Paul L Bigliardi

Professor

Accepting PhD Students

1993 …2019
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Research Output 1993 2019

2019
12 Citations (Scopus)

Controversies in drug allergy: Testing for delayed reactions

Phillips, E. J., Bigliardi, P., Bircher, A. J., Broyles, A., Chang, Y. S., Chung, W. H., Lehloenya, R., Mockenhaupt, M., Peter, J., Pirmohamed, M., Roujeau, J. C., Shear, N. H., Tanno, L. K., Trubiano, J., Valluzzi, R. & Barbaud, A., Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 66-73 8 p.

Research output: Contribution to journalReview article

Open Access
Drug Eruptions
Drug Hypersensitivity
Stevens-Johnson Syndrome
Drug-Related Side Effects and Adverse Reactions
Acute Generalized Exanthematous Pustulosis

Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity

Venkatesan, G., Dancik, Y., Sinha, A., Bigliardi, M., Srinivas, R., Dawson, T., Valiyaveettil, S., Bigliardi, P. & Pastorin, G., Jan 1 2019, In : New Journal of Chemistry. 43, 41, p. 16188-16199 12 p.

Research output: Contribution to journalArticle

Aniline Compounds
Hair Dyes
Chemical modification
Aniline
Toxicity

Full-thickness human skin equivalent models of atopic dermatitis

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 367-383 17 p. (Methods in Molecular Biology; vol. 1879).

Research output: Chapter in Book/Report/Conference proceedingChapter

Atopic Dermatitis
Skin
Tissue Engineering
Fibrin
Keratinocytes

Microbiome in the hair follicle of androgenetic alopecia patients

Ho, B. S. Y., Ho, E. X. P., Chu, C. W., Ramasamy, S., Bigliardi-Qi, M., de Sessions, P. F. & Bigliardi, P. L., Jan 1 2019, In : PloS one. 14, 5, p. e0216330

Research output: Contribution to journalArticle

Open Access
hair follicles
Hair Follicle
alopecia
Microbiota
Alopecia

Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

Ho, B. S. Y., Vaz, C., Ramasamy, S., Chew, E. G. Y., Mohamed, J. S., Jaffar, H., Hillmer, A., Tanavde, V., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2019, In : Scientific reports. 9, 1, 8771.

Research output: Contribution to journalArticle

Open Access
Miniaturization
Alopecia
Hair
Peroxisome Proliferator-Activated Receptors
Hair Follicle
2018
24 Citations (Scopus)

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

Sriram, G., Alberti, M., Dancik, Y., Wu, B., Wu, R., Feng, Z., Ramasamy, S., Bigliardi, P. L., Bigliardi-Qi, M. & Wang, Z., May 1 2018, In : Materials Today. 21, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

fibrin
Skin
chips
organs
matrices
2 Citations (Scopus)

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

Dancik, Y., Sriram, G., Rout, B., Zou, Y., Bigliardi-Qi, M. & Bigliardi, P. L., Mar 7 2018, In : Analyst. 143, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Raman spectroscopy
skin
Skin
Cornea
5 Citations (Scopus)

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells

Leong, C., Bigliardi, P. L., Sriram, G., Au, V. B., Connolly, J. & Bigliardi-Qi, M., Jan 1 2018, In : Photochemistry and Photobiology. 94, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Coculture Techniques
Keratinocytes
Interleukin-4
Dosimetry
Photosensitizing Agents
3 Citations (Scopus)

Role of Skin pH in Psoriasis

Bigliardi, P. L., Jan 1 2018, In : Current Problems in Dermatology (Switzerland). 54, p. 108-114 7 p.

Research output: Contribution to journalArticle

Psoriasis
Skin
Homeostasis
Inflammation
Aquaporins
2 Citations (Scopus)

The roles of opioid receptors in cutaneous wound healing

Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 335-345 11 p. (Handbook of Experimental Pharmacology; vol. 247).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sensation Disorders
Opioid Receptors
Cosmetics
Wound Healing
Cicatrix
2017
3 Citations (Scopus)

Aging in hair follicle stem cells and niche microenvironment

Ji, J., Ho, B. S. Y., Qian, G., Xie, X. M., Bigliardi, P. L. & Bigliardi-Qi, M., Oct 1 2017, In : Journal of Dermatology. 44, 10, p. 1097-1104 8 p.

Research output: Contribution to journalReview article

Stem Cell Niche
Hair Follicle
Alopecia
Hair
Stem Cells
5 Citations (Scopus)

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi, P., Langer, S., Cruz, J. J., Kim, S. W., Nair, H. & Srisawasdi, G., Oct 1 2017, In : Dermatology. 233, 2-3, p. 223-233 11 p.

Research output: Contribution to journalArticle

Povidone-Iodine
Wound Healing
Local Anti-Infective Agents
Poisons
Wounds and Injuries

An expedient multiple information processing pattern-generating chromophore

Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Sensors and Actuators, B: Chemical. 251, p. 164-170 7 p.

Research output: Contribution to journalArticle

Chromophores
chromophores
Absorption spectra
absorption spectra
decoders
5 Citations (Scopus)

Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

Chew, E. G. Y., Ho, B. S. Y., Ramasamy, S., Dawson, T., Tennakoon, C., Liu, X., Leong, W. M. S., Yang, S. Y. S., Lim, S. Y. D., Jaffar, H., Hillmer, A. M., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : British Journal of Dermatology. 176, 1, p. 265-269 5 p.

Research output: Contribution to journalLetter

Hair Follicle
Alopecia
Gene Expression Profiling
Oxidation-Reduction
Disease Progression

Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand

Leong, C., Neumann, C., Ramasamy, S., Rout, B., Wee, L. Y., Bigliardi-Qi, M. & Bigliardi, P. L., Dec 1 2017, In : PloS one. 12, 12, e0188607.

Research output: Contribution to journalArticle

Open Access
Naltrexone
keratinocytes
narcotics
Opioid Receptors
Keratinocytes
11 Citations (Scopus)

Multi-chamber microfluidic platform for high-precision skin permeation testing

Alberti, M., Dancik, Y., Sriram, G., Wu, B., Teo, Y. L., Feng, Z., Bigliardi-Qi, M., Wu, R. G., Wang, Z. P. & Bigliardi, P. L., Jan 1 2017, In : Lab on a Chip. 17, 9, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

Microfluidics
Permeation
Skin
Testing
Chemical Models
4 Citations (Scopus)

Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Rout, B. & Bigliardi, P. L., Jun 1 2017, In : Synlett. 28, 9, p. 1005-1010 6 p., st-2016-p0798-sp.

Research output: Contribution to journalArticle

Sensors
Logic devices
Molecules
4 Citations (Scopus)

Peripheral nerve fibres form multifacet interactions with keratinocytes in a novel complete human 2D culture model

Krishnan-Kutty, V., Bigliardi, P. L., Dykas, M. M., Pomp, O., Kyaw, H. M., Poddar, K., Venkatesan, T. & Bigliardi-Qi, M., Mar 1 2017, In : Experimental Dermatology. 26, 3, p. 281-284 4 p.

Research output: Contribution to journalLetter

Receptor Cross-Talk
Peripheral Nervous System
Coculture Techniques
Keratinocytes
Peripheral Nerves
29 Citations (Scopus)

Povidone iodine in wound healing: A review of current concepts and practices

Bigliardi, P. L., Alsagoff, S. A. L., El-Kafrawi, H. Y., Pyon, J. K., Wa, C. T. C. & Villa, M. A., Aug 1 2017, In : International Journal of Surgery. 44, p. 260-268 9 p.

Research output: Contribution to journalReview article

Povidone-Iodine
Wound Healing
Biofilms
Antisepsis
Inflammation
1 Citation (Scopus)

Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Bigliardi, P. L., Rout, B., Pant, A., Krishnan-Kutty, V., Eberle, A. N., Srinivas, R., Burkett, B. A. & Bigliardi-Qi, M., Dec 1 2017, In : Scientific reports. 7, 1, 15750.

Research output: Contribution to journalArticle

Open Access
Photosensitizing Agents
Photochemotherapy
Melanoma
Receptor, Melanocortin, Type 1
Hutchinson's Melanotic Freckle
3 Citations (Scopus)

Stevens-Johnson syndrome/toxic epidermal necrolysis overlap induced by fexofenadine

Teo, S. L., Santosa, A. & Bigliardi, P. L., Jan 1 2017, In : Journal of Investigational Allergology and Clinical Immunology. 27, 3, p. 191-193 3 p.

Research output: Contribution to journalComment/debate

fexofenadine
Terfenadine
Drug Hypersensitivity
Anti-Allergic Agents
Stevens-Johnson Syndrome
2 Citations (Scopus)

Synthetic peptide drugs for targeting skin cancer: Malignant melanoma and melanotic lesions

Eberle, A. N., Rout, B., Bigliardi-Qi, M. & Bigliardi, P. L., Jan 1 2017, In : Current Medicinal Chemistry. 24, 17, p. 1797-1826 30 p.

Research output: Contribution to journalReview article

Skin Neoplasms
Drug Delivery Systems
Photosensitizing Agents
Melanoma
Skin
2016
13 Citations (Scopus)

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

Chew, E. G. Y., Tan, J. H. J., Bahta, A. W., Ho, B. S. Y., Liu, X., Lim, T. C., Sia, Y. Y., Bigliardi, P. L., Heilmann, S., Wan, A. C. A., Nöthen, M. M., Philpott, M. P. & Hillmer, A. M., Aug 1 2016, In : Journal of Investigative Dermatology. 136, 8, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Alopecia
Scalp
Genes
Skin
Hair Follicle
13 Citations (Scopus)

Expression of peropsin in human skin is related to phototransduction of violet light in keratinocytes

Toh, P. P. C., Bigliardi-Qi, M., Yap, A. M. Y., Sriram, G. & Bigliardi, P. L., Dec 1 2016, In : Experimental Dermatology. 25, 12, p. 1002-1005 4 p.

Research output: Contribution to journalLetter

Opsins
Rhodopsin
Skin
Photobiology
Keratinocytes

High-throughput microfluidic chip for automated in vitro release testing

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L. & Wang, Z. P., Jan 1 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 589-590 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microfluidics
Throughput
Permeation
Testing
Salicylic acid
8 Citations (Scopus)

Opioids and skin homeostasis, regeneration and ageing – What's the evidence?

Bigliardi, P. L., Dancik, Y., Neumann, C. & Bigliardi-Qi, M., Aug 1 2016, In : Experimental Dermatology. 25, 8, p. 586-591 6 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Regeneration
Skin
Homeostasis
Aging of materials
4 Citations (Scopus)

Reconstructing human skin equivalents on fibrin-based dermal matrix: Reproducible human skin equivalents with superior epidermal reconstruction

Sriram, G., Dykas, M. M., Ramasamy, S., Poddar, K., Krishnan-Kutty, V., Patra, A., Venkatesan, T., Bigliardi-Qi, M. & Bigliardi, P. L., Apr 1 2016, In : Materials Today. 19, 3, p. 178-179 2 p.

Research output: Contribution to journalArticle

Fibrin
Skin
16 Citations (Scopus)

Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography

Ford, S. J., Bigliardi, P. L., Sardella, T. C. P., Urich, A., Burton, N. C., Kacprowicz, M., Bigliardi, M., Olivo, M. & Razansky, D., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 753-761 9 p.

Research output: Contribution to journalArticle

Functional analysis
Photoacoustic effect
Hair Follicle
Structural analysis
Hair
2015
21 Citations (Scopus)

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi, P. L., Neumann, C., Teo, Y. L., Pant, A. & Bigliardi-Qi, M., Jan 1 2015, In : British Journal of Pharmacology. 172, 2, p. 501-514 14 p.

Research output: Contribution to journalReview article

Opioid Receptors
Keratinocytes
Wound Healing
Skin
Desmosomal Cadherins
7 Citations (Scopus)

Evaluation of the applicability of the Immuno-solidphase allergen chip (ISAC) assay in atopic patients in Singapore

Santosa, A., Andiappan, A. K., Rotzschke, O., Wong, H. C., Chang, A., Bigliardi-Qi, M., Wang, D. Y. & Bigliardi, P. L., Feb 27 2015, In : Clinical and Translational Allergy. 5, 1, 9.

Research output: Contribution to journalArticle

Singapore
Allergens
Skin Tests
Pyroglyphidae
Atopic Dermatitis
75 Citations (Scopus)

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

Sriram, G., Bigliardi, P. L. & Bigliardi-Qi, M., Jan 1 2015, In : European Journal of Cell Biology. 94, 11, p. 483-512 30 p.

Research output: Contribution to journalReview article

Fibroblasts
Skin
Wound Healing
Hypertrophic Cicatrix
Keloid
2 Citations (Scopus)

Pyoderma gangrenosum mimicking early acute infection following total knee arthroplasty

Yik, J. H., Bigliardi, P. L., Sebastin, S. J., Cabucana, N. J., Venkatachalam, I. & Krishna, L., Jan 1 2015, In : Annals of the Academy of Medicine Singapore. 44, 4, p. 150-151 2 p.

Research output: Contribution to journalLetter

Pyoderma Gangrenosum
Surgical Wound Infection
Knee Replacement Arthroplasties
Acute Disease
Knee Joint
4 Citations (Scopus)
Opioid Receptors
Keratinocytes
Fibroblasts
Wound Healing
Skin
15 Citations (Scopus)

The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3

Neumann, C., Bigliardi-Qi, M., Widmann, C. & Bigliardi, P. L., Feb 13 2015, In : Journal of Investigative Dermatology. 135, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Opioid Receptors
Keratinocytes
Homeostasis
Transcription Factors
6 Citations (Scopus)
Permeation
Toxicity
Skin
Toxicology
Kinetics
2014
52 Citations (Scopus)

Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection

Cerny, D., Haniffa, M., Shin, A., Bigliardi, P., Tan, B. K., Lee, B., Poidinger, M., Tan, E. Y., Ginhoux, F. & Fink, K., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

Dengue Virus
Langerhans Cells
Antigen-Presenting Cells
Virus Diseases
Dendritic Cells
3 Citations (Scopus)

Wheat-dependent exercise-induced anaphylaxis: A retrospective case review from a tertiary hospital

Thalayasingam, M., Allameen, N. A., Soh, J. Y., Bigliardi, P., Van Bever, H. & Shek, L. P. C., Jan 1 2014, In : Postgraduate Medical Journal. 90, 1067, p. 488-492 5 p.

Research output: Contribution to journalArticle

Anaphylaxis
Tertiary Care Centers
Triticum
Exercise
Wheat Hypersensitivity
2012
43 Citations (Scopus)

Caspase-3 protects stressed organs against cell death

Khalil, H., Peltzer, N., Walicki, J., Yang, J. Y., Dubuis, G., Gardiol, N., Held, W., Bigliardi, P., Marsland, B., Liaudet, L. & Widmann, C., Nov 1 2012, In : Molecular and cellular biology. 32, 22, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Knockout Mice
Sunburn
Aptitude
4 Citations (Scopus)

Chronic idiopathic urticaria successfully treated by anticoagulant drug

Spring, P., Angelillo-Scherrer, A. & Bigliardi, P., Dec 1 2012, In : European Journal of Dermatology. 22, 6, p. 788-790 3 p.

Research output: Contribution to journalComment/debate

Nadroparin
Acenocoumarol
Fibrin Fibrinogen Degradation Products
Peptide Fragments
Antithrombin III

Eczéma chronique des mains: Traitements conventionnels et nouveautés

Translated title of the contribution: Chronic hand eczema, conventional and new treatmentsSpring, P. & Bigliardi, P., Apr 4 2012, In : Revue Medicale Suisse. 8, 335, p. 736-742 7 p.

Research output: Contribution to journalReview article

Eczema
Hand
Pruritus
Ultraviolet Rays
Switzerland
3 Citations (Scopus)

UV-B induces cytoplasmic survivin expression in mouse epidermis

Peltzer, N., Bigliardi, P. & Widmann, C., Sep 1 2012, In : Journal of Dermatological Science. 67, 3, p. 196-199 4 p.

Research output: Contribution to journalLetter

Gene expression regulation
Inhibitor of Apoptosis Proteins
Repressor Proteins
Fluorescence microscopy
Chromosomes
2011
9 Citations (Scopus)

Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers

Grouzmann, E., Bigliardi, P., Appenzeller, M., Pannatier, A. & Buclin, T., Mar 1 2011, In : Biological Chemistry. 392, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

Substance P
Volunteers
Skin
Inflammation
Neprilysin
2010
3 Citations (Scopus)

Pansements bioactifs

Translated title of the contribution: Bioactive dressingsGrasset, N., Raffoul, W. & Bigliardi, P., Feb 17 2010, In : Revue Medicale Suisse. 6, 236, p. 354-357 4 p.

Research output: Contribution to journalShort survey

Bandages
Intercellular Signaling Peptides and Proteins
Skin
Peripheral Vascular Diseases
Wounds and Injuries
2009
80 Citations (Scopus)

Opioids and the skin - Where do we stand?

Bigliardi, P. L., Tobin, D. J., Gaveriaux-Ruff, C. & Bigliardi-Qi, M., Apr 29 2009, In : Experimental Dermatology. 18, 5, p. 424-430 7 p.

Research output: Contribution to journalReview article

Opioid Analgesics
Skin
Peripheral Nerves
Skin Physiological Phenomena
Immune system
2008

Kortikosteroide zur lokalen Anwendung auf der Haut

Translated title of the contribution: Corticosteroids for topical skin applicationKahmann, I. V., Gabard, B. & Bigliardi, P. L., Dec 5 2008, In : Pharma-Kritik. 30, 8-9, p. 29-36 8 p.

Research output: Contribution to journalReview article

Adrenal Cortex Hormones
Skin
2007
42 Citations (Scopus)

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L. & Bigliardi, P. L., Jun 1 2007, In : Journal of Investigative Dermatology. 127, 6, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

Nerve Endings
Opioid Receptors
Peripheral Nerves
Hypertrophy
Dermatitis

Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis

Translated title of the contribution: Toxic epidermal necrolysisBigliardi, P. L., Raffoul, W. & Berger, M. M., May 2 2007, In : Revue Medicale Suisse. 3, 109, p. 1112-1118 7 p.

Research output: Contribution to journalReview article

Stevens-Johnson Syndrome
Apoptosis
Liver Failure
Mucus
Burns
81 Citations (Scopus)

Treatment of pruritus with topically applied opiate receptor antagonist

Bigliardi, P. L., Stammer, H., Jost, G., Rufli, T., Büchner, S. & Bigliardi-Qi, M., Jun 1 2007, In : Journal of the American Academy of Dermatology. 56, 6, p. 979-988 10 p.

Research output: Contribution to journalArticle

Naltrexone
Opioid Receptors
Pruritus
Placebos
Atopic Dermatitis
2006

Arnica - Une plante magnifique?

Translated title of the contribution: Arnica - a splendid plant?Schwarzkopf, S., Bigliardi, P. L., Panizzon, R. G. & Laffitte, E., Dec 13 2006, In : Revue Medicale Suisse. 2, 91, p. 2884-2885 2 p.

Research output: Contribution to journalArticle

Physical Therapy Specialty
Arnica
Occupational Dermatitis
Allergic Contact Dermatitis
42 Citations (Scopus)

Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B. & Bigliardi, P. L., Jan 1 2006, In : Differentiation. 74, 4, p. 174-185 12 p.

Research output: Contribution to journalArticle

Opioid Receptors
Knockout Mice
Wound Healing
Skin
Differentiation Antigens