Paul L Bigliardi

Professor

Accepting PhD Students

1993 …2020

Research output per year

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Research Output

2020

Superior differentiation in full thickness human skin-on-a-chip

Alberti, M., Sriram, G., Dancik, Y., Wu, B., Wu, R., Ramasamy, S., Bigliardi-Qi, M., Bigliardi, P. L. & Wang, Z., Jan 1 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 1121-1122 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2019

Controversies in drug allergy: Testing for delayed reactions

Phillips, E. J., Bigliardi, P., Bircher, A. J., Broyles, A., Chang, Y. S., Chung, W. H., Lehloenya, R., Mockenhaupt, M., Peter, J., Pirmohamed, M., Roujeau, J. C., Shear, N. H., Tanno, L. K., Trubiano, J., Valluzzi, R. & Barbaud, A., Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 66-73 8 p.

Research output: Contribution to journalReview article

Open Access
22 Scopus citations

Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity

Venkatesan, G., Dancik, Y., Sinha, A., Bigliardi, M., Srinivas, R., Dawson, T., Valiyaveettil, S., Bigliardi, P. & Pastorin, G., Jan 1 2019, In : New Journal of Chemistry. 43, 41, p. 16188-16199 12 p.

Research output: Contribution to journalArticle

Full-thickness human skin equivalent models of atopic dermatitis

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 367-383 17 p. (Methods in Molecular Biology; vol. 1879).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Microbiome in the hair follicle of androgenetic alopecia patients

Ho, B. S. Y., Ho, E. X. P., Chu, C. W., Ramasamy, S., Bigliardi-Qi, M., de Sessions, P. F. & Bigliardi, P. L., May 3 2019, In : PloS one. 14, 5, e0216330.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

Ho, B. S. Y., Vaz, C., Ramasamy, S., Chew, E. G. Y., Mohamed, J. S., Jaffar, H., Hillmer, A., Tanavde, V., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2019, In : Scientific reports. 9, 1, 8771.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

Sriram, G., Alberti, M., Dancik, Y., Wu, B., Wu, R., Feng, Z., Ramasamy, S., Bigliardi, P. L., Bigliardi-Qi, M. & Wang, Z., May 2018, In : Materials Today. 21, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

Dancik, Y., Sriram, G., Rout, B., Zou, Y., Bigliardi-Qi, M. & Bigliardi, P. L., Mar 7 2018, In : Analyst. 143, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells

Leong, C., Bigliardi, P. L., Sriram, G., Au, V. B., Connolly, J. & Bigliardi-Qi, M., Jan 1 2018, In : Photochemistry and Photobiology. 94, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Role of Skin pH in Psoriasis

Bigliardi, P. L., Jan 1 2018, In : Current Problems in Dermatology (Switzerland). 54, p. 108-114 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

The roles of opioid receptors in cutaneous wound healing

Bigliardi-Qi, M. & Bigliardi, P., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 335-345 11 p. (Handbook of Experimental Pharmacology; vol. 247).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2017

Aging in hair follicle stem cells and niche microenvironment

Ji, J., Ho, B. S. Y., Qian, G., Xie, X. M., Bigliardi, P. L. & Bigliardi-Qi, M., Oct 2017, In : Journal of Dermatology. 44, 10, p. 1097-1104 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi, P., Langer, S., Cruz, J. J., Kim, S. W., Nair, H. & Srisawasdi, G., Oct 1 2017, In : Dermatology. 233, 2-3, p. 223-233 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

An expedient multiple information processing pattern-generating chromophore

Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Sensors and Actuators, B: Chemical. 251, p. 164-170 7 p.

Research output: Contribution to journalArticle

Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

Chew, E. G. Y., Ho, B. S. Y., Ramasamy, S., Dawson, T., Tennakoon, C., Liu, X., Leong, W. M. S., Yang, S. Y. S., Lim, S. Y. D., Jaffar, H., Hillmer, A. M., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : British Journal of Dermatology. 176, 1, p. 265-269 5 p.

Research output: Contribution to journalLetter

8 Scopus citations

Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand

Leong, C., Neumann, C., Ramasamy, S., Rout, B., Wee, L. Y., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 2017, In : PloS one. 12, 12, e0188607.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multi-chamber microfluidic platform for high-precision skin permeation testing

Alberti, M., Dancik, Y., Sriram, G., Wu, B., Teo, Y. L., Feng, Z., Bigliardi-Qi, M., Wu, R. G., Wang, Z. P. & Bigliardi, P. L., May 7 2017, In : Lab on a chip. 17, 9, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Rout, B. & Bigliardi, P. L., Jun 1 2017, In : Synlett. 28, 9, p. 1005-1010 6 p., st-2016-p0798-sp.

Research output: Contribution to journalArticle

4 Scopus citations

Peripheral nerve fibres form multifacet interactions with keratinocytes in a novel complete human 2D culture model

Krishnan-Kutty, V., Bigliardi, P. L., Dykas, M. M., Pomp, O., Kyaw, H. M., Poddar, K., Venkatesan, T. & Bigliardi-Qi, M., Mar 1 2017, In : Experimental Dermatology. 26, 3, p. 281-284 4 p.

Research output: Contribution to journalLetter

Open Access
4 Scopus citations

Povidone iodine in wound healing: A review of current concepts and practices

Bigliardi, P. L., Alsagoff, S. A. L., El-Kafrawi, H. Y., Pyon, J. K., Wa, C. T. C. & Villa, M. A., Aug 2017, In : International Journal of Surgery. 44, p. 260-268 9 p.

Research output: Contribution to journalReview article

Open Access
42 Scopus citations

Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Bigliardi, P. L., Rout, B., Pant, A., Krishnan-Kutty, V., Eberle, A. N., Srinivas, R., Burkett, B. A. & Bigliardi-Qi, M., Dec 1 2017, In : Scientific reports. 7, 1, 15750.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Stevens-Johnson syndrome/toxic epidermal necrolysis overlap induced by fexofenadine

Teo, S. L., Santosa, A. & Bigliardi, P. L., Jan 1 2017, In : Journal of Investigational Allergology and Clinical Immunology. 27, 3, p. 191-193 3 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Synthetic peptide drugs for targeting skin cancer: Malignant melanoma and melanotic lesions

Eberle, A. N., Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Current medicinal chemistry. 24, 17, p. 1797-1826 30 p.

Research output: Contribution to journalReview article

4 Scopus citations
2016

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

Chew, E. G. Y., Tan, J. H. J., Bahta, A. W., Ho, B. S. Y., Liu, X., Lim, T. C., Sia, Y. Y., Bigliardi, P. L., Heilmann, S., Wan, A. C. A., Nöthen, M. M., Philpott, M. P. & Hillmer, A. M., Aug 1 2016, In : Journal of Investigative Dermatology. 136, 8, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Expression of peropsin in human skin is related to phototransduction of violet light in keratinocytes

Toh, P. P. C., Bigliardi-Qi, M., Yap, A. M. Y., Sriram, G. & Bigliardi, P., Dec 1 2016, In : Experimental Dermatology. 25, 12, p. 1002-1005 4 p.

Research output: Contribution to journalLetter

14 Scopus citations

High-throughput microfluidic chip for automated in vitro release testing

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L. & Wang, Z. P., Jan 1 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 589-590 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Opioids and skin homeostasis, regeneration and ageing – What's the evidence?

Bigliardi, P. L., Dancik, Y., Neumann, C. & Bigliardi-Qi, M., Aug 1 2016, In : Experimental Dermatology. 25, 8, p. 586-591 6 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Reconstructing human skin equivalents on fibrin-based dermal matrix: Reproducible human skin equivalents with superior epidermal reconstruction

Sriram, G., Dykas, M. M., Ramasamy, S., Poddar, K., Krishnan-Kutty, V., Patra, A., Venkatesan, T., Bigliardi-Qi, M. & Bigliardi, P. L., Apr 1 2016, In : Materials Today. 19, 3, p. 178-179 2 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography

Ford, S. J., Bigliardi, P. L., Sardella, T. C. P., Urich, A., Burton, N. C., Kacprowicz, M., Bigliardi, M., Olivo, M. & Razansky, D., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 753-761 9 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2015

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi, P. L., Neumann, C., Teo, Y. L., Pant, A. & Bigliardi-Qi, M., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 501-514 14 p.

Research output: Contribution to journalReview article

23 Scopus citations

Evaluation of the applicability of the Immuno-solidphase allergen chip (ISAC) assay in atopic patients in Singapore

Santosa, A., Andiappan, A. K., Rotzschke, O., Wong, H. C., Chang, A., Bigliardi-Qi, M., Wang, D. Y. & Bigliardi, P. L., Feb 27 2015, In : Clinical and Translational Allergy. 5, 1, 9.

Research output: Contribution to journalArticle

8 Scopus citations

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2015, In : European Journal of Cell Biology. 94, 11, p. 483-512 30 p.

Research output: Contribution to journalReview article

90 Scopus citations

Pyoderma gangrenosum mimicking early acute infection following total knee arthroplasty

Yik, J. H., Bigliardi, P. L., Sebastin, S. J., Cabucana, N. J., Venkatachalam, I. & Krishna, L., Jan 1 2015, In : Annals of the Academy of Medicine Singapore. 44, 4, p. 150-151 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
4 Scopus citations

The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3

Neumann, C., Bigliardi-Qi, M., Widmann, C. & Bigliardi, P. L., Feb 13 2015, In : Journal of Investigative Dermatology. 135, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
6 Scopus citations
2014

Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection

Cerny, D., Haniffa, M., Shin, A., Bigliardi, P., Tan, B. K., Lee, B., Poidinger, M., Tan, E. Y., Ginhoux, F. & Fink, K., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

55 Scopus citations

Wheat-dependent exercise-induced anaphylaxis: A retrospective case review from a tertiary hospital

Thalayasingam, M., Allameen, N. A., Soh, J. Y., Bigliardi, P., Van Bever, H. & Shek, L. P. C., Sep 2014, In : Postgraduate Medical Journal. 90, 1067, p. 488-492 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2012

Caspase-3 protects stressed organs against cell death

Khalil, H., Peltzer, N., Walicki, J., Yang, J. Y., Dubuis, G., Gardiol, N., Held, W., Bigliardi, P., Marsland, B., Liaudet, L. & Widmann, C., Nov 1 2012, In : Molecular and cellular biology. 32, 22, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chronic idiopathic urticaria successfully treated by anticoagulant drug

Spring, P., Angelillo-Scherrer, A. & Bigliardi, P., Dec 1 2012, In : European Journal of Dermatology. 22, 6, p. 788-790 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Eczéma chronique des mains: Traitements conventionnels et nouveautés

Translated title of the contribution: Chronic hand eczema, conventional and new treatmentsSpring, P. & Bigliardi, P., Apr 4 2012, In : Revue Medicale Suisse. 8, 335, p. 736-742 7 p.

Research output: Contribution to journalReview article

UV-B induces cytoplasmic survivin expression in mouse epidermis

Peltzer, N., Bigliardi, P. & Widmann, C., Sep 1 2012, In : Journal of Dermatological Science. 67, 3, p. 196-199 4 p.

Research output: Contribution to journalLetter

3 Scopus citations
2011

Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers

Grouzmann, E., Bigliardi, P., Appenzeller, M., Pannatier, A. & Buclin, T., Mar 1 2011, In : Biological Chemistry. 392, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Pansements bioactifs

Translated title of the contribution: Bioactive dressingsGrasset, N., Raffoul, W. & Bigliardi, P., Feb 17 2010, In : Revue Medicale Suisse. 6, 236, p. 354-357 4 p.

Research output: Contribution to journalShort survey

3 Scopus citations
2009

Opioids and the skin - Where do we stand?

Bigliardi, P. L., Tobin, D. J., Gaveriaux-Ruff, C. & Bigliardi-Qi, M., Apr 29 2009, In : Experimental Dermatology. 18, 5, p. 424-430 7 p.

Research output: Contribution to journalReview article

82 Scopus citations
2008

Kortikosteroide zur lokalen Anwendung auf der Haut

Translated title of the contribution: Corticosteroids for topical skin applicationKahmann, I. V., Gabard, B. & Bigliardi, P. L., Dec 5 2008, In : Pharma-Kritik. 30, 8-9, p. 29-36 8 p.

Research output: Contribution to journalReview article

2007

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L. & Bigliardi, P. L., Jun 1 2007, In : Journal of Investigative Dermatology. 127, 6, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis

Translated title of the contribution: Toxic epidermal necrolysisBigliardi, P. L., Raffoul, W. & Berger, M. M., May 2 2007, In : Revue Medicale Suisse. 3, 109, p. 1112-1118 7 p.

Research output: Contribution to journalReview article

Treatment of pruritus with topically applied opiate receptor antagonist

Bigliardi, P. L., Stammer, H., Jost, G., Rufli, T., Büchner, S. & Bigliardi-Qi, M., Jun 1 2007, In : Journal of the American Academy of Dermatology. 56, 6, p. 979-988 10 p.

Research output: Contribution to journalArticle

83 Scopus citations
2006

Arnica - Une plante magnifique?

Translated title of the contribution: Arnica - a splendid plant?Schwarzkopf, S., Bigliardi, P. L., Panizzon, R. G. & Laffitte, E., Dec 13 2006, In : Revue Medicale Suisse. 2, 91, p. 2884-2885 2 p.

Research output: Contribution to journalArticle