Paul L Bigliardi

Professor

Accepting PhD Students

1993 …2019
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Research Output 1993 2019

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Article
2019

Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity

Venkatesan, G., Dancik, Y., Sinha, A., Bigliardi, M., Srinivas, R., Dawson, T., Valiyaveettil, S., Bigliardi, P. & Pastorin, G., Jan 1 2019, In : New Journal of Chemistry. 43, 41, p. 16188-16199 12 p.

Research output: Contribution to journalArticle

Aniline Compounds
Hair Dyes
Chemical modification
Aniline
Toxicity

Microbiome in the hair follicle of androgenetic alopecia patients

Ho, B. S. Y., Ho, E. X. P., Chu, C. W., Ramasamy, S., Bigliardi-Qi, M., de Sessions, P. F. & Bigliardi, P. L., Jan 1 2019, In : PloS one. 14, 5, p. e0216330

Research output: Contribution to journalArticle

Open Access
hair follicles
Hair Follicle
alopecia
Microbiota
Alopecia

Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

Ho, B. S. Y., Vaz, C., Ramasamy, S., Chew, E. G. Y., Mohamed, J. S., Jaffar, H., Hillmer, A., Tanavde, V., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2019, In : Scientific reports. 9, 1, 8771.

Research output: Contribution to journalArticle

Open Access
Miniaturization
Alopecia
Hair
Peroxisome Proliferator-Activated Receptors
Hair Follicle
2018
24 Citations (Scopus)

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

Sriram, G., Alberti, M., Dancik, Y., Wu, B., Wu, R., Feng, Z., Ramasamy, S., Bigliardi, P. L., Bigliardi-Qi, M. & Wang, Z., May 1 2018, In : Materials Today. 21, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

fibrin
Skin
chips
organs
matrices
2 Citations (Scopus)

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

Dancik, Y., Sriram, G., Rout, B., Zou, Y., Bigliardi-Qi, M. & Bigliardi, P. L., Mar 7 2018, In : Analyst. 143, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Raman spectroscopy
skin
Skin
Cornea
5 Citations (Scopus)

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells

Leong, C., Bigliardi, P. L., Sriram, G., Au, V. B., Connolly, J. & Bigliardi-Qi, M., Jan 1 2018, In : Photochemistry and Photobiology. 94, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Coculture Techniques
Keratinocytes
Interleukin-4
Dosimetry
Photosensitizing Agents
3 Citations (Scopus)

Role of Skin pH in Psoriasis

Bigliardi, P. L., Jan 1 2018, In : Current Problems in Dermatology (Switzerland). 54, p. 108-114 7 p.

Research output: Contribution to journalArticle

Psoriasis
Skin
Homeostasis
Inflammation
Aquaporins
2017
5 Citations (Scopus)

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi, P., Langer, S., Cruz, J. J., Kim, S. W., Nair, H. & Srisawasdi, G., Oct 1 2017, In : Dermatology. 233, 2-3, p. 223-233 11 p.

Research output: Contribution to journalArticle

Povidone-Iodine
Wound Healing
Local Anti-Infective Agents
Poisons
Wounds and Injuries

An expedient multiple information processing pattern-generating chromophore

Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Sensors and Actuators, B: Chemical. 251, p. 164-170 7 p.

Research output: Contribution to journalArticle

Chromophores
chromophores
Absorption spectra
absorption spectra
decoders

Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand

Leong, C., Neumann, C., Ramasamy, S., Rout, B., Wee, L. Y., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2017, In : PloS one. 12, 12, e0188607.

Research output: Contribution to journalArticle

Open Access
Naltrexone
keratinocytes
narcotics
Opioid Receptors
Keratinocytes
11 Citations (Scopus)

Multi-chamber microfluidic platform for high-precision skin permeation testing

Alberti, M., Dancik, Y., Sriram, G., Wu, B., Teo, Y. L., Feng, Z., Bigliardi-Qi, M., Wu, R. G., Wang, Z. P. & Bigliardi, P. L., Jan 1 2017, In : Lab on a Chip. 17, 9, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

Microfluidics
Permeation
Skin
Testing
Chemical Models
4 Citations (Scopus)

Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Rout, B. & Bigliardi, P. L., Jun 1 2017, In : Synlett. 28, 9, p. 1005-1010 6 p., st-2016-p0798-sp.

Research output: Contribution to journalArticle

Sensors
Logic devices
Molecules
1 Citation (Scopus)

Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Bigliardi, P. L., Rout, B., Pant, A., Krishnan-Kutty, V., Eberle, A. N., Srinivas, R., Burkett, B. A. & Bigliardi-Qi, M., Dec 1 2017, In : Scientific reports. 7, 1, 15750.

Research output: Contribution to journalArticle

Open Access
Photosensitizing Agents
Photochemotherapy
Melanoma
Receptor, Melanocortin, Type 1
Hutchinson's Melanotic Freckle
2016
13 Citations (Scopus)

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

Chew, E. G. Y., Tan, J. H. J., Bahta, A. W., Ho, B. S. Y., Liu, X., Lim, T. C., Sia, Y. Y., Bigliardi, P. L., Heilmann, S., Wan, A. C. A., Nöthen, M. M., Philpott, M. P. & Hillmer, A. M., Aug 1 2016, In : Journal of Investigative Dermatology. 136, 8, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Alopecia
Scalp
Genes
Skin
Hair Follicle
8 Citations (Scopus)

Opioids and skin homeostasis, regeneration and ageing – What's the evidence?

Bigliardi, P. L., Dancik, Y., Neumann, C. & Bigliardi-Qi, M., Aug 1 2016, In : Experimental Dermatology. 25, 8, p. 586-591 6 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Regeneration
Skin
Homeostasis
Aging of materials
4 Citations (Scopus)

Reconstructing human skin equivalents on fibrin-based dermal matrix: Reproducible human skin equivalents with superior epidermal reconstruction

Sriram, G., Dykas, M. M., Ramasamy, S., Poddar, K., Krishnan-Kutty, V., Patra, A., Venkatesan, T., Bigliardi-Qi, M. & Bigliardi, P. L., Apr 1 2016, In : Materials Today. 19, 3, p. 178-179 2 p.

Research output: Contribution to journalArticle

Fibrin
Skin
16 Citations (Scopus)

Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography

Ford, S. J., Bigliardi, P. L., Sardella, T. C. P., Urich, A., Burton, N. C., Kacprowicz, M., Bigliardi, M., Olivo, M. & Razansky, D., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 753-761 9 p.

Research output: Contribution to journalArticle

Functional analysis
Photoacoustic effect
Hair Follicle
Structural analysis
Hair
2015
7 Citations (Scopus)

Evaluation of the applicability of the Immuno-solidphase allergen chip (ISAC) assay in atopic patients in Singapore

Santosa, A., Andiappan, A. K., Rotzschke, O., Wong, H. C., Chang, A., Bigliardi-Qi, M., Wang, D. Y. & Bigliardi, P. L., Feb 27 2015, In : Clinical and Translational Allergy. 5, 1, 9.

Research output: Contribution to journalArticle

Singapore
Allergens
Skin Tests
Pyroglyphidae
Atopic Dermatitis
4 Citations (Scopus)
Opioid Receptors
Keratinocytes
Fibroblasts
Wound Healing
Skin
15 Citations (Scopus)

The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3

Neumann, C., Bigliardi-Qi, M., Widmann, C. & Bigliardi, P. L., Feb 13 2015, In : Journal of Investigative Dermatology. 135, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Opioid Receptors
Keratinocytes
Homeostasis
Transcription Factors
2014
52 Citations (Scopus)

Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection

Cerny, D., Haniffa, M., Shin, A., Bigliardi, P., Tan, B. K., Lee, B., Poidinger, M., Tan, E. Y., Ginhoux, F. & Fink, K., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

Dengue Virus
Langerhans Cells
Antigen-Presenting Cells
Virus Diseases
Dendritic Cells
3 Citations (Scopus)

Wheat-dependent exercise-induced anaphylaxis: A retrospective case review from a tertiary hospital

Thalayasingam, M., Allameen, N. A., Soh, J. Y., Bigliardi, P., Van Bever, H. & Shek, L. P. C., Jan 1 2014, In : Postgraduate Medical Journal. 90, 1067, p. 488-492 5 p.

Research output: Contribution to journalArticle

Anaphylaxis
Tertiary Care Centers
Triticum
Exercise
Wheat Hypersensitivity
2012
43 Citations (Scopus)

Caspase-3 protects stressed organs against cell death

Khalil, H., Peltzer, N., Walicki, J., Yang, J. Y., Dubuis, G., Gardiol, N., Held, W., Bigliardi, P., Marsland, B., Liaudet, L. & Widmann, C., Nov 1 2012, In : Molecular and cellular biology. 32, 22, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Knockout Mice
Sunburn
Aptitude
2011
9 Citations (Scopus)

Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers

Grouzmann, E., Bigliardi, P., Appenzeller, M., Pannatier, A. & Buclin, T., Mar 1 2011, In : Biological Chemistry. 392, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

Substance P
Volunteers
Skin
Inflammation
Neprilysin
2007
42 Citations (Scopus)

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L. & Bigliardi, P. L., Jun 1 2007, In : Journal of Investigative Dermatology. 127, 6, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

Nerve Endings
Opioid Receptors
Peripheral Nerves
Hypertrophy
Dermatitis
81 Citations (Scopus)

Treatment of pruritus with topically applied opiate receptor antagonist

Bigliardi, P. L., Stammer, H., Jost, G., Rufli, T., Büchner, S. & Bigliardi-Qi, M., Jun 1 2007, In : Journal of the American Academy of Dermatology. 56, 6, p. 979-988 10 p.

Research output: Contribution to journalArticle

Naltrexone
Opioid Receptors
Pruritus
Placebos
Atopic Dermatitis
2006

Arnica - Une plante magnifique?

Translated title of the contribution: Arnica - a splendid plant?Schwarzkopf, S., Bigliardi, P. L., Panizzon, R. G. & Laffitte, E., Dec 13 2006, In : Revue Medicale Suisse. 2, 91, p. 2884-2885 2 p.

Research output: Contribution to journalArticle

Physical Therapy Specialty
Arnica
Occupational Dermatitis
Allergic Contact Dermatitis
42 Citations (Scopus)

Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B. & Bigliardi, P. L., Jan 1 2006, In : Differentiation. 74, 4, p. 174-185 12 p.

Research output: Contribution to journalArticle

Opioid Receptors
Knockout Mice
Wound Healing
Skin
Differentiation Antigens

Ursachen, diagnose und therapie von pruritus

Translated title of the contribution: Causes, diagnosis and treatment of pruritusBigliardi, P. L., Nov 1 2006, In : Aktuelle Dermatologie. 32, 11, p. 468-473 6 p.

Research output: Contribution to journalArticle

Pruritus
Therapeutics
Skin
Thyroid Diseases
Kidney Diseases
2005
66 Citations (Scopus)

Changes of epidermal mu-opiate receptor expression and nerve endings in chronic atopic dermatitis

Bigliardi-Qi, M., Lipp, B., Sumanovski, L. T., Buechner, S. A. & Bigliardi, P. L., Apr 18 2005, In : Dermatology. 210, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

Nerve Endings
mu Opioid Receptor
Opioid Receptors
Atopic Dermatitis
Epidermis
78 Citations (Scopus)

How best to fight that nasty itch - From new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches

Bíró, T., Ko, M. C., Bromm, B., Wei, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N. V., Kamei, C., Schouenborg, J., Roostermann, D., Szabó, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J. G., Hossen, M. A., Schmelz, M. & Steinhoff, M., Mar 1 2005, In : Experimental Dermatology. 14, 3, p. 225-240 16 p.

Research output: Contribution to journalArticle

Pruritus
Dermatology
Neurophysiology
Histamine Receptors
Medicine
2004
77 Citations (Scopus)

Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin

Bigliardi-Qi, M., Sumanovski, L. T., Büchner, S., Rufli, T. & Bigliardi, P. L., Oct 27 2004, In : Dermatology. 209, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Nerve Endings
beta-Endorphin
mu Opioid Receptor
Endorphins
Opioid Receptors
17 Citations (Scopus)

Unilateral aplasia cutis congenita on the leg

Bigliardi, P. L., Braschler, C., Kuhn, P., Sigrist, J., Buechner, S. & Rufli, T., Jul 1 2004, In : Pediatric Dermatology. 21, 4, p. 454-457 4 p.

Research output: Contribution to journalArticle

Ectodermal Dysplasia
Leg
Silver Sulfadiazine
Ointments
Nails
2003
45 Citations (Scopus)

Anaphylaxis to the carbohydrate carboxymethylcellulose in parenteral corticosteroid preparations.

Bigliardi, P. L., Izakovic, J., Weber, J. M. & Bircher, A. J., Jan 1 2003, In : Dermatology (Basel, Switzerland). 207, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

Carboxymethylcellulose Sodium
Anaphylaxis
Adrenal Cortex Hormones
Carbohydrates
Skin Tests
46 Citations (Scopus)
Keratin-16
Endorphins
Growth Factor Receptors
Transforming Growth Factors
Opioid Receptors
2002
37 Citations (Scopus)

Specific stimulation of migration of human keratinocytes by μ-opiate receptor agonists

Bigliardi, P. L., Büchner, S., Rufli, T. & Bigliardi-Qi, M., Dec 1 2002, In : Journal of Receptors and Signal Transduction. 22, 1-4, p. 191-199 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Endorphins
Keratinocytes
Wound Healing
Foreskin
2000
20 Citations (Scopus)

Delayed generalized allergic reactions to corticosteroids

Bircher, A. J., Bigliardi, P., Zaugg, T. & Mäkinen-Kiljunen, S., Jan 1 2000, In : Dermatology. 200, 4, p. 349-351 3 p.

Research output: Contribution to journalArticle

Budesonide
Adrenal Cortex Hormones
Hypersensitivity
Prednisone
Exanthema
52 Citations (Scopus)

β-Endorphin stimulates cytokeratin 16 expression and downregulates μ- opiate receptor expression in human epidermis

Bigliardi-Qi, M., Bigliardi, P. L., Eberle, A. N., Büchner, S. & Rufli, T., Jan 1 2000, In : Journal of Investigative Dermatology. 114, 3, p. 527-532 6 p.

Research output: Contribution to journalArticle

Keratin-16
Endorphins
Opioid Receptors
Epidermis
Skin
1999
23 Citations (Scopus)

Anaphylaxis resulting from selective sensitization to Americana grapes

Bircher, A. J., Bigliardi, P. & Yilmaz, B., Jan 1 1999, In : Journal of Allergy and Clinical Immunology. 104, 5, p. 1111-1113 3 p.

Research output: Contribution to journalArticle

Vitis
Anaphylaxis
24 Citations (Scopus)

Characterization of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi-Qi, M., Bigliardi, P. L., Büchner, S. & Rufli, T., Jan 1 1999, In : Annals of the New York Academy of Sciences. 885, p. 368-371 4 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Opioid Receptors
Keratinocytes
Epidermis
9 Citations (Scopus)

Occupational airborne contact dermatitis from diphencyprone in a pharmacy employee

Bircher, A. J., Bigliardi, P., Messmer, S. L. & Surber, C., Jan 1 1999, In : Contact Dermatitis. 41, 1, 1 p.

Research output: Contribution to journalArticle

Dermatitis
Allergic Contact Dermatitis
Contact Dermatitis
Personnel
diphenylcyclopropenone
1998
84 Citations (Scopus)

Expression of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi, P. L., Bigliardi-Qi, M., Buechner, S. & Rufli, T., Jan 1 1998, In : Journal of Investigative Dermatology. 111, 2, p. 297-301 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Keratinocytes
Epidermis
Opiate Alkaloids
Skin
1995
70 Citations (Scopus)

Keratinocyte muscarinic acetylcholine receptors: Immunolocalization and partial characterization

Grando, S. A., Zelickson, B. D., Kist, D. A., Weinshenker, D., Bigliardi, P. L., Wendelschafer-Crabb, G., Kennedy, W. R. & Dahl, M. V., Jan 1 1995, In : Journal of Investigative Dermatology. 104, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
Keratinocytes
Cholinergic Receptors
Cholinergic Agents
Electrophoresis
1994
24 Citations (Scopus)

Effects of detergents on proliferation and metabolism of human keratinocytes

Bigliardi, P. L., Herron, M. J., Nelson, R. D. & Dahl, M. V., Jan 1 1994, In : Experimental Dermatology. 3, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Metabolism
Detergents
Poisons
Dermatitis
1993
11 Citations (Scopus)

Computerized microassay of keratinocyte cell-plastic attachment and proliferation for assessing net stimulatory, inhibitory and toxic effects of compounds on nonimmortalized cell lines

Grando, S. A., Cabrera, R., Hostager, B. S., Bigliardi, P. L., Blake, J. S., Herron, M. J., Dahl, M. V. & Nelson, R. D., Jan 1 1993, In : Skin Pharmacology and Physiology. 6, 2, p. 135-147 13 p.

Research output: Contribution to journalArticle

Poisons
Keratinocytes
Plastics
Cell Line
Cell Count