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Research Output 1999 2019

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Article
2019
5 Citations (Scopus)

Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma

Elahi-Gedwillo, K. Y., Carlson, M., Zettervall, J. & Provenzano, P., Jan 15 2019, In : Cancer Research. 79, 2, p. 372-386 15 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Architectural Accessibility
Pharmaceutical Preparations
Therapeutics
Neoplasms
2018
2 Citations (Scopus)
cues
Fluidics
Cadherins
Cues
Adhesion

Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices

Ray, A., Morford, R. K. & Provenzano, P., Aug 1 2018, In : Current Protocols in Stem Cell Biology. 46, 1, e57.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell Movement
Collagen
Carcinoma
Extracellular Matrix
1 Citation (Scopus)

Dynamics of 3D carcinoma cell invasion into aligned collagen

Ray, A., Morford, R. K., Ghaderi, N., Odde, D. J. & Provenzano, P., Feb 1 2018, In : Integrative Biology (United Kingdom). 10, 2, p. 100-112 13 p.

Research output: Contribution to journalArticle

Collagen
Cells
Carcinoma
Tumors
Military electronic countermeasures

Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing

Tabdanov, E. D., Puram, V., Zhovmer, A. & Provenzano, P., Oct 9 2018, In : Cell Reports. 25, 2, p. 328-338.e6

Research output: Contribution to journalArticle

Actomyosin
Microtubules
Tumors
Cells
Stiffness
2 Citations (Scopus)

Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer

Shao, Q., Liu, F., Chung, C., Elahi-Gedwillo, K., Provenzano, P., Forsyth, B. & Bischof, J. C., Jan 1 2018, In : Annals of Biomedical Engineering. 46, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

Tumors
Cells
Glucose
Hot Temperature
Heterografts
2017
47 Citations (Scopus)

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

Ray, A., Lee, O., Win, Z., Edwards, R. M., Alford, P. W., Kim, D. H. & Provenzano, P., Apr 12 2017, In : Nature communications. 8, 14923.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Movement
adhesion
Adhesion
cells
24 Citations (Scopus)
Neoplastic Stem Cells
Collagen
Cell Movement
Breast Neoplasms
Cell Size
4 Citations (Scopus)
Chemotherapy
chemotherapy
Doxorubicin
Tumors
tumors
2016
12 Citations (Scopus)
Stem cells
Mesenchymal Stromal Cells
Extracellular Matrix Proteins
Extracellular Matrix
Collagen Type I
27 Citations (Scopus)
Adenocarcinoma
Gels
Pressure
Hyaluronic Acid
Extracellular Fluid
15 Citations (Scopus)

Multiscale Cues Drive Collective Cell Migration

Nam, K. H., Kim, P., Wood, D. K., Kwon, S., Provenzano, P. & Kim, D. H., Jul 27 2016, In : Scientific reports. 6, 29749.

Research output: Contribution to journalArticle

Cell Movement
Cues
Biomimetics
Anisotropy
Contracts
2012
842 Citations (Scopus)
Architectural Accessibility
Hyaluronic Acid
Adenocarcinoma
Extracellular Fluid
gemcitabine
2011
415 Citations (Scopus)
Collagen
Breast Neoplasms
Survival
Neoplasms
Syndecan-1
221 Citations (Scopus)

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

Provenzano, P. P. & Keely, P. J., Apr 15 2011, In : Journal of Cell Science. 124, 8, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Focal Adhesions
Cytoskeleton
Cell Proliferation
Extracellular Matrix
2009
72 Citations (Scopus)

Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast

Conklin, M. W., Provenzano, P. P., Eliceiri, K. W., Sullivan, R. & Keely, P. J., Apr 1 2009, In : Cell Biochemistry and Biophysics. 53, 3, p. 145-157 13 p.

Research output: Contribution to journalArticle

Fluorophores
Optical Imaging
Tumors
Epithelium
Fluorescence
326 Citations (Scopus)

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

Provenzano, P. P., Inman, D. R., Eliceiri, K. W. & Keely, P. J., Dec 1 2009, In : Oncogene. 28, 49, p. 4326-4343 18 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Breast
Phosphotransferases
Collagen
Epithelial Cells
2008
613 Citations (Scopus)

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C. T., White, J. G. & Keely, P. J., Apr 23 2008, In : BMC Medicine. 6, 11.

Research output: Contribution to journalArticle

Collagen
Breast Neoplasms
Neoplasms
Breast
Neoplasm Metastasis
278 Citations (Scopus)
Cell Movement
Collagen
Extracellular Matrix
rho-Associated Kinases
Neoplasms
102 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Transgenic Mice
Breast
Breast Neoplasms
Neoplasm Metastasis
48 Citations (Scopus)

Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer

Provenzano, P. P., Rueden, C. T., Trier, S. M., Yan, L., Ponik, S. M., Inman, D. R., Keely, P. J. & Eliceiri, K. W., Dec 1 2008, In : Journal of Biomedical Optics. 13, 3, 031220.

Research output: Contribution to journalArticle

Fluorophores
breast
cancer
adenines
Imaging techniques
45 Citations (Scopus)

Nonlinear optical imaging of cellular processes in breast cancer

Provenzano, P. P., Eliceiri, K. W., Yan, L., Ada-Nguema, A., Conklin, M. W., Inman, D. R. & Keely, P. J., Dec 1 2008, In : Microscopy and Microanalysis. 14, 6, p. 532-548 17 p.

Research output: Contribution to journalArticle

Harmonic generation
breast
harmonic generations
cancer
Fluorescence
2007
10 Citations (Scopus)
Neuropeptides
Ligaments
Connective Tissue
Collateral Ligaments
Neuropeptide Y
32 Citations (Scopus)

Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: Evaluation of loaded and unloaded ligaments

Provenzano, P. P., Alejandro-Osorio, A. L., Grorud, K. W., Martinez, D. A., Vailas, A. C., Grindeland, R. E. & Vanderby, R., Apr 19 2007, In : BMC Physiology. 7, 2.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Ligaments
Extracellular Matrix
Hindlimb
Growth Hormone
2006
210 Citations (Scopus)

Collagen fibril morphology and organization: Implications for force transmission in ligament and tendon

Provenzano, P. P. & Vanderby, R., Mar 1 2006, In : Matrix Biology. 25, 2, p. 71-84 14 p.

Research output: Contribution to journalArticle

Ligaments
Tendons
Collagen
Felidae
Proteoglycans
737 Citations (Scopus)

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G. & Keely, P. J., Dec 1 2006, In : BMC Medicine. 4, 38.

Research output: Contribution to journalArticle

Collagen
Neoplasms
Breast Neoplasms
Breast
Human Mammary Glands
2005
43 Citations (Scopus)

Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo

Provenzano, P. P., Alejandro-Osorio, A. L., Valhmu, W. B., Jensen, K. T. & Vanderby, R., Jan 1 2005, In : Matrix Biology. 23, 8, p. 543-555 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Cicatrix
Collagen
Proteoglycans
Collagen Type I
2004
23 Citations (Scopus)
Guanethidine
Collateral Ligaments
Sympathetic Nervous System
Ligaments
Matrix Metalloproteinase 13
69 Citations (Scopus)
Ligaments
Viscoelasticity
Creep
Stress relaxation
Tissue
2003
25 Citations (Scopus)
Toes
Statistical Models
Connective Tissue
Tissue
Fibers
40 Citations (Scopus)

Hindlimb unloading alters ligament healing

Provenzano, P. P., Martinez, D. A., Grindeland, R. E., Dwyer, K. W., Turner, J., Vailas, A. C. & Vanderby, R., Jan 1 2003, In : Journal of Applied Physiology. 94, 1, p. 314-324 11 p.

Research output: Contribution to journalArticle

Hindlimb Suspension
Ligaments
Connective Tissue
Thigh
Cicatrix
6 Citations (Scopus)
Ligaments
32 Citations (Scopus)

Scanning electron microscopic characterization of healing and normal rat ligament microstructure under slack and loaded conditions

Hurschler, C., Provenzano, P. P. & Vanderby, R., Jan 1 2003, In : Connective Tissue Research. 44, 2, p. 59-68 10 p.

Research output: Contribution to journalArticle

Ligaments
Rats
Electrons
Scanning
Microstructure
2002
4 Citations (Scopus)

A boundary layer model for wall shear stress in arterial stenosis

Provenzano, P. P. & Rutland, C. J., Jan 1 2002, In : Biorheology. 39, 6, p. 743-754 12 p.

Research output: Contribution to journalArticle

Pathologic Constriction
Constriction
Blood Vessels
Thrombosis
Research Personnel
100 Citations (Scopus)
Viscoelastic Model
ligaments
Nonlinear Dynamics
Ligaments
Nonlinear Model
39 Citations (Scopus)

Healing of subfailure ligament injury: Comparison between immature and mature ligaments in a rat model

Provenzano, P. P., Hayashi, K., Kunz, D. N., Markel, M. D. & Vanderby, R., Jan 1 2002, In : Journal of Orthopaedic Research. 20, 5, p. 975-983 9 p.

Research output: Contribution to journalArticle

Ligaments
Wounds and Injuries
Ankle Lateral Ligament
Sprains and Strains
Joint Instability
134 Citations (Scopus)

Subfailure damage in ligament: A structural and cellular evaluation

Provenzano, P. P., Heisey, D., Hayashi, K., Lakesand, R. & Vanderby, R., Jul 3 2002, In : Journal of applied physiology. 92, 1, p. 362-371 10 p.

Research output: Contribution to journalArticle

Ligaments
Collateral Ligaments
Toes
Cell Count
Fluorescence
2001
20 Citations (Scopus)

Microstructural morphology in the transition region between scar and intact residual segments of a healing rat medial collateral ligament

Provenzano, P. P., Hurschler, C. & Vanderby R., J., Jan 1 2001, In : Connective Tissue Research. 42, 2, p. 123-133 11 p.

Research output: Contribution to journalArticle

Collateral Ligaments
Ligaments
Cicatrix
Rats
Tissue
171 Citations (Scopus)

Nonlinear ligament viscoelasticity

Provenzano, P., Lakes, R., Keenan, T. & Vanderby, R., Dec 31 2001, In : Annals of Biomedical Engineering. 29, 10, p. 908-914 7 p.

Research output: Contribution to journalArticle

Ligaments
Viscoelasticity
Creep
Tissue
Stress relaxation
1 Citation (Scopus)

Sub-failure damage in ligament

Provenzano, P. P., Heisey, D., Hayashi, K., Lakes, R. S. & Vanderby, R., Dec 1 2001, In : American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 50, p. 49-50 2 p.

Research output: Contribution to journalArticle

Ligaments
Regain
Rats
Recovery
Mechanical properties
2000

Experimental evaluation and comparison of stress relaxation and creep in ligament

Keenan, T., Provenzano, P., Lakes, R. & Vanderby, R., Dec 1 2000, In : Annals of Biomedical Engineering. 28, SUPPL. 1

Research output: Contribution to journalArticle

Ligaments
Stress relaxation
Creep
Rats