19982020
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Research Output 1998 2020

2020
1 Citation (Scopus)

Open questions on the nature of parkinson's disease: From triggers to spreading pathology

Mou, L., Ding, W. & Fernandez-Funez, P., Feb 1 2020, In : Journal of medical genetics. 57, 2, p. 73-81 9 p.

Research output: Contribution to journalReview article

Parkinson Disease
Pathology
Parkinsonian Disorders
Olfactory Mucosa
Smell
2018
5 Citations (Scopus)

D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals

Sanchez-Garcia, J. & Fernandez-Funez, P., Nov 2018, In : Neurobiology of Disease. 119, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
Prions
Horses
Dogs
Prion Diseases
Rabbits
2 Citations (Scopus)

Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer's disease

Martín-Peña, A., Rincón-Limas, D. E. & Fernandez-Fúnez, P., Dec 1 2018, In : Scientific reports. 8, 1, 9915.

Research output: Contribution to journalArticle

Open Access
HSP70 Heat-Shock Proteins
Amyloid
Drosophila
Alzheimer Disease
Protein Isoforms
6 Citations (Scopus)

Genetics of Parkinson's disease and related disorders

Zhang, P. L., Chen, Y., Zhang, C. H., Wang, Y. X. & Fernandez-Funez, P., Feb 1 2018, In : Journal of medical genetics. 55, 2, p. 73-80 8 p.

Research output: Contribution to journalReview article

Inborn Genetic Diseases
Parkinson Disease
Secondary Parkinson Disease
Synucleins
Pathology
7 Citations (Scopus)

Short Aβ peptides attenuate Aβ42 toxicity in vivo

Moore, B. D., Martin, J., de Mena, L., Sanchez, J., Cruz, P. E., Ceballos-Diaz, C., Ladd, T. B., Ran, Y., Levites, Y., Kukar, T. L., Kurian, J. J., McKenna, R., Koo, E. H., Borchelt, D. R., Janus, C., Rincon-Limas, D., Fernandez-Funez, P. & Golde, T. E., Jan 1 2018, In : Journal of Experimental Medicine. 215, 1, p. 283-301 19 p.

Research output: Contribution to journalArticle

Open Access
Peptides
Serum Amyloid A Protein
Amyloid Precursor Protein Secretases
Poisons
Dependovirus
2017
7 Citations (Scopus)

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking

Khare, S., Nick, J. A., Zhang, Y., Galeano, K., Butler, B., Khoshbouei, H., Rayaprolu, S., Hathorn, T., Ranum, L. P. W., Smithson, L., Golde, T. E., Paucar, M., Morse, R., Raff, M., Simon, J., Nordenskjold, M., Wirdefeldt, K., Rincon-Limas, D. E., Lewis, J., Kaczmarek, L. K. & 3 others, Fernandez-Funez, P., Nick, H. S. & Waters, M. F., May 2017, In : PloS one. 12, 5, e0173565.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Drosophila
mutation
Mutation
eyes
4 Citations (Scopus)

Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease

Martin-Peña, A., Rincon-Limas, D. E. & Fernandez-Funez, P., Dec 1 2017, In : Scientific reports. 7, 1, 11268.

Research output: Contribution to journalArticle

Open Access
Single-Chain Antibodies
Amyloid
Drosophila
Alzheimer Disease
Aptitude
3 Citations (Scopus)

Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity

Fernandez-Funez, P., Sanchez-Garcia, J. & Rincon-Limas, D. E., Jun 1 2017, In : Current Opinion in Genetics and Development. 44, p. 141-148 8 p.

Research output: Contribution to journalReview article

Open Access
Drosophila
Protein Conformation
Prion Diseases
Prion Proteins
Prions
16 Citations (Scopus)

Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target

Wang, Y., Yan, T., Lu, H., Yin, W., Lin, B., Fan, W., Zhang, X. & Fernandez-Funez, P., Dec 1 2017, In : Neurodegenerative Diseases. 17, 6, p. 242-250 9 p.

Research output: Contribution to journalReview article

Amyloid
Immunotherapy
Alzheimer Disease
Antibodies
solanezumab
6 Citations (Scopus)

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids

De Mena, L., Chhangani, D., Fernandez-Funez, P. & Rincon-Limas, D. E., Jul 3 2017, In : Fly. 11, 3, p. 179-184 6 p.

Research output: Contribution to journalComment/debate

Open Access
amyloid
toxicity
neurodegenerative diseases
protein aggregates
heat shock proteins
2016
5 Citations (Scopus)

A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila

Sanchez-Garcia, J., Jensen, K., Zhang, Y., Rincon-Limas, D. E. & Fernandez-Funez, P., Nov 1 2016, In : Neurobiology of Disease. 95, p. 204-209 6 p.

Research output: Contribution to journalArticle

Drosophila
Dogs
Amino Acids
Prion Diseases
Prions
19 Citations (Scopus)

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Fernandez-Funez, P., Sanchez-Garcia, J., De Mena, L., Zhang, Y., Levites, Y., Khare, S., Golde, T. E. & Rincon-Limas, D. E., Aug 30 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. E5212-E5221

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Masks
Amyloid
Drosophila
Alzheimer Disease
2015
11 Citations (Scopus)

Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease

Fernandez-Funez, P., Zhang, Y., Sanchez-Garcia, J., de Mena, L., Khare, S., Golde, T. E., Levites, Y. & Rincon-Limas, D. E., Jan 1 2015, In : Human molecular genetics. 24, 21, p. 6093-6105 13 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Amyloid
Drosophila
Alzheimer Disease
Epitopes
29 Citations (Scopus)

Modeling the complex pathology of Alzheimer's disease in Drosophila

Fernandez-Funez, P., de Mena, L. & Rincon-Limas, D. E., Jan 6 2015, In : Experimental Neurology. 274, p. 58-71 14 p.

Research output: Contribution to journalArticle

Drosophila
Alzheimer Disease
Pathology
Amyloid beta-Protein Precursor
Transport Vesicles
10 Citations (Scopus)

Visualization of synaptic domains in the Drosophila brain by magnetic resonance microscopy at 10 micron isotropic resolution

Lee, C. H., Blackband, S. J. & Fernandez-Funez, P., Mar 2015, In : Scientific reports. 5, 8920.

Research output: Contribution to journalArticle

Drosophila
Microscopy
Magnetic Resonance Spectroscopy
Brain
Head
2014
6 Citations (Scopus)

Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in drosophila

Zhang, Y., Casas-Tinto, S., Rincon-Limas, D. E. & Fernandez-Funez, P., Feb 11 2014, In : PloS one. 9, 2, e88522.

Research output: Contribution to journalArticle

neurotoxicity
prions
Drosophila
Pharmacology
Prion Diseases
12 Citations (Scopus)

KCNC3R420H, a K+ channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking

Gallego-Iradi, C., Bickford, J. S., Khare, S., Hall, A., Nick, J. A., Salmasinia, D., Wawrowsky, K., Bannykh, S., Huynh, D. P., Rincon-Limas, D. E., Pulst, S. M., Nick, H. S., Fernandez-Funez, P. & Waters, M. F., Nov 1 2014, In : Neurobiology of Disease. 71, p. 270-279 10 p.

Research output: Contribution to journalArticle

Mutation
Biotinylation
Voltage-Gated Potassium Channels
Mutant Proteins
Post Translational Protein Processing
3 Citations (Scopus)

Launching Hsp70 neuroprotection: Two drugs better than one

Fernandez-Funez, P. & Rincon-Limas, D. E., Jun 1 2014, In : Cell Cycle. 13, 11, p. 1657-1658 2 p.

Research output: Contribution to journalEditorial

Proteostasis Deficiencies
HSP90 Heat-Shock Proteins
Biological Models
Molecular Chaperones
HSP70 Heat-Shock Proteins
2013

Alternative models of prion diseases

Fernandez-Funez, P., Málaga-Trillo, E. & Rincon-Limas, D. E., Jan 1 2013, Prions and Diseases: Volume 2, Animals, Humans and the Environment. Springer New York, p. 183-199 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prion Diseases
Zebrafish
Prions
Caenorhabditis elegans
Protein Transport

Alternative models of prion diseases

Fernandez-Funez, P., Málaga-Trillo, E. & Rincon-Limas, D. E., Nov 1 2013, Animals, Humans and the Environment. Springer New York, Vol. 2. p. 183-199 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prion Diseases
Prions
Zebrafish
Caenorhabditis elegans
Protein Transport
3 Citations (Scopus)

Pâ̂†TubHA4C, a new versatile vector for constitutive expression in Drosophila

Zhang, Y., Arcia, S., Perez, B., Fernandez-Funez, P. & Rincon-Limas, D. E., Sep 1 2013, In : Molecular Biology Reports. 40, 9, p. 5407-5415 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Drosophila
Organism Cloning
Viral Hemagglutinins
Arsenicals
4 Citations (Scopus)

Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking

Arbelaez, D., Jensen, K., Rincon-Limas, D. E. & Fernandez-Funez, P., Nov 1 2013, In : Human molecular genetics. 22, 21, p. 4253-4266 14 p., ddt276.

Research output: Contribution to journalArticle

Protein Isoforms
Prion Diseases
Prion Proteins
Protein Folding
Protein Sorting Signals
5 Citations (Scopus)

Purification of transcripts and metabolites from Drosophila heads

Jensen, K., Sanchez-Garcia, J., Williams, C., Khare, S., Mathur, K., Graze, R. M., Hahn, D. A., Mcintyre, L. M., Rincon-Limas, D. E. & Fernandez-Funez, P., Mar 27 2013, In : Journal of Visualized Experiments. 73, p. e50245

Research output: Contribution to journalArticle

Neurodegenerative diseases
Metabolites
Diptera
Drosophila
Purification

Unraveling the basis of neurodegeneration using the drosophila eye

Fernandez-Funez, P., Sanchez-Garcia, J. & Rincon-Limas, D. E., May 1 2013, Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Springer New York, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drosophila
Brain
Diptera
Bearings (structural)
RNA
2012
22 Citations (Scopus)

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

Factor X
Amyloid
Carrier Proteins
Oligomers
Chemical activation
36 Citations (Scopus)

Drosophila models of proteinopathies: The little fly that could

Rincon-Limas, D. E., Jensen, K. & Fernandez-Funez, P., Mar 1 2012, In : Current pharmaceutical design. 18, 8, p. 1108-1122 15 p.

Research output: Contribution to journalArticle

Diptera
Drosophila
Proteins
Explosions
Poisons
2011
42 Citations (Scopus)

Activation of JNK signaling mediates amyloid-ß-dependent cell death

Tare, M., Modi, R. M., Nainaparampil, J. J., Puli, O. R., Bedi, S., Fernandez-Funez, P., Kango-Singh, M. & Singh, A., Sep 14 2011, In : PloS one. 6, 9, e24361.

Research output: Contribution to journalArticle

Cell death
amyloid
mitogen-activated protein kinase
Amyloid
cell death
59 Citations (Scopus)

Amyloid-β42 interacts mainly with insoluble prion protein in the Alzheimer brain

Zou, W. Q., Xiao, X., Yuan, J., Puoti, G., Fujioka, H., Wang, X., Richardson, S., Zhou, X., Zou, R., Li, S., Zhu, X., McGeer, P. L., McGeehan, J., Kneale, G., Rincon-Limas, D. E., Fernandez-Funez, P., Lee, H. G., Smith, M. A., Petersen, R. B. & Guo, J. P., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 15095-15105 11 p.

Research output: Contribution to journalArticle

Amyloid
Brain
Alzheimer Disease
Oligomers
Binding Sites
15 Citations (Scopus)

Pulling rabbits to reveal the secrets of the prion protein

Fernandez-Funez, P., Zhang, Y., Sanchez-Garcia, J., Jensen, K., Zou, W. Q. & Rincon-Limas, D. E., May 1 2011, In : Communicative and Integrative Biology. 4, 3, p. 262-266 5 p.

Research output: Contribution to journalShort survey

prions
rabbits
Rabbits
Prion Diseases
Neurodegenerative Diseases
149 Citations (Scopus)

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

Casas-Tinto, S., Zhang, Y., Sanchez-Garcia, J., Gomez-Velazquez, M., Rincon-Limas, D. E. & Fernandez-Funez, P., Jun 1 2011, In : Human molecular genetics. 20, 11, p. 2144-2160 17 p., ddr100.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Amyloid
Alzheimer Disease
Ryanodine Receptor Calcium Release Channel
Diptera
2010
10 Citations (Scopus)

Exploring prion protein biology in flies: Genetics and beyond

Rincon-Limas, D. E., Casas-Tinto, S. & Fernandez-Funez, P., Jan 1 2010, In : Prion. 4, 1

Research output: Contribution to journalComment/debate

Neurodegenerative diseases
Protein folding
Prions
Protein Folding
Drosophila melanogaster
31 Citations (Scopus)

Sequence-dependent prion protein misfolding and neurotoxicity

Fernandez-Funez, P., Zhang, Y., Casas-Tinto, S., Xiao, X., Zou, W. Q. & Rincon-Limas, D. E., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36897-36908 12 p.

Research output: Contribution to journalArticle

Scrapie
Diptera
Prion Diseases
Prions
Cricetinae
2009
57 Citations (Scopus)

In vivo generation of neurotoxic prion protein: Role for Hsp70 in accumulation of misfolded isoforms

Fernandez-Funez, P., Casas-Tinto, S., Zhang, Y., Gómez-Velazquez, M., Morales-Garza, M. A., Cepeda-Nieto, A. C., Castilla, J., Soto, C. & Rincon-Limas, D. E., Jun 1 2009, In : PLoS genetics. 5, 6, e1000507.

Research output: Contribution to journalArticle

PrPSc proteins
prions
Diptera
Protein Isoforms
Peptide Hydrolases
2008
52 Citations (Scopus)

Comparative analysis of genetic modifiers in drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

Branco, J., Al-ramahi, I., Ukani, L., Pérez, A. M., Fernandez-funez, P., Rincón-Limas, D. & Botas, J., Feb 1 2008, In : Human molecular genetics. 17, 3, p. 376-390 15 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Huntington Disease
Modifier Genes
Drosophila
Intranuclear Inclusion Bodies
7 Citations (Scopus)

FoxK mediates TGF-β signalling during midgut differentiation in flies

Casas-Tinto, S., Gomez-Velazquez, M., Granadino, B. & Fernandez-Funez, P., Dec 15 2008, In : Journal of Cell Biology. 183, 6, p. 1049-1060 12 p.

Research output: Contribution to journalArticle

Endoderm
Transforming Growth Factors
Diptera
Lip
Viverridae
2006
68 Citations (Scopus)

Age-independent synaptogenesis by phosphoinositide 3 kinase

Martín-Peña, A., Acebes, A., Rodríguez, J. R., Sorribes, A., De Polavieja, G. G., Fernández-Fúnez, P. & Ferrús, A., Oct 4 2006, In : Journal of Neuroscience. 26, 40, p. 10199-10208 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Synapses
Neurons
Aptitude
Brain
2003
326 Citations (Scopus)

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1

Chen, H. K., Fernandez-Funez, P., Acevedo, S. F., Lam, Y. C., Kaytor, M. D., Fernandez, M. H., Aitken, A., Skoulakis, E. M. C., Orr, H. T., Botas, J. & Zoghbi, H. Y., May 16 2003, In : Cell. 113, 4, p. 457-468 12 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Phosphatidylinositol 3-Kinase
14-3-3 Proteins
Phosphorylation
Mutant Proteins
2000
502 Citations (Scopus)

Identification of genes that modify ataxin-1-induced neurodegeneration

Fernandez-Funez, P., Nino-Rosales, M. L., De Gouyon, B., She, W. C., Luchak, J. M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P. J., McCall, A., Canal, I., Orr, H. T., Zoghbi, H. Y. & Botas, J., Nov 2 2000, In : Nature. 408, 6808, p. 101-106 6 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Genes
Neurodegenerative Diseases
Proteins
Protein Folding
1998
82 Citations (Scopus)

The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing

Fernández-Fúnez, P., Lu, C. H., Rincón-Limas, D. E., García-Bellido, A. & Botas, J., Dec 1 1998, In : EMBO Journal. 17, 23, p. 6846-6853 8 p.

Research output: Contribution to journalArticle

Drosophila
LIM-Homeodomain Proteins
Phenotype
Proteins