Paul L Bigliardi

Professor

Accepting PhD Students

1993 …2019

Research output per year

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Research Output

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi, P. L., Neumann, C., Teo, Y. L., Pant, A. & Bigliardi-Qi, M., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 501-514 14 p.

Research output: Contribution to journalReview article

23 Scopus citations

Aging in hair follicle stem cells and niche microenvironment

Ji, J., Ho, B. S. Y., Qian, G., Xie, X. M., Bigliardi, P. L. & Bigliardi-Qi, M., Oct 2017, In : Journal of Dermatology. 44, 10, p. 1097-1104 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

Anaphylaxis resulting from selective sensitization to Americana grapes

Bircher, A. J., Bigliardi, P. & Yilmaz, B., Jan 1 1999, In : Journal of Allergy and Clinical Immunology. 104, 5, p. 1111-1113 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Anaphylaxis to the carbohydrate carboxymethylcellulose in parenteral corticosteroid preparations.

Bigliardi, P. L., Izakovic, J., Weber, J. M. & Bircher, A. J., 2003, In : Dermatology (Basel, Switzerland). 207, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi, P., Langer, S., Cruz, J. J., Kim, S. W., Nair, H. & Srisawasdi, G., Oct 1 2017, In : Dermatology. 233, 2-3, p. 223-233 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

An expedient multiple information processing pattern-generating chromophore

Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Sensors and Actuators, B: Chemical. 251, p. 164-170 7 p.

Research output: Contribution to journalArticle

Arnica - Une plante magnifique?

Translated title of the contribution: Arnica - a splendid plant?Schwarzkopf, S., Bigliardi, P. L., Panizzon, R. G. & Laffitte, E., Dec 13 2006, In : Revue Medicale Suisse. 2, 91, p. 2884-2885 2 p.

Research output: Contribution to journalArticle

Caspase-3 protects stressed organs against cell death

Khalil, H., Peltzer, N., Walicki, J., Yang, J. Y., Dubuis, G., Gardiol, N., Held, W., Bigliardi, P., Marsland, B., Liaudet, L. & Widmann, C., Nov 1 2012, In : Molecular and cellular biology. 32, 22, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Changes of epidermal mu-opiate receptor expression and nerve endings in chronic atopic dermatitis

Bigliardi-Qi, M., Lipp, B., Sumanovski, L. T., Buechner, S. A. & Bigliardi, P. L., Apr 18 2005, In : Dermatology. 210, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Characterization of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi-Qi, M., Bigliardi, P. L., Büchner, S. & Rufli, T., Jan 1 1999, In : Annals of the New York Academy of Sciences. 885, p. 368-371 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Chronic idiopathic urticaria successfully treated by anticoagulant drug

Spring, P., Angelillo-Scherrer, A. & Bigliardi, P., Dec 1 2012, In : European Journal of Dermatology. 22, 6, p. 788-790 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

Chew, E. G. Y., Ho, B. S. Y., Ramasamy, S., Dawson, T., Tennakoon, C., Liu, X., Leong, W. M. S., Yang, S. Y. S., Lim, S. Y. D., Jaffar, H., Hillmer, A. M., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : British Journal of Dermatology. 176, 1, p. 265-269 5 p.

Research output: Contribution to journalLetter

7 Scopus citations

Computerized microassay of keratinocyte cell-plastic attachment and proliferation for assessing net stimulatory, inhibitory and toxic effects of compounds on nonimmortalized cell lines

Grando, S. A., Cabrera, R., Hostager, B. S., Bigliardi, P. L., Blake, J. S., Herron, M. J., Dahl, M. V. & Nelson, R. D., Jan 1 1993, In : Skin Pharmacology and Physiology. 6, 2, p. 135-147 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Controversies in drug allergy: Testing for delayed reactions

Phillips, E. J., Bigliardi, P., Bircher, A. J., Broyles, A., Chang, Y. S., Chung, W. H., Lehloenya, R., Mockenhaupt, M., Peter, J., Pirmohamed, M., Roujeau, J. C., Shear, N. H., Tanno, L. K., Trubiano, J., Valluzzi, R. & Barbaud, A., Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 66-73 8 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Delayed generalized allergic reactions to corticosteroids

Bircher, A. J., Bigliardi, P., Zaugg, T. & Mäkinen-Kiljunen, S., Jan 1 2000, In : Dermatology. 200, 4, p. 349-351 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B. & Bigliardi, P. L., Apr 2006, In : Differentiation. 74, 4, p. 174-185 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L. & Bigliardi, P. L., Jun 1 2007, In : Journal of Investigative Dermatology. 127, 6, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
46 Scopus citations

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

Chew, E. G. Y., Tan, J. H. J., Bahta, A. W., Ho, B. S. Y., Liu, X., Lim, T. C., Sia, Y. Y., Bigliardi, P. L., Heilmann, S., Wan, A. C. A., Nöthen, M. M., Philpott, M. P. & Hillmer, A. M., Aug 1 2016, In : Journal of Investigative Dermatology. 136, 8, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Eczéma chronique des mains: Traitements conventionnels et nouveautés

Translated title of the contribution: Chronic hand eczema, conventional and new treatmentsSpring, P. & Bigliardi, P., Apr 4 2012, In : Revue Medicale Suisse. 8, 335, p. 736-742 7 p.

Research output: Contribution to journalReview article

Effects of detergents on proliferation and metabolism of human keratinocytes

Bigliardi, P. L., Herron, M. J., Nelson, R. D. & Dahl, M. V., Apr 1994, In : Experimental Dermatology. 3, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis

Translated title of the contribution: Toxic epidermal necrolysisBigliardi, P. L., Raffoul, W. & Berger, M. M., May 2 2007, In : Revue Medicale Suisse. 3, 109, p. 1112-1118 7 p.

Research output: Contribution to journalReview article

Evaluation of the applicability of the Immuno-solidphase allergen chip (ISAC) assay in atopic patients in Singapore

Santosa, A., Andiappan, A. K., Rotzschke, O., Wong, H. C., Chang, A., Bigliardi-Qi, M., Wang, D. Y. & Bigliardi, P. L., Feb 27 2015, In : Clinical and Translational Allergy. 5, 1, 9.

Research output: Contribution to journalArticle

7 Scopus citations

Expression of peropsin in human skin is related to phototransduction of violet light in keratinocytes

Toh, P. P. C., Bigliardi-Qi, M., Yap, A. M. Y., Sriram, G. & Bigliardi, P., Dec 1 2016, In : Experimental Dermatology. 25, 12, p. 1002-1005 4 p.

Research output: Contribution to journalLetter

14 Scopus citations

Expression of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi, P. L., Bigliardi-Qi, M., Buechner, S. & Rufli, T., Jan 1 1998, In : Journal of Investigative Dermatology. 111, 2, p. 297-301 5 p.

Research output: Contribution to journalArticle

84 Scopus citations

Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity

Venkatesan, G., Dancik, Y., Sinha, A., Bigliardi, M., Srinivas, R., Dawson, T., Valiyaveettil, S., Bigliardi, P. & Pastorin, G., Jan 1 2019, In : New Journal of Chemistry. 43, 41, p. 16188-16199 12 p.

Research output: Contribution to journalArticle

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2015, In : European Journal of Cell Biology. 94, 11, p. 483-512 30 p.

Research output: Contribution to journalReview article

84 Scopus citations

Full-thickness human skin equivalent models of atopic dermatitis

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 367-383 17 p. (Methods in Molecular Biology; vol. 1879).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

Sriram, G., Alberti, M., Dancik, Y., Wu, B., Wu, R., Feng, Z., Ramasamy, S., Bigliardi, P. L., Bigliardi-Qi, M. & Wang, Z., May 2018, In : Materials Today. 21, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

High-throughput microfluidic chip for automated in vitro release testing

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L. & Wang, Z. P., Jan 1 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 589-590 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

How best to fight that nasty itch - From new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches

Bíró, T., Ko, M. C., Bromm, B., Wei, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N. V., Kamei, C., Schouenborg, J., Roostermann, D., Szabó, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J. G., Hossen, M. A., Schmelz, M. & Steinhoff, M., Mar 2005, In : Experimental Dermatology. 14, 3, 1 p.

Research output: Contribution to journalArticle

79 Scopus citations

Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand

Leong, C., Neumann, C., Ramasamy, S., Rout, B., Wee, L. Y., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 2017, In : PloS one. 12, 12, e0188607.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Keratinocyte muscarinic acetylcholine receptors: Immunolocalization and partial characterization

Grando, S. A., Zelickson, B. D., Kist, D. A., Weinshenker, D., Bigliardi, P. L., Wendelschafer-Crabb, G., Kennedy, W. R. & Dahl, M. V., Jan 1 1995, In : Journal of Investigative Dermatology. 104, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Kortikosteroide zur lokalen Anwendung auf der Haut

Translated title of the contribution: Corticosteroids for topical skin applicationKahmann, I. V., Gabard, B. & Bigliardi, P. L., Dec 5 2008, In : Pharma-Kritik. 30, 8-9, p. 29-36 8 p.

Research output: Contribution to journalReview article

Microbiome in the hair follicle of androgenetic alopecia patients

Ho, B. S. Y., Ho, E. X. P., Chu, C. W., Ramasamy, S., Bigliardi-Qi, M., de Sessions, P. F. & Bigliardi, P. L., Jan 1 2019, In : PloS one. 14, 5, p. e0216330

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Multi-chamber microfluidic platform for high-precision skin permeation testing

Alberti, M., Dancik, Y., Sriram, G., Wu, B., Teo, Y. L., Feng, Z., Bigliardi-Qi, M., Wu, R. G., Wang, Z. P. & Bigliardi, P. L., Jan 1 2017, In : Lab on a chip. 17, 9, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin

Bigliardi-Qi, M., Sumanovski, L. T., Büchner, S., Rufli, T. & Bigliardi, P. L., Oct 27 2004, In : Dermatology. 209, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Occupational airborne contact dermatitis from diphencyprone in a pharmacy employee

Bircher, A. J., Bigliardi, P., Messmer, S. L. & Surber, C., Jan 1 1999, In : Contact Dermatitis. 41, 1, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations

Opioids and skin homeostasis, regeneration and ageing – What's the evidence?

Bigliardi, P. L., Dancik, Y., Neumann, C. & Bigliardi-Qi, M., Aug 1 2016, In : Experimental Dermatology. 25, 8, p. 586-591 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Opioids and the skin - Where do we stand?

Bigliardi, P. L., Tobin, D. J., Gaveriaux-Ruff, C. & Bigliardi-Qi, M., Apr 29 2009, In : Experimental Dermatology. 18, 5, p. 424-430 7 p.

Research output: Contribution to journalReview article

81 Scopus citations

Oral tolerance of carboxymethylcellulose in patients with anaphylaxis to parenteral carboxymethylcellulose [2]

Bircher, A. J., Izakovic, J. & Bigliardi, P. L., May 2004, In : Annals of Allergy, Asthma and Immunology. 92, 5, p. 580-581 2 p.

Research output: Contribution to journalLetter

10 Scopus citations

Pansements bioactifs

Translated title of the contribution: Bioactive dressingsGrasset, N., Raffoul, W. & Bigliardi, P., Feb 17 2010, In : Revue Medicale Suisse. 6, 236, p. 354-357 4 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Rout, B. & Bigliardi, P. L., Jun 1 2017, In : Synlett. 28, 9, p. 1005-1010 6 p., st-2016-p0798-sp.

Research output: Contribution to journalArticle

4 Scopus citations

Peripheral nerve fibres form multifacet interactions with keratinocytes in a novel complete human 2D culture model

Krishnan-Kutty, V., Bigliardi, P. L., Dykas, M. M., Pomp, O., Kyaw, H. M., Poddar, K., Venkatesan, T. & Bigliardi-Qi, M., Mar 1 2017, In : Experimental Dermatology. 26, 3, p. 281-284 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

Dancik, Y., Sriram, G., Rout, B., Zou, Y., Bigliardi-Qi, M. & Bigliardi, P. L., Mar 7 2018, In : Analyst. 143, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells

Leong, C., Bigliardi, P. L., Sriram, G., Au, V. B., Connolly, J. & Bigliardi-Qi, M., Jan 1 2018, In : Photochemistry and Photobiology. 94, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Povidone iodine in wound healing: A review of current concepts and practices

Bigliardi, P. L., Alsagoff, S. A. L., El-Kafrawi, H. Y., Pyon, J. K., Wa, C. T. C. & Villa, M. A., Aug 2017, In : International Journal of Surgery. 44, p. 260-268 9 p.

Research output: Contribution to journalReview article

38 Scopus citations

Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

Ho, B. S. Y., Vaz, C., Ramasamy, S., Chew, E. G. Y., Mohamed, J. S., Jaffar, H., Hillmer, A., Tanavde, V., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2019, In : Scientific reports. 9, 1, 8771.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Prurit: Causes, diagnostic et traitement

Translated title of the contribution: Pruritus - Causes, diagnostics and treatmentBigliardi, P. L., Apr 26 2006, In : Revue Medicale Suisse. 2, 63, p. 1115-1121 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Pyoderma gangrenosum mimicking early acute infection following total knee arthroplasty

Yik, J. H., Bigliardi, P. L., Sebastin, S. J., Cabucana, N. J., Venkatachalam, I. & Krishna, L., Jan 1 2015, In : Annals of the Academy of Medicine Singapore. 44, 4, p. 150-151 2 p.

Research output: Contribution to journalLetter

2 Scopus citations