Paolo Provenzano

19992021
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Research Output 1999 2019

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Article
2019
9 Citations (Scopus)

Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma

Elahi-Gedwillo, K. Y., Carlson, M., Zettervall, J. & Provenzano, P. P., Jan 15 2019, In : Cancer Research. 79, 2, p. 372-386 15 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Architectural Accessibility
Pharmaceutical Preparations
Therapeutics
Neoplasms

Non-invasive monitoring of stromal biophysics with targeted depletion of hyaluronan in pancreatic ductal adenocarcinoma

Maloney, E., Dufort, C. C., Provenzano, P. P., Farr, N., Carlson, M. A., Vohra, R., Park, J., Hingorani, S. R. & Lee, D., Jun 2019, In : Cancers. 11, 6, 772.

Research output: Contribution to journalArticle

Open Access
Biophysics
Hyaluronic Acid
Adenocarcinoma
Glycosaminoglycans
Collagen

The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance

Zhovmer, A. S., Tabdanov, E. D., Miao, H., Wen, H., Chen, J., Luo, X., Ma, X., Provenzano, P. P. & Adelstein, R. S., Jul 22 2019, In : Molecular biology of the cell. 30, 16, p. 1961-1973 13 p.

Research output: Contribution to journalArticle

Open Access
Actomyosin
Myosins
Cell Polarity
Microtubules
Aptitude
2018
4 Citations (Scopus)

Bimodal sensing of guidance cues in mechanically distinct microenvironments

Tabdanov, E. D. & Provenzano, P., Nov 20 2018, In : Nature Communications.

Research output: Contribution to journalArticle

cues
Fluidics
Cadherins
Cues
Adhesion

Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices

Ray, A., Morford, R. K. & Provenzano, P., Aug 1 2018, In : Current Protocols in Stem Cell Biology. 46, 1, e57.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell Movement
Collagen
Carcinoma
Extracellular Matrix
3 Citations (Scopus)

Dynamics of 3D carcinoma cell invasion into aligned collagen

Ray, A., Morford, R. K., Ghaderi, N., Odde, D. J. & Provenzano, P., Feb 1 2018, In : Integrative Biology (United Kingdom). 10, 2, p. 100-112 13 p.

Research output: Contribution to journalArticle

Collagen
Cells
Carcinoma
Tumors
Military electronic countermeasures
2 Citations (Scopus)

Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing

Tabdanov, E. D., Puram, V., Zhovmer, A. & Provenzano, P., Oct 9 2018, In : Cell reports. 25, 2, p. 328-338.e6

Research output: Contribution to journalArticle

Actomyosin
Microtubules
Tumors
Cells
Stiffness
2 Citations (Scopus)

Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer

Shao, Q., Liu, F., Chung, C., Elahi-Gedwillo, K., Provenzano, P., Forsyth, B. & Bischof, J. C., Jan 1 2018, In : Annals of Biomedical Engineering. 46, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

Tumors
Cells
Glucose
Hot Temperature
Heterografts
2017
55 Citations (Scopus)

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

Ray, A., Lee, O., Win, Z., Edwards, R. M., Alford, P. W., Kim, D. H. & Provenzano, P. P., Apr 12 2017, In : Nature communications. 8, 14923.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Movement
adhesion
Adhesion
cells
32 Citations (Scopus)

Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices

Ray, A., Slama, Z. M., Morford, R. K., Madden, S. A. & Provenzano, P. P., Mar 14 2017, In : Biophysical journal. 112, 5, p. 1023-1036 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Collagen
Cell Movement
Breast Neoplasms
Cell Size
5 Citations (Scopus)

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

Carlson, M., Watson, A. L., Anderson, L., Largaespada, D. A. & Provenzano, P. P., Nov 1 2017, In : Journal of biomedical optics. 22, 11, 116010.

Research output: Contribution to journalArticle

Open Access
Chemotherapy
chemotherapy
Doxorubicin
Tumors
tumors
2016
14 Citations (Scopus)

Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites

Jung, J. P., Bache-Wiig, M. K., Provenzano, P. & Ogle, B. M., Jan 1 2016, In : BioResearch Open Access. 5, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Extracellular Matrix Proteins
Extracellular Matrix
Collagen Type I
32 Citations (Scopus)

Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

Dufort, C. C., DelGiorno, K. E., Carlson, M. A., Osgood, R. J., Zhao, C., Huang, Z., Thompson, C. B., Connor, R. J., Thanos, C. D., Scott Brockenbrough, J., Provenzano, P. P., Frost, G. I., Michael Shepard, H. & Hingorani, S. R., May 10 2016, In : Biophysical journal. 110, 9, p. 2106-2119 14 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Gels
Pressure
Hyaluronic Acid
Extracellular Fluid
16 Citations (Scopus)

Multiscale Cues Drive Collective Cell Migration

Nam, K. H., Kim, P., Wood, D. K., Kwon, S., Provenzano, P. & Kim, D. H., Jul 27 2016, In : Scientific reports. 6, 29749.

Research output: Contribution to journalArticle

Cell Movement
Cues
Biomimetics
Anisotropy
Contracts
2012
883 Citations (Scopus)

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D. & Hingorani, S. R., Mar 20 2012, In : Cancer Cell. 21, 3, p. 418-429 12 p.

Research output: Contribution to journalArticle

Architectural Accessibility
Hyaluronic Acid
Adenocarcinoma
Extracellular Fluid
gemcitabine
2011
442 Citations (Scopus)

Aligned collagen is a prognostic signature for survival in human breast carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A. & Keely, P. J., Jan 1 2011, In : American Journal of Pathology. 178, 3, p. 1221-1232 12 p.

Research output: Contribution to journalArticle

Collagen
Breast Neoplasms
Survival
Neoplasms
Syndecan-1
236 Citations (Scopus)

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

Provenzano, P. P. & Keely, P. J., Apr 15 2011, In : Journal of cell science. 124, 8, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Focal Adhesions
Cytoskeleton
Cell Proliferation
Extracellular Matrix
2009
74 Citations (Scopus)

Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast

Conklin, M. W., Provenzano, P. P., Eliceiri, K. W., Sullivan, R. & Keely, P. J., Apr 1 2009, In : Cell biochemistry and biophysics. 53, 3, p. 145-157 13 p.

Research output: Contribution to journalArticle

Fluorophores
Optical Imaging
Tumors
Epithelium
Fluorescence
342 Citations (Scopus)

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

Provenzano, P. P., Inman, D. R., Eliceiri, K. W. & Keely, P. J., Dec 1 2009, In : Oncogene. 28, 49, p. 4326-4343 18 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Breast
Phosphotransferases
Collagen
Epithelial Cells
2008
642 Citations (Scopus)

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C. T., White, J. G. & Keely, P. J., Apr 23 2008, In : BMC medicine. 6, 11.

Research output: Contribution to journalArticle

Collagen
Breast Neoplasms
Neoplasms
Breast
Neoplasm Metastasis
285 Citations (Scopus)

Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization

Provenzano, P., Inman, D. R., Eliceiri, K. W., Trier, S. M. & Keely, P. J., Dec 1 2008, In : Biophysical journal. 95, 11, p. 5374-5384 11 p.

Research output: Contribution to journalArticle

Cell Movement
Collagen
Extracellular Matrix
rho-Associated Kinases
Neoplasms
104 Citations (Scopus)

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E. & Keely, P. J., Jan 1 2008, In : American Journal of Pathology. 173, 5, p. 1551-1565 15 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Transgenic Mice
Breast
Breast Neoplasms
Neoplasm Metastasis
50 Citations (Scopus)

Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer

Provenzano, P. P., Rueden, C. T., Trier, S. M., Yan, L., Ponik, S. M., Inman, D. R., Keely, P. J. & Eliceiri, K. W., Dec 1 2008, In : Journal of Biomedical Optics. 13, 3, 031220.

Research output: Contribution to journalArticle

Fluorophores
breast
cancer
adenines
Imaging techniques
47 Citations (Scopus)

Nonlinear optical imaging of cellular processes in breast cancer

Provenzano, P. P., Eliceiri, K. W., Yan, L., Ada-Nguema, A., Conklin, M. W., Inman, D. R. & Keely, P. J., Dec 1 2008, In : Microscopy and Microanalysis. 14, 6, p. 532-548 17 p.

Research output: Contribution to journalArticle

Harmonic generation
breast
harmonic generations
cancer
Fluorescence
2007
10 Citations (Scopus)

Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model

Grorud, K. W., Jensen, K. T., Provenzano, P. P. & Vanderby, R., Jun 1 2007, In : Journal of Orthopaedic Research. 25, 6, p. 703-712 10 p.

Research output: Contribution to journalArticle

Neuropeptides
Ligaments
Connective Tissue
Collateral Ligaments
Neuropeptide Y
33 Citations (Scopus)

Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: Evaluation of loaded and unloaded ligaments

Provenzano, P. P., Alejandro-Osorio, A. L., Grorud, K. W., Martinez, D. A., Vailas, A. C., Grindeland, R. E. & Vanderby, R., Apr 19 2007, In : BMC Physiology. 7, 2.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Ligaments
Extracellular Matrix
Hindlimb
Growth Hormone
2006
214 Citations (Scopus)

Collagen fibril morphology and organization: Implications for force transmission in ligament and tendon

Provenzano, P. P. & Vanderby, R., Mar 1 2006, In : Matrix Biology. 25, 2, p. 71-84 14 p.

Research output: Contribution to journalArticle

Ligaments
Tendons
Collagen
Felidae
Proteoglycans
774 Citations (Scopus)

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G. & Keely, P. J., Dec 1 2006, In : BMC medicine. 4, 38.

Research output: Contribution to journalArticle

Collagen
Neoplasms
Breast Neoplasms
Breast
Human Mammary Glands
2005
44 Citations (Scopus)

Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo

Provenzano, P. P., Alejandro-Osorio, A. L., Valhmu, W. B., Jensen, K. T. & Vanderby, R., Jan 1 2005, In : Matrix Biology. 23, 8, p. 543-555 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Cicatrix
Collagen
Proteoglycans
Collagen Type I
2004
23 Citations (Scopus)

Blockade of the sympathetic nervous system degrades ligament in a rat MCL model

Dwyer, K. W., Provenzano, P. P., Muir, P., Valhmu, W. B. & Vanderby, R., Feb 1 2004, In : Journal of applied physiology. 96, 2, p. 711-718 8 p.

Research output: Contribution to journalArticle

Guanethidine
Collateral Ligaments
Sympathetic Nervous System
Ligaments
Matrix Metalloproteinase 13
69 Citations (Scopus)

Nonlinear viscoelasticity in rabbit medial collateral ligament

Hingorani, R. V., Provenzano, P. P., Lakes, R. S., Escarcega, A. & Vanderby, R., Feb 1 2004, In : Annals of Biomedical Engineering. 32, 2, p. 306-312 7 p.

Research output: Contribution to journalArticle

Ligaments
Viscoelasticity
Creep
Stress relaxation
Tissue
2003
25 Citations (Scopus)
Toes
Statistical Models
Connective Tissue
Tissue
Fibers
40 Citations (Scopus)

Hindlimb unloading alters ligament healing

Provenzano, P. P., Martinez, D. A., Grindeland, R. E., Dwyer, K. W., Turner, J., Vailas, A. C. & Vanderby, R., Jan 1 2003, In : Journal of Applied Physiology. 94, 1, p. 314-324 11 p.

Research output: Contribution to journalArticle

Hindlimb Suspension
Ligaments
Connective Tissue
Thigh
Cicatrix
6 Citations (Scopus)

Required test duration for group comparisons in ligament viscoelasticity: A statistical approach

Manley, E., Provenzano, P. P., Heisey, D., Lakes, R. & Vanderby, R., Jun 20 2003, In : Biorheology. 40, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

Ligaments
32 Citations (Scopus)

Scanning electron microscopic characterization of healing and normal rat ligament microstructure under slack and loaded conditions

Hurschler, C., Provenzano, P. P. & Vanderby, R., Jan 1 2003, In : Connective Tissue Research. 44, 2, p. 59-68 10 p.

Research output: Contribution to journalArticle

Ligaments
Rats
Electrons
Scanning
Microstructure
2002
4 Citations (Scopus)

A boundary layer model for wall shear stress in arterial stenosis

Provenzano, P. P. & Rutland, C. J., Jan 1 2002, In : Biorheology. 39, 6, p. 743-754 12 p.

Research output: Contribution to journalArticle

Pathologic Constriction
Constriction
Blood Vessels
Thrombosis
Research Personnel
101 Citations (Scopus)

Application of nonlinear viscoelastic models to describe ligament behavior

Provenzano, P. P., Lakes, R. S., Corr, D. T. & Vanderby, R., Jun 1 2002, In : Biomechanics and Modeling in Mechanobiology. 1, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

Viscoelastic Model
ligaments
Nonlinear Dynamics
Ligaments
Nonlinear Model
39 Citations (Scopus)

Healing of subfailure ligament injury: Comparison between immature and mature ligaments in a rat model

Provenzano, P. P., Hayashi, K., Kunz, D. N., Markel, M. D. & Vanderby, R., Jan 1 2002, In : Journal of Orthopaedic Research. 20, 5, p. 975-983 9 p.

Research output: Contribution to journalArticle

Ligaments
Wounds and Injuries
Ankle Lateral Ligament
Sprains and Strains
Joint Instability
138 Citations (Scopus)

Subfailure damage in ligament: A structural and cellular evaluation

Provenzano, P. P., Heisey, D., Hayashi, K., Lakesand, R. & Vanderby, R., Jul 3 2002, In : Journal of applied physiology. 92, 1, p. 362-371 10 p.

Research output: Contribution to journalArticle

Ligaments
Collateral Ligaments
Toes
Cell Count
Fluorescence
2001
20 Citations (Scopus)

Microstructural morphology in the transition region between scar and intact residual segments of a healing rat medial collateral ligament

Provenzano, P. P., Hurschler, C. & Vanderby R., J., Jan 1 2001, In : Connective Tissue Research. 42, 2, p. 123-133 11 p.

Research output: Contribution to journalArticle

Collateral Ligaments
Ligaments
Cicatrix
Rats
Tissue
172 Citations (Scopus)

Nonlinear ligament viscoelasticity

Provenzano, P., Lakes, R., Keenan, T. & Vanderby, R., Dec 31 2001, In : Annals of Biomedical Engineering. 29, 10, p. 908-914 7 p.

Research output: Contribution to journalArticle

Ligaments
Viscoelasticity
Creep
Tissue
Stress relaxation