19982020

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2018

D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals

Sanchez-Garcia, J. & Fernandez-Funez, P., Nov 2018, In : Neurobiology of Disease. 119, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer's disease

Martín-Peña, A., Rincón-Limas, D. E. & Fernandez-Fúnez, P., Dec 1 2018, In : Scientific reports. 8, 1, 9915.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Short Aβ peptides attenuate Aβ42 toxicity in vivo

Moore, B. D., Martin, J., de Mena, L., Sanchez, J., Cruz, P. E., Ceballos-Diaz, C., Ladd, T. B., Ran, Y., Levites, Y., Kukar, T. L., Kurian, J. J., McKenna, R., Koo, E. H., Borchelt, D. R., Janus, C., Rincon-Limas, D., Fernandez-Funez, P. & Golde, T. E., Jan 1 2018, In : Journal of Experimental Medicine. 215, 1, p. 283-301 19 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2017

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking

Khare, S., Nick, J. A., Zhang, Y., Galeano, K., Butler, B., Khoshbouei, H., Rayaprolu, S., Hathorn, T., Ranum, L. P. W., Smithson, L., Golde, T. E., Paucar, M., Morse, R., Raff, M., Simon, J., Nordenskjold, M., Wirdefeldt, K., Rincon-Limas, D. E., Lewis, J., Kaczmarek, L. K. & 3 others, Fernandez-Funez, P., Nick, H. S. & Waters, M. F., May 2017, In : PloS one. 12, 5, e0173565.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease

Martin-Peña, A., Rincon-Limas, D. E. & Fernandez-Funez, P., Dec 1 2017, In : Scientific reports. 7, 1, 11268.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2016

A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila

Sanchez-Garcia, J., Jensen, K., Zhang, Y., Rincon-Limas, D. E. & Fernandez-Funez, P., Nov 1 2016, In : Neurobiology of Disease. 95, p. 204-209 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Fernandez-Funez, P., Sanchez-Garcia, J., De Mena, L., Zhang, Y., Levites, Y., Khare, S., Golde, T. E. & Rincon-Limas, D. E., Aug 30 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. E5212-E5221

Research output: Contribution to journalArticle

20 Scopus citations
2015

Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease

Fernandez-Funez, P., Zhang, Y., Sanchez-Garcia, J., de Mena, L., Khare, S., Golde, T. E., Levites, Y. & Rincon-Limas, D. E., Jan 1 2015, In : Human molecular genetics. 24, 21, p. 6093-6105 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modeling the complex pathology of Alzheimer's disease in Drosophila

Fernandez-Funez, P., de Mena, L. & Rincon-Limas, D. E., Jan 6 2015, In : Experimental Neurology. 274, p. 58-71 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Visualization of synaptic domains in the Drosophila brain by magnetic resonance microscopy at 10 micron isotropic resolution

Lee, C. H., Blackband, S. J. & Fernandez-Funez, P., Mar 2015, In : Scientific reports. 5, 8920.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in drosophila

Zhang, Y., Casas-Tinto, S., Rincon-Limas, D. E. & Fernandez-Funez, P., Feb 11 2014, In : PloS one. 9, 2, e88522.

Research output: Contribution to journalArticle

6 Scopus citations

KCNC3R420H, a K+ channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking

Gallego-Iradi, C., Bickford, J. S., Khare, S., Hall, A., Nick, J. A., Salmasinia, D., Wawrowsky, K., Bannykh, S., Huynh, D. P., Rincon-Limas, D. E., Pulst, S. M., Nick, H. S., Fernandez-Funez, P. & Waters, M. F., Nov 1 2014, In : Neurobiology of Disease. 71, p. 270-279 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Pâ̂†TubHA4C, a new versatile vector for constitutive expression in Drosophila

Zhang, Y., Arcia, S., Perez, B., Fernandez-Funez, P. & Rincon-Limas, D. E., Sep 1 2013, In : Molecular Biology Reports. 40, 9, p. 5407-5415 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking

Arbelaez, D., Jensen, K., Rincon-Limas, D. E. & Fernandez-Funez, P., Nov 1 2013, In : Human molecular genetics. 22, 21, p. 4253-4266 14 p., ddt276.

Research output: Contribution to journalArticle

4 Scopus citations

Purification of transcripts and metabolites from Drosophila heads

Jensen, K., Sanchez-Garcia, J., Williams, C., Khare, S., Mathur, K., Graze, R. M., Hahn, D. A., Mcintyre, L. M., Rincon-Limas, D. E. & Fernandez-Funez, P., Mar 27 2013, In : Journal of Visualized Experiments. 73, p. e50245

Research output: Contribution to journalArticle

5 Scopus citations
2012

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Drosophila models of proteinopathies: The little fly that could

Rincon-Limas, D. E., Jensen, K. & Fernandez-Funez, P., Mar 1 2012, In : Current pharmaceutical design. 18, 8, p. 1108-1122 15 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

Activation of JNK signaling mediates amyloid-ß-dependent cell death

Tare, M., Modi, R. M., Nainaparampil, J. J., Puli, O. R., Bedi, S., Fernandez-Funez, P., Kango-Singh, M. & Singh, A., Sep 14 2011, In : PloS one. 6, 9, e24361.

Research output: Contribution to journalArticle

44 Scopus citations

Amyloid-β42 interacts mainly with insoluble prion protein in the Alzheimer brain

Zou, W. Q., Xiao, X., Yuan, J., Puoti, G., Fujioka, H., Wang, X., Richardson, S., Zhou, X., Zou, R., Li, S., Zhu, X., McGeer, P. L., McGeehan, J., Kneale, G., Rincon-Limas, D. E., Fernandez-Funez, P., Lee, H. G., Smith, M. A., Petersen, R. B. & Guo, J. P., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 15095-15105 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

Casas-Tinto, S., Zhang, Y., Sanchez-Garcia, J., Gomez-Velazquez, M., Rincon-Limas, D. E. & Fernandez-Funez, P., Jun 1 2011, In : Human molecular genetics. 20, 11, p. 2144-2160 17 p., ddr100.

Research output: Contribution to journalArticle

151 Scopus citations
2010

Sequence-dependent prion protein misfolding and neurotoxicity

Fernandez-Funez, P., Zhang, Y., Casas-Tinto, S., Xiao, X., Zou, W. Q. & Rincon-Limas, D. E., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36897-36908 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

In vivo generation of neurotoxic prion protein: Role for Hsp70 in accumulation of misfolded isoforms

Fernandez-Funez, P., Casas-Tinto, S., Zhang, Y., Gómez-Velazquez, M., Morales-Garza, M. A., Cepeda-Nieto, A. C., Castilla, J., Soto, C. & Rincon-Limas, D. E., Jun 1 2009, In : PLoS genetics. 5, 6, e1000507.

Research output: Contribution to journalArticle

57 Scopus citations
2008

Comparative analysis of genetic modifiers in drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

Branco, J., Al-ramahi, I., Ukani, L., Pérez, A. M., Fernandez-funez, P., Rincón-Limas, D. & Botas, J., Feb 1 2008, In : Human molecular genetics. 17, 3, p. 376-390 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

FoxK mediates TGF-β signalling during midgut differentiation in flies

Casas-Tinto, S., Gomez-Velazquez, M., Granadino, B. & Fernandez-Funez, P., Dec 15 2008, In : Journal of Cell Biology. 183, 6, p. 1049-1060 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

Age-independent synaptogenesis by phosphoinositide 3 kinase

Martín-Peña, A., Acebes, A., Rodríguez, J. R., Sorribes, A., De Polavieja, G. G., Fernández-Fúnez, P. & Ferrús, A., Oct 4 2006, In : Journal of Neuroscience. 26, 40, p. 10199-10208 10 p.

Research output: Contribution to journalArticle

68 Scopus citations
2003

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1

Chen, H. K., Fernandez-Funez, P., Acevedo, S. F., Lam, Y. C., Kaytor, M. D., Fernandez, M. H., Aitken, A., Skoulakis, E. M. C., Orr, H. T., Botas, J. & Zoghbi, H. Y., May 16 2003, In : Cell. 113, 4, p. 457-468 12 p.

Research output: Contribution to journalArticle

326 Scopus citations
2000

Identification of genes that modify ataxin-1-induced neurodegeneration

Fernandez-Funez, P., Nino-Rosales, M. L., De Gouyon, B., She, W. C., Luchak, J. M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P. J., McCall, A., Canal, I., Orr, H. T., Zoghbi, H. Y. & Botas, J., Nov 2 2000, In : Nature. 408, 6808, p. 101-106 6 p.

Research output: Contribution to journalArticle

505 Scopus citations
1998

The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing

Fernández-Fúnez, P., Lu, C. H., Rincón-Limas, D. E., García-Bellido, A. & Botas, J., Dec 1 1998, In : EMBO Journal. 17, 23, p. 6846-6853 8 p.

Research output: Contribution to journalArticle

82 Scopus citations