, E., Champlin, R. E. & Cooper, L. J. N., May 1 2012, In : Human gene therapy. 23, 5, p. 444-450 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Precision Editing of Large Animal Genomes

Tan, W. S., Carlson, D. F., Walton, M. W., Fahrenkrug, S. C. & Hackett, P. B., 2012, Advances in Genetics. Academic Press Inc., p. 37-97 61 p. (Advances in Genetics; vol. 80).

Research output: Chapter in Book/Report/Conference proceedingChapter

68 Scopus citations

Targeting DNA with fingers and TALENs

Carlson, D. F., Fahrenkrug, S. C. & Hackett, P. B., Jan 1 2012, In : Molecular Therapy - Nucleic Acids. 1, 1, p. e3 e3.

Research output: Contribution to journalReview article

66 Scopus citations
2011

Characterization of the human artemis promoter by heterologous gene expression in vitro and in vivo

Multhaup, M. M., Gurram, S., Podetz-Pedersen, K. M., Karlen, A. D., Swanson, D. L., Somia, N. V., Hackett, P. B., Cowan, M. J. & Mc Ivor, R. S., Oct 1 2011, In : DNA and Cell Biology. 30, 10, p. 751-761 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Efficacy and safety of sleeping beauty transposon-mediated gene transfer in preclinical animal studies

Hackett, P. B., Aronovich, E. L., Hunter, D., Urness, M., Bell, J. B., Kass, S. J., Cooper, L. J. N. & Mc Ivor, R. S., Oct 1 2011, In : Current gene therapy. 11, 5, p. 341-349 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells

Castilho-Fernandes, A., de Almeida, D. C., Fontes, A. M., Melo, F. U. F., Picanço-Castro, V., Freitas, M. C., Orellana, M. D., Palma, P. V. B., Hackett, P. B., Friedman, S. L. & Covas, D. T., Dec 1 2011, In : Experimental and Molecular Pathology. 91, 3, p. 664-672 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Sleeping Beauty-mediated correction of Fanconi anemia type C

Hyland, K. A., Olson, E. R., Clark, K. J., Aronovich, E. L., Hackett, P. B., Blazar, B. R., Tolar, J. & Scott Mcivor, R., Sep 1 2011, In : Journal of Gene Medicine. 13, 9, p. 462-469 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system

Carlson, D. F., Garbe, J. R., Tan, W., Martin, M. J., Dobrinsky, J. R., Hackett, P. B., Clark, K. J. & Fahrenkrug, S. C., Oct 1 2011, In : Transgenic Research. 20, 5, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Sleeping Beauty transposon system: A non-viral vector for gene therapy

Aronovich, E. L., McIvor, R. S. & Hackett, P. B., Apr 1 2011, In : Human molecular genetics. 20, p. R14-R20 ddr140.

Research output: Contribution to journalArticle

91 Scopus citations

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

Izsvák, Z., Hackett, P. B., Cooper, L. J. N. & Ivics, Z., Jun 1 2011, In : BioEssays. 33, 6, p. 478-479 2 p.

Research output: Contribution to journalComment/debate

2010

A transposon and transposase system for human application

Hackett, P. B., Largaespada, D. A. & Cooper, L. J. N., Apr 1 2010, In : Molecular Therapy. 18, 4, p. 674-683 10 p.

Research output: Contribution to journalReview article

151 Scopus citations

DDE transposases: Structural similarity and diversity

Nesmelova, I. V. & Hackett, P. B., Sep 30 2010, In : Advanced Drug Delivery Reviews. 62, 12, p. 1187-1195 9 p.

Research output: Contribution to journalReview article

38 Scopus citations

Duration of expression and activity of sleeping beauty transposase in mouse liver following hydrodynamic DNA delivery

Bell, J. B., Aronovich, E. L., Schreifels, J. M., Beadnell, T. C. & Hackett, P. B., Oct 2010, In : Molecular Therapy. 18, 10, p. 1796-1802 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons

Podetz-Pedersen, K. M., Bell, J. B., Steele, T. W. J., Wilber, A., Shier, W. T., Belur, L., Mc Ivor, R. S. & Hackett, P. B., Feb 1 2010, In : Human gene therapy. 21, 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

Wang, Y., Kaiser, M. S., Larson, J. D., Nasevicius, A., Clark, K. J., Wadman, S. A., Roberg-Perez, S. E., Ekker, S. C., Hackett, P. B., McGrail, M. & Essner, J. J., Sep 15 2010, In : Development. 137, 18, p. 3119-3128 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Precision genetics for complex objectives in animal agriculture

Fahrenkrug, S. C., Blake, A., Carlson, D. F., Doran, T., Eenennaam, V. A., Faber, D., Galli, C., Gao, Q., Hackett, P. B., Li, N., Maga, E. A., Muir, W. M., Murray, J. D., Shi, D., Stotish, R., Sullivan, E., Taylor, J. F., Walton, M., Wheeler, M., Whitelaw, B. & 1 others, Glennfff, B. P., Jun 25 2010, In : Journal of animal science. 88, 7, p. 2530-2539 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

Izsvák, Z., Hackett, P. B., Cooper, L. J. N. & Ivics, Z., Sep 1 2010, In : BioEssays. 32, 9, p. 756-767 12 p.

Research output: Contribution to journalReview article

77 Scopus citations
2009

Combination of Reverse and Chemical Genetic Screens Reveals Angiogenesis Inhibitors and Targets

Kalén, M., Wallgard, E., Asker, N., Nasevicius, A., Athley, E., Billgren, E., Larson, J. D., Wadman, S. A., Norseng, E., Clark, K. J., He, L., Karlsson-Lindahl, L., Häger, A. K., Weber, H., Augustin, H., Samuelsson, T., Kemmet, C. K., Utesch, C. M., Essner, J. J., Hackett, P. B. & 1 others, Hellström, M., Apr 24 2009, In : Chemistry and Biology. 16, 4, p. 432-441 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system

Aronovich, E. L., Bell, J. B., Khan, S. A., Belur, L. R., Gunther, R., Koniar, B., Schachern, P. A., Parker, J. B., Carlson, C. S., Whitley, C. B., McIvor, R. S., Gupta, P. & Hackett, P. B., Apr 22 2009, In : Molecular Therapy. 17, 7, p. 1136-1144 9 p.

Research output: Contribution to journalArticle

69 Scopus citations
2008

Redirecting specificity of T-cell populations for CD19 using the sleeping beauty system

Singh, H., Manuri, P. R., Olivares, S., Dara, N., Dawson, M. J., Huls, H., Hackett, P. B., Kohn, D. B., Shpall, E. J., Champlin, R. E. & Cooper, L. J. N., Apr 15 2008, In : Cancer Research. 68, 8, p. 2961-2971 11 p.

Research output: Contribution to journalArticle

181 Scopus citations

Transgene expression and silencing in a tick cell line: A model system for functional tick genomics

Kurtti, T. J., Mattila, J. T., Herron, M. J., Felsheim, R. F., Baldridge, G. D., Burkhardt, N. Y., Blazar, B. R., Hackett, P. B., Meyer, J. M. & Munderloh, U. G., Oct 1 2008, In : Insect Biochemistry and Molecular Biology. 38, 10, p. 963-968 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Integrating DNA vectors for gene therapy

Hackett, P. B., Jan 1 2007, In : Molecular Therapy. 15, 1, p. 10-12 3 p.

Research output: Contribution to journalComment/debate

30 Scopus citations

Predicting preferential DNA vector insertion sites: Implications for functional genomics and gene therapy

Hackett, C. S., Geurts, A. M. & Hackett, P. B., Oct 31 2007, In : Genome biology. 8, SUPPL. 1, S12.

Research output: Contribution to journalReview article

49 Scopus citations

Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: Implications for non-viral gene therapy of mucopolysaccharidoses

Aronovich, E. L., Bell, J. B., Belur, L. R., Gunther, R., Koniar, B., Erickson, D. C. C., Schachern, P. A., Matise, I., Mclvor, R. S., Whitley, C. B. & Hackett, P. B., May 1 2007, In : Journal of Gene Medicine. 9, 5, p. 403-415 13 p.

Research output: Contribution to journalArticle

88 Scopus citations