Paul L Bigliardi

Professor

Accepting PhD Students

1993 …2020

Research output per year

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Research Output

1993

Computerized microassay of keratinocyte cell-plastic attachment and proliferation for assessing net stimulatory, inhibitory and toxic effects of compounds on nonimmortalized cell lines

Grando, S. A., Cabrera, R., Hostager, B. S., Bigliardi, P. L., Blake, J. S., Herron, M. J., Dahl, M. V. & Nelson, R. D., Jan 1 1993, In : Skin Pharmacology and Physiology. 6, 2, p. 135-147 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
1994

Effects of detergents on proliferation and metabolism of human keratinocytes

Bigliardi, P. L., Herron, M. J., Nelson, R. D. & Dahl, M. V., Apr 1994, In : Experimental Dermatology. 3, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
1995

Keratinocyte muscarinic acetylcholine receptors: Immunolocalization and partial characterization

Grando, S. A., Zelickson, B. D., Kist, D. A., Weinshenker, D., Bigliardi, P. L., Wendelschafer-Crabb, G., Kennedy, W. R. & Dahl, M. V., Jan 1 1995, In : Journal of Investigative Dermatology. 104, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

70 Scopus citations
1998

Expression of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi, P. L., Bigliardi-Qi, M., Buechner, S. & Rufli, T., Jan 1 1998, In : Journal of Investigative Dermatology. 111, 2, p. 297-301 5 p.

Research output: Contribution to journalArticle

86 Scopus citations
1999

Anaphylaxis resulting from selective sensitization to Americana grapes

Bircher, A. J., Bigliardi, P. & Yilmaz, B., Jan 1 1999, In : Journal of Allergy and Clinical Immunology. 104, 5, p. 1111-1113 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of μ-opiate receptor in human epidermis and keratinocytes

Bigliardi-Qi, M., Bigliardi, P. L., Büchner, S. & Rufli, T., 1999, In : Annals of the New York Academy of Sciences. 885, p. 368-371 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Occupational airborne contact dermatitis from diphencyprone in a pharmacy employee

Bircher, A. J., Bigliardi, P., Messmer, S. L. & Surber, C., Jan 1 1999, In : Contact Dermatitis. 41, 1, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations
2000

Delayed generalized allergic reactions to corticosteroids

Bircher, A. J., Bigliardi, P., Zaugg, T. & Mäkinen-Kiljunen, S., Jan 1 2000, In : Dermatology. 200, 4, p. 349-351 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

β-Endorphin stimulates cytokeratin 16 expression and downregulates μ- opiate receptor expression in human epidermis

Bigliardi-Qi, M., Bigliardi, P. L., Eberle, A. N., Büchner, S. & Rufli, T., Jan 1 2000, In : Journal of Investigative Dermatology. 114, 3, p. 527-532 6 p.

Research output: Contribution to journalArticle

54 Scopus citations
2002

Specific stimulation of migration of human keratinocytes by μ-opiate receptor agonists

Bigliardi, P. L., Büchner, S., Rufli, T. & Bigliardi-Qi, M., Dec 1 2002, In : Journal of Receptors and Signal Transduction. 22, 1-4, p. 191-199 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2003

Anaphylaxis to the carbohydrate carboxymethylcellulose in parenteral corticosteroid preparations.

Bigliardi, P. L., Izakovic, J., Weber, J. M. & Bircher, A. J., 2003, In : Dermatology (Basel, Switzerland). 207, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

45 Scopus citations
46 Scopus citations
2004

Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin

Bigliardi-Qi, M., Sumanovski, L. T., Büchner, S., Rufli, T. & Bigliardi, P. L., Oct 27 2004, In : Dermatology. 209, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Oral tolerance of carboxymethylcellulose in patients with anaphylaxis to parenteral carboxymethylcellulose [2]

Bircher, A. J., Izakovic, J. & Bigliardi, P. L., May 2004, In : Annals of Allergy, Asthma and Immunology. 92, 5, p. 580-581 2 p.

Research output: Contribution to journalLetter

10 Scopus citations

Unilateral aplasia cutis congenita on the leg

Bigliardi, P. L., Braschler, C., Kuhn, P., Sigrist, J., Buechner, S. & Rufli, T., Jul 1 2004, In : Pediatric Dermatology. 21, 4, p. 454-457 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2005

Changes of epidermal mu-opiate receptor expression and nerve endings in chronic atopic dermatitis

Bigliardi-Qi, M., Lipp, B., Sumanovski, L. T., Buechner, S. A. & Bigliardi, P. L., Apr 18 2005, In : Dermatology. 210, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

How best to fight that nasty itch - From new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches

Bíró, T., Ko, M. C., Bromm, B., Wei, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N. V., Kamei, C., Schouenborg, J., Roostermann, D., Szabó, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J. G., Hossen, M. A., Schmelz, M. & Steinhoff, M., Mar 2005, In : Experimental Dermatology. 14, 3, 1 p.

Research output: Contribution to journalArticle

78 Scopus citations
2006

Arnica - Une plante magnifique?

Translated title of the contribution: Arnica - a splendid plant?Schwarzkopf, S., Bigliardi, P. L., Panizzon, R. G. & Laffitte, E., Dec 13 2006, In : Revue Medicale Suisse. 2, 91, p. 2884-2885 2 p.

Research output: Contribution to journalArticle

Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B. & Bigliardi, P. L., Apr 2006, In : Differentiation. 74, 4, p. 174-185 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Prurit: Causes, diagnostic et traitement

Translated title of the contribution: Pruritus - Causes, diagnostics and treatmentBigliardi, P. L., Apr 26 2006, In : Revue Medicale Suisse. 2, 63, p. 1115-1121 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Ursachen, diagnose und therapie von pruritus

Translated title of the contribution: Causes, diagnosis and treatment of pruritusBigliardi, P. L., Nov 1 2006, In : Aktuelle Dermatologie. 32, 11, p. 468-473 6 p.

Research output: Contribution to journalArticle

2007

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L. & Bigliardi, P. L., Jun 1 2007, In : Journal of Investigative Dermatology. 127, 6, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis

Translated title of the contribution: Toxic epidermal necrolysisBigliardi, P. L., Raffoul, W. & Berger, M. M., May 2 2007, In : Revue Medicale Suisse. 3, 109, p. 1112-1118 7 p.

Research output: Contribution to journalReview article

Treatment of pruritus with topically applied opiate receptor antagonist

Bigliardi, P. L., Stammer, H., Jost, G., Rufli, T., Büchner, S. & Bigliardi-Qi, M., Jun 1 2007, In : Journal of the American Academy of Dermatology. 56, 6, p. 979-988 10 p.

Research output: Contribution to journalArticle

84 Scopus citations
2008

Kortikosteroide zur lokalen Anwendung auf der Haut

Translated title of the contribution: Corticosteroids for topical skin applicationKahmann, I. V., Gabard, B. & Bigliardi, P. L., Dec 5 2008, In : Pharma-Kritik. 30, 8-9, p. 29-36 8 p.

Research output: Contribution to journalReview article

2009

Opioids and the skin - Where do we stand?

Bigliardi, P. L., Tobin, D. J., Gaveriaux-Ruff, C. & Bigliardi-Qi, M., Apr 29 2009, In : Experimental Dermatology. 18, 5, p. 424-430 7 p.

Research output: Contribution to journalReview article

84 Scopus citations
2010

Pansements bioactifs

Translated title of the contribution: Bioactive dressingsGrasset, N., Raffoul, W. & Bigliardi, P., Feb 17 2010, In : Revue Medicale Suisse. 6, 236, p. 354-357 4 p.

Research output: Contribution to journalShort survey

3 Scopus citations
2011

Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers

Grouzmann, E., Bigliardi, P., Appenzeller, M., Pannatier, A. & Buclin, T., Mar 1 2011, In : Biological Chemistry. 392, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Caspase-3 protects stressed organs against cell death

Khalil, H., Peltzer, N., Walicki, J., Yang, J. Y., Dubuis, G., Gardiol, N., Held, W., Bigliardi, P., Marsland, B., Liaudet, L. & Widmann, C., Nov 2012, In : Molecular and cellular biology. 32, 22, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chronic idiopathic urticaria successfully treated by anticoagulant drug

Spring, P., Angelillo-Scherrer, A. & Bigliardi, P., Dec 1 2012, In : European Journal of Dermatology. 22, 6, p. 788-790 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Eczéma chronique des mains: Traitements conventionnels et nouveautés

Translated title of the contribution: Chronic hand eczema, conventional and new treatmentsSpring, P. & Bigliardi, P., Apr 4 2012, In : Revue Medicale Suisse. 8, 335, p. 736-742 7 p.

Research output: Contribution to journalReview article

UV-B induces cytoplasmic survivin expression in mouse epidermis

Peltzer, N., Bigliardi, P. & Widmann, C., Sep 2012, In : Journal of Dermatological Science. 67, 3, p. 196-199 4 p.

Research output: Contribution to journalLetter

3 Scopus citations
2014

Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection

Cerny, D., Haniffa, M., Shin, A., Bigliardi, P., Tan, B. K., Lee, B., Poidinger, M., Tan, E. Y., Ginhoux, F. & Fink, K., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

55 Scopus citations

Wheat-dependent exercise-induced anaphylaxis: A retrospective case review from a tertiary hospital

Thalayasingam, M., Allameen, N. A., Soh, J. Y., Bigliardi, P., Van Bever, H. & Shek, L. P. C., Sep 2014, In : Postgraduate Medical Journal. 90, 1067, p. 488-492 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi, P. L., Neumann, C., Teo, Y. L., Pant, A. & Bigliardi-Qi, M., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 501-514 14 p.

Research output: Contribution to journalReview article

25 Scopus citations

Evaluation of the applicability of the Immuno-solidphase allergen chip (ISAC) assay in atopic patients in Singapore

Santosa, A., Andiappan, A. K., Rotzschke, O., Wong, H. C., Chang, A., Bigliardi-Qi, M., Wang, D. Y. & Bigliardi, P. L., Feb 27 2015, In : Clinical and Translational Allergy. 5, 1, 9.

Research output: Contribution to journalArticle

8 Scopus citations

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2015, In : European Journal of Cell Biology. 94, 11, p. 483-512 30 p.

Research output: Contribution to journalReview article

99 Scopus citations

Pyoderma gangrenosum mimicking early acute infection following total knee arthroplasty

Yik, J. H., Bigliardi, P. L., Sebastin, S. J., Cabucana, N. J., Venkatachalam, I. & Krishna, L., Jan 1 2015, In : Annals of the Academy of Medicine Singapore. 44, 4, p. 150-151 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
5 Scopus citations

The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3

Neumann, C., Bigliardi-Qi, M., Widmann, C. & Bigliardi, P. L., Feb 13 2015, In : Journal of Investigative Dermatology. 135, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
6 Scopus citations
2016

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

Chew, E. G. Y., Tan, J. H. J., Bahta, A. W., Ho, B. S. Y., Liu, X., Lim, T. C., Sia, Y. Y., Bigliardi, P. L., Heilmann, S., Wan, A. C. A., Nöthen, M. M., Philpott, M. P. & Hillmer, A. M., Aug 1 2016, In : Journal of Investigative Dermatology. 136, 8, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Expression of peropsin in human skin is related to phototransduction of violet light in keratinocytes

Toh, P. P. C., Bigliardi-Qi, M., Yap, A. M. Y., Sriram, G. & Bigliardi, P., Dec 1 2016, In : Experimental Dermatology. 25, 12, p. 1002-1005 4 p.

Research output: Contribution to journalLetter

15 Scopus citations

High-throughput microfluidic chip for automated in vitro release testing

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L. & Wang, Z. P., Jan 1 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 589-590 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Opioids and skin homeostasis, regeneration and ageing – What's the evidence?

Bigliardi, P. L., Dancik, Y., Neumann, C. & Bigliardi-Qi, M., Aug 1 2016, In : Experimental Dermatology. 25, 8, p. 586-591 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Reconstructing human skin equivalents on fibrin-based dermal matrix: Reproducible human skin equivalents with superior epidermal reconstruction

Sriram, G., Dykas, M. M., Ramasamy, S., Poddar, K., Krishnan-Kutty, V., Patra, A., Venkatesan, T., Bigliardi-Qi, M. & Bigliardi, P. L., Apr 1 2016, In : Materials Today. 19, 3, p. 178-179 2 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography

Ford, S. J., Bigliardi, P. L., Sardella, T. C. P., Urich, A., Burton, N. C., Kacprowicz, M., Bigliardi, M., Olivo, M. & Razansky, D., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 753-761 9 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2017

Aging in hair follicle stem cells and niche microenvironment

Ji, J., Ho, B. S. Y., Qian, G., Xie, X. M., Bigliardi, P. L. & Bigliardi-Qi, M., Oct 2017, In : Journal of Dermatology. 44, 10, p. 1097-1104 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi, P., Langer, S., Cruz, J. J., Kim, S. W., Nair, H. & Srisawasdi, G., Oct 1 2017, In : Dermatology. 233, 2-3, p. 223-233 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

An expedient multiple information processing pattern-generating chromophore

Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Sensors and Actuators, B: Chemical. 251, p. 164-170 7 p.

Research output: Contribution to journalArticle