20022019
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Research Output 2002 2019

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Article
2019

Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory

Hartman, P., Beckman, K. B., Silverstein, K. A., Yohe, S. L., Schomaker, M., Henzler, C., Onsongo, G., Lam, H. C., Munro, S. A., Daniel, J., Billstein, B., Deshpande, A., Hauge, A., Mroz, P. A., Lee, W., Holle, J., Wiens, K., Karnuth, K., Kemmer, T., Leary, M. & 6 others, Michel, S., Pohlman, L., Thayanithy, V., Nelson, A. C., Bower, M. & Thyagarajan, B., Jun 1 2019, In : Molecular Genetics and Metabolism Reports. 19, 100464.

Research output: Contribution to journalArticle

Open Access
Gastrointestinal Diseases
Genetic Testing
Ophthalmology
Dermatology
Lung Diseases
2014
31 Citations (Scopus)

5-Aza-2′-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy

Wachowska, M., Gabrysiak, M., Muchowicz, A., Bednarek, W., Barankiewicz, J., Rygiel, T., Boon, L., Mroz, P., Hamblin, M. R. & Golab, J., Jan 1 2014, In : European Journal of Cancer. 50, 7, p. 1370-1381 12 p.

Research output: Contribution to journalArticle

decitabine
Photochemotherapy
Neoplasms
Neoplasm Antigens
Epigenomics
21 Citations (Scopus)

CpG oligodeoxynucleotide as immune adjuvant enhances photodynamic therapy response in murine metastatic breast cancer

Xia, Y., Gupta, G. K., Castano, A. P., Mroz, P., Avci, P. & Hamblin, M. R., Jan 1 2014, In : Journal of Biophotonics. 7, 11-12, p. 897-905 9 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Oligodeoxyribonucleotides
Photochemotherapy
breast
therapy
2013
10 Citations (Scopus)

Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis

Tanaka, M., Mroz, P., Dai, T., Huang, L., Morimoto, Y., Kinoshita, M., Yoshihara, Y., Shinomiya, N., Seki, S., Nemoto, K. & Hamblin, M. R., May 1 2013, In : Photochemistry and Photobiology. 89, 3, p. 679-682 4 p.

Research output: Contribution to journalArticle

Linezolid
arthritis
Infectious Arthritis
Photodynamic therapy
Methicillin
22 Citations (Scopus)

Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A

Mroz, P., Vatansever, F., Muchowicz, A. & Hamblin, M. R., Nov 1 2013, In : Cancer Research. 73, 21, p. 6462-6470 9 p.

Research output: Contribution to journalArticle

Mastocytoma
Testicular Neoplasms
Photochemotherapy
Antigens
Neoplasms
25 Citations (Scopus)

Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen

Reginato, E., Mroz, P. A., Chung, H., Kawakubo, M., Wolf, P. & Hamblin, M. R., Oct 15 2013, In : British Journal of Cancer. 109, 8, p. 2167-2174 8 p.

Research output: Contribution to journalArticle

Photochemotherapy
Autoantigens
Regulatory T-Lymphocytes
Immunity
Cyclophosphamide
2012
25 Citations (Scopus)

Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle

García-Díaz, M., Kawakubo, M., Mroz, P., Sagristà, M. L., Mora, M., Nonell, S. & Hamblin, M. R., Sep 10 2012, In : Journal of Controlled Release. 162, 2, p. 355-363 9 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Blood Vessels
Drug Delivery Systems
Micelles
Liposomes
31 Citations (Scopus)

Photodynamic therapy can induce a protective innate immune response against murine bacterial Arthritis via Neutrophil accumulation

Tanaka, M., Mroz, P., Dai, T., Huang, L., Morimoto, Y., Kinoshita, M., Yoshihara, Y., Nemoto, K., Shinomiya, N., Seki, S. & Hamblin, M. R., Jun 26 2012, In : PloS one. 7, 6, e39823.

Research output: Contribution to journalArticle

Infectious Arthritis
Photodynamic therapy
Photochemotherapy
arthritis
Innate Immunity
2011
45 Citations (Scopus)

Epha2 is a critical oncogene in melanoma

Udayakumar, D., Zhang, G., Ji, Z., Njauw, C. N., Mroz, P. & Tsao, H., Dec 15 2011, In : Oncogene. 30, 50, p. 4921-4929 9 p.

Research output: Contribution to journalArticle

Oncogenes
Melanoma
Eph Family Receptors
Apoptosis
Cell Line
42 Citations (Scopus)

Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma

Mroz, P., Xia, Y., Asanuma, D., Konopko, A., Zhiyentayev, T., Huang, Y. Y., Sharma, S. K., Dai, T., Khan, U. J., Wharton, T. & Hamblin, M. R., Dec 1 2011, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 6, p. 965-974 10 p.

Research output: Contribution to journalArticle

Fullerenes
Photodynamic therapy
Photochemotherapy
Colon
Adenocarcinoma
1931 Citations (Scopus)

Photodynamic therapy of cancer: An update

Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., Korbelik, M., Moan, J., Mroz, P., Nowis, D., Piette, J., Wilson, B. C. & Golab, J., Jul 1 2011, In : CA Cancer Journal for Clinicians. 61, 4, p. 250-281 32 p.

Research output: Contribution to journalArticle

Photochemotherapy
Neoplasms
Therapeutics
Photosensitizing Agents
Microvessels
2010
15 Citations (Scopus)

Dye-enhanced multimodal confocal microscopy for noninvasive detection of skin cancers in mouse models

Park, J., Mroz, P., Hamblin, M. R. & Yaroslavsky, A. N., Dec 1 2010, In : Journal of Biomedical Optics. 15, 2, 026023.

Research output: Contribution to journalArticle

Confocal microscopy
mice
Skin
Coloring Agents
Dyes
76 Citations (Scopus)

In vitro photodynamic therapy and quantitative structure-activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers

Huang, Y. Y., Mroz, P., Zhiyentayev, T., Sharma, S. K., Balasubramanian, T., Ruzié, C., Krayer, M., Fan, D., Borbas, K. E., Yang, E., Kee, H. L., Kirmaier, C., Diers, J. R., Bocian, D. F., Holten, D., Lindsey, J. S. & Hamblin, M. R., May 27 2010, In : Journal of Medicinal Chemistry. 53, 10, p. 4018-4027 10 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Quantitative Structure-Activity Relationship
Photochemotherapy
Neoplasms
Tetrapyrroles
78 Citations (Scopus)

Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response

Mroz, P., Szokalska, A., Wu, M. X. & Hamblin, M. R., Dec 1 2010, In : PloS one. 5, 12, e15194.

Research output: Contribution to journalArticle

Photodynamic therapy
Histocompatibility Antigens Class II
Photochemotherapy
Tumors
immune response
68 Citations (Scopus)

Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy

Mroz, P., Huang, Y. Y., Szokalska, A., Zhiyentayev, T., Janjua, S., Nifli, A. P., Sherwood, M. E., Ruzié, C., Borbas, K. E., Fan, D., Krayer, M., Balasubramanian, T., Yang, E., Kee, H. L., Kirmaier, C., Diers, J. R., Bocian, D. F., Holten, D., Lindsey, J. S. & Hamblin, M. R., Sep 1 2010, In : FASEB Journal. 24, 9, p. 3160-3170 11 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Photochemotherapy
Melanoma
Melanins
Dihematoporphyrin Ether
95 Citations (Scopus)

Stable synthetic cationic bacteriochlorins as selective antimicrobial photosensitizers

Huang, L., Huang, Y. Y., Mroz, P., Tegos, G. P., Zhiyentayev, T., Sharma, S. K., Lu, Z., Balasubramanian, T., Krayer, M., Ruzié, C., Yang, E., Kee, H. L., Kirmaier, C., Diers, J. R., Bocian, D. F., Holten, D., Lindsey, J. S. & Hamblin, M. R., Sep 1 2010, In : Antimicrobial agents and chemotherapy. 54, 9, p. 3834-3841 8 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Tetrapyrroles
Candida albicans
Staphylococcus aureus
Escherichia coli
2009
74 Citations (Scopus)

Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production

Mroz, P. A., Bhaumik, J., Dogutan, D. K., Aly, Z., Kamal, Z., Khalid, L., Kee, H. L., Bocian, D. F., Holten, D., Lindsey, J. S. & Hamblin, M. R., Sep 8 2009, In : Cancer Letters. 282, 1, p. 63-76 14 p.

Research output: Contribution to journalArticle

Metalloporphyrins
Photosensitizing Agents
Porphyrins
Photochemotherapy
Hydroxyl Radical
68 Citations (Scopus)

Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response

Szokalska, A., Makowski, M., Nowis, D., Wilczyński, G. M., Kujawa, M., Wójcik, C., Młynarczuk-Biały, I., Salwa, P., Bil, J., Janowska, S., Agostinis, P., Verfaillie, T., Bugajski, M., Gietka, J., Issat, T., Głodkowska, E., Mrówka, P., Stoklosa, T., Hamblin, M. R., Mróz, P. & 2 others, Jakóbisiak, M. & Golab, J., May 15 2009, In : Cancer Research. 69, 10, p. 4235-4243 9 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum Stress
Photochemotherapy
Proteasome Endopeptidase Complex
Heat-Shock Proteins
2008
124 Citations (Scopus)

Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model

Castano, A. P., Mroz, P., Wu, M. X. & Hamblin, M. R., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5495-5500 6 p.

Research output: Contribution to journalArticle

Photochemotherapy
Cyclophosphamide
Immunity
Neoplasms
Light
58 Citations (Scopus)

Photophysical characterization of imidazolium-substituted Pd(II), In(III), and Zn(II) porphyrins as photosensitizers for photodynamic therapy

Kee, H. L., Bhaumik, J., Diers, J. R., Mroz, P., Hamblin, M. R., Bocian, D. F., Lindsey, J. S. & Holten, D., Dec 15 2008, In : Journal of Photochemistry and Photobiology A: Chemistry. 200, 2-3, p. 346-355 10 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Photosensitizing Agents
Photosensitizers
Porphyrins
Palladium
2007
165 Citations (Scopus)

Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism

Mroz, P., Pawlak, A., Satti, M., Lee, H., Wharton, T., Gali, H., Sarna, T. & Hamblin, M. R., Sep 1 2007, In : Free Radical Biology and Medicine. 43, 5, p. 711-719 9 p.

Research output: Contribution to journalArticle

Fullerenes
Photosensitizing Agents
Cells
Neoplasms
Superoxides
2006
44 Citations (Scopus)

Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility

Borbas, K. E., Mroz, P., Hamblin, M. R. & Lindsey, J. S., May 1 2006, In : Bioconjugate Chemistry. 17, 3, p. 638-653 16 p.

Research output: Contribution to journalArticle

Bearings (structural)
Porphyrins
Solubility
Water
Diphosphonates
17 Citations (Scopus)

Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection

Anatelli, F., Mroz, P., Liu, Q., Yang, C., Castano, A. P., Swietlik, E. & Hamblin, M. R., Nov 1 2006, In : Molecular Pharmaceutics. 3, 6, p. 654-664 11 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Macrophages
Injections
Neoplasms
Intravenous Injections
131 Citations (Scopus)

Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation

Tegos, G. P., Anbe, M., Yang, C., Demidova, T. N., Satti, M., Mroz, P., Janjua, S., Gad, F. & Hamblin, M. R., Apr 1 2006, In : Antimicrobial agents and chemotherapy. 50, 4, p. 1402-1410 9 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Photosensitizing Agents
Peptide Hydrolases
Lysine
Polylysine
11 Citations (Scopus)

Role of Src kinases in neu-induced tumorigenesis: Challenging the paradigm using Csk homologous kinase transgenic mice

Kaminski, R., Zagozdzon, R., Fu, Y., Mroz, P., Fu, W., Seng, S., Avraham, S. & Avraham, H. K., Jun 1 2006, In : Cancer Research. 66, 11, p. 5757-5762 6 p.

Research output: Contribution to journalArticle

src-Family Kinases
Transgenic Mice
Carcinogenesis
Phosphotransferases
erbB-2 Genes
2004
4 Citations (Scopus)

AAF-cmk sensitizes tumor cells to trail-mediated apoptosis

Młnarczuk, I., Mroz, P. A., Hoser, G., Nowis, D., Biały, Ł. P., Ziemba, H., Grzela, T., Feleszko, W., Malejczyk, J., Wójcik, C., Jakóbisiak, M. & Goła̧b, J., Jan 1 2004, In : Leukemia research. 28, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Tumor Necrosis Factor-alpha
Cytokines
Poisons
107 Citations (Scopus)

Effective photoimmunotherapy of murine colon carcinoma induced by the combination of photodynamic therapy and dendritic cells

Jalili, A., Makowski, M., Świtaj, T., Nowis, D., Wilczyński, G. M., Wilczek, E., Chora̧zy-Massalska, M., Radzikowska, A., Maśliński, W., Białly, Ł., Sieńko, J., Sieroń, A., Adamek, M., Basak, G., Mróz, P., Krasnodȩbski, I. W., Jakóbisiak, M. & Goła̧b, J., Jul 1 2004, In : Clinical Cancer Research. 10, 13, p. 4498-4508 11 p.

Research output: Contribution to journalArticle

Photochemotherapy
Dendritic Cells
Colon
Carcinoma
Interleukin-12
2003
96 Citations (Scopus)

Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol: A superoxide dismutase inhibitor

Gołab, J., Nowis, D., Skrzycki, M., Czeczot, H., Barańczyk-Kuźma, A., Wilczyński, G. M., Makowski, M., Mróz, P., Kozar, K., Kamiński, R., Jalili, A., Kopeć, M., Grzela, T. & Jakóbisiak, M., Jan 3 2003, In : Journal of Biological Chemistry. 278, 1, p. 407-414 8 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Photochemotherapy
Superoxide Dismutase
Tumors
Cells
50 Citations (Scopus)

Inhibition of Cyclooxygenase-2 Indirectly Potentiates Antitumor Effects of Photodynamic Therapy in Mice

Makowski, M., Grzela, T., Niderla, J., Łazarczyk, M., Mróz, P., Kopeć, M., Legat, M., Strusińska, K., Koziak, K., Nowis, D., Mrówka, P., Wa̧sik, M., Jakóbisiak, M. & Goła̧b, J., Nov 1 2003, In : Clinical Cancer Research. 9, 14, p. 5417-5422 6 p.

Research output: Contribution to journalArticle

Photochemotherapy
Cyclooxygenase 2
nimesulide
Cyclooxygenase 2 Inhibitors
Neoplasms
2002
30 Citations (Scopus)

Erythropoietin restores the antitumor effectiveness of photodynamic therapy in mice with chemotherapy-induced anemia

Golłab, J., Olszewska, D., Mróz, P., Kozar, K., Kamiński, R., Jalili, A. & Jakóbisiak, M., May 27 2002, In : Clinical Cancer Research. 8, 5, p. 1265-1270 6 p.

Research output: Contribution to journalArticle

Photochemotherapy
Erythropoietin
Anemia
Drug Therapy
Carboplatin